Details of the Target

General Information of Target

Target ID LDTP08814
Target Name Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)
Gene Name GPD1L
Gene ID 23171
Synonyms
KIAA0089; Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDH
ENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITL
IKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK
ELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF
ARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQ
GPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT
Target Bioclass
Enzyme
Family
NAD-dependent glycerol-3-phosphate dehydrogenase family
Subcellular location
Cytoplasm
Function
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Uniprot ID
Q8N335
Ensemble ID
ENST00000282541.10
HGNC ID
HGNC:28956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y65(12.07)  LDD0257  [1]
BTD
 Probe Info  		C104(1.28)  LDD1699  [2]
Probe 1
 Probe Info  		Y309(225.87)  LDD3495  [3]
DBIA
 Probe Info  		C164(7.34); C104(7.43)  LDD0209  [4]
IPM
 Probe Info  		C343(2.20)  LDD1701  [2]
HHS-465
 Probe Info  		Y65(9.25)  LDD2237  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C164(0.00); C104(0.00); C202(0.00); C216(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C164(0.00); C331(0.00); C343(0.00); C104(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C164(0.00); C202(0.00); C216(0.00); C343(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Phosphinate-6
 Probe Info  		C202(0.00); C331(0.00)  LDD0018  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		C164(0.00); C104(0.00); C202(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C164(0.00); C343(0.00); C331(0.00); C104(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C164(0.64)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C164(0.74)  LDD2130  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C164(0.55)  LDD2131  [2]
 LDCM0214  AC1 HCT 116 C104(1.02); C164(1.18)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C104(1.32)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C164(0.68); C216(0.61); C9(0.73)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C164(0.88); C216(0.50); C9(0.81)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C164(0.74); C216(0.38); C9(0.73)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C164(0.40); C216(0.27); C9(0.26)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C164(0.52); C216(0.30); C9(0.41)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C164(0.56); C216(0.32); C9(0.39)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C164(0.59); C216(0.27); C9(0.38)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C164(0.57); C216(0.34); C9(0.56)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C164(0.66); C216(0.30); C9(0.41)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C164(0.61); C216(0.28); C9(0.41)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C104(1.24)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C164(0.60); C216(0.33); C9(0.37)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C164(0.67); C216(0.53); C9(0.35)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C164(0.65); C216(0.37); C9(0.49)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C164(1.00)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C164(0.90)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C164(0.65)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C164(0.51)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C164(0.88)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C164(0.81)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C164(0.84)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C104(1.17)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C164(0.74)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C164(0.86)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C164(1.36)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C164(0.92)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C164(0.98)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C164(0.93)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C164(0.66)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C164(0.79)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C164(0.60)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C164(1.27)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C164(0.80)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C164(0.96)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C164(1.17)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C164(1.09)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C164(0.82)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C164(0.84)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C164(1.04)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C164(1.37)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C164(1.01)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C164(1.21)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C104(1.28)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C164(0.92)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C164(1.07)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C164(1.27)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