Details of the Target

General Information of Target

Target ID LDTP07946
Target Name ATP-dependent RNA helicase DHX30 (DHX30)
Gene Name DHX30
Gene ID 22907
Synonyms
DDX30; KIAA0890; ATP-dependent RNA helicase DHX30; EC 3.6.4.13; DEAH box protein 30
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFSLDSFRKDRAQHRQRQCKLPPPRLPPMCVNPTPGGTISRASRDLLKEFPQPKNLLNSV
IGRALGISHAKDKLVYVHTNGPKKKKVTLHIKWPKSVEVEGYGSKKIDAERQAAAAACQL
FKGWGLLGPRNELFDAAKYRVLADRFGSPADSWWRPEPTMPPTSWRQLNPESIRPGGPGG
LSRSLGREEEEDEEEELEEGTIDVTDFLSMTQQDSHAPLRDSRGSSFEMTDDDSAIRALT
QFPLPKNLLAKVIQIATSSSTAKNLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEA
ENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIET
FLNHYPVESSWIAPELRLQSDDILPLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLEL
WRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGR
GARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGIL
LRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFS
RYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVL
HIDARGEPGGILCFLPGWQEIKGVQQRLQEALGMHESKYLILPVHSNIPMMDQKAIFQQP
PVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRR
GRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKTAVEFLSKAV
DSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLL
VVVSCLTRDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSREN
YLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEYSEEEELVKGVLM
AGLYPNLIQVRQGKVTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAV
KSNGSVFVRDSSQVHPLAVLLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVRLLKE
LRRALGRMVERSLRSELAALPPSVQEEHGQLLALLAELLRGPCGSFDVRKTADD
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily
Subcellular location
Cytoplasm
Function
RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD.
Uniprot ID
Q7L2E3
Ensemble ID
ENST00000445061.6
HGNC ID
HGNC:16716
ChEMBL ID
CHEMBL4105814

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.S772Ter DBIA    Probe Info 
COLO678 Substitution: p.K1034E DBIA    Probe Info 
DU145 SNV: p.L652V DBIA    Probe Info 
HCT15 SNV: p.P703T; p.L870M; p.R873H DBIA    Probe Info 
IGR1 SNV: p.A691S DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.E1013del DBIA    Probe Info 
JURKAT SNV: p.G529D Compound 10    Probe Info 
LNCaP clone FGC Deletion: p.G177DfsTer9 DBIA    Probe Info 
MCC26 SNV: p.H639Y DBIA    Probe Info 
MDAMB468 SNV: p.D381H DBIA    Probe Info 
MOLT4 SNV: .
Substitution: p.P324L		 IA-alkyne    Probe Info 
SUPT1 SNV: p.V588A DBIA    Probe Info 
TOV21G SNV: p.L675M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.20  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K310(10.00); K632(0.10); K698(0.77); K73(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y866(10.46)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C606(5.87)  LDD0168  [5]
DBIA
 Probe Info  		C461(37.13); C346(5.83); C1183(42.84)  LDD0209  [6]
ATP probe
 Probe Info  		K73(0.00); K830(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C309(0.00); C484(0.00); C786(0.00); C461(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C895(0.00); C309(0.00); C765(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C309(0.00); C484(0.00); C786(0.00); C461(0.00)  LDD0037  [8]
BTD
 Probe Info  		N.A.  LDD0004  [11]
NAIA_4
 Probe Info  		C286(0.00); C461(0.00)  LDD2226  [12]
WYneN
 Probe Info  		C346(0.00); C1183(0.00)  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
Compound 10
 Probe Info  		C118(0.00); C1183(0.00); C309(0.00); C346(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C118(0.00); C1183(0.00); C346(0.00); C461(0.00)  LDD2213  [13]
ENE
 Probe Info  		C346(0.00); C1183(0.00)  LDD0006  [11]
IPM
 Probe Info  		C461(0.00); C1183(0.00); C30(0.00); C346(0.00)  LDD0005  [11]
NHS
 Probe Info  		K838(0.00); K138(0.00)  LDD0010  [11]
TFBX
 Probe Info  		C309(0.00); C1183(0.00); C786(0.00); C346(0.00)  LDD0148  [14]
VSF
 Probe Info  		C461(0.00); C1183(0.00)  LDD0007  [11]
YN-1
 Probe Info  		N.A.  LDD0447  [15]
1c-yne
 Probe Info  		K73(0.00); K838(0.00); K400(0.00); K388(0.00)  LDD0228  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
Acrolein
 Probe Info  		H621(0.00); C461(0.00); C309(0.00); C606(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		C1183(0.00); C346(0.00)  LDD0236  [18]
AOyne
 Probe Info  		7.90  LDD0443  [19]
NAIA_5
 Probe Info  		C309(0.00); C484(0.00); C786(0.00); C673(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.02  LDD0471  [20]
FFF probe13
 Probe Info  		13.32  LDD0475  [20]
FFF probe2
 Probe Info  		13.35  LDD0463  [20]
FFF probe3
 Probe Info  		5.71  LDD0464  [20]
JN0003
 Probe Info  		5.19  LDD0469  [20]
STS-1
 Probe Info  		N.A.  LDD0136  [21]
STS-2
 Probe Info  		1.00  LDD0138  [21]
OEA-DA
 Probe Info  		3.06  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C346(0.90)  LDD2142  [23]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C346(1.00); C1183(0.51)  LDD2112  [23]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C346(0.90); C1183(0.98); C118(0.98)  LDD2117  [23]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C346(1.19); C309(1.42)  LDD2152  [23]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C346(0.93)  LDD2103  [23]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C346(0.52)  LDD2132  [23]
