Details of the Target

General Information of Target

Target ID LDTP05661
Target Name Nucleosome-remodeling factor subunit BPTF (BPTF)
Gene Name BPTF
Gene ID 2186
Synonyms
FAC1; FALZ; Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAP
KTRLSSPRGGSSSRRKPPPPPPAPPSTSAPGRGGRGGGGGRTGGGGGGGHLARTTAARRA
VNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPN
EHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDT
SNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPP
LEEVPEDEWQCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIE
EDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQ
SLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGC
LSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQ
SESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRL
RNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYF
KLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKV
LTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPV
VMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWK
QKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKC
SRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEE
PMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLE
EKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPE
DLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVS
DLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALH
SSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNES
ISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNK
CSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSG
NVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEE
SNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVV
SSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVT
SMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARK
GGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWD
DMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKET
PTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQ
QAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPA
TVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT
IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMT
QIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQ
LTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPL
ATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQ
PSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSN
VQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
PQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVA
QIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKK
KQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQV
MKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLD
KDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQ
HTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESK
FYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVL
RSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIF
DNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAS
Target Bioclass
Other
Family
PBTF family
Subcellular location
Cytoplasm
Function
Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Uniprot ID
Q12830
Ensemble ID
ENST00000306378.11
HGNC ID
HGNC:3581
ChEMBL ID
CHEMBL3085621

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y1010(6.61)  LDD0257  [2]
ONAyne
 Probe Info  		K1209(6.25)  LDD0274  [3]
STPyne
 Probe Info  		K3032(6.86); K804(10.00)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K609(8.91); K604(8.91)  LDD3494  [4]
BTD
 Probe Info  		C940(0.86)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C1969(2.72); C1471(2.41); C1460(2.65); C1156(2.17)  LDD0168  [6]
Acrolein
 Probe Info  		N.A.  LDD0227  [7]
DBIA
 Probe Info  		C1241(1.58); C1266(1.24); C1460(1.00); C1471(1.00)  LDD0078  [8]
N1
 Probe Info  		E1517(0.00); E1520(0.00)  LDD0245  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C2888(0.00); C1241(0.00); C882(0.00); C2697(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C1241(0.00); C882(0.00); C3016(0.00); C1969(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C2888(0.00); C882(0.00); C1357(0.00); C1241(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		C1305(0.00); C1357(0.00)  LDD2226  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C1963(0.00); C20(0.00); C1357(0.00); C1501(0.00)  LDD0147  [14]
NPM
 Probe Info  		N.A.  LDD0016  [13]
TFBX
 Probe Info  		C882(0.00); C1969(0.00); C2697(0.00); C20(0.00)  LDD0148  [14]
VSF
 Probe Info  		C1460(0.00); C20(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C1357(0.00); C1305(0.00); C1501(0.00); C1548(0.00)  LDD0018  [15]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
W1
 Probe Info  		C445(0.00); C1969(0.00); C506(0.00)  LDD0236  [17]
AOyne
 Probe Info  		10.10  LDD0443  [18]
NAIA_5
 Probe Info  		C1241(0.00); C940(0.00); C1357(0.00); C1548(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C940(0.62)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C1969(2.72); C1471(2.41); C1460(2.65); C1156(2.17)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1969(4.98); C1471(2.33); C1156(2.50); C1137(3.25)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C1241(0.97); C1357(0.78); C1460(1.12); C1471(1.13)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1241(0.89); C1460(1.20); C1471(1.20); C334(1.19)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1241(0.80); C1357(1.03); C1460(0.98); C1471(0.98)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1241(1.34); C1357(1.08); C1460(1.00); C1471(1.00)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1241(0.76); C1357(1.00); C1460(0.97); C1471(0.97)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1241(2.46); C1357(1.47); C1460(1.43); C1471(1.43)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1241(1.26); C1357(1.28); C1460(1.09); C1471(1.09)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1241(1.23); C1357(1.30); C1460(1.31); C1471(1.31)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1241(0.85); C1357(1.19); C1460(1.42); C1471(1.42)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1241(1.43); C1357(1.31); C1460(1.20); C1471(1.20)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1241(0.72); C1357(0.92); C1460(1.05); C1471(1.05)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