C164(0.75); C216(0.85)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C164(0.48); C216(0.70)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C164(0.95); C216(1.03)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C164(0.93); C216(0.95)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C164(0.39); C216(0.68)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C164(0.22); C216(0.32)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C164(0.34); C216(0.65)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C104(1.42)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C164(1.06); C216(1.15)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C216(1.18); C164(1.28)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C164(0.32); C216(0.41)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C164(0.24); C216(0.29)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C164(0.59); C216(0.75)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C164(0.72); C216(0.74)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C164(0.99); C216(1.03)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C164(0.78); C216(1.28)  LDD2161  [16]
 LDCM0276  AC17 PaTu 8988t C258(1.01); C267(1.01)  LDD1155  [16]
 LDCM0277  AC18 PaTu 8988t C258(0.47); C267(0.47)  LDD1156  [16]
 LDCM0278  AC19 PaTu 8988t C258(0.67); C267(0.67)  LDD1157  [16]
 LDCM0279  AC2 HCT 116 C164(0.98); C104(1.09)  LDD0596  [16]
 LDCM0280  AC20 PaTu 8988t C258(0.52); C267(0.52)  LDD1159  [16]
 LDCM0281  AC21 PaTu 8988t C258(0.49); C267(0.49)  LDD1160  [16]
 LDCM0282  AC22 PaTu 8988t C258(0.48); C267(0.48)  LDD1161  [16]
 LDCM0283  AC23 PaTu 8988t C258(0.45); C267(0.45)  LDD1162  [16]
 LDCM0284  AC24 PaTu 8988t C258(1.27); C267(1.27)  LDD1163  [16]
 LDCM0285  AC25 PaTu 8988t C258(0.96); C267(0.96)  LDD1164  [16]
 LDCM0286  AC26 PaTu 8988t C258(1.11); C267(1.11)  LDD1165  [16]
 LDCM0287  AC27 PaTu 8988t C258(0.88); C267(0.88)  LDD1166  [16]
 LDCM0288  AC28 PaTu 8988t C258(0.77); C267(0.77)  LDD1167  [16]
 LDCM0289  AC29 PaTu 8988t C258(0.90); C267(0.90)  LDD1168  [16]
 LDCM0290  AC3 HCT 116 C104(0.98); C164(1.11)  LDD0607  [16]
 LDCM0291  AC30 PaTu 8988t C258(0.64); C267(0.64)  LDD1170  [16]
 LDCM0292  AC31 PaTu 8988t C258(0.99); C267(0.99)  LDD1171  [16]
 LDCM0293  AC32 PaTu 8988t C258(1.18); C267(1.18)  LDD1172  [16]
 LDCM0294  AC33 PaTu 8988t C258(0.96); C267(0.96)  LDD1173  [16]
 LDCM0295  AC34 PaTu 8988t C258(0.59); C267(0.59)  LDD1174  [16]
 LDCM0296  AC35 HCT 116 C104(1.69); C216(2.03)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C104(1.50); C216(2.85)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C104(1.00); C216(1.77)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C104(1.73); C216(2.03)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C216(1.12); C104(1.27)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C164(1.08); C104(1.13)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C216(0.70); C104(1.01)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C104(1.64); C216(1.71)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C216(1.11); C104(1.13)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C216(1.51); C104(1.58)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C216(1.03); C104(1.25)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C216(0.63); C104(0.95)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C104(1.23); C216(1.29)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C216(1.09); C104(1.11)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C104(1.17); C216(1.44)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C216(0.50); C104(1.01)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C164(1.12); C104(1.24)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C216(0.60); C104(0.96)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C104(0.95); C216(1.82)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C104(0.78); C216(1.16)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C216(0.64); C104(0.93)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C216(0.50); C104(0.96)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C216(0.66); C104(0.94)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C216(0.54); C104(0.87)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C164(0.65); C216(0.65); C104(0.71)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C104(0.60); C216(0.66); C164(0.74)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C216(0.37); C164(0.52); C104(0.55)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C104(1.35)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C216(0.78); C104(0.80); C164(1.03)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C216(1.12); C104(1.24); C164(1.26)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C216(0.35); C164(0.45); C104(0.60)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C216(0.68); C164(0.85); C104(0.86)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C216(0.36); C104(0.50); C164(0.50)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C216(0.62); C164(0.77); C104(0.80)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C216(0.79); C164(0.95); C104(1.07)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