Details of the Target

General Information of Target

Target ID LDTP06525
Target Name Programmed cell death protein 2 (PDCD2)
Gene Name PDCD2
Gene ID 5134
Synonyms
RP8; ZMYND7; Programmed cell death protein 2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGARPVELGFAESAPAWRLRSEQFPSKVGGRPAWLGAAGLPGPQALACELCGRPLSF
LLQVYAPLPGRPDAFHRCIFLFCCREQPCCAGLRVFRNQLPRKNDFYSYEPPSENPPPET
GESVCLQLKSGAHLCRVCGCLGPKTCSRCHKAYYCSKEHQTLDWRLGHKQACAQPDHLDH
IIPDHNFLFPEFEIVIETEDEIMPEVVEKEDYSEIIGSMGEALEEELDSMAKHESREDKI
FQKFKTQIALEPEQILRYGRGIAPIWISGENIPQEKDIPDCPCGAKRILEFQVMPQLLNY
LKADRLGKSIDWGILAVFTCAESCSLGTGYTEEFVWKQDVTDTP
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Nucleus
Function May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
TTD ID
T27736
Uniprot ID
Q16342
DrugMap ID
TTYOVWN
Ensemble ID
ENST00000392090.6
HGNC ID
HGNC:8762

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.Y109C .
SSP25 SNV: p.Y109C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C135(0.82)  LDD2123  [1]
DBIA
 Probe Info  		C89(2.62); C90(2.62); C281(1.63); C283(1.63)  LDD0080  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C281(1.22); C283(1.22); C78(0.53); C83(0.68)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C281(1.10); C283(1.10); C83(0.88); C84(0.95)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C281(0.79); C283(0.79); C78(0.55); C83(0.66)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C281(0.76); C283(0.76); C78(0.75); C83(0.79)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C281(0.85); C283(0.85); C78(0.45); C83(0.83)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C281(0.70); C283(0.70); C78(0.42); C83(0.62)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C281(0.94); C283(0.94); C78(0.42); C83(0.70)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C281(0.81); C283(0.81); C78(0.43); C83(0.73)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C281(0.78); C283(0.78); C78(0.47); C83(0.61)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C281(0.83); C283(0.83); C78(0.36); C83(0.74)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C281(0.73); C283(0.73); C78(0.83); C83(0.67)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C281(0.96); C283(0.96); C78(0.77); C83(0.70)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C281(0.94); C283(0.94); C83(0.90); C84(0.98)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C281(0.75); C283(0.75); C78(0.58); C83(0.67)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C281(0.67); C283(0.67); C78(0.66); C83(0.58)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C281(0.71); C283(0.71); C78(0.39); C83(0.59)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C140(0.95); C78(1.04); C83(1.00); C84(1.12)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C140(0.99); C78(1.09); C83(0.98); C84(1.04)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C140(0.92); C78(0.89); C83(0.75); C84(0.91)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C140(0.85); C78(0.84); C83(0.79); C84(0.90)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C140(1.10); C78(1.09); C83(0.89); C84(0.99)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C140(1.20); C78(1.11); C83(0.93); C84(1.03)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C140(0.98); C78(1.01); C83(1.02); C84(0.84)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C281(1.36); C283(1.36); C83(1.06); C84(1.11)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C140(0.72); C78(0.60); C83(0.95); C84(0.98)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C140(1.16); C78(0.79); C83(1.02); C84(1.04)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C140(1.19); C78(0.93); C83(0.99); C84(0.97)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C140(1.20); C78(0.91); C83(1.00); C84(1.27)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C140(1.24); C78(1.28); C83(1.16); C84(1.20)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C140(1.00); C78(1.09); C83(1.12); C84(1.17)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C140(1.19); C78(0.75); C83(0.89); C84(0.88)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C140(1.23); C78(0.82); C83(0.85); C84(0.88)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C78(0.88); C83(1.15); C84(0.85); C89(0.75)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C78(1.55); C83(1.53); C84(1.51); C89(1.21)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C78(1.06); C83(1.07); C84(1.03); C89(0.74)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C78(1.79); C83(1.57); C84(1.48); C89(1.19)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C78(1.85); C83(1.37); C84(1.67); C89(1.32)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C78(1.30); C83(1.19); C84(1.23); C89(1.00)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C78(1.12); C83(1.17); C84(1.20); C89(0.86)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C78(1.11); C83(1.11); C84(1.15); C89(0.82)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C78(1.26); C83(1.10); C84(1.17); C89(1.01)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