Details of the Target

General Information of Target

Target ID LDTP05964
Target Name Ras and Rab interactor 1 (RIN1)
Gene Name RIN1
Gene ID 9610
Synonyms
Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGGQAGGPQRPGRVVSLRE
RLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSH
YILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQLPRAIHHAATHKELEAISHL
GIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREK
FKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPSQTERLPPCQLLRRESSVGYRVPAG
SGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSPATSPHLGRRRPLLRSMSAAFCSLLAP
ERQVGRAAAALMQDRHTAAGQLVQDLLTQVRAGPEPQELQGIRQALSRARAMLSAELGPE
KLLSPKRLEHVLEKSLHCSVLKPLRPILAARLRRRLAADGSLGRLAEGLRLARAQGPGAF
GSHLSLPSPVELEQVRQKLLQLLRTYSPSAQVKRLLQACKLLYMALRTQEGEGAGADEFL
PLLSLVLAHCDLPELLLEAEYMSELLEPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPL
SPVQELRRSLSLWEQRRLPATHCFQHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCA
TKFRVTQPNTFGLFLYKEQGYHRLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSG
QSEARSRGEEQGCQGDGDAGVKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRA
AEE
Target Bioclass
Other
Family
RIN (Ras interaction/interference) family
Subcellular location
Cytoplasm
Function
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Uniprot ID
Q13671
Ensemble ID
ENST00000311320.9
HGNC ID
HGNC:18749

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.Y578S .
ETK1 SNV: p.Y578S .
HT115 SNV: p.L522F .
HT1197 SNV: p.Q667H .
JURKAT SNV: p.A26V; p.P88R .
KMRC1 SNV: p.R348W DBIA    Probe Info 
MFE319 SNV: p.T21I DBIA    Probe Info 
MOLT4 SNV: p.A176V .
NCIH1155 Deletion: p.P283LfsTer68 .
OCUG1 SNV: p.E420Ter DBIA    Probe Info 
RPMI7951 SNV: p.G48R DBIA    Probe Info 
RPMI8226 SNV: p.E398K DBIA    Probe Info 
RVH421 SNV: p.P211L DBIA    Probe Info 
T98G SNV: p.K498N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K662(7.69)  LDD0277  [2]
BTD
 Probe Info  		C284(1.23)  LDD2090  [3]
NAIA_5
 Probe Info  		C733(1.63)  LDD2227  [4]
AHL-Pu-1
 Probe Info  		C355(3.40)  LDD0170  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C733(1.41); C639(0.98); C101(0.86); C105(0.86)  LDD0078  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
NAIA_4
 Probe Info  		C223(0.00); C355(0.00); C639(0.00); C659(0.00)  LDD2226  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		C639(0.00); C733(0.00); C284(0.00); C438(0.00)  LDD0147  [10]
TFBX
 Probe Info  		C639(0.00); C284(0.00)  LDD0148  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C355(3.40)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C355(2.15)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C355(0.64); C101(0.77); C105(0.77); C223(0.57)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C355(0.93); C101(0.88); C105(0.88); C623(0.90)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C355(0.93); C101(0.88); C105(0.88); C284(1.20)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C355(1.15); C101(0.85); C105(0.85); C284(1.13)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C355(1.10); C101(0.94); C105(0.94); C284(1.30)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C355(1.26); C101(0.89); C105(0.89); C284(1.21)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C355(1.19); C101(0.96); C105(0.96); C284(0.93)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C355(1.10); C101(0.85); C105(0.85); C284(1.18)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C355(1.12); C101(0.88); C105(0.88); C284(1.28)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C355(0.98); C101(0.87); C105(0.87); C284(1.14)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C355(0.94); C101(0.79); C105(0.79); C284(1.10)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C355(0.95); C101(0.87); C105(0.87); C284(0.95)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C355(1.08); C101(1.14); C105(1.14); C623(1.02)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C355(1.05); C101(0.90); C105(0.90); C284(1.30)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C355(1.18); C101(0.93); C105(0.93); C284(1.10)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C355(1.06); C101(0.89); C105(0.89); C284(1.02)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C355(0.95); C101(1.09); C105(1.15); C623(0.95)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C355(0.88); C101(0.95); C105(0.95); C623(1.11)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C355(1.02); C101(1.05); C105(1.08); C623(1.14)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C355(0.95); C101(0.98); C105(1.03); C623(1.18)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C355(0.95); C101(1.09); C105(1.06); C623(1.06)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C355(0.85); C101(0.93); C105(0.91); C623(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C355(0.97); C101(0.93); C105(0.96); C623(1.00)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C355(0.92); C101(1.02); C105(1.02); C623(0.93)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C355(1.24); C101(1.02); C105(1.09); C623(1.07)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C355(1.06); C101(0.95); C105(0.98); C623(1.01)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C355(0.97); C101(0.98); C105(0.96); C623(0.91)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C355(1.01); C101(0.78); C105(0.78); C623(1.01)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C355(0.