Details of the Target

General Information of Target

Target ID LDTP06172
Target Name Bridge-like lipid transfer protein family member 2 (BLTP2)
Gene Name BLTP2
Gene ID 9703
Synonyms
BCOX1; KIAA0100; Bridge-like lipid transfer protein family member 2; Antigen MLAA-22; Breast cancer-overexpressed gene 1 protein; Protein hobbit homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLFFSALLVLLLVALSALFLGRWLVVRLATKWCQRKLQAELKIGSFRFFWIQNVSLKFQ
QHQQTVEIDNLWISSKLLSHDLPHYVALCFGEVRIRTDLQKVSDLSAPFSQSAGVDQKEL
SFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLDSDGKRLICEVSLC
KINSKVLKSGQLEDTCLVELSLALDLCLKVGISSRHLTAITVDVWTLHAELHEGLFQSQL
LCQGPSLASKPVPCSEVTENLVEPTLPGLFLLQQLPDQVKVKMENTSVVLSMNSQKRHLT
WTLKLLQFLYHRDEDQLPLRSFTANSDMAQMSTELLLEDGLLLSQSRQRIVCLNSLKASV
QVTTIDLSASLVLNTCIIHYRHQEFSHWLHLLALETQGSSSPVLKQRKKRTFPQILAPII
FSTSISNVNISIQLGDTPPFALGFNSISLDYQHLRPQSIHQRGVLTVDHLCWRVGSDSHI
QRAPHPPNMHVWGEALVLDSFTLQGSYNQPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQ
CLSRILSLMGPQSGKSAVSRHSSFGESVSLLWKVDLKVEDMNLFTLSALVGASEVRLDTL
TILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEV
QCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAP
EPLPPKRLLNLTLEVSTAKLTAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGN
SIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDE
AVGVQKWLKGLHQGTRAWASPSPVPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDE
SKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMR
RALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVK
SFLVRIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPL
KFYHDFHSEIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDW
HMDIEQANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCC
FLHLPDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIK
MDLTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYK
QLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVT
QMVSDLSQVTVHLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELSARDG
DPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKIDPQMPAK
KPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEEESGMSDQL
CGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLK
QKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSVQELMESGQAVGG
MVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKE
DLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQ
LEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSLQDDSKNENLLDLNQKLQL
QLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQEDVSVVRRTEFYFAQARWRL
TEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWFTMNNLLPNAVYKVVLRPQSSCQ
SGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQLTHQFFHRMMGFFFPGRSVEDDEV
GDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPGKGVAQGLTRSSGVRRSFRKSPEHPVD
DIDKMKERAAMNNSFIYIKIPQVPLCVSYKGEKNSVDWGDLNLVLPCLEYHNNTWTWLDF
AMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKSDLNMQQQEEEEKARLLIGLSV
GDKNPGKKSIFGRRK
Target Bioclass
Other
Family
SABRE family
Subcellular location
Cell membrane
Function Tube-forming lipid transport protein which binds to phosphatidylinositols and affects phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution.
Uniprot ID
Q14667
Ensemble ID
ENST00000528896.7
HGNC ID
HGNC:28960

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.T423I .
A101D SNV: p.G1531E DBIA    Probe Info 
AN3CA Deletion: p.W51GfsTer77
SNV: p.A1916T		 DBIA    Probe Info 
CAL27 SNV: p.S823Ter DBIA    Probe Info 
DANG SNV: p.H1174R DBIA    Probe Info 
HCT116 SNV: p.R528Ter DBIA    Probe Info 
HCT15 SNV: p.G822D .
HEC1 SNV: p.L126S DBIA    Probe Info 
HT115 SNV: p.I73M .
HUPT3 SNV: p.W2138L DBIA    Probe Info 
ICC4 SNV: p.A1104D DBIA    Probe Info 
IGR37 SNV: p.P1001S DBIA    Probe Info 
IGR39 SNV: p.P1001S DBIA    Probe Info 
KASUMI2 SNV: p.L521P .
KMS27 SNV: p.Y1470C DBIA    Probe Info 
KNS81FD SNV: p.N582S .
LS180 SNV: p.M581V .
PF382 SNV: p.V701I DBIA    Probe Info 
REH SNV: p.R2092H .