1241(0.74); C1357(0.93); C1460(0.88); C1471(0.88)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1241(1.26); C1460(1.29); C1471(1.29); C334(1.26)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1241(0.72); C1357(0.92); C1460(1.18); C1471(1.18)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1241(0.82); C1357(1.19); C1460(1.08); C1471(1.08)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1241(1.04); C1357(1.35); C1460(1.40); C1471(1.40)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1241(0.91); C1460(1.05); C1471(1.05); C334(1.06)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1241(0.83); C1460(1.25); C1471(1.27); C334(1.02)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1241(0.90); C1460(1.50); C1471(1.54); C334(1.06)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1241(0.96); C1460(1.47); C1471(1.51); C334(1.10)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1241(0.87); C1460(1.19); C1471(1.19); C334(1.34)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1241(0.86); C1460(1.18); C1471(1.18); C334(1.05)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1241(1.02); C1460(1.16); C1471(1.17); C334(1.01)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1241(1.06); C1460(1.10); C1471(1.10); C334(1.33)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1241(1.07); C1460(1.17); C1471(1.19); C334(1.00)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1241(0.88); C1460(1.15); C1471(1.13); C334(1.29)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1241(1.05); C1460(1.16); C1471(1.20); C334(0.93)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1241(0.73); C1460(0.97); C1471(0.98); C334(1.25)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1241(0.80); C1460(1.19); C1471(1.21); C334(1.30)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1241(0.91); C1460(1.22); C1471(1.21); C334(1.16)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1241(0.99); C1460(1.40); C1471(1.41); C334(1.15)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1241(0.79); C1460(1.57); C1471(1.57); C334(1.19)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1241(0.40); C1357(0.33); C1460(1.20); C1471(1.20)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1241(0.32); C1357(0.34); C1460(0.99); C1471(0.99)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1241(0.54); C1357(0.38); C1460(1.36); C1471(1.36)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1241(0.42); C1357(0.35); C1460(1.22); C1471(1.22)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1241(0.46); C1357(0.38); C1460(1.01); C1471(1.01)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1241(0.45); C1357(0.39); C1460(1.06); C1471(1.06)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1241(0.49); C1357(0.43); C1460(1.10); C1471(1.10)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1241(0.46); C1357(0.36); C1460(1.10); C1471(1.10)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1241(0.50); C1357(0.40); C1460(0.92); C1471(0.92)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1241(0.46); C1357(0.39); C1460(0.86); C1471(0.86)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1241(0.46); C1357(0.41); C1460(0.97); C1471(0.97)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1241(0.46); C1357(0.40); C1460(1.00); C1471(1.00)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1241(0.87); C1460(1.20); C1471(1.20); C334(1.47)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1241(1.07); C1357(0.43); C1460(1.11); C1471(1.11)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1241(0.60); C1357(0.44); C1460(1.09); C1471(1.09)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1241(0.42); C1357(0.34); C1460(0.83); C1471(0.83)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1241(1.00); C1357(1.28); C1460(1.18); C1471(1.18)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1241(0.94); C393(1.04); C940(1.09); C1357(1.36)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C940(0.88); C1241(1.08); C393(1.11); C1471(1.20)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C940(1.10); C1241(1.13); C1471(1.30); C1460(1.30)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1241(0.91); C940(1.16); C393(1.35); C1357(1.45)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1241(0.95); C940(1.44); C393(1.56); C1471(1.93)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1241(1.06); C393(1.29); C940(1.42); C1471(1.66)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1241(0.84); C393(0.92); C334(1.02); C506(1.09)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C940(0.93); C1460(1.09); C1471(1.10); C1357(1.10)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C940(0.94); C393(1.07); C1357(1.13); C1241(1.16)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1241(0.91); C940(1.09); C393(1.35); C1471(1.36)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1241(1.09); C940(1.40); C393(1.67); C1471(2.37)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1241(1.11); C1357(1.70); C1460(1.48); C1471(1.47)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1241(1.09); C1357(1.86); C1460(1.61); C1471(1.60)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1241(0.94); C1357(1.24); C1460(1.22); C1471(1.21)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1241(1.00); C1357(1.29); C1460(1.49); C1471(1.49)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C517(0.94); C1241(0.99); C1460(1.00); C1471(1.00)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C1241(0.76); C1460(0.96); C1471(0.96); C882(1.20)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C1241(0.91); C882(1.06); C517(1.08); C1460(1.14)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C393(0.93); C1357(0.96); C506(1.04); C882(1.05)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C1241(0.96); C517(0.99); C882(1.07); C1460(1.25)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C1241(0.89); C517(0.99); C1460(1.05); C1471(1.05)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C1241(0.83); C1460(0.98); C1471(0.98); C517(1.00)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C1241(0.91); C882(1.02); C517(1.07); C1460(1.11)