93); C101(1.13); C105(1.18); C623(1.03)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C355(1.12); C101(0.95); C105(0.97); C623(0.93)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C355(0.86); C101(1.02); C105(1.01); C623(1.12)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C355(0.88); C101(0.92); C105(0.92); C623(1.07)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C355(0.52); C101(0.88); C105(0.88); C284(0.69)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C355(0.49); C101(0.93); C105(0.93); C284(0.66)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C355(0.54); C101(0.82); C105(0.82); C284(0.67)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C355(0.66); C101(0.78); C105(0.78); C284(0.69)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C355(0.63); C101(0.78); C105(0.78); C284(0.71)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C355(0.63); C101(0.85); C105(0.85); C284(0.71)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C355(0.91); C101(0.98); C105(0.98); C284(0.81)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C355(0.62); C101(0.82); C105(0.82); C284(0.71)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C355(0.80); C101(0.96); C105(0.96); C284(0.74)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C355(0.72); C101(0.73); C105(0.73); C284(0.72)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C355(1.15); C101(0.99); C105(0.99); C284(0.84)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C355(0.82); C101(0.91); C105(0.91); C284(0.77)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C355(1.09); C101(1.03); C105(1.03); C623(0.86)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C355(1.04); C101(0.85); C105(0.85); C284(0.88)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C355(1.02); C101(0.82); C105(0.82); C284(0.90)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C355(0.80); C101(0.79); C105(0.79); C284(0.76)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C355(1.47); C101(0.94); C105(0.94); C284(1.04)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C284(0.89); C101(0.89); C105(0.90); C355(0.95)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C105(0.85); C101(0.88); C355(1.08); C639(1.13)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C284(0.92); C105(1.04); C101(1.10); C623(1.11)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C105(0.94); C101(0.96); C355(1.03); C623(1.06)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C284(0.95); C623(1.07); C355(1.34); C639(1.55)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C284(0.85); C355(1.19); C101(1.20); C623(1.24)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C623(0.85); C355(0.93); C733(1.02); C101(1.06)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C284(0.87); C101(0.96); C105(0.97); C355(1.02)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C284(0.75); C105(0.84); C101(0.93); C623(1.06)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C284(0.79); C105(1.14); C101(1.16); C355(1.18)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C284(0.89); C623(1.25); C105(1.41); C101(1.44)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C355(1.07); C101(0.99); C105(0.94); C223(1.63)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C355(1.13); C101(0.88); C105(0.83); C223(1.81)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C355(1.22); C101(0.91); C105(0.89); C223(1.33)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C355(1.17); C101(1.07); C105(1.00); C223(1.67)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C355(0.72); C223(0.75); C101(0.81); C105(0.81)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C355(0.60); C284(0.95); C733(0.97); C623(1.04)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C355(0.63); C223(0.65); C284(0.87); C733(0.88)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C223(0.59); C101(0.80); C105(0.80); C355(0.86)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C223(0.88); C284(1.02); C101(1.04); C105(1.04)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C223(0.71); C355(0.82); C284(1.04); C101(1.09)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C101(0.91); C105(0.91); C355(0.93); C223(1.01)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C355(0.84); C733(0.95); C223(0.95); C101(0.99)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C223(0.71); C355(0.90); C284(0.93); C639(0.98)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C223(0.70); C284(0.90); C623(0.96); C101(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C223(0.68); C623(0.96); C101(1.01); C105(1.01)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C223(0.72); C623(0.94); C101(1.04); C105(1.04)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C223(0.82); C101(0.98); C105(0.98); C284(1.12)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C223(0.81); C101(1.04); C105(1.04); C623(1.07)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C355(0.59); C223(0.65); C623(0.80); C101(0.86)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C223(0.66); C284(1.06); C101(1.08); C105(1.08)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C223(0.69); C101(0.95); C105(0.95); C623(0.97)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C223(0.65); C101(0.98); C105(0.98); C623(1.07)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C223(0.83); C101(1.09); C105(1.09); C623(1.11)