 LDCM0025  4SU-RNA HEK-293T C606(5.87)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C346(2.45); C286(2.01)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C1183(0.94); C484(1.06); C309(0.59); C786(0.98)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C1183(0.91); C484(1.01); C786(0.90); C346(1.00)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C1183(1.04); C484(1.04); C786(0.95); C346(1.03)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C484(1.04); C786(0.97); C346(1.04); C118(0.97)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C1183(1.00); C484(1.08); C786(0.97); C346(1.01)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C1183(0.95); C484(1.06); C786(0.95); C346(0.95)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C1183(0.91); C484(1.03); C309(0.79); C786(0.99)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C1183(0.87); C484(1.05); C786(1.00); C346(0.96)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C1183(0.89); C484(1.18); C786(0.89); C346(0.88)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C1183(0.93); C484(1.05); C786(0.98); C346(0.97)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C484(1.07); C786(1.07); C346(1.00); C118(1.04)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C484(1.03); C786(0.98); C346(1.03); C118(1.09)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C1183(1.02); C484(1.03); C786(1.00); C346(1.04)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C1183(0.95); C484(1.04); C786(0.89); C346(0.92)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C1183(0.91); C484(1.06); C786(0.99); C346(0.98)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C1183(0.95); C484(1.08); C309(0.87); C786(0.96)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C1183(0.93); C484(1.04); C786(0.90); C346(0.98)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C1183(1.04); C484(1.07); C786(0.98); C346(1.01)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C484(1.05); C786(1.01); C346(0.95); C118(1.05)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C484(1.06); C786(1.06); C346(1.02); C118(1.08)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C1183(1.04); C484(0.96); C786(0.86); C346(1.02)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C1183(0.98); C484(1.00); C786(0.95); C346(1.04)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C1183(0.97); C484(1.05); C786(1.07); C346(0.93)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C1183(1.01); C484(1.01); C786(1.02); C346(0.97)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C1183(0.92); C484(1.04); C309(0.77); C786(0.97)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C1183(0.89); C484(1.11); C786(1.02); C346(1.01)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C1183(0.98); C484(1.03); C786(1.04); C346(0.97)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C484(1.11); C786(1.00); C346(1.02); C118(0.95)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C484(1.03); C786(1.13); C346(1.00); C118(1.07)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C1183(1.03); C484(1.08); C786(0.95); C346(1.03)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C1183(0.82); C484(1.06); C786(0.97); C346(0.95)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C484(1.04); C786(1.07); C346(0.98); C118(1.11)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C1183(0.89); C484(1.08); C786(0.98); C346(0.98)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C1183(0.97); C484(1.04); C309(0.75); C786(0.89)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C1183(0.88); C484(1.12); C786(0.87); C346(1.03)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C1183(1.05); C484(1.18); C786(0.96); C346(1.06)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C484(1.06); C786(1.10); C346(0.97); C118(1.01)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C484(1.09); C786(1.09); C346(1.04); C118(1.10)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C1183(1.00); C484(1.07); C786(1.10); C346(1.03)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C1183(1.00); C484(1.06); C786(1.10); C346(1.01)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C1183(0.90); C484(1.04); C786(1.00); C346(1.00)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C1183(0.92); C484(1.15); C309(0.86); C786(1.03)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C484(0.99); C786(1.13); C346(1.03); C118(1.07)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C1183(0.89); C484(1.06); C786(0.91); C346(0.99)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C1183(1.00); C484(1.08); C786(0.96); C346(1.01)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C484(1.06); C786(0.99); C346(0.99); C118(1.02)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C484(1.10); C786(1.04); C346(1.07); C118(0.96)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C1183(1.04); C484(1.07); C786(1.03); C346(1.06)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C1183(0.98); C484(1.05); C786(0.95); C346(0.98)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C1183(0.91); C484(1.05); C786(0.98); C346(0.96)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C1183(0.96); C484(1.02); C309(0.81); C786(0.89