Details of the Target

General Information of Target

Target ID LDTP07972
Target Name EPM2A-interacting protein 1 (EPM2AIP1)
Gene Name EPM2AIP1
Gene ID 9852
Synonyms
KIAA0766; EPM2A-interacting protein 1; Laforin-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWMTPKRSKMEVDEALVFRPEWTQRYLVVEPPEGDGALCLVCRRLIVATRERDVRRHYEA
EHEYYERYVADGERAALVERLRQGDLPVASFTPEERAARAGLGLCRLLALKGRGWGEGDF
VYQCMEVLLREVLPEHVSVLQGVDLSPDITRQRILSIDRNLRNQLFNRARDFKAYSLALD
DQAFVAYENYLLVFIRGVGPELEVQEDLLTIINLTHHFSVGALMSAILESLQTAGLSLQR
MVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINT
ISEWIVLIKTRGVRRPEFQTLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEMEA
FLVSVGATTVHFSDKQWLCDFGFLVDIMEHLRELSEELRVSKVFAAAAFDHICTFEVKLN
LFQRHIEEKNLTDFPALREVVDELKQQNKEDEKIFDPDRYQMVICRLQKEFERHFKDLRF
IKKDLELFSNPFNFKPEYAPISVRVELTKLQANTNLWNEYRIKDLGQFYAGLSAESYPII
KGVACKVASLFDSNQICEKAFSYLTRNQHTLSQPLTDEHLQALFRVATTEMEPGWDDLVR
ERNESNP
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum
Uniprot ID
Q7L775
Ensemble ID
ENST00000322716.8
HGNC ID
HGNC:19735

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K111(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y68(14.07); Y563(14.55)  LDD3495  [3]
HHS-475
 Probe Info  		Y68(0.63); Y64(1.24)  LDD0264  [4]
IPM
 Probe Info  		C465(3.06)  LDD1701  [5]
Acrolein
 Probe Info  		N.A.  LDD0225  [6]
DBIA
 Probe Info  		C465(0.99)  LDD0078  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C337(1.08)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C337(1.30); C465(1.38)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C337(0.98); C465(1.12)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C337(1.13); C465(1.29)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C337(0.91); C465(0.93)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C337(1.33); C465(1.05)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C337(1.02); C465(1.51)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C337(1.11); C465(1.38)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C337(1.37); C465(1.68)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C337(1.48); C465(0.68)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C337(0.86); C465(2.10)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C337(0.80); C465(2.18)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C337(1.27); C465(1.34)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C337(0.78); C465(1.60)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C337(0.88); C465(1.63)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C337(0.98); C465(1.16)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C337(1.11); C465(0.85)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C337(1.13); C465(1.27)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C337(1.40); C465(1.41)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C337(1.32); C465(1.19)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C337(1.20); C465(1.16)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C337(1.19); C465(1.07)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C337(1.09); C465(1.18)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C337(1.13); C465(1.13)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C337(1.06); C465(1.54)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C337(1.11); C465(1.26)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C337(1.17); C465(1.37)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C337(1.07); C465(0.88)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C337(1.20); C465(1.02)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C337(1.26); C465(1.03)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C337(1.30); C465(1.58)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C337(1.40); C465(1.37)  LDD0562  [7]
 LDCM0246  AC128 PaTu 8988t C557(0.88); C413(0.85); C337(1.07); C465(1.40)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C557(0.87); C413(0.79); C337(1.19); C465(1.43)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C557(1.11); C413(0.92); C337(1.10); C465(1.25)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C557(0.98); C413(0.89); C337(0.97); C465(1.24)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C557(0.97); C413(1.04); C337(0.95); C465(1.34)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C557(0.81); C413(0.78); C337(1.10); C465(1.74)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C557(0.91); C413(0.78); C337(1.02); C465(1.61)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C557(0.78); C413(0.91); C337(1.22); C465(1.78)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C557(0.92); C413(0.88); C337(1.16); C465(2.23)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C557(0.85); C413(0.82); C337(1.05); C465(1.69)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C557(0.90); C413(0.84); C337(0.96); C465(1.33)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C557(0.86); C413(0.76); C337(0.98); C465(1.62)  LDD1137  [7]
 LDCM0259  AC14 HCT 116 C337(1.25); C465(1.31)  LDD0576  [7]
 LDCM0260  AC140 PaTu 8988t C557(0.99); C413(0.93); C337(1.15); C465(1.52)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C557(0.92); C413(0.90); C337(1.11); C465(1.15)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C557(0.89); C413(0.82); C337(1.11); C465(1.37)  LDD1141  [7]
 LDCM0263  AC143 HCT 116 C337(0.84); C465(1.16)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C337(1.61); C465(1.66)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C337(1.30); C465(1.72)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C465(1.49); C337(1.50)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C337(1.33); C465(1.82)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C465(2.24); C337(2.52)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C337(1.81); C465(2.02)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C337(1.14); C465(1.24)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C337(0.92); C465(1.61)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C337(1.01); C465(1.84)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C337(1.33); C465(1.73)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C337(2.48); C465(2.98)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C337(1.20); C465(1.61)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C337(1.21); C465(1.70)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C337(1.00); C465(1.72)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C337(0.85); C465(1.00)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C337(1.17); C465(1.19)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C337(1.46); C465(1.69)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C337(1.17); C465(1.29)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C337(1.14)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C465(1.02); C337(1.16)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C337(1.11); C465(1.16)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C465(0.86); C337(1.34)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C337(1.06); C465(1.41)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C465(0.79); C337(0.98)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C465(0.79); C337(0.96)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C465(0.98); C337(1.23)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C337(1.26); C465(1.44)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C337(1.30); C465(1.48)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C465(0.98); C337(1.29)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C337(1.23)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C465(1.13); C337(1.19)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C465(1.03); C337(1.13)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C337(1.62); C465(1.86)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C465(1.11); C337(1.39)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C337(1.48); C465(1.49)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C337(0.85); C465(0.92)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C465(0.77); C337(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C465(0.66); C337(0.94)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C465(0.87); C337(0.90)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C465(0.95); C337(1.11)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C337(1.26)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C337(1.18); C465(1.51)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C465(0.81); C337(0.99)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