Details of the Target

General Information of Target

Target ID LDTP08710
Target Name Abl interactor 1 (ABI1)
Gene Name ABI1
Gene ID 10006
Synonyms
SSH3BP1; Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVI
AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI
SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD
YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND
DGWYEGVCNRVTGLFPGNYVESIMHYTD
Target Bioclass
Other
Family
ABI family
Subcellular location
Cytoplasm
Function
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Uniprot ID
Q8IZP0
Ensemble ID
ENST00000346832.10
HGNC ID
HGNC:11320

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K159(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y23(10.97); Y457(21.46)  LDD3495  [2]
HHS-475
 Probe Info  		Y333(0.56)  LDD0264  [3]
HHS-465
 Probe Info  		Y333(10.00)  LDD2237  [4]
Acrolein
 Probe Info  		C33(0.00); C488(0.00)  LDD0222  [5]
DBIA
 Probe Info  		C488(1.66)  LDD0080  [6]
5E-2FA
 Probe Info  		H321(0.00); H151(0.00); H224(0.00); H239(0.00)  LDD2235  [7]
m-APA
 Probe Info  		H321(0.00); H239(0.00); H151(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C488(0.00); C33(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C488(0.00); C33(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C488(0.00); C33(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD0147  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
NAIA_5
 Probe Info  		C488(0.00); C33(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C33(0.75); C488(0.79)  LDD0812  [6]
 LDCM0215  AC10 HCT 116 C33(0.82); C488(0.73)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C33(1.38); C488(0.61)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C33(0.95); C488(0.65)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C33(1.21); C488(0.48)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C33(1.27); C488(0.43)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C33(1.25); C488(0.38)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C33(1.23); C488(0.46)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C33(1.83); C488(0.64)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C33(1.44); C488(0.51)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C33(1.19); C488(0.53)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C33(1.34); C488(0.52)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C33(0.65); C488(0.88)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C33(1.10); C488(0.51)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C33(1.03); C488(0.51)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C33(1.34); C488(0.53)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C33(0.97); C488(1.15)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C33(0.86); C488(0.89)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C33(0.92); C488(0.63)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C33(1.03); C488(0.71)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C33(1.56); C488(0.94)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C33(1.14); C488(1.06)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C33(1.10); C488(0.96)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C33(0.82); C488(1.14)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C33(0.81); C488(0.44)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C33(1.74); C488(1.29)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C33(0.98); C488(1.11)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C33(1.90); C488(1.39)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C33(1.23); C488(1.78)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C33(0.73); C488(0.86)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C33(0.91); C488(0.62)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C33(1.12); C488(0.65)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C33(0.53); C488(0.82)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C33(0.47); C488(1.98)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C33(0.41); C488(1.21)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C33(0.42); C488(1.48)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C33(0.48); C488(2.00)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C33(0.40); C488(1.29)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C33(0.47); C488(1.11)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C33(0.50); C488(1.28)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C33(0.43); C488(1.04)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C33(0.46); C488(1.27)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C33(0.39); C488(1.24)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C33(0.42); C488(1.70)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C33(0.66); C488(1.06)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C33(0.40); C488(1.16)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C33(0.40); C488(1.79)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C33(0.40); C488(2.33)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C488(0.74)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C488(0.42)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C488(0.57)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C488(0.43)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C488(0.35)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C488(0.24)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C488(0.35)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C33(0.82); C488(1.10)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C488(0.68)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C488(0.70)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C488(0.31)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C488(0.22)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C488(0.42)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C488(0.50)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C488(0.91)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C488(0.85)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C33(0.76); C488(0.99)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C488(0.29); C33(0.63)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C33(0.68); C488(0.89)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C33(0.86); C488(0.74)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C488(0.82); C33(0.83)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C488(0.65); C33(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C488(1.08); C33(1.10)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C488(0.76); C33(0.84)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C488(0.66); C33(0.99)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C33(0.87); C488(1.07)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C33(0.80); C488(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C33(0.74); C488(0.94)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C33(0.77); C488(1.00)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C33(0.73); C488(0.82)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C33(0.68); C488(0.86)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C33(0.62); C488(0.69)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C33(0.55); C488(0.86)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C33(0.61); C488(0.69)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C33(0.64); C488(0.84)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C33(0.64); C488(0.65)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C33(1.02); C488(1.06)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C488(0.87); C33(0.90)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C33(1.16); C488(1.18)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C488(1.10); C33(1.10)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C488(0.85); C33(0.89)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C33(0.60); C488(1.05)  LDD0899  [6]
