Details of the Target

General Information of Target

Target ID LDTP09524
Target Name Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B)
Gene Name UBASH3B
Gene ID 84959
Synonyms
KIAA1959; STS1; Ubiquitin-associated and SH3 domain-containing protein B; EC 3.1.3.48; Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; STS-1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALAS
TGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKA
HNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKED
SAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGC
DWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTS
LTTGCSGLLPENYITKADECSTWIFHGSYSILNTSSSNSLTFGDGVLERRPYEDQGLGET
TPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLN
MPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHN
ILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKL
VVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQ
MVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Uniprot ID
Q8TF42
Ensemble ID
ENST00000284273.6
HGNC ID
HGNC:29884

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.72  LDD0403  [1]
DBIA
 Probe Info  		C407(1.51)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C446(0.00); C240(0.00); C468(0.00); C367(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C474(0.00); C446(0.00); C240(0.00); C468(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C474(0.00); C564(0.00); C240(0.00); C468(0.00)  LDD0037  [3]
W1
 Probe Info  		N.A.  LDD0236  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C367(3.91)  LDD0371  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C367(3.36)  LDD0372  [5]
 LDCM0214  AC1 HCT 116 C407(1.51)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C240(0.57)  LDD1094  [2]
 LDCM0216  AC100 PaTu 8988t C240(1.46)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C240(1.72)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C240(2.12)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C240(1.06)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C240(1.30)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C240(1.10)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C240(1.07)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C240(0.82)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C240(1.05)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C240(1.58)  LDD1104  [2]
 LDCM0226  AC11 PaTu 8988t C240(0.46)  LDD1105  [2]
 LDCM0227  AC110 PaTu 8988t C240(2.20)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C240(1.14)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C240(1.44)  LDD1108  [2]
 LDCM0230  AC113 HCT 116 C407(0.93)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C407(0.96)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C407(0.90)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C407(1.12)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C407(0.95)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C407(1.18)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C407(0.97)  LDD0553  [2]
 LDCM0237  AC12 PaTu 8988t C240(0.49)  LDD1116  [2]
 LDCM0238  AC120 HCT 116 C407(1.12)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C407(0.97)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C407(1.13)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C407(1.13)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C407(1.04)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C407(1.17)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C407(1.10)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C407(1.15)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C407(0.75)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C407(1.15)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C407(0.73)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C407(1.03)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C407(1.30)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C407(0.95)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C407(0.95)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C407(0.91)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C407(0.93)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C407(1.03)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C407(0.99)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C407(0.92)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C240(1.01)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C407(1.03)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C407(0.97)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C407(1.06)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C407(0.76)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C407(0.55)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C407(0.78)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C407(0.52)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C407(0.51)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C407(0.40)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C407(0.45)  LDD0586  [2]
 LDCM0270  AC15 PaTu 8988t C240(0.61)  LDD1149  [2]
 LDCM0271  AC150 HCT 116 C407(0.77)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C407(0.74)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C407(0.46)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C407(0.33)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C407(0.53)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C407(0.57)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C407(0.73)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C407(0.80)  LDD2161  [2]
 LDCM0276  AC17 PaTu 8988t C407(0.88)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C407(0.69)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C407(0.97)  LDD1157  [2]
 LDCM0279  AC2 HCT 116 C407(1.14)  LDD0596  [2]
 LDCM0280  AC20 PaTu 8988t C407(0.76)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C407(0.78)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C407(0.69)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C407(0.55)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C407(0.60)  LDD1163  [2]
 LDCM0285  AC25 HCT 116 C407(1.03)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C407(0.77)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C407(0.69)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C407(0.76)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C407(0.46)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C407(1.21)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C407(0.48)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C407(0.55)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C407(0.50)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C407(0.74)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C407(0.67)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C367(2.96); C407(0.51); C240(0.77)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C367(0.97); C407(0.38); C240(0.57)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C367(1.09); C407(0.80); C240(1.07)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C367(0.59); C407(0.48); C240(0.65)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C367(0.75); C407(0.37); C240(0.54)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C407(1.57)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C367(1.04); C407(0.35); C240(0.57)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C367(1.31); C407(1.04); C240(0.91)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C367(0.95); C407(0.83); C240(1.02)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C367(0.79); C407(0.76); C240(0.76)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C367(1.75); C407(0.76); C240(0.64)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C367(1.99); C407(0.86); C240(1.24)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C407(0.91); C240(0.50)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C407(0.85); C240(0.52)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C407(0.82); C240(0.50)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C407(0.72); C240(0.25)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C407(1.43)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C407(0.70); C240(0.20)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C407(0.88); C240(0.68)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C407(0.66); C240(0.49)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C407(0.56); C240(0.20)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C407(0.56); C240(0.18)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C407(0.77); C240(0.48)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C407(0.62); C240(0.33)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C407(1.19)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C407(1.18)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C407(0.85)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C240(0.72)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C407(0.87)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C407(1.01)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C407(0.99)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C407(0.99)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C407(0.96)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C407(1.00)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C407(0.97)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C407(0.81)  LDD0648  [2]
 LDCM0332  AC68 PaTu 8988t C240(1.03)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C240(0.72)  LDD1212  [2]
 LDCM0334  AC7 PaTu 8988t C240(1.07)  LDD1213  [2]
 LDCM0335  AC70 PaTu 8988t C240(1.06)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C240(1.08)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C240(1.70)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C240(1.20)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C240(1.17)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C240(0.82)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C240(1.09)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C240(0.89)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C240(1.30)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C240(0.86)  LDD1223  [2]
 LDCM0345  AC8 PaTu 8988t C240(0.94)  LDD1224  [2]
 LDCM0346  AC80 PaTu 8988t C240(1.02)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C240(1.13)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C240(1.63)  LDD1227  [2]