)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C1183(0.96); C484(1.02); C786(0.96); C346(0.99)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C1183(0.98); C484(1.07); C786(0.96); C346(0.98)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C1183(0.91); C484(1.01); C786(0.97); C346(1.03)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C484(1.02); C786(1.00); C346(1.05); C118(0.95)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C484(1.00); C786(0.99); C346(0.99); C118(1.13)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C1183(1.02); C484(1.02); C786(0.94); C346(1.11)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C1183(0.92); C484(0.98); C786(0.95); C346(0.92)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C1183(0.94); C484(1.07); C786(0.97); C346(1.02)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C1183(0.92); C484(1.00); C786(1.04); C346(0.96)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C1183(1.00); C484(1.02); C786(0.91); C346(0.98)  LDD1569  [24]
 LDCM0545  Acetamide MDA-MB-231 C346(0.45)  LDD2138  [23]
 LDCM0248  AKOS034007472 HEK-293T C484(1.03); C786(1.09); C346(0.99); C118(1.08)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C1183(0.95); C484(1.12); C309(0.86); C786(0.94)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C1183(0.98); C484(1.04); C786(1.01); C346(0.97)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C346(0.44)  LDD2091  [23]
 LDCM0108  Chloroacetamide HeLa C461(0.00); H505(0.00); C309(0.00); C346(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C346(0.21)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C1183(0.92); C484(0.94); C309(0.78); C786(0.88)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C1183(1.02); C484(1.00); C786(0.91); C346(0.89)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C1183(0.88); C484(0.97); C786(1.43); C346(1.05)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C1183(0.97); C484(1.06); C309(0.75); C786(0.95)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C1183(0.89); C484(1.00); C786(1.00); C346(1.00)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C1183(0.96); C484(1.00); C786(1.11); C346(0.95)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C1183(0.91); C484(0.93); C786(1.29); C346(0.95)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C1183(0.96); C484(0.98); C309(1.00); C786(0.93)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C1183(1.01); C484(1.06); C786(1.08); C346(0.95)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C1183(0.95); C484(1.16); C786(1.10); C346(0.91)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C1183(0.91); C484(1.09); C786(1.18); C346(1.01)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C1183(0.95); C484(0.97); C309(0.96); C786(1.01)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C1183(0.93); C484(1.06); C786(1.01); C346(1.06)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C1183(0.88); C484(1.01); C786(0.91); C346(0.98)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C1183(0.96); C484(1.03); C786(0.93); C346(0.91)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C1183(0.95); C484(1.00); C786(1.14); C346(1.06)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C1183(1.00); C484(1.06); C309(1.02); C786(1.04)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C1183(0.91); C484(1.04); C786(1.13); C346(0.98)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C1183(0.93); C484(1.00); C786(1.25); C346(1.06)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C1183(0.88); C484(1.08); C786(1.05); C346(1.06)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C1183(0.99); C484(1.06); C309(1.04); C786(1.03)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C1183(0.97); C484(1.02); C786(0.95); C346(1.00)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C1183(0.94); C484(1.10); C786(1.10); C346(1.01)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C1183(0.96); C484(1.00); C786(0.88); C346(0.99)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C1183(0.88); C484(1.01); C786(1.27); C346(0.98)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C1183(0.94); C484(1.03); C309(0.86); C786(0.95)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C1183(0.97); C484(1.04); C786(1.22); C346(1.04)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C1183(0.88); C484(1.00); C786(1.24); C346(0.87)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C1183(0.84); C484(1.07); C786(1.30); C346(0.99)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C1183(0.97); C484(1.10); C309(0.90); C786(0.90)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C1183(0.93); C484(0.96); C786(1.03); C346(1.01)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C1183(1.01); C484(0.89); C786(0.96); C346(0.94)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C1183(0.89); C484(0.94); C786(0.92); C346(0.94)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C1183(0.86); C484(0.97); C309(0.83); C786(0.85)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C1183(0.99); C484(1.05); C786(0.90); C346(1.00)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C1183(0.78); C484(1.15); C786(0.99); C346(0.90)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