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C223(0.73); C284(1.12); C623(1.16); C101(1.54)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C733(0.82); C284(0.86); C639(0.90); C355(0.97)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C733(0.80); C639(0.86); C284(0.87); C101(1.18)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C733(0.79); C639(0.83); C284(0.86); C101(1.15)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C639(0.84); C284(0.85); C733(0.86); C101(0.98)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C101(0.90); C105(0.90); C639(0.93); C284(0.95)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C355(0.57); C223(0.61); C623(0.83); C101(0.83)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C284(0.93); C733(1.00); C639(1.05); C101(1.10)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C284(0.86); C733(0.95); C101(0.98); C105(0.98)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C733(0.99); C639(1.00); C101(1.01); C105(1.01)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C733(0.90); C639(0.98); C101(1.00); C105(1.00)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C639(0.89); C733(0.98); C284(1.01); C101(1.27)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C101(1.02); C105(1.02); C639(1.06); C284(1.10)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C284(0.92); C101(1.01); C105(1.01); C733(1.03)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C101(0.97); C105(0.97); C733(0.99); C623(1.03)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C101(0.77); C105(0.77); C355(0.90); C733(1.03)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C355(1.02); C101(1.18); C105(1.18); C623(1.19)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C355(0.52); C223(0.53); C101(0.82); C105(0.82)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C355(1.06); C623(1.17); C284(1.21); C101(1.21)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C101(0.95); C105(0.95); C639(1.04); C733(1.06)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C284(1.01); C101(1.03); C105(1.03); C733(1.08)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C101(1.06); C105(1.06); C623(1.18); C733(1.20)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C355(1.06); C284(1.06); C101(1.10); C105(1.10)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C101(1.07); C105(1.07); C284(1.22); C623(1.23)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C623(1.33); C284(1.44); C101(1.66); C105(1.66)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C284(0.95); C101(0.98); C105(0.98); C623(1.19)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C284(1.03); C101(1.06); C105(1.06); C639(1.26)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C101(0.98); C105(0.98); C284(1.12); C623(1.25)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C101(0.95); C105(0.95); C623(1.08); C355(1.11)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C101(0.93); C105(0.93); C284(1.02); C623(1.18)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C101(0.89); C105(0.89); C284(0.93); C623(1.06)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C101(0.89); C105(0.89); C284(1.08); C639(1.40)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C101(0.83); C105(0.83); C284(0.97); C623(1.16)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C101(0.92); C105(0.92); C284(1.03); C639(1.24)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C284(0.78); C101(0.82); C105(0.82); C623(1.21)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C284(0.72); C101(0.97); C105(0.97); C623(1.20)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C284(0.82); C101(1.05); C105(1.05); C623(1.37)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C355(0.84); C623(0.89); C639(1.06); C101(1.20)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C355(0.65); C623(0.88); C639(1.08); C101(1.29)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C101(0.97); C105(0.97); C623(1.02); C355(1.13)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C355(0.61); C623(1.01); C639(1.07); C284(1.13)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C355(0.67); C623(0.90); C639(0.97); C101(1.18)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C355(0.74); C623(0.88); C639(1.13); C101(1.28)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C355(0.90); C623(1.09); C639(1.38); C101(1.58)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C355(0.75); C623(0.95); C639(1.39); C101(1.67)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C355(0.73); C623(0.92); C639(1.45); C101(1.54)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C355(0.82); C623(0.90); C639(1.11); C101(1.26)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C355(0.96); C623(1.05); C639(1.17); C101(1.39)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C623(0.89); C355(0.92); C639(1.02); C101(1.06)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C355(0.71); C623(1.01); C101(1.09); C105(1.09)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C623(0.92); C355(0.98); C101(1.05); C105(1.05)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C623(0.87); C355(1.00); C639(1.04); C101(1.20)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C355(0.69); C623(1.00); C639(1.12); C101(1.20)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C355(0.73); C623(0.92); C639(1.37); C101(1.68)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