C216(0.28); C104(0.44); C164(0.45)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C216(0.64); C9(0.68); C164(0.91)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C9(0.50); C216(0.54); C164(0.91)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C104(1.10)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C216(0.31); C9(0.34); C164(0.81)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C164(0.90); C9(1.04); C216(1.58)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C9(0.40); C216(0.50); C164(1.10)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C216(0.31); C9(0.34); C164(1.00)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C216(0.29); C9(0.37); C164(1.13)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C216(0.38); C9(0.42); C164(0.98)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C216(0.41); C9(0.44); C164(1.00)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C9(0.36); C216(0.44); C164(0.75)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C9(0.75); C216(0.81); C164(0.83)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C216(0.68); C9(0.70); C164(0.99)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C104(1.12)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C216(0.45); C9(0.48); C164(1.09)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C216(0.77); C9(0.78); C164(0.92)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C216(0.28); C9(0.38); C164(0.90)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C9(0.25); C164(0.37); C104(0.79)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C9(0.31); C164(0.41); C104(1.13)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C104(0.80); C164(0.88); C9(0.92)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C9(0.92); C104(0.95); C164(1.04)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C164(0.81); C104(0.94); C9(1.09)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C104(0.77); C164(0.88); C9(0.89)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C9(0.46); C164(0.56); C104(0.86)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C164(1.02); C104(1.16); C9(2.32)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C9(0.21); C164(0.30); C104(0.95)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C9(0.26); C164(0.29); C104(0.86)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C9(0.78); C164(0.82); C104(0.94)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C104(0.89); C164(1.22); C9(1.47)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C104(0.89); C9(1.04); C164(1.09)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C9(0.67); C164(0.77); C104(0.90)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C9(0.33); C164(0.47); C104(0.93)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C216(0.11); C9(0.16); C164(0.18)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C216(0.80); C164(0.82); C9(0.87)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C104(1.12)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C104(1.27)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C104(1.03)  LDD0592  [16]
 LDCM0020  ARS-1620 HCC44 C258(1.04); C267(1.04)  LDD2171  [16]
 LDCM0108  Chloroacetamide HeLa C343(0.00); C216(0.00); C202(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C202(2.81); C104(2.04); C216(0.69)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C216(0.59); C164(0.78)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C216(0.24); C164(0.65)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C164(1.09); C104(1.19)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C104(1.03)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C104(1.50)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C104(1.08)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C104(1.08)  LDD0690  [16]
 LDCM0374  CL105 PaTu 8988t C258(0.87); C267(0.87)  LDD1253  [16]
 LDCM0375  CL106 PaTu 8988t C258(1.17); C267(1.17)  LDD1254  [16]
 LDCM0376  CL107 PaTu 8988t C258(0.91); C267(0.91)  LDD1255  [16]
 LDCM0377  CL108 PaTu 8988t C258(0.96); C267(0.96)  LDD1256  [16]
 LDCM0378  CL109 PaTu 8988t C258(0.73); C267(0.73)  LDD1257  [16]
 LDCM0379  CL11 HCT 116 C216(0.17); C164(0.47)  LDD0696  [16]
 LDCM0380  CL110 PaTu 8988t C258(0.66); C267(0.66)  LDD1259  [16]
 LDCM0381  CL111 PaTu 8988t C258(0.41); C267(0.41)  LDD1260  [16]
 LDCM0382  CL112 PaTu 8988t C258(0.89); C267(0.89)  LDD1261  [16]
 LDCM0383  CL113 PaTu 8988t C258(1.33); C267(1.33)  LDD1262  [16]
 LDCM0384  CL114 PaTu 8988t C258(1.09); C267(1.09)  LDD1263  [16]
 LDCM0385  CL115 PaTu 8988t C258(0.92); C267(0.92)  LDD1264  [16]
 LDCM0386  CL116 PaTu 8988t C258(0.98); C267(0.98)  LDD1265  [16]