C78(1.18); C83(1.06); C84(1.15); C89(1.23)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C78(1.29); C83(1.22); C84(1.24); C89(0.95)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C78(1.21); C83(0.95); C84(1.24); C89(0.83)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C281(0.96); C283(0.96); C83(1.44); C84(1.67)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C78(1.01); C83(0.93); C84(1.04); C89(0.80)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C78(1.03); C83(0.95); C84(1.10); C89(0.92)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C78(1.75); C83(1.04); C84(1.88); C89(1.38)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C90(0.85); C89(0.92); C83(1.14); C84(1.15)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C90(0.62); C78(0.64); C89(0.64); C84(0.75)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C90(0.72); C89(0.75); C78(0.98); C84(1.03)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C78(0.64); C90(0.66); C89(0.67); C83(0.79)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C90(0.53); C78(0.61); C89(0.61); C84(0.78)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C78(0.56); C90(0.58); C89(0.60); C84(0.81)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C78(0.59); C90(0.61); C89(0.61); C84(0.73)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C89(0.80); C90(0.80); C281(0.86); C283(0.86)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C89(0.87); C90(0.88); C84(0.94); C83(0.95)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C89(0.92); C83(0.95); C84(1.05); C90(1.12)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C89(0.60); C78(0.62); C90(0.74); C84(0.79)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C78(0.48); C90(0.57); C89(0.61); C84(0.65)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C78(0.70); C83(0.95); C84(0.87); C89(0.67)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C78(0.55); C83(0.76); C84(0.71); C89(0.74)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C78(0.97); C83(0.94); C84(0.97); C89(1.06)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C78(1.49); C83(1.16); C84(1.24); C89(1.07)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C78(0.91); C90(0.95); C89(0.99); C84(1.02)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C78(0.59); C89(0.67); C90(0.69); C84(0.78)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C140(0.90); C89(0.91); C90(0.94); C78(1.00)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C89(0.76); C90(0.76); C78(0.86); C84(0.86)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C89(0.93); C90(0.96); C281(0.97); C283(0.97)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C78(0.84); C140(0.89); C89(0.90); C90(0.92)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C84(0.99); C89(1.05); C83(1.06); C90(1.10)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C89(0.80); C90(0.82); C78(0.87); C84(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C90(0.99); C89(1.00); C140(1.06); C78(1.19)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C90(0.90); C89(0.98); C281(1.08); C283(1.08)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C90(0.71); C89(0.77); C83(0.80); C84(0.81)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C90(0.71); C83(0.78); C84(0.78); C89(0.82)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C83(0.68); C84(0.72); C90(0.74); C89(0.82)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C90(0.66); C89(0.74); C84(0.75); C83(0.78)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C78(0.62); C84(0.65); C89(0.80); C90(0.80)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C90(0.59); C89(0.63); C83(0.75); C84(0.78)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C90(0.64); C83(0.73); C89(0.77); C84(0.79)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C90(0.46); C89(0.52); C84(0.69); C83(0.70)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C90(0.58); C89(0.73); C83(0.77); C84(0.78)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C90(0.57); C89(0.67); C281(0.85); C283(0.85)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C83(1.32); C84(1.44); C89(1.46); C90(1.46)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C281(1.20); C283(1.20); C89(1.25); C90(1.25)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C281(1.18); C283(1.18); C83(1.27); C89(1.38)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C83(1.03); C89(1.11); C90(1.11); C78(1.27)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C83(0.79); C78(0.80); C84(0.83); C281(0.99)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C78(0.48); C84(0.55); C83(0.66); C89(0.69)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C281(0.82); C283(0.82); C84(0.91); C83(0.96)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C89(0.95); C90(0.95); C84(1.12); C83(1.15)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C83(0.96); C89(0.98); C90(0.98); C281(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C281(0.85); C283(0.85); C89(0.92); C90(0.92)