 LDCM0302  AC40 HCT 116 C488(0.69); C33(0.82)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C33(0.92); C488(0.97)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C488(0.86); C33(0.91)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C488(0.80); C33(0.82)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C488(0.86); C33(0.96)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C488(0.62); C33(0.91)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C33(1.00); C488(1.04)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C488(0.93); C33(0.94)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C33(0.83); C488(0.92)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C488(0.51); C33(0.87)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C33(0.59); C488(0.90)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C488(0.61); C33(0.89)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C33(1.11); C488(1.60)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C488(0.94); C33(0.99)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C488(0.69); C33(0.92)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C488(0.67); C33(0.98)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C488(0.54); C33(0.95)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C488(0.50); C33(0.91)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C488(0.74); C33(0.81)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C488(0.70); C33(0.78)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C488(0.67); C33(0.73)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C488(0.72); C33(0.73)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C33(0.68); C488(0.74)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C488(0.81); C33(1.02)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C488(0.76); C33(0.79)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C33(0.89); C488(0.90)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C488(0.59); C33(0.75)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C33(0.89); C488(0.97)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C488(0.78); C33(0.95)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C488(0.42); C33(0.74)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C488(0.66)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C488(0.51)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C33(0.70); C488(1.02)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C488(0.36)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C488(0.80)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C488(0.69)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C488(0.38)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C488(0.37)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C488(0.31)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C488(0.45)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C488(0.42)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C488(0.71)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C488(0.77)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C488(0.48); C33(0.72)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C488(0.54)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C488(1.18)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C488(0.31)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C488(0.50); C33(0.76)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C488(0.54); C33(0.85)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C488(0.63); C33(0.67)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C33(0.76); C488(1.20)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C33(0.89); C488(1.20)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C33(0.94); C488(0.96)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C488(0.79); C33(0.82)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C33(1.04); C488(1.78)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C488(0.67); C33(0.80)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C33(0.71); C488(0.77)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C33(0.78); C488(0.86)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C488(0.62); C33(0.81)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C33(0.83); C488(1.14)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C33(0.75); C488(0.90)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C488(0.60); C33(0.87)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C488(0.18); C33(1.18)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C488(0.70); C33(0.93)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C33(0.88); C488(0.89)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C33(0.77); C488(1.00)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C488(0.50); C33(0.78)  LDD0592  [6]
 LDCM0108  Chloroacetamide HeLa C33(0.00); C488(0.00)  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C33(0.96); C488(1.05)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C488(0.55); C33(0.91)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C33(0.52); C488(0.77)  LDD0967  [6]
 LDCM0370  CL101 HCT 116 C33(0.67); C488(0.83)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C33(0.74); C488(2.08)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C33(0.77); C488(1.42)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C33(0.80); C488(1.62)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C488(0.46); C33(0.72)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C488(0.24); C33(0.54)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C488(0.44); C33(0.63)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C488(0.33); C33(0.64)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C488(0.56); C33(0.69)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C488(0.70); C33(0.96)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C488(0.58); C33(0.64)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C488(0.63); C33(0.63)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C488(0.82); C33(0.86)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C33(0.60); C488(0.71)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C33(0.63); C488(1.00)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C33(0.74); C488(0.78)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C33(0.67); C488(0.98)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C488(0.44); C33(0.82)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C488(0.72); C33(0.95)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C488(0.80); C33(0.98)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C488(0.78); C33(1.11)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C33(1.06); C488(1.17)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C488(0.72); C33(0.84)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C488(0.70); C33(0.79)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C488(0.67); C33(0.80)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C488(0.58); C33(0.89)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C33(0.79); C488(1.41)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C33(0.65); C488(1.00)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C33(0.63); C488(1.05)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C488(0.78); C33(0.87)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C488(0.65); C33(0.87)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C33(1.22); C488(1.34)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C488(0.50); C33(0.81)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C488(0.88); C33(0.99)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C33(0.85); C488(0.87)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C488(0.65); C33(0.90)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C33(0.78); C488(0.83)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C33(1.00); C488(1.13)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C33(0.82); C488(0.87)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C488(0.64); C33(0.72)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C488(0.57); C33(0.88)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C488(0.98); C33(1.09)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C488(0.65); C33(0.79)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C33(0.89); C488(0.69)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C33(0.79); C488(0.82)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C33(0.93); C488(1.18)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C33(0.78); C488(0.73)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C33(0.78); C488(0.72)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C33(0.78); C488(1.05)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C33(1.07); C488(0.81)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C33(0.89); C488(1.09)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C33(1.13); C488(0.93