Details of the Target

General Information of Target

Target ID LDTP05696
Target Name Epidermal growth factor receptor kinase substrate 8 (EPS8)
Gene Name EPS8
Gene ID 2059
Synonyms
Epidermal growth factor receptor kinase substrate 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGHISNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNYARDSVSSVS
DISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLE
SKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDI
ESAISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWA
ADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKR
KKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHF
LFTPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEW
PKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHS
SVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKY
DFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADP
PYTHTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSS
SSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVIN
ITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQ
KAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH
Target Bioclass
Other
Family
EPS8 family
Subcellular location
Cytoplasm, cell cortex
Function
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
Uniprot ID
Q12929
Ensemble ID
ENST00000281172.10
HGNC ID
HGNC:3420

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.Y22Ter; p.L637F .
HCC1419 SNV: p.T390K DBIA    Probe Info 
HEC1 SNV: p.M407V; p.Q467R; p.W567L .
HEC1B SNV: p.M407V; p.W567L .
HT115 SNV: p.K649N DBIA    Probe Info 
JHH1 SNV: p.L528R DBIA    Probe Info 
JURKAT SNV: p.G190E .
KYM1 SNV: p.A355G .
LS123 SNV: p.Y22Ter DBIA    Probe Info 
MCC13 Substitution: p.S29F DBIA    Probe Info 
MDAMB468 SNV: p.E68K .
MELHO SNV: p.Y22Ter DBIA    Probe Info 
SW1116 SNV: p.Y22Ter .
TE4 SNV: p.E458Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K514(9.09); K569(0.54); K708(10.00); K97(3.99)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
HHS-475
 Probe Info  		Y498(0.55); Y252(0.67); Y485(0.80); Y540(0.86)  LDD0264  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C767(1.16)  LDD0531  [5]
W1
 Probe Info  		C767(1.81)  LDD0239  [2]
IA-alkyne
 Probe Info  		C168(0.00); C331(0.00)  LDD0162  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C767(1.16)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C331(1.12); C767(1.43)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C331(0.62); C767(1.02)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C331(0.62); C767(0.97)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C331(0.67); C767(1.00)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C331(0.59); C767(1.20)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C331(0.68); C767(1.16)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C331(0.62); C767(1.14)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C331(0.64); C767(1.25)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C331(0.48); C767(0.92)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C331(1.11); C767(1.53)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C331(1.47); C767(1.47)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C331(0.95); C767(1.26)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C331(1.17); C767(1.32)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C331(1.22); C767(1.45)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C331(0.41); C767(1.10)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C331(0.88); C767(1.07)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C331(0.76); C767(1.20)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C331(0.81); C767(1.57)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C331(0.80); C767(1.27)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C331(1.10); C767(1.07)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C331(0.97); C767(1.14)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C331(1.02); C767(1.44)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C331(1.17); C767(1.95)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C331(0.84); C767(1.30)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C331(1.03); C767(1.32)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C331(1.29); C767(1.33)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C331(1.15); C767(1.27)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C331(0.88); C767(1.15)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C331(0.88); C767(1.20)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C331(0.82); C767(1.13)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C331(0.94); C767(1.22)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C331(0.98); C767(0.91)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C331(0.97); C767(1.05)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C331(0.95); C767(0.99)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C331(1.03); C767(1.01)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C331(1.14); C767(1.23)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C331(0.99); C767(0.94)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C331(1.05); C767(0.92)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C331(1.09); C767(0.84)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C331(0.96); C767(1.22)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C331(1.20); C767(0.99)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C331(1.00); C767(1.42)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C331(1.09); C767(1.28)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C331(1.07); C767(1.40)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C331(0.97); C767(1.37)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C331(1.17); C767(1.40)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C331(1.25); C767(1.14)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C331(1.13); C767(1.17)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C331(0.78); C767(1.33)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C331(0.81); C767(1.26)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C767(0.98); C331(1.01)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C331(0.98); C767(1.05)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C331(0.82); C767(1.14)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C331(0.96); C767(1.04)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C331(1.05); C767(1.68)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C331(0.89); C767(0.95)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C331(0.99); C767(1.12)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C331(0.96); C767(0.97)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C331(0.73); C767(1.15)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C331(0.96); C767(1.03)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C331(0.98); C767(1.12)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C331(1.02); C767(1.03)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C331(1.08); C767(1.60)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C767(0.83); C331(0.89)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C331(0.83); C767(0.88)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C331(0.76); C767(0.98)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C767(1.34)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C767(0.89); C331(0.94)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C767(0.76); C331(0.79)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C767(0.73); C331(0.82)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C331(0.87); C767(0.89)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C767(0.88); C331(1.03)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C331(0.77); C767(1.07)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C331(0.99); C767(1.34)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C331(0.86); C767(1.31)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C331(0.83); C767(1.08)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C331(0.83); C767(1.27)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C767(1.13)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C331(0.83); C767(1.61)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C331(0.82); C767(1.26)