C1183(0.97); C484(1.11); C786(1.02); C346(1.09)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C1183(0.92); C484(1.13); C309(0.87); C786(0.81)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C1183(0.88); C484(1.11); C786(1.03); C346(0.96)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C1183(1.00); C484(1.18); C786(0.88); C346(1.01)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C1183(0.94); C484(1.02); C786(0.89); C346(1.01)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C484(1.05); C786(0.99); C346(1.08); C118(0.97)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C484(1.21); C786(0.91); C346(0.98); C118(0.90)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C1183(1.09); C484(1.15); C786(0.93); C346(1.17)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C1183(0.97); C484(1.11); C786(1.02); C346(1.04)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C1183(1.00); C484(0.97); C786(0.89); C346(1.03)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C1183(0.94); C484(0.89); C309(0.75); C786(0.81)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C1183(0.89); C484(0.97); C786(1.09); C346(0.97)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C1183(1.03); C484(1.03); C786(1.12); C346(0.96)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C1183(0.90); C484(0.90); C786(1.19); C346(1.00)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C1183(0.92); C484(1.12); C309(0.98); C786(0.93)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C1183(0.95); C484(1.19); C786(1.17); C346(1.00)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C1183(0.93); C484(1.16); C786(0.90); C346(1.00)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C1183(1.06); C484(1.08); C786(0.87); C346(1.07)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C484(1.11); C786(1.01); C346(1.06); C118(0.96)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C484(1.08); C786(0.83); C346(1.01); C118(0.96)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C1183(1.09); C484(1.05); C786(1.08); C346(1.14)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C1183(1.11); C484(1.11); C786(1.03); C346(1.06)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C1183(1.04); C484(0.98); C786(0.89); C346(1.02)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C1183(0.92); C484(0.91); C309(0.71); C786(0.98)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C1183(1.19); C484(1.09); C786(1.16); C346(1.42)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C1183(0.93); C484(1.11); C786(1.11); C346(1.06)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C1183(0.94); C484(1.07); C786(1.01); C346(0.95)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C1183(0.99); C484(1.08); C309(0.83); C786(0.88)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C1183(0.99); C484(1.07); C786(0.97); C346(1.01)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C1183(1.03); C484(1.16); C786(0.84); C346(1.03)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C484(1.13); C786(0.92); C346(0.99); C118(0.98)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C484(0.86); C786(0.88); C346(1.03); C118(0.97)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C1183(1.05); C484(1.01); C786(0.99); C346(1.18)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C1183(1.06); C484(1.09); C786(0.97); C346(1.02)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C1183(1.03); C484(1.07); C786(0.86); C346(1.00)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C1183(0.94); C484(1.02); C309(0.84); C786(0.91)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C1183(0.94); C484(1.05); C309(0.91); C786(0.93)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C1183(0.99); C484(0.98); C786(0.89); C346(1.00)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C1183(0.96); C484(1.12); C786(1.16); C346(1.04)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C1183(0.89); C484(1.10); C309(0.75); C786(0.89)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C1183(0.78); C484(1.23); C786(0.93); C346(0.98)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C1183(0.96); C484(1.20); C786(0.98); C346(1.04)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C484(1.13); C786(0.94); C346(1.13); C118(0.95)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C484(1.17); C786(0.91); C346(1.01); C118(0.96)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C1183(0.98); C484(1.13); C786(0.95); C346(1.12)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C1183(1.01); C484(1.15); C786(0.90); C346(1.02)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C1183(0.83); C484(1.07); C786(0.89); C346(0.92)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C1183(1.01); C484(1.05); C786(0.99); C346(1.07)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C1183(0.96); C484(0.99); C309(0.97); C786(0.97)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C1183(0.99); C484(0.99); C786(1.07); C346(1.07)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C1183(0.99); C484(1.02); C786(1.03); C346(1.02)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C1183(0.86); C484(1.10); C786(0.84); C346(0.95)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