)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C33(0.95); C488(1.08)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C33(0.83); C488(0.83)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C33(0.79); C488(0.99)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C33(1.01); C488(1.05)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C33(1.00); C488(1.03)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C33(1.45); C488(0.79)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C33(1.03); C488(0.91)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C33(1.19); C488(1.00)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C33(0.93); C488(1.29)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C33(1.04); C488(0.61)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C33(1.39); C488(0.92)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C33(1.29); C488(0.86)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C33(0.91); C488(0.85)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C33(0.81)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C33(0.90)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C33(0.80)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C33(1.10)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C33(1.21); C488(1.27)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C33(0.89)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C33(1.09)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C33(0.83)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C33(1.13)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C33(0.92)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C33(1.06)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C33(0.90)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C33(0.95)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C33(0.78)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C33(1.09)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C33(0.94); C488(0.84)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C33(0.80)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C488(1.12)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C488(0.99)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C488(1.04)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C488(0.91)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C488(0.86)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C488(0.84)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C488(0.85)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C488(0.68)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C488(0.88)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C33(1.06); C488(0.93)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C488(0.82)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C488(0.77)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C488(1.01)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C488(0.72)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C488(0.85)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C33(1.09); C488(1.19)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C33(1.18); C488(0.83)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C33(1.01); C488(0.77)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C33(1.35); C488(0.64)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C33(0.92); C488(0.58)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C33(1.21); C488(0.62)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C33(1.21); C488(0.86)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C33(1.59); C488(0.58)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C33(2.09); C488(0.56)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C33(1.57); C488(0.60)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C33(1.31); C488(1.32)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C33(1.23); C488(0.92)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C33(1.60); C488(0.76)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C33(1.53); C488(0.64)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C33(1.06); C488(0.41)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C33(1.29); C488(1.00)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C33(1.41); C488(1.08)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C33(1.31); C488(1.15)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C33(0.67); C488(0.83)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C33(0.63); C488(0.89)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C33(0.70); C488(0.85)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C33(0.71); C488(0.79)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C33(0.59); C488(0.87)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C33(0.85); C488(0.88)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C33(0.66); C488(0.82)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C33(0.47); C488(0.81)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C488(1.30); C33(1.07)  LDD1698  [12]
 LDCM0625  F8 Ramos C488(1.12); C33(1.33)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C488(0.52); C33(0.78)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C488(0.44); C33(0.84)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C488(0.55); C33(0.84)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C488(0.68); C33(1.05)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C488(1.39); C33(1.38)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C488(0.43); C33(0.64)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C488(0.76); C33(0.88)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C488(0.83); C33(1.43)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C488(0.70); C33(0.80)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C488(0.99); C33(0.90)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C488(0.90); C33(1.23)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C488(0.79); C33(1.14)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C488(0.50); C33(0.79)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C488(0.70)  LDD1066  [6]
 LDCM0596  Fragment38 Ramos C488(0.66); C33(1.13)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C488(0.67); C33(1.11)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C33(0.65); C488(0.68)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C488(0.81); C33(0.93)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C488(0.91); C33(1.23)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C488(0.70); C33(0.88)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C488(0.46); C33(0.74)  LDD2188  [13]
 LDCM0116  HHS-0101 DM93 Y333(0.56)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y333(0.60); Y213(2.15)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y333(0.71); Y213(2.11)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y333(0.76)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y333(0.43)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C488(1.66)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C488(1.66)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C488(1.53)  LDD0082  [6]
 LDCM0131  RA190 MM1.R C33(1.27)  LDD0304  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Valine--tRNA ligase, mitochondrial (VARS2) Class-I aminoacyl-tRNA synthetase family Q5ST30
Protein mab-21-like 2 (MAB21L2) Mab-21 family Q9Y586
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
E3 ubiquitin-protein ligase CBL (CBL) . P22681
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) Calcium channel alpha-1 subunit (TC 1.A.1.11) family O00555
Guanine nucleotide exchange factor VAV2 (VAV2) . P52735
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hematopoietically-expressed homeobox protein HHEX (HHEX) . Q03014
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372
Vasodilator-stimulated phosphoprotein (VASP) Ena/VASP family P50552
Nck-associated protein 1 (NCKAP1) HEM-1/HEM-2 family Q9Y2A7
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Integrin alpha-4 (ITGA4) Integrin alpha chain family P13612
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Four and a half LIM domains protein 2 (FHL2) . Q14192
Neutrophil cytosol factor 1 (NCF1) . P14598
Proto-oncogene vav (VAV1) . P15498
Ras GTPase-activating protein 1 (RASA1) . P20936
Rhombotin-1 (LMO1) . P25800
Suppressor of cytokine signaling 7 (SOCS7) . O14512

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.