Details of the Target

General Information of Target

Target ID LDTP06288
Target Name Sorting nexin-17 (SNX17)
Gene Name SNX17
Gene ID 9784
Synonyms
KIAA0064; Sorting nexin-17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFP
PKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLE
VLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQ
EFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVT
KEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQ
LRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQ
WVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLE
SPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Cytoplasm
Function
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
Uniprot ID
Q15036
Ensemble ID
ENST00000233575.7
HGNC ID
HGNC:14979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T228M .
LNCaP clone FGC SNV: p.G158V .
LS180 SNV: p.R177L .
P31FUJ SNV: p.M1? .
SKMEL30 Deletion: p.L346RfsTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K435(5.88); K63(5.75)  LDD0277  [1]
Probe 1
 Probe Info  		Y210(14.52)  LDD3495  [2]
DBIA
 Probe Info  		C277(0.91)  LDD0531  [3]
CY4
 Probe Info  		K253(0.00); K256(0.00)  LDD0247  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C277(0.91)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C277(1.05)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C277(0.82)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C277(0.67)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C277(0.78)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C277(0.75)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C277(0.68)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C277(0.73)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C277(0.77)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C277(1.11)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C277(0.74)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C277(0.73)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C277(1.18)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C277(0.70)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C277(0.70)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C277(0.78)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C277(1.01)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C277(0.85)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C277(0.93)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C277(1.04)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C277(1.03)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C277(0.99)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C277(0.96)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C277(1.11)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C277(0.90)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C277(1.05)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C277(0.87)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C277(0.91)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C277(0.99)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C277(0.95)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C277(0.94)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C277(0.98)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C277(0.96)  LDD0576  [3]
 LDCM0263  AC143 HEK-293T C277(0.92); C286(0.53)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C277(1.02); C286(0.69)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C277(0.92); C286(0.97)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C277(0.89); C286(0.66)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C277(1.25); C286(0.33)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C277(0.91); C286(0.50)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C277(1.17); C286(0.58)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C277(0.90)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C277(0.95); C286(0.84)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C277(1.07); C286(0.54)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C277(1.15); C286(0.95)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C277(0.92); C286(0.57)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C277(1.30); C286(0.87)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C277(0.97); C286(0.94)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C277(1.07); C286(0.42)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C277(1.40); C286(0.26)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C277(1.06)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C277(1.06)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C277(1.18)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C277(0.98)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C277(1.13)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C277(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C277(1.15)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C277(1.14)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C277(1.14)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C277(1.17)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C277(1.14)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C277(1.03)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C277(0.99)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C277(1.10)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C277(0.97)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C277(1.12)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C277(1.09)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C277(1.11)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C277(1.03)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C277(0.94)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C277(0.76)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C277(0.62)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C277(0.60)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C277(0.59)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C277(0.65)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C277(0.91)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C277(0.56)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C277(0.62)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C277(0.53)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C277(0.60)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C277(0.61)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C277(0.53)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C277(0.92)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C277(0.92)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C277(0.96)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C277(0.95)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C277(0.92)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C277(0.91)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C277(0.88)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C277(0.93)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C277(0.88)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C277(0.99)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C277(1.12)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C277(0.94)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C277(0.98)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C277(0.80)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C277(0.88)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C277(0.95)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C277(0.80)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C277(0.74)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C277(0.85)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C277(0.88)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C277(0.90)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C277(0.90)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C277(0.89)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C277(0.86)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C277(0.72)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C277(0.82)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C277(0.96)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C277(0.89)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C277(0.95)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C277(0.80)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C277(0.91)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C277(1.02)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C277(0.82)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C277(0.86)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C277(0.79)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C277(0.88)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C277(0.83)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C277(0.95)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C277(0.94)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C277(0.78)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C277(0.74)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C277(0.86)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C277(0.95)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C277(0.86)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C277(0.87)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C277(0.98)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C277(1.01)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C277(0.84)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C277(0.98)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C277(0.88)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C277(0.91)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C277(0.90)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C277(1.12)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C277(0.88)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C277(0.97)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C277(0.83)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C277(0.68)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C277(0.87)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C277(1.09)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C277(1.01)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C277(0.97)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C277(0.97)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C277(0.85)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C277(0.96)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C277(0.93)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C277(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C277(1.23)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C277(0.99)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C277(1.06)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C277(1.21)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C277(1.12)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C277(1.21)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C277(1.07)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C277(0.91)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C277(1.20)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C277(1.07)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C277(1.02)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C277(0.95)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C277(0.97)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C277(1.00)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C277(1.03)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C277(0.53)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C277(0.39)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C277(0.53)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C277(0.97)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C277(0.65)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C277(0.88)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C277(0.87)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C277(0.93)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C277(0.87)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C277(0.91)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C277(0.81)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C277(0.76)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C277(0.92)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C277(0.81)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C277(0.87)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C277(0.84)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C277(1.07)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C277(0.77)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C277(1.07)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C277(1.38)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C277(0.88)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C277(1.23)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C277(1.63)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C277(1.52)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C277(1.24)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C277(1.10)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C277(0.99)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C277(1.35)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C277(1.19)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C277(0.98)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C277(1.19)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C277(0.86)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C277(1.20)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C277(1.08)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C277(1.00)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C277(0.87)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C277(1.03)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C277(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C277(1.03)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C277(1.09)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C277(1.09)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C277(0.88)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C277(1.03)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C277(1.02)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C277(0.97)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C277(1.14)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C277(1.21)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C277(1.17)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C277(0.88)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C277(0.80)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C277(0.87)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C277(1.12)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C277(0.95)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C277(1.05)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C277(1.07)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C277(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C277(0.74)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C277(0.90)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C277(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C277(0.85)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C277(0.85)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C277(1.05)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C277(0.96)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C277(0.73)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C277(0.94)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C277(0.76)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C277(1.01)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C277(0.89)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C277(0.78)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C277(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C277(0.75)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C277(0.97)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C277(0.70)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C277(0.65)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C277(0.98)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C277(0.83)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C277(0.78)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C277(0.79)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C277(0.79)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C277(0.86)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C277(0.90)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C277(0.95)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C277(0.96)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C277(0.95)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C277(0.86)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C277(0.86)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C277(0.95)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C277(0.97)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C277(0.95)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C277(1.06)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C277(0.93)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C277(0.96)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C277(0.94)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C277(0.95)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C277(1.15)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C277(0.81)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C277(1.23)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C277(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C277(0.88)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C277(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C277(0.90)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C277(0.82)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C277(0.88)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C277(0.85)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C277(0.79)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C277(0.87)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C286(0.74)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C277(0.81)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C277(1.05)  LDD0744  [3]
 LDCM0022  KB02 EoL-1 C277(1.90)  LDD2324  [7]
 LDCM0023  KB03 EoL-1 C277(2.70)  LDD2741  [7]
 LDCM0024  KB05 EoL-1 C277(2.41)  LDD3158  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
E3 ubiquitin-protein ligase RNF128 (RNF128) . Q8TEB7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840