 LDCM0387  CL117 HCT 116 C216(0.50); C104(0.90)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C216(0.98); C104(1.30)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C216(0.75); C104(1.05)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C216(0.19); C164(0.41)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C216(1.83); C104(2.36)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C216(1.02); C104(1.05)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C104(0.99); C216(1.10)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C216(0.61); C104(1.02)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C216(0.59); C104(0.90)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C104(0.76); C164(1.19); C216(1.33)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C216(0.83); C164(1.11); C104(1.26)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C104(1.09); C164(1.12); C216(1.43)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C216(0.44); C104(0.57); C164(0.58)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C216(0.47); C164(0.79)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C216(0.56); C164(0.83)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C216(0.34); C164(0.87)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C216(0.96); C164(0.97)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C104(0.89); C164(0.93); C216(0.96)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C216(0.86); C104(0.97); C164(1.08)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C104(0.73); C216(0.94); C164(1.00)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C216(0.75); C164(0.89)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C216(0.44); C164(0.55); C104(0.85)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C216(0.30); C164(0.49); C104(0.78)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C216(0.29); C164(0.50); C104(0.93)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C216(0.58); C104(0.71); C164(0.71)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C216(0.27); C164(0.51); C104(0.77)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C104(0.69); C164(0.52); C216(0.33)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C104(0.70); C164(0.69); C216(0.59)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C104(0.81); C164(0.92); C216(0.84)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C104(0.82); C164(0.66); C216(0.48)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C104(0.76); C164(0.67); C216(0.49)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C164(1.05); C216(1.22)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C104(0.77); C164(0.85); C216(0.78)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C104(0.88); C164(0.91); C9(0.96)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C164(1.01); C9(0.75)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C164(0.88); C9(0.58)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C164(0.70); C9(0.30)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C164(0.68); C9(0.34)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C164(0.63); C9(0.26)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C164(0.59); C9(0.25)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C164(0.62); C9(0.33)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C164(0.94); C216(0.58)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C164(0.65); C9(0.40)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C164(0.78); C9(0.59)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C164(0.53); C9(0.26)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C164(0.58); C9(0.29)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C164(0.79); C9(0.44)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C164(0.64); C9(0.39)  LDD0752  [16]
 LDCM0436  CL46 PaTu 8988t C164(0.88); C258(0.53); C267(0.53)  LDD1315  [16]
 LDCM0437  CL47 PaTu 8988t C164(0.73); C258(0.49); C267(0.49)  LDD1316  [16]
 LDCM0438  CL48 PaTu 8988t C164(0.95); C258(1.22); C267(1.22)  LDD1317  [16]
 LDCM0439  CL49 PaTu 8988t C164(1.22); C258(0.60); C267(0.60)  LDD1318  [16]
 LDCM0440  CL5 HCT 116 C164(0.89); C216(0.44)  LDD0757  [16]
 LDCM0441  CL50 PaTu 8988t C164(1.03); C258(0.36); C267(0.36)  LDD1320  [16]
 LDCM0442  CL51 PaTu 8988t C164(0.88); C258(0.42); C267(0.42)  LDD1321  [16]
 LDCM0443  CL52 PaTu 8988t C164(1.02); C258(0.58); C267(0.58)  LDD1322  [16]
 LDCM0444  CL53 PaTu 8988t C164(0.87); C258(0.42); C267(0.42)  LDD1323  [16]
 LDCM0445  CL54 PaTu 8988t C164(1.03); C258(0.69); C267(0.69)  LDD1324  [16]
 LDCM0446  CL55 PaTu 8988t C164(1.12); C258(0.71); C267(0.71)  LDD1325  [16]
 LDCM0447  CL56 PaTu 8988t C164(0.24); C258(0.15); C267(0.15)  LDD1326  [16]
 LDCM0448  CL57 PaTu 8988t C164(0.38); C258(0.25); C267(0.25)  LDD1327  [16]
 LDCM0449  CL58 PaTu 8988t C164(0.59); C258(0.32); C267(0.32)  LDD1328  [16]
 LDCM0450  CL59 PaTu 8988t C164(0.35); C258(0.24); C267(0.24)  LDD1329  [16]
 LDCM0451  CL6 HCT 116 C164(0.96); C216(0.44)  LDD0768  [16]
 LDCM0452  CL60 PaTu 8988t C164(0.39); C258(0.20); C267(0.20)  LDD1331  [16]
 LDCM0453  CL61 PaTu 8988t C216(1.02); C164(1.41); C258(1.30); C267(1.30)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C216(0.62); C164(1.83); C258(1.37); C267(1.37)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C216(0.67); C164(1.61); C258(0.98); C267(0.98)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C216(0.67); C164(0.97); C258(1.33); C267(1.33)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C216(0.97); C164(1.00); C258(0.93); C267(0.93)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C216(0.64); C164(1.00); C258(1.03); C267(1.03)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C216(0.35); C164(0.50); C258(0.77); C267(0.77)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C216(1.01); C164(0.51); C258(0.78); C267(0.78)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C216(0.48); C164(0.47); C258(0.72); C267(0.72)  LDD1340  [16]
