Details of the Target

General Information of Target

Target ID LDTP06167
Target Name Plastin-1 (PLS1)
Gene Name PLS1
Gene ID 5357
Synonyms
Plastin-1; Intestine-specific plastin; I-plastin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL
SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY
SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER
AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA
DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA
YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN
PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD
LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA
GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS
SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA
LPDDLVEVKPKMVMTVFACLMGKGLNRIK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.
Uniprot ID
Q14651
Ensemble ID
ENST00000337777.7
HGNC ID
HGNC:9090

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E270(10.00)  LDD2208  [1]
DBIA
 Probe Info  		C142(1.25); C166(0.81)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C142(0.00); C377(0.00); C166(0.00); C347(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C347(0.00); C142(0.00); C377(0.00); C166(0.00)  LDD0036  [3]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [4]
IPIAA_L
 Probe Info  		C461(0.00); C377(0.00)  LDD0031  [4]
Lodoacetamide azide
 Probe Info  		C347(0.00); C142(0.00); C377(0.00); C166(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD2156  [5]
PF-06672131
 Probe Info  		N.A.  LDD0017  [6]
PPMS
 Probe Info  		N.A.  LDD0008  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
STPyne
 Probe Info  		K58(0.00); K457(0.00)  LDD0009  [7]
TFBX
 Probe Info  		C461(0.00); C166(0.00)  LDD0148  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
W1
 Probe Info  		C142(0.00); C166(0.00)  LDD0236  [11]
AOyne
 Probe Info  		7.70  LDD0443  [12]
NAIA_5
 Probe Info  		C347(0.00); C461(0.00); C377(0.00); C166(0.00)  LDD2223  [13]
HHS-475
 Probe Info  		Y503(0.84)  LDD2238  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]
DA-2
 Probe Info  		N.A.  LDD0072  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C142(1.25); C166(0.81)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C142(0.61); C166(0.73)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C142(0.48)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C142(0.51)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C142(0.47)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C142(0.35)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C142(0.36)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C142(0.42)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C142(0.42)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C142(0.33)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C142(0.65)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C142(0.52)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C142(0.58); C166(0.73)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C142(0.51)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C142(0.55)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C142(0.38)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C142(1.15)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C142(0.73)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C142(0.51)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C142(0.51)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C142(0.85)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C142(0.61)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C142(0.68)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C142(0.71); C166(0.86)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C142(0.62)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C142(1.08)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C142(0.81)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C142(0.78)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C142(0.99)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C142(0.69)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C142(0.62)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C142(0.77)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C142(0.87)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C142(1.39)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C142(1.02)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C142(1.37)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C142(1.54)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C142(1.08)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C142(1.16)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C142(1.11)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C142(1.14)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C142(1.19)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C142(1.16)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C142(1.13)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C142(0.64); C166(0.74)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C142(1.20)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C142(1.23)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C142(1.81)  LDD0579  [2]
 LDCM0263  AC143 PaTu 8988t C166(0.80)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C166(0.88)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C166(0.81)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C166(0.92)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C166(0.88)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C166(0.79)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C166(0.84)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C142(0.61); C166(0.74)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C166(0.98)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C166(0.82)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C166(0.75)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C166(0.77)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C166(0.79)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C166(0.87)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C166(0.76)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C166(1.03)  LDD2169  [2]
 LDCM0276  AC17 HEK-293T C166(0.87)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C377(0.75)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C377(0.77); C619(0.70); C166(0.92)  LDD1517  [17]
 LDCM0279  AC2 HCT 116 C166(0.89); C142(1.18)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C377(1.20)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C377(0.99); C619(1.09)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C377(0.93)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C377(0.73); C619(1.10)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C377(0.80)  LDD1523  [17]
 LDCM0285  AC25 PaTu 8988t C619(1.08)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C619(1.04)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C619(1.30)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C619(1.29)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C619(1.20)  LDD1168  [2]
 LDCM0290  AC3 HCT 116 C166(0.89); C142(1.27)  LDD0607  [2]
 LDCM0291  AC30 PaTu 8988t C619(1.34)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C619(1.09)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C619(1.03)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C619(1.02)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C619(1.19)  LDD1174  [2]
 LDCM0296  AC35 HCT 116 C142(1.37)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C142(1.25)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C142(1.16)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C142(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C142(1.08)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C166(0.76); C142(1.41)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C142(0.93)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C142(1.29)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C142(0.96)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C142(1.08)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C142(1.01)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C142(0.93)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C142(1.03)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C142(0.99)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C142(1.22)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C142(0.67)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C166(0.82); C142(1.21)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C142(0.68)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C142(1.58)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C142(1.16)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C142(0.73)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C142(0.76)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C142(0.71)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C142(0.73)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C142(0.30)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C142(0.24)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C142(0.27)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C142(0.62); C166(0.74)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C142(0.31)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C142(0.31)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C142(0.22)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C142(0.29)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C142(0.22)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C142(0.30)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C142(0.29)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C142(0.19)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C142(0.88); C166(0.94)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C142(0.65); C166(0.83)  LDD0662  [2]