C465(0.91); C337(1.00)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C465(0.92); C337(1.23)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C465(0.81); C337(1.03)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C337(1.07); C465(1.08)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C465(0.77); C337(1.18)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C465(0.71); C337(1.19)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C465(1.22); C337(1.24)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C337(1.26); C465(1.84)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C337(1.20)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C465(1.32); C337(1.32)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C465(0.69); C337(1.25)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C465(0.70); C337(1.26)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C465(1.29); C337(1.38)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C465(0.95); C337(1.14)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C465(1.04); C337(1.40)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C465(1.95); C337(1.96)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C465(1.64); C337(1.98)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C465(1.80); C337(2.28)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C337(1.84); C465(2.18)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C337(1.20); C465(1.33)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C465(1.79); C337(1.96)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C465(1.46); C337(1.82)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C465(1.61); C337(1.94)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C465(1.31); C337(2.14)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C465(1.89); C337(2.64)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C465(2.41); C337(2.91)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C465(2.29); C337(2.63)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C465(2.64); C337(3.07)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C465(1.19); C337(1.33)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C465(1.29); C337(1.42)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C337(1.28); C465(1.44)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C465(1.13); C337(1.48)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C465(1.09); C337(1.31)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C465(1.06); C337(1.49)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C465(1.93); C337(2.16)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C465(1.51); C337(1.89)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C465(1.92); C337(2.31)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C465(1.16); C337(1.55)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C465(1.43); C337(1.73)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C465(1.14); C337(1.28)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C465(1.29); C337(1.33)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C337(1.16); C465(1.35)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C465(1.26); C337(1.46)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C465(0.96); C337(1.22)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C465(1.67); C337(1.96)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C337(1.68)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C337(1.39)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C337(1.26)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C337(1.16)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C337(1.19)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C337(1.07)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C337(1.35)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C337(1.02)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C337(1.79)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C337(1.69)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C337(1.08)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C337(1.27)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C337(1.08)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C337(1.54)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C337(1.63)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C337(1.60); C465(1.84)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C337(0.82); C465(1.04)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C337(1.13); C465(1.29)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C337(1.22); C465(1.51)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C337(1.72); C465(1.92)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C465(0.99)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C337(1.16)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C337(1.73)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C337(1.33)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C337(1.26); C465(1.47)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C337(1.05); C465(1.19)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C337(0.97); C465(1.13)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C465(1.25); C337(1.39)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C337(1.17); C465(1.18)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C465(1.37); C337(1.66)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C465(1.42); C337(1.56)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C337(1.35); C465(1.77)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C465(1.60); C337(1.61)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C337(1.57)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C337(1.70); C465(1.90)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C465(1.44); C337(1.60)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C465(1.12); C337(1.17)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C465(1.21); C337(1.38)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C465(0.86); C337(1.38)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C337(1.23); C465(1.61)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C337(1.27); C465(1.47)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C337(1.42); C465(1.77)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C465(0.96); C337(1.00)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C337(0.97); C465(1.14)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C337(1.77)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C465(0.94); C337(1.04)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C337(0.79); C465(1.18)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C465(1.25); C337(1.25)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C465(1.24); C337(1.41)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C465(0.95); C337(1.70)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C465(1.14); C337(1.36)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C465(1.11); C337(1.51)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C465(1.22); C337(1.45)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C465(1.42); C337(1.79)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C337(1.54)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C337(1.39)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C337(1.44)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C465(1.00)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C337(1.00); C465(1.27)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C337(0.69); C465(1.19)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C337(1.24); C465(1.35)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C337(0.94)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C337(1.35); C465(1.37)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C337(1.00); C465(1.53)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C337(0.97); C465(2.22)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C337(1.26); C465(1.36)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C337(1.04); C465(1.39)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C337(0.94); C465(1.20)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C337(1.09); C465(1.15)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C337(0.97); C465(1.25)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C337(1.31); C465(1.40)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C337(1.00); C465(1.51)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C337(1.31)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C337(1.02); C465(1.10)