C1183(0.97); C484(1.13); C309(0.93); C786(0.90)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C1183(0.87); C484(1.15); C786(0.96); C346(1.08)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C1183(1.00); C484(1.18); C786(0.94); C346(1.01)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C484(1.09); C786(0.92); C346(1.01); C118(1.01)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C484(1.11); C786(0.96); C346(1.06); C118(0.98)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C1183(0.95); C484(0.98); C786(0.88); C346(1.02)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C1183(1.03); C484(1.11); C786(0.92); C346(1.05)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C1183(1.13); C484(1.12); C786(0.97); C346(1.01)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C1183(1.02); C484(1.10); C786(0.92); C346(0.97)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C1183(1.02); C484(1.06); C309(0.87); C786(0.88)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C1183(1.00); C484(1.00); C786(0.88); C346(1.03)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C1183(0.92); C484(0.97); C786(1.18); C346(0.94)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C1183(1.05); C484(1.07); C309(0.88); C786(0.86)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C1183(0.94); C484(1.15); C786(1.05); C346(1.02)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C1183(0.98); C484(1.07); C786(0.96); C346(0.97)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C484(1.08); C786(0.72); C346(0.98); C118(0.96)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C484(1.09); C786(0.98); C346(1.03); C118(1.06)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C484(1.07); C786(1.04); C346(1.06); C118(0.99)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C1183(0.91); C484(1.13); C786(0.99); C346(1.17)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C1183(0.95); C484(1.14); C786(0.96); C346(1.14)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C1183(0.94); C484(1.08); C786(0.89); C346(0.97)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C1183(0.95); C484(1.04); C309(0.77); C786(1.07)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C1183(0.98); C484(0.90); C786(0.90); C346(1.00)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C1183(0.97); C484(0.96); C786(1.07); C346(0.97)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C1183(0.87); C484(1.00); C786(0.98); C346(1.01)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C1183(0.97); C484(1.03); C309(0.87); C786(0.95)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C484(1.14); C786(0.95); C346(1.14); C118(0.96)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C1183(0.81); C484(1.09); C786(0.78); C346(1.12)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C1183(0.98); C484(1.03); C786(0.83); C346(0.98)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C484(1.05); C786(0.89); C346(0.97); C118(1.04)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C484(1.14); C786(1.00); C346(1.05); C118(0.96)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C1183(1.11); C484(1.01); C786(0.88); C346(1.12)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C1183(0.90); C484(1.00); C786(0.83); C346(0.87)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C1183(0.93); C484(0.97); C786(0.82); C346(0.99)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C1183(0.91); C484(1.01); C309(0.80); C786(1.24)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C1183(0.93); C484(0.97); C786(1.08); C346(1.10)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C1183(0.99); C484(0.92); C786(1.33); C346(0.98)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C1183(1.06); C484(0.93); C786(1.05); C346(1.06)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C346(1.43); C786(0.79); C1183(0.77)  LDD1702  [23]
 LDCM0625  F8 Ramos C346(1.12); C461(0.07)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C346(4.38); C461(3.16)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C346(0.49); C461(1.21)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C1183(0.41); C346(0.44); C461(2.11)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C1183(0.85); C346(0.56)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C1183(0.44); C346(0.57); C461(1.97)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C1183(0.40); C346(0.79); C461(0.78)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C1183(1.55); C346(0.51)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C346(0.74); C461(1.02)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C1183(1.18); C346(0.57)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C1183(0.59); C346(0.72)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C1183(0.93); C346(0.57); C461(20.00)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C1183(1.16); C346(0.48)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C346(0.97); C461(1.76)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C1183(0.94); C484(1.12); C786(1.17); C346(1.05)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C1183(0.86); C346(0.40)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C346(1.26); C461(0.82)  LDD2184  [25]