 LDCM0349  AC83 PaTu 8988t C166(1.23)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C166(1.44)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C166(1.21)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C166(1.36)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C166(1.15)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C166(1.14)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C166(1.46)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C166(1.14)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C166(1.10)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C166(1.30)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C166(1.20)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C166(1.22)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C166(1.13)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C166(1.31)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C166(1.43)  LDD1243  [2]
 LDCM0365  AC98 HCT 116 C142(0.23)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C142(0.57)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C142(0.79); C166(0.95)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C142(0.73); C166(0.88)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C142(0.49); C166(0.58)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C166(1.64)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C166(0.88)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C166(0.58)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C166(0.80); C142(1.15)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C166(0.79); C142(0.80)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C142(0.83); C166(0.83)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C166(0.91); C142(0.95)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C142(0.80); C166(0.91)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C377(0.92)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C377(0.74); C619(0.84)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C377(1.08); C142(0.99)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C377(0.80); C619(1.01); C166(0.98)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C377(0.89)  LDD1582  [17]
 LDCM0379  CL11 HCT 116 C166(0.60)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C377(0.86); C619(0.79)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C377(0.90); C142(0.79)  LDD1585  [17]
 LDCM0382  CL112 PaTu 8988t C619(0.88)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C619(1.28)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C619(1.11)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C619(1.22)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C619(1.09)  LDD1265  [2]
 LDCM0387  CL117 HCT 116 C142(0.80)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C142(1.13)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C142(1.14)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C166(0.67)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C142(1.32)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C142(0.99)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C142(0.89)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C142(0.68)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C142(0.71)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C142(0.58)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C142(0.57)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C142(0.48)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C142(0.30)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C166(0.79)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C166(0.80)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C166(0.55)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C142(1.10)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C142(0.98)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C142(0.69)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C142(0.65)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C166(0.85)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C142(0.63)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C142(0.61)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C142(0.51)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C142(0.70)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C142(0.52)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C142(0.66)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C142(0.52)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C142(0.80)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C142(0.69)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C142(0.58)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C166(1.20)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C142(0.64)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C142(0.80)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C142(0.82)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C142(0.67)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C142(0.71)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C142(0.66)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C142(0.77)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C142(0.69)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C142(0.74)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C166(0.68)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C142(0.69)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C142(0.78)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C142(0.58)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C142(0.73)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C142(0.72)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C142(0.74)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C377(0.92)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C377(1.30); C619(0.81)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C377(0.98)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C377(1.20)  LDD1643  [17]
 LDCM0440  CL5 HCT 116 C166(0.78)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C377(0.76); C619(0.84)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C377(0.95); C619(0.82); C166(1.01)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C166(0.74)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C377(0.69)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C377(1.03); C619(0.84); C166(1.06)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C377(0.86)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C377(1.16); C619(0.89)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C377(1.12)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C377(1.00); C619(0.84)  LDD1653  [17]
 LDCM0451  CL6 HCT 116 C166(0.82)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C377(0.89)  LDD1655  [17]
 LDCM0453  CL61 PaTu 8988t C166(1.01)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C166(0.65)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C166(0.80)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C166(0.76)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C166(0.87)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C166(0.71)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C166(0.84)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C166(0.70)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C166(0.62)  LDD1340  [2]
 LDCM0462  CL7 HCT 116 C166(0.73)  LDD0779  [2]
 LDCM0463  CL70 PaTu 8988t C166(0.75)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C166(0.79)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C166(0.89)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C166(0.60)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C166(0.80)  LDD1346  [2]
 LDCM0469  CL76 HCT 116 C166(0.82)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C166(0.79)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C166(0.71)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C166(0.63)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C166(0.60)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C166(0.88)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C166(1.04)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C166(0.66)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C166(0.63)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C166(0.68)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C166(0.69)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C166(0.76)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C166(0.75)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C166(0.54)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C166(0.60)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C166(0.76)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C166(1.05)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C142(0.91); C166(0.96)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C142(0.98); C166(1.01)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C142(1.02); C166(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C142(1.13); C166(0.86)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C142(0.89); C166(0.79)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C142(0.91); C166(0.90)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C142(0.95); C166(0.89)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C142(1.13); C166(0.79)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C142(1.14); C166(0.78)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C377(0.94); C142(0.84)  LDD1698  [17]
 LDCM0468  Fragment33 PaTu 8988t C166(0.65)  LDD1347  [2]
 LDCM0427  Fragment51 HCT 116 C142(0.50)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C377(1.05)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C377(1.07)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C619(1.44); C166(2.19)  LDD3310  [18]

References

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2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840