C623(1.14); C101(1.29); C105(1.29); C284(1.37)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C101(1.24); C105(1.24); C284(1.24); C623(1.33)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C101(0.96); C105(0.96); C284(1.26); C623(1.27)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C101(0.90); C105(0.90); C639(1.16); C355(1.16)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C101(0.89); C105(0.89); C355(0.99); C284(0.99)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C101(1.01); C105(1.01); C355(1.11); C639(1.11)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C284(1.20); C623(1.21); C101(1.23); C105(1.23)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C355(0.78); C284(1.00); C639(1.01); C101(1.08)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C623(1.17); C101(1.25); C105(1.25); C284(1.33)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C101(1.20); C105(1.20); C623(1.25); C284(1.33)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C355(1.12); C101(1.15); C105(1.15); C284(1.18)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C355(1.15); C101(1.15); C105(1.15); C284(1.21)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C101(0.96); C105(0.96); C355(1.02); C623(1.10)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C101(1.14); C105(1.14); C639(1.22); C355(1.29)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C101(1.09); C105(1.09); C623(1.22); C355(1.43)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C101(1.09); C105(1.09); C284(1.18); C355(1.35)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C101(0.86); C105(0.86); C355(0.97); C623(1.08)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C355(0.93); C101(1.03); C105(1.03); C623(0.95)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C101(0.92); C105(0.92); C623(1.00); C639(1.14)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C623(1.00); C355(1.04); C101(1.09); C105(1.09)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C733(1.41); C639(0.98); C101(0.86); C105(0.86)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C733(1.63)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C101(0.99); C105(0.99); C623(1.02); C639(1.09)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C623(0.82); C101(1.10); C105(1.10); C639(1.40)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C223(0.65); C355(0.78); C101(0.86); C105(0.86)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C623(0.94); C733(1.16); C355(1.20); C101(1.29)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C101(0.93); C105(0.93); C623(1.15); C639(1.23)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C623(0.95); C355(1.02); C101(1.10); C105(1.10)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C623(0.95); C355(1.13); C639(1.15); C101(1.17)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C355(0.84); C101(0.91); C105(0.91); C223(1.02)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C355(0.54); C223(0.80); C101(1.06); C105(1.06)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C355(0.61); C223(0.62); C101(0.91); C105(0.91)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C223(0.61); C355(0.65); C623(0.95); C101(0.95)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C223(0.88); C733(1.03); C623(1.10); C101(1.11)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C101(0.95); C105(0.95); C623(0.99); C284(1.42)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C223(0.81); C355(0.97); C733(1.06); C623(1.13)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C223(0.70); C355(0.86); C733(0.92); C101(1.06)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C223(0.80); C623(0.99); C733(1.02); C284(1.18)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C223(0.66); C101(1.15); C105(1.15); C284(1.16)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C223(1.10); C623(1.23); C101(1.24); C105(1.24)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C223(0.68); C623(1.20); C101(1.30); C105(1.30)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C223(0.69); C284(1.09); C623(1.17); C101(1.19)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C639(1.19); C101(1.35); C105(1.35); C623(1.45)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C639(0.94); C284(0.97); C733(1.02); C355(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C639(0.98); C733(1.05); C623(1.07); C284(1.10)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C623(0.78); C101(1.25); C105(1.25); C284(1.34)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C733(0.90); C284(0.92); C639(0.99); C101(1.00)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C284(0.60); C101(1.05); C105(1.05); C623(1.10)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C284(0.99); C101(1.11); C105(1.11); C733(1.12)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C733(1.12); C101(1.26); C105(1.26); C623(1.53)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C101(1.21); C105(1.21); C623(1.29); C733(1.29)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C101(0.87); C105(0.87); C623(1.00); C284(1.02)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C101(0.89); C105(0.89); C284(1.07); C639(1.11)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C284(0.93); C101(0.96); C105(0.96); C623(1.06)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C101(0.84); C105(0.84); C284(1.03); C623(1.15)