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C331(0.78); C767(1.34)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C331(0.75); C767(1.43)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C331(0.73); C767(1.56)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C767(0.93); C331(1.02)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C767(1.01); C331(1.17)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C331(1.08); C767(1.11)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C767(0.95); C331(1.02)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C331(1.08); C767(1.27)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C767(1.01)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C331(0.89); C767(1.18)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C331(0.94); C767(1.31)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C331(1.07); C767(1.11)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C331(0.95); C767(1.43)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C331(0.96); C767(1.94)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C767(0.94); C331(1.00)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C331(1.04); C767(1.14)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C331(1.02); C767(1.20)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C331(1.14); C767(1.20)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C331(0.81); C767(1.32)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C767(1.05)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C331(0.84); C767(1.37)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C331(1.10); C767(1.13)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C331(0.81); C767(1.18)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C331(0.92); C767(1.10)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C331(0.88); C767(1.47)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C331(0.82); C767(1.41)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C331(0.88); C767(1.53)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C331(0.72); C767(1.42)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C331(0.73); C767(1.40)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C331(0.80); C767(2.09)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C331(0.99); C767(1.65)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C331(0.79); C767(2.21)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C331(1.11); C767(1.86)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C331(0.74); C767(1.56)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C331(0.75); C767(1.71)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C331(0.82); C767(1.90)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C331(0.94); C767(1.80)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C331(1.01); C767(1.88)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C331(0.65); C767(2.57)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C331(1.08); C767(1.16)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C331(0.91); C767(1.05)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C331(0.92); C767(1.72)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C331(0.87); C767(1.03)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C767(0.84); C331(1.10)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C331(0.76); C767(0.89)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C331(0.82); C767(1.05)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C331(0.84); C767(1.05)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C331(0.89); C767(1.53)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C331(0.80); C767(0.89)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C331(0.87); C767(1.16)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C767(1.00); C331(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C767(0.83); C331(0.92)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C331(0.99); C767(1.23)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C331(0.90); C767(1.25)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C767(0.90); C331(1.10)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C331(0.99); C767(1.18)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C331(0.79); C767(1.26)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C331(0.90); C767(1.40)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C331(1.00); C767(1.19)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C331(0.84); C767(1.24)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C767(1.08); C331(1.19)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C331(0.89); C767(1.21)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C331(0.83); C767(1.45)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C331(1.30); C767(1.45)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C331(0.71); C767(1.10)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C331(0.85); C767(1.09)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C331(1.01); C767(1.18)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C331(0.96); C767(1.13)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C331(1.04); C767(1.18)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C331(0.90); C767(1.03)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C331(0.73); C767(1.29)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C331(0.41); C767(1.37)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C331(0.78); C767(1.01)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C331(1.26); C767(2.00)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C331(0.92); C767(1.80)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C331(0.85); C767(1.00)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C767(1.90)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C767(0.72); C331(0.86)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C331(0.81); C767(1.04)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C767(1.04)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C331(0.79); C767(1.14)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C331(1.03); C767(1.35)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C331(0.91); C767(1.14)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C331(0.84); C767(1.26)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C331(0.74); C767(0.88)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C331(0.69); C767(0.93)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C331(0.85); C767(1.10)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C331(0.84); C767(1.04)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C331(0.74); C767(0.95)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C331(0.77); C767(1.23)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C331(0.66); C767(0.93)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C331(0.76); C767(1.19)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C767(0.81); C331(1.15)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C331(0.80); C767(1.24)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C331(0.80); C767(1.02)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C331(0.79); C767(1.03)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C331(1.00); C767(1.31)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C331(0.97); C767(1.50)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C331(1.01); C767(1.48)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C767(0.96); C331(0.97)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C331(0.95); C767(1.39)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C331(1.12); C767(1.26)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C331(0.81); C767(1.02)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C331(0.92); C767(1.18)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C331(0.76); C767(1.45)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C331(0.78); C767(1.28)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C331(0.78); C767(1.34)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C331(0.74); C767(1.14)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C331(0.79); C767(1.46)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C331(0.67); C767(1.39)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C331(1.11); C767(1.17)