 LDCM0349  AC83 HCT 116 C407(1.04)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C407(0.87)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C407(0.71)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C407(0.84)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C407(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C407(0.98)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C407(0.81)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C407(0.98)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C407(0.83)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C407(0.98)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C407(0.99)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C407(0.91)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C407(1.11)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C407(0.82)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C407(0.82)  LDD0681  [2]
 LDCM0365  AC98 PaTu 8988t C240(1.50)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C240(1.23)  LDD1245  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C240(0.84)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C240(0.30)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C240(0.44)  LDD1154  [2]
 LDCM0156  Aniline NCI-H1299 12.72  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C367(1.64)  LDD2214  [6]
 LDCM0367  CL1 HCT 116 C407(0.89)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C407(0.54)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C407(1.36)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C240(0.83)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C240(0.63)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C240(0.55)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C240(0.92)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C407(0.90)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C407(0.87)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C407(0.88)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C407(0.86)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C407(0.81)  LDD1257  [2]
 LDCM0379  CL11 HCT 116 C407(0.53)  LDD0696  [2]
 LDCM0380  CL110 PaTu 8988t C407(0.49)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C407(0.49)  LDD1260  [2]
 LDCM0382  CL112 HCT 116 C407(0.75)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C407(0.50)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C407(0.42)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C407(0.58)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C407(0.74)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C367(0.93); C407(0.84); C240(0.85)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C367(1.00); C407(0.93); C240(1.14)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C367(1.06); C407(0.74); C240(0.64)  LDD1268  [2]
 LDCM0390  CL12 HCT 116 C407(0.70)  LDD0707  [2]
 LDCM0391  CL120 PaTu 8988t C367(1.00); C407(0.48); C240(0.61)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C407(0.93); C240(0.44)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C407(0.71); C240(0.41)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C407(0.58); C240(0.37)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C407(0.67); C240(0.30)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C407(0.99)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C407(1.01)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C407(0.86)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C407(1.09)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C407(0.61)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C407(0.81)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C407(0.56)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C407(0.76)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C407(0.66)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C407(0.39)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C407(0.53)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C407(1.05)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C407(0.58)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C407(0.40)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C407(0.41)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C407(0.62)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C407(0.47)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C407(0.48)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C407(0.70)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C407(0.78)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C407(0.48)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C407(0.53)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C407(0.96)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C407(0.75)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C407(0.74)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C407(0.52)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C407(0.61)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C407(0.50)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C407(0.68)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C407(0.66)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C407(0.58)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C407(0.61)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C407(0.87)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C407(0.72)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C407(0.76)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C407(0.49)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C407(0.51)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C407(0.45)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C407(0.38)  LDD0752  [2]
 LDCM0436  CL46 PaTu 8988t C367(1.22); C240(0.94)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C367(0.95); C240(0.95)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C367(0.98); C240(0.93)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C367(1.45); C240(0.84)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C407(0.98)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C367(1.13); C240(1.03)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C367(1.12); C240(0.66)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C367(1.75); C240(0.69)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C367(1.40); C240(0.40)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C367(0.93); C240(0.79)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C367(2.28); C240(0.77)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C367(1.15); C240(0.63)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C367(1.40); C240(0.67)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C367(1.02); C240(0.83)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C367(1.16); C240(0.97)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C407(0.57)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C367(1.45); C240(0.78)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C407(0.86)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C407(0.82)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C407(0.80)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C407(0.60)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C407(0.76)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C407(0.44)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C407(0.56)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C407(0.48)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C407(0.50)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C407(0.72)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C407(0.56)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C407(0.62)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C407(0.88)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C407(0.63)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C407(0.67)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C407(0.60)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C407(0.71)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C407(0.79)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C407(0.56)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C407(0.64)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C407(0.54)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C407(0.69)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C407(0.45)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C407(0.46)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C407(0.45)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C407(0.73)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C407(0.87)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C407(0.63)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C407(0.48)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C407(0.36)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C407(0.86)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C407(0.83)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C407(0.75)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C407(0.91)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C407(1.17)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C407(1.46)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C407(1.05)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C407(0.99)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C407(0.97)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C407(1.06)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C407(1.18)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C407(0.61)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C407(0.51)  LDD0744  [2]
 LDCM0022  KB02 42-MG-BA C240(1.36)  LDD2244  [7]
 LDCM0023  KB03 42-MG-BA C240(2.80); C70(1.34)  LDD2661  [7]
 LDCM0024  KB05 COLO792 C474(2.71)  LDD3310  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-1 (TNKS) ARTD/PARP family O95271
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 25 member 48 (SLC25A48) Mitochondrial carrier (TC 2.A.29) family Q6ZT89
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B2 (HOXB2) Antp homeobox family P14652
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM168A (FAM168A) FAM168 family Q92567
Protein INCA1 (INCA1) INCA family Q0VD86
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Actin nucleation-promoting factor WASL (WASL) . O00401
Bcl-2-binding component 3, isoforms 3/4 (BBC3) . Q96PG8
DAZ-associated protein 2 (DAZAP2) . Q15038
Double C2-like domain-containing protein alpha (DOC2A) . Q14183
Keratinocyte proline-rich protein (KPRP) . Q5T749
Proline-rich protein 35 (PRR35) . P0CG20

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840