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C623(0.93); C355(1.20); C284(1.21); C639(1.23)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C623(0.87); C639(1.38); C284(1.43); C101(1.53)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C623(1.22); C284(1.55); C355(1.58); C639(1.84)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C284(0.92); C639(1.05); C623(1.11); C101(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C355(1.13); C639(1.18); C101(1.22); C105(1.22)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C101(0.94); C105(0.94); C639(0.97); C623(1.03)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C639(0.93); C101(0.95); C105(0.95); C623(1.08)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C623(0.93); C101(1.05); C105(1.05); C284(1.07)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C101(1.02); C105(1.02); C355(1.05); C639(1.06)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C101(1.14); C105(1.14); C355(1.19); C623(1.34)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C101(1.09); C105(1.09); C355(1.15); C623(1.43)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C101(0.79); C105(0.79); C623(1.04); C639(1.07)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C355(0.88); C101(0.78); C105(0.78); C623(1.13)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C355(0.90); C101(1.33); C105(1.33); C623(1.26)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C355(1.23); C101(0.98); C105(0.98); C623(1.09)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C355(0.82); C101(0.63); C105(0.63); C623(0.97)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C355(1.13); C101(0.75); C105(0.75); C623(1.10)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C355(0.78); C101(0.95); C105(0.95); C623(1.07)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C355(1.07); C101(1.03); C105(1.03); C284(1.07)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C355(0.90); C101(0.81); C105(0.81); C623(0.97)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C101(1.33); C105(1.33); C623(1.00); C639(1.19)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C101(1.01); C105(1.01); C284(1.23); C623(1.13)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C101(1.30); C105(1.30); C284(2.67); C623(1.57)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C101(1.01); C105(1.01); C284(1.12); C623(0.97)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C101(1.01); C105(1.01); C284(1.32); C623(1.02)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C101(0.98); C105(0.98); C284(1.29); C623(1.21)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C101(1.05); C105(1.05); C284(1.06); C623(0.99)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C101(0.91); C105(0.91); C284(1.31); C623(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C355(1.18); C101(1.30); C105(1.30); C284(1.64)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C101(1.21); C105(1.21); C284(1.02); C623(1.38)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C101(1.14); C105(1.14); C284(1.27); C623(1.13)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C101(0.95); C105(0.95); C284(1.08); C623(1.14)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C101(1.02); C105(1.02); C284(1.12); C623(1.03)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C101(1.01); C105(1.01); C284(1.05); C623(0.99)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C101(1.16); C105(1.16); C284(1.18); C623(1.20)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C355(1.61); C101(0.79); C105(0.79); C284(1.03)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C355(1.07); C101(0.97); C105(0.97); C284(0.92)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C355(0.98); C101(0.91); C105(0.91); C284(1.08)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C355(0.89); C101(0.92); C105(0.92); C284(1.13)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C355(1.02); C101(1.41); C105(1.41); C284(1.11)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C355(0.93); C101(1.34); C105(1.34); C284(1.14)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C355(1.23); C101(1.00); C105(1.00); C284(1.19)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C355(1.28); C101(1.05); C105(1.05); C284(1.10)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C355(0.89); C101(1.19); C105(1.19); C284(0.87)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C355(0.88); C101(0.98); C105(0.98); C284(0.88)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C355(1.54); C101(0.88); C105(0.88); C284(0.93)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C355(0.71); C101(0.90); C105(0.90); C284(0.85)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C355(0.77); C101(1.06); C105(1.06); C284(0.98)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C355(0.76); C101(0.92); C105(0.92); C284(0.86)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C355(0.83); C101(0.82); C105(0.82); C284(0.98)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C355(1.07); C101(1.38); C105(1.38); C284(1.55)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C355(0.95); C101(0.99); C105(0.99); C284(1.02)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C101(0.85); C105(1.09); C623(0.94); C639(1.09)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C101(0.80); C105(1.02); C623(0.93); C639(1.16)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C101(0.