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C281(0.96); C283(0.96); C83(1.02); C84(1.19)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C281(0.79); C283(0.79); C83(0.85); C84(1.06)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C281(0.64); C283(0.64); C89(0.97); C90(0.97)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C281(0.83); C283(0.83); C89(0.90); C90(0.90)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C78(0.62); C281(0.64); C283(0.64); C84(0.81)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C281(0.51); C283(0.51); C89(0.70); C90(0.70)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C78(0.59); C84(0.66); C89(0.74); C90(0.74)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C281(0.56); C283(0.56); C89(0.68); C90(0.68)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C281(0.58); C283(0.58); C78(1.18); C83(1.19)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C281(0.60); C283(0.60); C89(0.87); C90(0.87)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C89(0.92); C90(0.92); C78(0.97); C84(1.00)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C281(0.65); C283(0.65); C89(0.83); C90(0.83)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C84(0.91); C89(0.95); C90(0.95); C83(1.01)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C281(0.55); C283(0.55); C89(0.72); C90(0.72)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C140(0.37); C78(0.63); C281(0.72); C283(0.72)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C140(0.27); C78(0.63); C281(0.66); C283(0.66)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C140(0.27); C78(0.56); C281(0.58); C283(0.58)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C89(0.73); C90(0.73); C83(0.98); C84(1.01)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C140(0.32); C281(0.55); C283(0.55); C90(0.69)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C140(0.30); C281(0.57); C283(0.57); C78(0.72)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C140(0.22); C281(0.52); C283(0.52); C83(0.68)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C140(0.31); C281(0.56); C283(0.56); C78(0.60)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C140(0.26); C281(0.55); C283(0.55); C78(0.66)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C140(0.24); C281(0.61); C283(0.61); C78(0.61)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C140(0.25); C78(0.53); C83(0.61); C84(0.65)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C140(0.15); C281(0.43); C283(0.43); C78(0.45)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C90(0.68); C89(0.68); C78(0.77); C84(0.86)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C281(0.52); C283(0.52); C90(0.60); C89(0.62)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C89(0.84); C90(0.84); C281(0.92); C283(0.92)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C78(0.53); C90(0.58); C83(0.68); C89(0.69)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C89(0.65); C90(0.70); C78(0.74); C83(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C89(0.66); C78(0.73); C90(0.74); C281(0.78)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C90(0.54); C89(0.58); C78(0.67); C281(0.71)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C90(0.55); C89(0.58); C281(0.63); C283(0.63)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C90(0.50); C89(0.55); C281(0.64); C283(0.64)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C90(0.62); C281(0.66); C283(0.66); C78(0.67)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C90(0.54); C281(0.57); C283(0.57); C89(0.68)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C78(0.64); C90(0.71); C89(0.73); C83(0.81)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C78(0.67); C89(0.74); C83(0.76); C90(0.80)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C89(0.77); C90(0.77); C84(1.05); C83(1.05)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C90(0.65); C89(0.71); C281(0.73); C283(0.73)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C78(0.67); C83(0.72); C89(0.78); C84(0.91)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C90(0.55); C89(0.56); C281(0.65); C283(0.65)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C90(0.58); C89(0.67); C83(0.77); C84(0.80)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C90(0.56); C89(0.61); C84(0.72); C78(0.82)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C90(0.70); C83(0.72); C89(0.74); C84(0.75)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C90(0.77); C83(0.79); C89(0.82); C84(1.03)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C90(0.79); C83(0.81); C89(0.85); C84(1.05)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C83(0.67); C90(0.79); C84(0.84); C89(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C90(0.61); C83(0.66); C89(0.68); C84(0.79)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C83(0.60); C89(1.09); C90(1.11); C84(1.31)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C90(0.67); C89(0.71); C83(0.75); C84(0.77)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C90(0.63); C84(0.64); C89(0.66); C83(0.68)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C83(0.67); C90(0.73); C84(0.74); C89(0.75)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C90(0.72); C89(0.79); C83(0.79); C84(0.94)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C90(0.69); C89(0.76); C83(0.86); C84(1.01)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C83(0.69); C90(0.70); C89(0.75); C84(0.87)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C83(0.53); C90(0.58); C89(0.62); C84(0.72)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C89(0.18); C90(0.18); C78(0.36); C83(0.59)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C78(0.59); C89(0.66); C90(0.66); C83(0.75)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C281(1.24); C283(1.24); C83(1.08); C84(1.19)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C89(0.82); C90(0.82); C83(0.97); C84(1.03)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C89(0.57); C90(0.57); C83(1.17); C84(1.17)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C83(1.15); C84(1.15)  LDD2171  [2]
 LDCM0102  BDHI 8 Jurkat C78(13.73)  LDD0204  [8]
 LDCM0367  CL1 HCT 116 C125(0.89); C83(0.90); C84(0.92); C89(0.93)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C281(0.40); C283(0.40); C78(0.46); C83(0.51)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C78(0.52); C84(0.56); C83(0.72); C89(0.73)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C89(0.81); C90(0.81); C83(1.34); C84(1.58)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C281(1.14); C283(1.14); C83(1.18); C89(1.25)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C89(0.91); C90(0.91); C281(1.10); C283(1.10)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C281(0.72); C283(0.72); C89(0.88); C90(0.88)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C89(0.75); C90(0.77); C78(0.79); C84(0.94)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C78(0.53); C89(0.65); C90(0.66); C84(0.70)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C78(0.66); C89(0.69); C90(0.70); C84(0.75)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C78(0.57); C89(0.65); C90(0.67); C84(0.76)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C90(0.75); C84(0.77); C78(0.78); C89(0.80)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C281(0.47); C283(0.47); C78(0.56); C83(0.63)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C78(0.56); C89(0.62); C90(0.65); C84(0.74)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C78(0.67); C89(0.73); C84(0.75); C90(0.77)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C90(0.80); C89(0.83); C84(0.96); C83(0.98)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C90(0.51); C89(0.65); C84(0.82); C83(0.84)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C90(0.58); C89(0.66); C84(0.75); C281(0.77)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C90(0.64); C89(0.82); C84(0.85); C83(0.91)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C90(0.70); C84(0.84); C89(0.84); C83(0.91)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C281(0.77); C283(0.77); C83(0.93); C84(1.01)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C281(0.94); C283(0.94); C89(0.97); C90(0.97)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C281(0.94); C283(0.94); C89(0.97); C90(0.97)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C281(0.55); C283(0.55); C78(0.57); C83(0.63)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C83(0.90); C89(0.96); C90(0.96); C84(1.03)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C281(0.72); C283(0.72); C84(1.14); C89(1.36)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C281(0.68); C283(0.68); C89(0.69); C90(0.69)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C281(0.50); C283(0.50); C89(0.66); C90(0.66)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C281(0.59); C283(0.59); C89(0.70); C90(0.70)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C140(0.69); C83(0.71); C281(0.72); C283(0.72)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C140(0.54); C90(0.67); C281(0.69); C283(0.69)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C140(0.61); C281(0.72); C283(0.72); C90(0.85)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C140(0.43); C78(0.65); C281(0.65); C283(0.65)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C281(0.39); C283(0.39); C83(0.64); C78(0.67)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C281(0.68); C283(0.68); C83(0.75); C125(0.85)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C281(0.44); C283(0.44); C83(0.63); C89(0.70)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C90(0.65); C89(0.69); C140(0.74); C281(0.80)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C281(0.54); C283(0.54); C140(0.68); C90(0.84)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C281(0.54); C283(0.54); C90(0.73); C78(0.87)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C281(0.48); C283(0.48); C140(0.74); C90(0.89)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C125(0.96); C89(1.03); C90(1.03); C83(1.