RL952 SNV: p.S1991G DBIA    Probe Info 
SKMEL2 SNV: p.W1128R DBIA    Probe Info 
SW1990 SNV: p.V611M DBIA    Probe Info 
T98G SNV: p.S878Ter .
TE4 SNV: p.C196Y DBIA    Probe Info 
TGBC1TKB SNV: p.R462Q DBIA    Probe Info 
TKKK SNV: p.R349H DBIA    Probe Info 
TOV21G Deletion: p.R410EfsTer56 .
UACC257 SNV: p.F134L DBIA    Probe Info 
YSCCC SNV: p.S820F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K914(5.22); K930(1.37)  LDD0277  [1]
BTD
 Probe Info  		C1979(0.84)  LDD2107  [2]
DBIA
 Probe Info  		C1979(1.11); C471(0.95); C538(0.94); C541(0.94)  LDD0078  [3]
CY-1
 Probe Info  		N.A.  LDD0246  [4]
CY4
 Probe Info  		N.A.  LDD0247  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1979(1.04)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C1055(0.89); C1979(1.30); C471(0.85); C538(1.18)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1055(1.01); C1979(1.21); C471(0.98); C538(1.31)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C471(2.31)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C471(1.81)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C471(1.12)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C471(1.55)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C471(1.64)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C471(1.51)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C471(1.49)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C471(1.48)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C471(1.92)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C471(1.20)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1055(1.29); C1979(1.30); C471(0.96); C538(1.27)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C471(1.47)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C471(1.33)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C471(1.23)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1055(0.98); C471(1.03)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1055(0.92); C471(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1055(0.88); C471(1.07)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1055(0.92); C471(1.15)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1055(1.16); C471(1.20)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1055(1.01); C471(1.10)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1055(1.23); C471(1.20)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1055(0.98); C1979(1.26); C471(0.97); C538(0.96)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1055(0.95); C471(1.05)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1055(1.39); C471(1.33)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1055(0.86); C471(1.02)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1055(1.08); C471(0.85)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1055(1.29); C471(1.05)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1055(0.88); C471(0.97)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1055(0.91); C471(1.00)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1055(0.96); C471(1.02)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1055(0.97); C471(0.69)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1055(0.93); C471(1.25)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1055(0.97); C471(1.28)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1055(0.98); C471(0.80)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1055(1.01); C471(1.54)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1055(1.03); C471(1.11)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1055(1.24); C471(1.10)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1055(1.03); C471(1.36)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1055(1.18); C471(1.32)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1055(1.00); C471(1.26)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1055(1.15); C471(1.35)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1055(1.20); C471(1.57)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1055(1.22); C1979(1.31); C471(1.07); C538(1.08)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1055(1.43); C471(1.59)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1055(1.14); C471(1.46)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1055(1.26); C471(1.65)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C471(1.10)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C471(1.20)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C471(1.01)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C471(1.09)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C471(1.02)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C471(0.98)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C471(1.00)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1055(0.96); C538(1.06); C541(1.06); C471(1.11)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C471(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C471(1.50)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C471(0.85)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C471(1.07)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C471(1.09)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C471(1.31)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C471(1.08)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C471(1.14)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1979(1.24); C538(1.24); C541(1.24); C471(1.36)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1979(1.01); C471(1.06); C538(1.07); C541(1.07)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C471(1.27); C1979(1.27); C538(1.36); C541(1.36)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1055(0.81); C471(0.91); C1979(1.34); C538(1.56)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C471(0.90); C1979(1.01); C538(1.25); C541(1.25)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C471(0.92); C1979(0.99); C538(1.14); C541(1.14)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C471(0.99); C538(1.11); C541(1.11); C1979(1.27)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C471(1.02); C538(1.32); C541(1.32); C1979(1.51)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C471(1.02); C538(1.19); C541(1.19); C1979(2.05)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1979(0.77); C1055(0.87); C471(1.01)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1055(0.82); C1979(1.04); C471(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1055(0.79); C1979(1.03); C471(1.12)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C471(0.94); C1055(0.95); C1979(1.18)