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C1241(0.84); C882(0.96); C1460(1.06); C1471(1.06)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C506(0.88); C882(0.92); C517(0.96); C393(1.01)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C882(0.82); C506(0.94); C334(0.94); C517(1.01)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C334(0.88); C882(0.89); C506(0.92); C517(1.04)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C393(0.81); C506(0.91); C882(0.93); C334(0.97)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C882(0.77); C393(0.80); C334(0.92); C506(0.94)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C1357(0.81); C1969(1.00); C1241(1.00); C1460(1.01)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C882(0.83); C334(0.83); C506(0.84); C393(0.88)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C882(0.80); C334(1.01); C393(1.01); C506(1.08)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C393(0.83); C882(0.85); C506(1.01); C334(1.02)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C882(0.83); C506(1.00); C334(1.01); C517(1.05)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C882(0.70); C393(0.93); C506(0.99); C334(1.06)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C517(0.84); C1460(0.85); C1471(0.85); C882(1.01)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C517(0.67); C1460(1.01); C1471(1.01); C940(1.03)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C517(0.80); C1460(0.99); C1471(0.99); C882(1.01)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C334(0.99); C1460(1.04); C1471(1.04); C882(1.05)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C940(0.93); C1460(1.06); C1471(1.06); C334(1.09)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C1357(0.72); C1241(0.81); C1460(1.03); C1471(1.04)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C517(1.14); C1460(1.15); C1471(1.15); C882(1.17)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C517(0.88); C882(1.01); C1460(1.04); C1471(1.04)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C517(1.01); C882(1.02); C1460(1.06); C1471(1.06)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C517(0.96); C882(1.03); C334(1.04); C940(1.13)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C517(0.90); C1460(0.91); C1471(0.91); C882(1.03)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C882(1.06); C1969(1.23); C1460(1.29); C1471(1.29)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C940(0.63); C393(0.84); C882(0.84); C334(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C940(0.76); C882(0.89); C393(0.91); C334(0.94)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C940(0.64); C882(0.83); C393(0.97); C334(1.01)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C940(0.57); C393(0.79); C882(0.96); C334(0.98)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C1357(0.66); C1241(0.77); C1460(0.92); C1471(0.94)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C940(0.62); C882(0.88); C393(0.94); C334(1.01)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C940(0.64); C882(0.75); C334(0.89); C517(0.97)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C940(0.60); C882(0.80); C393(0.85); C334(0.90)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C940(0.65); C882(0.79); C334(0.93); C393(1.07)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C940(0.58); C882(0.84); C393(0.96); C334(0.97)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C940(0.95); C393(0.99); C334(1.03); C882(1.09)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C940(0.67); C393(0.77); C882(1.07); C334(1.12)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C1241(0.79); C1969(1.05); C517(1.20); C1357(1.34)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C1969(0.92); C1241(0.99); C334(1.17); C517(1.18)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C1241(0.93); C1969(1.15); C1357(1.29); C1460(1.31)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C940(1.02); C334(1.04); C882(1.06); C1241(1.07)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C1969(1.08); C517(1.33); C1460(1.34); C1471(1.34)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C1460(1.00); C1471(1.00); C1241(1.00); C1969(1.03)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1241(0.81); C1969(1.18); C1357(1.41); C1460(1.41)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C1969(0.98); C517(1.25); C1460(1.32); C1471(1.32)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C1969(1.07); C1357(1.30); C1241(1.38); C517(1.43)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C1357(0.75); C1460(0.81); C1471(0.81); C1241(0.85)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C1460(0.70); C1471(0.70); C1357(0.75); C1241(0.92)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C334(0.88); C1460(0.91); C1471(0.91); C1357(0.98)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C1241(0.75); C882(0.79); C393(0.82); C1357(0.97)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1241(0.70); C882(0.83); C393(0.90); C1460(1.08)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C1460(0.85); C1471(0.85); C506(0.98); C1241(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C882(0.71); C393(0.89); C1241(1.08); C1460(1.16)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C1241(0.81); C1357(0.94); C1460(0.94); C1471(0.94)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C882(0.70); C334(1.10); C1357(1.21); C393(1.30)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C882(0.73); C1241(1.13); C393(1.38); C334(1.38)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1241(0.89); C882(1.07); C1460(1.16); C1471(1.16)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C882(0.66); C393(1.10); C1241(1.51); C334(1.52)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C882(0.94); C393(0.99); C1357(1.27); C1460(1.29)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C1241(0.76); C393(0.77); C882(0.80); C334(1.19)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C882(0.65); C393(0.81); C334(0.86); C1241(1.02)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C882(0.65); C1241(0.71); C393(1.00); C334(1.03)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C506(0.80); C1241