81); C105(0.97); C623(1.00); C639(1.39)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C101(0.81); C105(1.03); C623(0.92); C639(2.01)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C101(0.96); C105(1.11); C623(1.00); C639(1.29)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C101(0.92); C105(1.10); C623(0.94); C639(1.57)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C101(1.02); C105(1.19); C623(1.00); C639(1.29)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C101(1.04); C105(1.03); C623(1.14); C639(1.44)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C101(0.84); C105(0.98); C623(1.09); C639(1.26)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C355(1.19); C101(1.43); C105(1.43); C284(1.22)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C101(0.92); C105(1.05); C623(1.01); C639(1.24)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C101(1.00); C105(1.10); C623(1.03); C639(1.51)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C101(0.91); C105(1.06); C623(1.12); C639(1.17)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C101(0.82); C105(0.90); C623(1.13); C639(1.39)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C101(0.97); C105(1.04); C623(1.30); C639(1.31)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C355(0.98); C101(1.11); C105(1.11); C623(0.96)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C355(0.96); C101(1.13); C105(1.13); C623(1.25)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C355(1.24); C101(0.99); C105(0.99); C623(0.93)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C355(0.75); C101(1.04); C105(1.04); C623(0.94)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C355(1.84); C101(0.99); C105(0.99); C284(2.84)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C355(0.82); C101(1.05); C105(1.05); C623(0.92)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C355(0.70); C101(1.01); C105(1.01); C623(0.97)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C355(0.59); C101(1.07); C105(1.07); C623(0.90)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C355(0.76); C101(1.02); C105(1.02); C623(1.31)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C355(1.12); C101(1.00); C105(1.00); C623(1.08)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C355(1.06); C101(1.07); C105(1.07); C623(1.05)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C355(1.20); C101(1.06); C105(1.06); C623(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C355(0.62); C101(1.07); C105(1.07); C623(0.98)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C355(0.62); C101(1.09); C105(1.09); C623(0.95)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C355(0.85); C101(1.14); C105(1.14); C623(0.96)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C355(1.31); C101(1.17); C105(1.17); C284(1.22)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C355(1.62); C101(1.15); C105(1.15); C623(1.99)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C355(0.95); C101(0.77); C105(0.77); C223(0.63)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C355(1.46); C101(0.86); C105(0.86); C223(0.91)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C355(0.83); C101(0.82); C105(0.82); C223(0.72)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C355(0.85); C101(0.78); C105(0.78); C223(0.79)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C355(2.17); C101(0.86); C105(0.86); C223(0.88)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C355(0.94); C101(0.84); C105(0.84); C223(0.72)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C355(0.97); C101(0.89); C105(0.89); C223(0.71)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C355(1.07); C101(0.79); C105(0.79); C223(0.60)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C355(0.72); C101(0.65); C105(0.65); C223(0.60)  LDD0811  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C284(4.81)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C101(1.03); C105(1.17); C623(0.96); C639(1.30)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C101(1.09); C105(1.09); C284(1.17); C623(1.34)  LDD0744  [7]
 LDCM0022  KB02 42-MG-BA C623(2.05); C733(2.09); C639(2.95)  LDD2244  [11]
 LDCM0023  KB03 42-MG-BA C623(2.40); C733(1.79); C639(3.40)  LDD2661  [11]
 LDCM0024  KB05 COLO792 C284(6.91)  LDD3310  [11]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C284(1.23)  LDD2090  [3]
 LDCM0021  THZ1 HCT 116 C733(1.04); C639(1.05); C623(0.81)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTPase HRas (HRAS) Ras family P01112
GTPase NRas (NRAS) Ras family P01111
Ras-related protein R-Ras2 (RRAS2) Ras family P62070
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM7 (TRIM7) TRIM/RBCC family Q9C029
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
MyoD family inhibitor (MDFI) MDFI family Q99750
Sorting nexin-17 (SNX17) Sorting nexin family Q15036
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cerebral cavernous malformations 2 protein (CCM2) CCM2 family Q9BSQ5
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Protein transport protein Sec23B (SEC23B) SEC23/SEC24 family Q15437
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Calpain small subunit 2 (CAPNS2) . Q96L46
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Heat shock factor 2-binding protein (HSF2BP) . O75031
Kelch-like protein 12 (KLHL12) . Q53G59
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840