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1055(0.86); C471(1.16); C1979(1.16)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C471(0.87); C1055(0.89); C538(1.23); C541(1.23)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1055(1.07); C471(1.11); C1979(1.27)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C471(1.01); C1979(1.10); C1055(1.25)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1055(1.07); C471(1.09); C1979(1.38)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1055(0.99); C471(1.06); C1979(1.16)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C471(0.97); C1979(0.97); C1055(1.37)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1055(1.03)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1055(0.61)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1055(0.62)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1055(0.84)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1055(0.76)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C471(0.84); C1055(0.98); C538(1.42); C541(1.42)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1055(0.89)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1055(0.64)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1055(0.78)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1055(0.75)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1055(0.73)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1055(0.84)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C538(1.16); C541(1.16); C471(1.26); C1979(1.71)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1055(0.95); C538(1.00); C541(1.00); C471(1.24)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1055(0.98); C538(1.04); C541(1.04); C471(1.27)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1055(0.87); C538(1.09); C541(1.09); C471(1.12)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C471(0.81); C1055(0.96); C1979(1.47); C538(1.50)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1055(0.98); C538(1.04); C541(1.04); C471(1.20)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C538(0.94); C541(0.94); C1055(1.06); C471(1.11)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C538(0.90); C541(0.90); C1055(1.04); C471(1.04)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1055(0.87); C538(1.03); C541(1.03); C471(1.10)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1055(0.85); C538(0.96); C541(0.96); C471(1.13)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C538(0.86); C541(0.86); C1055(1.16); C471(1.20)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1055(0.79); C538(0.88); C541(0.88); C471(1.11)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C538(0.88); C541(0.88); C471(1.04); C1055(1.13)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C471(0.91); C538(0.94); C541(0.94); C1979(1.16)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C538(0.88); C541(0.88); C471(0.91); C1055(1.22)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C471(0.86); C1055(0.97); C538(1.08); C541(1.08)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C538(0.79); C541(0.79); C471(0.97); C1055(1.07)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C538(0.93); C541(0.93); C471(0.96); C1055(1.15)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C538(0.92); C541(0.92); C471(0.96); C1055(1.14)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C538(0.80); C541(0.80); C471(0.90); C1055(1.20)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C538(0.88); C541(0.88); C471(0.94); C1055(1.20)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C471(0.99); C538(1.01); C541(1.01); C1055(1.47)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C471(0.93); C538(0.98); C541(0.98); C1055(1.20)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C471(0.91); C538(1.02); C541(1.02); C1055(1.43)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C471(0.83); C1055(0.86); C538(1.14); C541(1.14)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1055(0.76); C471(0.80); C538(0.88); C541(0.88)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1055(0.92); C471(0.99); C538(1.15); C541(1.15)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1055(0.86); C471(0.96); C538(1.19); C541(1.19)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C471(0.97); C538(0.98); C541(0.98); C1055(1.01)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1055(0.90); C471(1.01); C538(1.04); C541(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C471(0.85); C1055(1.23); C538(1.44); C541(1.44)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C471(0.90); C1055(1.24); C538(1.28); C541(1.28)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C471(0.91); C538(1.31); C541(1.31); C1055(1.46)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1055(0.85); C471(0.92); C538(0.97); C541(0.97)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C471(0.75); C538(0.84); C541(0.84); C1055(1.00)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C471(0.84); C1055(0.90); C538(1.03); C541(1.03)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C471(0.85); C1055(0.95); C538(1.09); C541(1.09)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1055(0.90); C538(0.97); C541(0.97); C471(1.03)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C471(0.84); C1055(0.91); C538(1.07); C541(1.07)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C538(0.74); C541(0.74); C471(0.79); C1055(1.05)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C471(0.90); C1055(1.25); C538(1.43); C541(1.43)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1055(0.94); C1979(1.38)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1055(1.05); C1979(1.12)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1979(0.97); C1055(1.01)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1055(1.03); C1979(1.09)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1055(1.24); C1979(1.31)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1055(0.97); C1979(1.28)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1055(0.80); C1979(1.36)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1055(0.90); C1979(1.02)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1055(0.90); C1979(1.06)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1055(0.90); C1979(1.25)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1979(0.95); C1055(0.99)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1055(0.81); C1979(0.90)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1055(1.08); C1979(1.29)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1979(1.04); C1055(1.14)