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C337(1.17)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C337(1.15)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C337(1.19)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C337(1.54)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C337(1.24)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C337(1.27)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C337(1.71)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C337(1.58)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C337(1.11)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C337(1.16)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C337(1.26)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C337(1.60)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C337(1.50)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C337(1.39)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C337(1.45)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C337(1.21)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C337(1.44)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C337(1.17)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C337(1.44)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C337(1.05)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C337(1.62)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C337(1.37)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C337(1.36)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C337(1.36)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C337(1.48)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C337(0.93)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C337(1.21)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C337(1.20)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C337(1.01)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C337(1.19)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C337(1.30)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C337(1.28)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C337(1.21); C465(0.97)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C337(1.35); C465(0.94)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C337(1.46); C465(1.41)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C337(1.64); C465(1.41)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C337(1.23); C465(1.44)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C337(1.63); C465(1.57)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C337(1.20); C465(1.33)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C337(1.33); C465(1.32)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C337(1.39); C465(0.93)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C337(1.63)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C337(1.31); C465(1.28)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C337(1.34); C465(1.36)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C337(1.18); C465(1.05)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C337(1.50); C465(1.42)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C337(1.45); C465(1.40)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C337(1.30); C465(0.74)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C337(1.29); C465(0.80)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C337(1.29); C465(0.99)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C337(1.90); C465(0.79)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C337(1.85)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C337(1.16); C465(1.04)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C337(1.38); C465(1.03)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C337(2.27); C465(1.05)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C337(2.50); C465(0.87)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C337(2.76); C465(0.78)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C337(1.57); C465(0.86)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C337(1.46); C465(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C337(1.97); C465(1.21)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C337(1.83); C465(0.99)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C337(3.11); C465(1.19)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C337(1.22)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C337(1.90); C465(1.36)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C337(0.97)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C337(0.91)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C337(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C337(1.43)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C337(1.42)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C337(1.09)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C337(1.32)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C337(1.26)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C337(1.03)  LDD0811  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C465(1.04)  LDD1702  [5]
 LDCM0625  F8 Ramos C337(1.27)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C557(0.61)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C557(2.12)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C337(3.65)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C557(0.67)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C337(1.22)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C557(0.49)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C557(0.81)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C337(1.02); C557(0.97)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C337(1.22); C557(0.83)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C337(0.88); C557(0.72)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C557(0.85)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C557(0.81)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C557(0.66)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C337(1.41); C465(0.99)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C337(1.55); C557(0.72)  LDD2203  [10]
 LDCM0427  Fragment51 HCT 116 C337(1.80)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C557(0.78)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C337(1.20); C557(1.18)  LDD2205  [10]
 LDCM0571  Fragment9 Ramos C557(0.80)  LDD2188  [10]
 LDCM0116  HHS-0101 DM93 Y68(0.63); Y64(1.24)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y68(0.29); Y64(1.03)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y68(0.60); Y64(1.06)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y68(0.71); Y64(1.21)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y64(1.62)  LDD0268  [4]
 LDCM0022  KB02 T cell-activated C337(5.43)  LDD1704  [11]
 LDCM0023  KB03 Jurkat C337(8.58)  LDD0209  [12]
 LDCM0024  KB05 HMCB C337(3.09)  LDD3312  [13]
 LDCM0109  NEM HeLa N.A.  LDD0225  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-1 (TNKS) ARTD/PARP family O95271
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
OTU domain-containing protein 7B (OTUD7B) Peptidase C64 family Q6GQQ9
Proteasome subunit alpha type-7 (PSMA7) Peptidase T1A family O14818
Phosphoribosyltransferase domain-containing protein 1 (PRTFDC1) Purine/pyrimidine phosphoribosyltransferase family Q9NRG1
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) . Q9NPC3
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Homeobox protein MOX-2 (MEOX2) . P50222
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-1 (ACTN1) Alpha-actinin family P12814
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Nucleolar complex protein 4 homolog (NOC4L) CBF/MAK21 family Q9BVI4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Zinc finger and SCAN domain-containing protein 18 (ZSCAN18) Krueppel C2H2-type zinc-finger protein family Q8TBC5
LIM domain-binding protein 2 (LDB2) LDB family O43679
Protein lin-52 homolog (LIN52) Lin-52 family Q52LA3
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) RRM CPSF6/7 family Q8N684
Pigment epithelium-derived factor (SERPINF1) Serpin family P36955
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
ATPase SWSAP1 (SWSAP1) . Q6NVH7
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Centrobin (CNTROB) . Q8N137
DCC-interacting protein 13-beta (APPL2) . Q8NEU8
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heat shock factor 2-binding protein (HSF2BP) . O75031
PRKCA-binding protein (PICK1) . Q9NRD5
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
Uncharacterized protein C1orf50 (C1orf50) . Q9BV19

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840