 LDCM0427  Fragment51 HEK-293T C1183(1.02); C484(0.98); C786(1.01); C346(1.01)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C1183(0.85); C346(0.66); C461(0.95)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C346(0.58); C461(11.95)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C1183(0.41); C346(0.87); C461(0.97)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C346(0.52)  LDD2188  [25]
 LDCM0107  IAA HeLa H621(0.00); H505(0.00); C309(0.00); H876(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C1183(1.02); C484(0.99); C786(1.04); C346(1.02)  LDD1492  [24]
 LDCM0023  KB03 Jurkat C461(37.13); C346(5.83); C1183(42.84)  LDD0209  [6]
 LDCM0024  KB05 G361 C337(5.19); C512(4.43); C814(1.99); C701(1.59)  LDD3311  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C346(1.00)  LDD2102  [23]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C309(0.74)  LDD2121  [23]
 LDCM0109  NEM HeLa H505(0.00); H695(0.00); H621(0.00); H78(0.00)  LDD0223  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C346(1.19)  LDD2090  [23]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C346(1.03)  LDD2092  [23]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C346(0.97); C309(0.94)  LDD2093  [23]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C346(1.12)  LDD2094  [23]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C346(0.65)  LDD2096  [23]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C346(0.94)  LDD2098  [23]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C346(0.93); C309(1.10); C1183(0.91); C118(1.01)  LDD2099  [23]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C346(0.94); C1183(1.02)  LDD2100  [23]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1183(0.47)  LDD2101  [23]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C346(0.70)  LDD2106  [23]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C346(0.88); C309(1.12); C118(0.99)  LDD2107  [23]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C346(0.96)  LDD2108  [23]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C346(0.74); C1183(0.82); C606(1.14)  LDD2109  [23]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C346(1.47)  LDD2110  [23]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C346(0.95); C309(1.17)  LDD2111  [23]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C346(0.61); C1183(0.45)  LDD2114  [23]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C346(0.48); C1183(0.51)  LDD2115  [23]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C346(1.01); C484(0.40)  LDD2116  [23]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C346(1.09)  LDD2118  [23]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C346(2.53); C1183(2.49)  LDD2119  [23]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C346(0.86)  LDD2120  [23]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C346(1.20); C118(0.48)  LDD2122  [23]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C346(0.92); C309(0.80); C1183(0.99); C118(0.99)  LDD2123  [23]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C346(1.06)  LDD2124  [23]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C118(0.84); C606(0.75)  LDD2125  [23]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C346(1.15)  LDD2126  [23]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C346(0.91); C309(1.03); C1183(1.08)  LDD2127  [23]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C346(1.01)  LDD2128  [23]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C346(1.00)  LDD2129  [23]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C346(0.39)  LDD2134  [23]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C346(1.02); C309(2.67); C118(1.71)  LDD2135  [23]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C346(0.98); C118(1.23)  LDD2136  [23]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C346(1.00); C309(0.97); C1183(1.05)  LDD2137  [23]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C346(0.80); C1183(0.79); C118(1.02)  LDD2140  [23]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C346(0.89)  LDD2141  [23]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C346(1.00); C309(1.01)  LDD2143  [23]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C309(2.63); C1183(2.35)  LDD2144  [23]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C346(13.83); C1183(1.60)  LDD2145  [23]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C346(0.78); C309(0.89)  LDD2146  [23]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C346(3.20)  LDD2147  [23]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C346(0.47)  LDD2148  [23]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C346(0.36)  LDD2150  [23]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C346(0.98)  LDD2151  [23]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C346(1.28)  LDD2153  [23]
 LDCM0131  RA190 MM1.R C1183(1.17)  LDD0304  [27]
 LDCM0112  W16 Hep-G2 C346(0.53)  LDD0239  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2'-5'-oligoadenylate synthase 3 (OAS3) 2-5A synthase family Q9Y6K5
ATP-dependent RNA helicase DHX58 (DHX58) Helicase family Q96C10
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) Ser/Thr protein kinase family P19525

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.