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1055(0.84); C1979(1.12)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C471(2.38)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C471(2.04)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1055(0.99); C1979(1.29); C471(1.13); C538(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C471(1.00); C538(1.05); C541(1.05); C1055(1.09)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1055(0.76); C471(1.12); C538(1.12); C541(1.12)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1979(1.11); C471(0.95); C538(0.94); C541(0.94)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C1055(0.72); C471(0.99); C1979(1.00)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1055(0.58); C1979(1.14); C471(1.25)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1055(0.90); C471(0.94); C538(1.01); C541(1.01)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C1055(0.86); C538(1.10); C541(1.10); C471(1.14)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C538(0.97); C541(0.97); C1055(1.13); C471(1.16)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1055(0.97); C471(1.15); C538(1.20); C541(1.20)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1055(0.99); C1979(1.08); C538(1.09); C541(1.09)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C471(1.01); C1979(1.23); C538(1.38); C541(1.38)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1979(0.76); C538(1.07); C541(1.07); C471(1.16)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1979(0.86); C538(1.15); C541(1.15); C471(1.27)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C538(1.23); C541(1.23); C1979(1.24); C471(1.30)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C471(0.89); C538(0.99); C541(0.99); C1979(1.83)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C1055(0.65); C1979(0.99); C471(1.25)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C538(1.16); C541(1.16); C471(1.27); C1979(1.76)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C471(1.05); C538(1.34); C541(1.34); C1979(1.64)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1055(0.96); C471(1.16); C1979(1.19)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1055(0.81); C471(1.04); C1979(1.14)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C471(0.93); C1979(0.93); C1055(1.07)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C471(1.02); C1055(1.24); C1979(1.32)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C471(0.94); C1055(1.00); C1979(1.09)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1055(0.93)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1055(1.04)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1055(0.69)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C1055(0.52); C1979(0.79); C471(1.31)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1055(0.76)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C538(0.94); C541(0.94); C471(1.09); C1055(1.12)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C538(0.87); C541(0.87); C1055(0.96); C471(1.12)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C538(0.85); C541(0.85); C1979(0.95); C1055(1.12)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C538(0.72); C541(0.72); C1055(1.02); C471(1.30)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C538(0.82); C541(0.82); C471(1.04); C1055(1.14)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C538(0.81); C541(0.81); C1055(0.90); C471(0.96)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C538(0.90); C541(0.90); C471(0.93); C1055(1.05)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C471(0.93); C538(0.98); C541(0.98); C1055(1.23)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1055(0.65); C1979(1.03); C471(1.19)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1055(0.83); C1979(1.02); C471(1.07)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1055(0.69); C471(1.12); C1979(1.32)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1055(0.88); C1979(0.89); C471(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1055(0.94); C471(0.94); C1979(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1055(0.86); C471(1.00); C1979(1.25)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1055(0.94); C471(1.05); C1979(1.21)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C1055(0.65); C471(1.00); C1979(1.20)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1055(0.98); C471(1.00); C1979(1.78)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C471(1.06); C1055(1.18); C1979(2.74)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C471(1.00); C1055(1.36); C1979(1.64)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C471(0.91); C1055(0.99); C1979(1.19)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1055(1.11); C471(1.15); C1979(1.56)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1055(1.45); C1979(1.79); C471(1.19)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1055(0.88); C1979(1.07); C471(0.83)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1055(1.01); C1979(1.22); C471(1.08)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1055(0.96); C1979(1.34); C471(1.24)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1055(1.00); C1979(1.44); C471(1.16)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1055(0.58); C1979(0.87); C471(1.11)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1055(0.98); C1979(1.34); C471(1.10)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1055(0.76); C1979(1.24); C471(1.17)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1055(0.97); C1979(1.06); C471(0.94)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1055(1.06); C1979(1.62); C471(1.01)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1055(1.00); C1979(1.51); C471(1.06)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1055(1.10); C1979(1.33); C471(0.89)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1055(1.03); C1979(1.34); C471(0.95)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1055(1.29); C1979(1.35); C471(0.94)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1055(0.96); C1979(1.46); C471(0.91)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1055(0.72); C1979(0.94); C471(1.20)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1055(0.92); C1979(1.24); C471(0.99)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1055(0.85); C1979(1.12); C471(0.99)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1055(1.26); C1979(1.48); C471(0.81)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1055(1.03); C1979(1.24); C471(0.96)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