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C767(1.00); C331(1.05)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C331(1.03); C767(1.25)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C331(0.66); C767(1.46)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C331(0.70); C767(0.97)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C331(0.78); C767(1.29)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C331(0.88); C767(1.35)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C331(0.78); C767(1.03)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C331(0.69); C767(1.52)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C331(0.64); C767(1.32)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C331(0.68); C767(1.72)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C331(0.69); C767(1.43)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C331(0.64); C767(1.40)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C331(0.61); C767(1.46)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C331(0.66); C767(1.50)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C331(0.77); C767(1.35)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C331(0.75); C767(1.50)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C331(0.87); C767(1.42)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C331(0.83); C767(0.94)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C331(0.62); C767(1.20)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C331(1.13); C767(1.02)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C331(1.02); C767(0.94)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C331(0.97); C767(0.92)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C331(0.97); C767(1.30)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C331(1.18); C767(1.17)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C331(1.06); C767(1.21)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C331(1.09); C767(1.29)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C331(0.93); C767(1.15)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C331(0.94); C767(1.10)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C331(0.56); C767(1.48)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C331(0.97); C767(1.03)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C331(1.01); C767(1.63)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C331(1.12); C767(1.28)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C331(0.95); C767(1.34)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C331(1.00); C767(1.44)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C331(1.20); C767(1.33)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C331(1.13); C767(1.23)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C331(0.95); C767(1.08)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C331(0.85); C767(0.95)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C331(1.01); C767(0.93)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C331(0.97); C767(0.94)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C331(1.11); C767(0.96)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C331(0.98); C767(1.11)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C331(0.83); C767(1.00)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C331(0.96); C767(0.98)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C331(0.86); C767(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C331(0.98); C767(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C331(1.01); C767(0.97)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C331(1.06); C767(1.17)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C331(0.96); C767(1.18)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C331(0.84); C767(0.97)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C331(1.00); C767(1.21)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C331(1.03); C767(0.84)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C331(0.95); C767(0.88)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C331(0.90); C767(1.12)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C331(0.87); C767(1.09)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C331(0.99); C767(0.84)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C331(0.85); C767(1.26)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C331(0.93); C767(1.10)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C331(0.85); C767(0.88)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C331(1.00); C767(0.91)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C331(1.08); C767(1.21)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C331(0.89); C767(1.03)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C331(0.90); C767(1.01)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C331(1.03); C767(0.87)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C331(0.90); C767(0.98)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C331(0.92); C767(0.95)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C331(0.78); C767(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C331(0.72); C767(1.17)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C331(0.80); C767(1.17)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C331(0.79); C767(1.33)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C331(0.39); C767(1.14)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C331(0.71); C767(0.97)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C331(0.77); C767(1.04)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C331(0.74); C767(1.00)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C331(0.83); C767(0.91)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C331(0.72); C767(1.23)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C331(0.86); C767(1.27)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C331(0.91); C767(1.04)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C331(0.93); C767(1.07)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C331(0.85); C767(1.01)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C331(0.88); C767(1.10)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C331(1.00); C767(1.01)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C331(0.93); C767(0.94)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C767(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C767(1.01)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C767(0.80)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C767(0.99)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C767(0.90)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C767(1.34)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C767(1.15)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C767(1.24)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C767(1.20)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C767(1.42)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C331(0.85); C767(0.95)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C331(0.37); C767(1.34)  LDD0744  [5]
 LDCM0116  HHS-0101 DM93 Y498(0.55); Y252(0.67); Y485(0.80); Y540(0.86)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y491(0.41); Y525(0.50); Y498(0.53); Y252(0.56)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y485(0.49); Y491(0.61); Y525(0.61); Y252(0.62)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y498(0.54); Y252(0.69); Y485(0.73); Y491(0.75)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y540(0.76); Y252(0.76); Y498(0.84); Y485(0.92)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C767(0.92)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C767(0.99)  LDD1497  [9]
 LDCM0024  KB05 HMCB C71(2.98); C767(0.84)  LDD3312  [10]
 LDCM0021  THZ1 HCT 116 C767(1.90)  LDD2173  [5]
 LDCM0112  W16 Hep-G2 C767(1.81)  LDD0239  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) Aldehyde dehydrogenase family P49419
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Peripheral plasma membrane protein CASK (CASK) CAMK Ser/Thr protein kinase family O14936
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Bystin (BYSL) Bystin family Q13895
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
UPF0449 protein C19orf25 (C19orf25) UPF0449 family Q9UFG5
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) . Q9UHR4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840