05)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C281(0.40); C283(0.40); C140(0.55); C90(0.83)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C281(0.30); C283(0.30); C90(0.56); C140(0.60)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C281(0.34); C283(0.34); C78(0.57); C140(0.59)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C281(0.46); C283(0.46); C140(0.60); C90(0.73)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C281(0.37); C283(0.37); C78(0.61); C90(0.64)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C125(1.01); C140(0.50); C281(0.47); C283(0.47)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C125(0.95); C140(0.74); C281(0.41); C283(0.41)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C125(1.16); C140(0.90); C281(0.45); C283(0.45)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C125(1.34); C140(0.64); C281(0.38); C283(0.38)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C125(1.27); C140(0.70); C281(0.46); C283(0.46)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C125(0.68); C140(0.98); C281(1.18); C283(1.18)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C125(1.32); C140(0.70); C281(0.60); C283(0.60)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C125(1.00); C281(0.35); C283(0.35); C78(0.82)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C125(0.95); C281(0.43); C283(0.43); C78(0.95)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C125(1.34); C281(0.36); C283(0.36); C78(0.63)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C125(1.23); C281(0.36); C283(0.36); C78(0.58)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C125(1.01); C281(0.45); C283(0.45); C78(0.87)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C125(1.11); C281(0.42); C283(0.42); C78(0.92)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C125(0.90); C281(0.43); C283(0.43); C78(0.88)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C125(1.01); C281(0.42); C283(0.42); C78(0.65)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C125(0.86); C140(1.30); C281(0.82); C283(0.82)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C125(0.98); C281(0.42); C283(0.42); C78(0.93)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C125(0.97); C281(0.41); C283(0.41); C78(1.01)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C125(1.03); C281(0.40); C283(0.40); C78(0.95)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C125(1.10); C281(0.40); C283(0.40); C78(0.75)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C125(1.07); C281(0.44); C283(0.44); C78(0.80)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C125(0.97); C281(0.44); C283(0.44); C78(0.44)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C281(2.08); C283(1.76); C83(0.73); C84(0.72)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C281(1.82); C283(1.61); C83(0.90); C84(0.92)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C281(2.18); C283(1.90); C83(1.08); C84(1.04)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C281(1.24); C283(1.29); C83(1.09); C84(1.06)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C125(0.75); C140(0.98); C281(0.77); C283(0.77)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C281(1.69); C283(1.50); C83(1.23); C84(1.26)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C281(2.06); C283(1.81); C83(1.00); C84(0.97)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C281(1.91); C283(1.57); C83(0.90); C84(0.88)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C281(1.69); C283(1.35); C83(1.40); C84(1.34)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C281(1.93); C283(1.50); C83(1.11); C84(1.14)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C281(2.27); C283(1.84); C83(1.21); C84(1.27)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C281(1.21); C283(1.08); C83(1.34); C84(1.24)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C281(1.28); C283(1.18); C83(1.24); C84(1.23)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C281(2.74); C283(2.08); C83(0.99); C84(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C281(1.52); C283(1.34); C83(1.20); C84(1.29)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C125(1.00); C140(0.77); C281(0.47); C283(0.47)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C281(1.11); C283(1.10); C83(1.00); C84(0.96)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C281(1.01); C283(1.01); C83(1.04); C84(0.96)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C281(0.92); C283(0.92); C83(0.98); C84(0.93)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C281(0.73); C283(0.73); C83(0.97); C84(0.74)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C281(0.72); C283(0.72); C83(1.06); C84(0.80)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C281(0.73); C283(0.73); C83(1.32); C84(1.09)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C281(0.57); C283(0.57); C83(0.90); C84(0.70)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C281(0.60); C283(0.60); C83(1.25); C84(0.80)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C281(