 LDCM0462  CL7 HCT 116 C164(0.56); C216(0.21)  LDD0779  [16]
 LDCM0463  CL70 PaTu 8988t C216(1.23); C164(0.51); C258(0.94); C267(0.94)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C216(0.71); C164(1.35); C258(1.05); C267(1.05)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C216(0.74); C164(1.25); C258(0.77); C267(0.77)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C216(0.54); C164(0.48); C258(0.97); C267(0.97)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C216(0.74); C164(1.45); C258(0.97); C267(0.97)  LDD1346  [16]
 LDCM0469  CL76 HCT 116 C104(0.81)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C104(0.87)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C104(0.87)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C104(0.66)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C164(0.37); C216(0.14)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C104(0.92)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C104(0.82)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C104(0.48)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C104(0.64)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C104(0.51)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C104(0.73)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C104(0.77)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C104(0.64)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C104(0.45)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C104(0.40)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C164(0.78); C216(0.37)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C104(0.88)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C104(1.01); C164(0.85)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C104(0.91); C164(0.97)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C104(0.93); C164(1.13)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C104(0.94); C164(0.95)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C104(0.93); C164(0.86)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C104(0.95); C164(1.10)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C104(1.08); C164(1.03)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C104(1.10); C164(1.06)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C104(1.19); C164(1.01)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C104(0.90); C164(0.86); C9(1.00); C216(1.14)  LDD1698  [17]
 LDCM0625  F8 Ramos C164(1.19); C104(1.66); C9(1.08); C202(0.82)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C164(0.87); C104(0.66); C9(0.70)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C164(6.32); C9(0.12)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C104(1.12)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C164(1.32); C104(0.68); C9(0.88); C202(0.89)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C104(1.52); C9(1.43); C202(1.73)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C164(2.66); C104(1.29); C9(2.28)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C164(1.20); C104(0.86); C9(0.83); C202(1.23)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C104(1.46); C9(0.66)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C164(1.15); C104(0.73); C9(0.88); C202(0.91)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C164(0.75); C104(0.65); C9(0.73); C202(1.14)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C164(1.25); C104(0.73); C9(0.86); C202(0.53)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C164(1.19); C104(0.77); C9(1.02)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C164(1.79); C104(0.63); C9(0.79)  LDD2201  [18]
 LDCM0468  Fragment33 PaTu 8988t C216(0.53); C164(0.87); C258(1.15); C267(1.15)  LDD1347  [16]
 LDCM0596  Fragment38 Ramos C164(1.26); C104(0.75); C9(0.56); C202(0.44)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C164(1.19); C104(1.26); C9(1.00)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C164(0.45); C9(0.26)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C164(1.13); C104(1.15); C9(0.84); C202(0.58)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C164(1.20); C104(1.15); C9(0.77); C202(0.44)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C164(1.28); C104(1.24); C9(1.05)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C164(3.41); C104(2.66); C9(1.54)  LDD2188  [18]
 LDCM0107  IAA HeLa C202(0.00); C216(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C104(0.93); C164(0.93); C9(1.02); C216(0.85)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C164(7.34); C104(7.43)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C164(1.27)  LDD3310  [19]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C104(0.90)  LDD2099  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C164(0.97); C104(1.16)  LDD2111  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C164(1.18)  LDD2137  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C104(1.52)  LDD2144  [2]
 LDCM0021  THZ1 HCT 116 C258(1.04); C267(1.04)  LDD2173  [16]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840