1055(0.93); C1979(1.28); C471(0.95)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1055(1.23); C1979(1.42); C471(1.09)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1055(1.10); C1979(1.50); C471(1.30); C538(0.81)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1055(1.08); C1979(1.14); C471(0.96); C538(1.05)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1055(1.05); C1979(1.46); C471(1.40); C538(0.84)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1055(1.02); C1979(2.43); C471(1.17); C538(0.86)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1055(0.80); C1979(1.34); C471(1.13)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1055(1.09); C1979(1.34); C471(1.10); C538(0.96)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1055(1.26); C1979(1.14); C471(1.07); C538(0.80)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1055(1.12); C1979(1.39); C471(1.15); C538(0.93)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1055(0.90); C1979(0.86); C471(0.80); C538(1.24)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1055(1.07); C1979(1.14); C471(1.02); C538(0.85)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1055(0.92); C1979(0.78); C471(0.92); C538(0.78)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1055(1.07); C1979(1.00); C471(0.84); C538(1.13)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1055(1.18); C1979(1.37); C471(1.17); C538(1.10)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1055(1.01); C1979(1.21); C471(1.11); C538(0.79)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1055(1.01); C1979(1.04); C471(1.09); C538(1.07)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1055(0.92); C1979(0.98); C471(1.14)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1055(1.26); C1979(1.07); C471(1.09); C538(0.82)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1055(1.23); C471(1.07)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1055(1.27); C471(1.20)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1055(1.21); C471(1.00)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1055(1.46); C471(1.17)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1055(1.12); C471(1.13)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1055(1.31); C471(1.09)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1055(1.27); C471(1.05)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1055(1.19); C471(0.95)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1055(1.28); C471(1.23)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C1055(0.89); C1979(1.27); C471(1.34)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1055(1.05); C471(0.96)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1055(1.21); C471(1.04)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1055(1.16); C471(1.15)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1055(1.30); C471(1.06)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1055(1.21); C471(0.96)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1055(0.90); C1979(1.27); C471(1.16); C538(1.15)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1055(0.81); C1979(1.61); C471(1.11); C538(1.10)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1055(0.72); C1979(1.29); C471(1.16); C538(0.99)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1055(0.81); C1979(1.81); C471(1.11); C538(1.01)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C1055(0.94); C1979(1.04); C471(1.25)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1055(0.78); C1979(1.38); C471(1.21); C538(1.19)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1055(0.81); C1979(3.18); C471(1.15); C538(0.98)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1055(0.86); C1979(1.42); C471(1.09); C538(1.25)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1055(0.87); C1979(1.79); C471(1.08); C538(1.32)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1055(0.92); C1979(1.62); C471(0.98); C538(1.40)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1055(0.80); C1979(1.36); C471(1.06); C538(1.02)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1055(0.76); C1979(1.19); C471(1.13); C538(1.23)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1055(0.83); C1979(1.51); C471(1.11); C538(1.06)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1055(0.67); C1979(1.21); C471(1.05); C538(1.49)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1055(0.80); C1979(1.51); C471(1.07); C538(1.80)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C1055(0.73); C1979(1.10); C471(1.07)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1055(1.10); C1979(1.20); C471(1.12); C538(1.23)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1055(0.83); C1979(1.79); C471(0.81); C538(1.47)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1055(0.78); C1979(1.40); C471(0.80); C538(1.39)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1055(0.84); C1979(1.30); C471(0.88); C538(0.98)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1055(0.95); C1979(1.72); C471(0.89); C538(1.23)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1055(0.94); C1979(1.76); C471(0.81); C538(1.26)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1055(0.79); C1979(1.43); C471(1.03); C538(1.08)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1055(0.88); C1979(1.75); C471(0.94); C538(1.26)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1055(0.79); C1979(1.83); C471(0.92); C538(1.36)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1055(0.90); C1979(1.53); C471(0.82); C538(1.53)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C1979(1.01)  LDD1698  [9]
 LDCM0625  F8 Ramos C1979(1.03)  LDD2187  [10]
 LDCM0576  Fragment14 Ramos C1979(4.42)  LDD2193  [10]
 LDCM0586  Fragment28 Ramos C1979(0.46)  LDD2198  [10]
 LDCM0468  Fragment33 HCT 116 C1055(1.25); C471(1.13)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1055(0.93); C1979(2.19); C471(0.91)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C1979(0.76)  LDD2186  [10]
 LDCM0022  KB02 HEK-293T C1979(0.97); C1055(0.95); C2126(1.07)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C1055(10.01)  LDD0209  [11]
 LDCM0024  KB05 HMCB C1055(2.66)  LDD3312  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1979(0.84)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1979(0.75)  LDD2109  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1979(0.71)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1979(0.93)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1979(0.86)  LDD2136  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840