0.90); C283(0.90); C83(1.18); C84(0.74)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C281(0.58); C283(0.58); C83(1.05); C84(1.02)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C125(0.88); C140(0.74); C281(0.47); C283(0.47)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C281(0.68); C283(0.68); C83(1.02); C84(1.00)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C281(0.79); C283(0.79); C83(1.01); C84(0.75)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C281(1.24); C283(1.24); C83(0.99); C84(0.90)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C281(0.82); C283(0.82); C83(1.24); C84(1.01)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C281(0.70); C283(0.70); C83(1.14); C84(0.86)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C125(0.75); C78(0.86); C83(0.93); C84(1.04)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C125(0.83); C78(0.74); C83(0.96); C84(0.93)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C125(0.78); C78(1.36); C83(1.56); C84(1.21)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C125(0.82); C78(0.68); C83(1.13); C84(1.11)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C125(0.89); C140(0.67); C281(0.46); C283(0.46)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C125(0.87); C78(0.79); C83(0.99); C84(1.03)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C125(0.90); C78(0.73); C83(1.05); C84(1.02)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C125(0.89); C78(0.53); C83(0.90); C84(0.94)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C125(0.79); C78(0.50); C83(0.70); C84(0.74)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C125(0.90); C78(0.47); C83(0.70); C84(0.78)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C125(0.77); C78(0.70); C83(0.85); C84(0.89)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C125(0.67); C78(0.77); C83(0.91); C84(0.98)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C125(0.74); C78(0.55); C83(0.97); C84(0.92)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C125(0.71); C78(0.47); C83(0.91); C84(0.96)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C125(0.72); C78(0.52); C83(0.86); C84(0.88)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C125(1.11); C140(0.84); C281(0.59); C283(0.59)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C125(0.81); C78(0.72); C83(0.79); C84(0.86)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C281(1.14); C283(1.14); C78(0.88); C83(0.93)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C281(1.00); C283(1.00); C78(0.53); C83(0.76)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C281(1.24); C283(1.24); C78(0.98); C83(1.00)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C281(0.84); C283(0.84); C78(0.74); C83(0.80)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C281(0.91); C283(0.91); C78(0.80); C83(0.85)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C281(0.94); C283(0.94); C78(1.35); C83(1.31)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C281(0.74); C283(0.74); C78(0.80); C83(0.94)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C281(0.76); C283(0.76); C78(0.53); C83(0.79)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C281(1.14); C283(1.14); C78(0.71); C83(0.88)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C135(0.98)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C140(1.21)  LDD1702  [1]
 LDCM0625  F8 Ramos C125(1.24)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C125(0.21)  LDD2190  [10]
 LDCM0576  Fragment14 Ramos C125(0.65)  LDD2193  [10]
 LDCM0586  Fragment28 Ramos C125(1.51)  LDD2198  [10]
 LDCM0468  Fragment33 HCT 116 C281(0.96); C283(0.96); C83(0.89); C84(0.79)  LDD0785  [2]
 LDCM0566  Fragment4 Ramos C125(0.91)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C125(1.05); C281(0.45); C283(0.45); C78(0.78)  LDD0744  [2]
 LDCM0569  Fragment7 Ramos C125(0.80)  LDD2186  [10]
 LDCM0022  KB02 HCT 116 C89(2.62); C90(2.62); C281(1.63); C283(1.63)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C89(20.00); C90(20.00); C281(6.10); C283(6.10)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C89(5.25); C90(5.25); C281(2.59); C283(2.59)  LDD0082  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C135(0.82)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C135(1.10)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C135(1.06)  LDD2127  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C135(0.96)  LDD2140  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C135(0.91)  LDD2146  [1]
 LDCM0021  THZ1 HCT 116 C83(1.15); C84(1.15)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c1, heme protein, mitochondrial (CYC1) Cytochrome c family P08574
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
E3 ubiquitin-protein ligase parkin (PRKN) RBR family, Parkin subfamily O60260
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TBC1 domain family member 21 (TBC1D21) . Q8IYX1

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rhigm12b7 Antibody D07BNG

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578