(0.96); C1460(0.97); C1471(0.97)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C393(0.90); C1241(1.14); C334(1.16); C882(1.27)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C882(0.72); C1241(0.94); C393(0.97); C1357(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C882(0.80); C393(0.90); C1241(1.16); C334(1.52)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C882(1.25); C517(1.25); C393(1.29); C1357(1.72)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C882(1.14); C517(1.14); C393(1.20); C1357(1.30)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C1357(1.03); C882(1.03); C517(1.07); C393(1.10)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C517(0.92); C882(0.96); C393(1.09); C1357(1.10)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C517(0.93); C882(0.97); C393(1.00); C1357(1.11)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C517(0.89); C882(0.90); C393(1.14); C1357(1.17)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C882(1.04); C517(1.04); C1357(1.07); C393(1.13)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C882(0.88); C517(0.95); C393(0.98); C1241(1.15)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C1357(0.99); C882(1.18); C517(1.21); C393(1.30)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C1357(0.94); C517(1.08); C882(1.11); C393(1.36)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C882(0.91); C1357(0.94); C1241(1.01); C517(1.10)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C1357(0.75); C517(0.90); C393(1.12); C882(1.38)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C882(0.96); C1357(1.15); C517(1.17); C393(1.29)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C1357(0.68); C517(0.98); C393(1.13); C882(1.36)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C517(0.99); C882(1.01); C393(1.21); C1357(1.25)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C882(0.71); C334(0.72); C506(0.78); C517(0.80)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C334(0.68); C506(0.69); C882(0.74); C517(0.75)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1241(0.95); C1460(1.10); C1471(1.10); C334(1.18)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C393(1.03); C1460(1.05); C1471(1.05); C882(1.11)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C1241(0.96); C940(1.06); C393(1.11); C882(1.21)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.93  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1241(1.58); C1266(1.24); C1460(1.00); C1471(1.00)  LDD0078  [8]
 LDCM0632  CL-Sc Hep-G2 C1746(20.00); C1969(20.00); C1241(1.50); C1357(1.22)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C882(0.83); C506(0.92); C1969(0.94); C517(0.97)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C882(0.96); C506(1.03); C1357(1.04); C517(1.06)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C393(0.75); C1241(0.82); C1357(0.87); C506(0.96)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C1241(0.79); C882(1.07); C940(1.07); C334(1.10)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C1241(0.77); C506(0.88); C882(1.01); C1460(1.05)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C1241(0.79); C506(0.93); C393(0.98); C882(1.05)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1241(0.82); C506(0.90); C882(1.02); C393(1.09)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C1241(0.79); C1460(1.00); C1471(1.00); C882(1.19)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C1241(0.92); C1460(0.94); C1471(0.94); C517(1.28)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C1241(0.93); C1460(1.16); C1471(1.16); C517(1.24)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C1241(0.85); C1460(1.02); C1471(1.02); C882(1.28)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C517(1.01); C882(1.07); C1460(1.32); C1471(1.32)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C1357(0.98); C1969(0.99); C506(1.17); C882(1.23)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C1241(0.98); C882(1.16); C517(1.27); C1460(1.28)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C1241(0.85); C882(1.06); C517(1.07); C1460(1.17)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C393(0.77); C882(0.85); C334(0.88); C506(0.89)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C882(0.70); C393(0.77); C506(0.82); C334(0.96)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C882(0.68); C393(0.78); C506(0.83); C334(0.92)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C882(0.75); C393(0.80); C334(0.85); C506(0.92)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C882(0.75); C393(0.76); C334(0.99); C506(1.00)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C940(0.94); C334(1.30); C1460(1.35); C1471(1.35)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1460(1.05); C1471(1.05); C1969(1.05); C882(1.08)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C940(0.94); C882(1.02); C334(1.06); C1969(1.17)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C1357(1.05); C1969(1.11); C882(1.20); C506(1.30)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C940(0.97); C882(1.01); C334(1.12); C517(1.15)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C882(0.75); C1241(0.82); C940(0.83); C334(0.97)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C940(0.73); C393(0.81); C882(0.84); C334(0.90)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C940(0.78); C882(0.86); C393(0.89); C334(0.90)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C940(0.64); C882(0.92); C393(0.98); C334(1.05)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C1241(0.96); C517(1.00); C1969(1.02); C334(1.02)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C1241(0.65); C1460(0.74); C1471(0.74); C1969(0.89)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C1241(0.80); C1460(0.84); C1471(0.84); C1357(0.97)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C1241(0.83); C1969(0.97); C517(1.25); C1357(1.30)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C1969(0.86); C1241(1.06); C882(1.08); C1357(1.10)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C882(0.88); C517(0.94); C506(0.96); C1969(1.00)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C1969(0.72); C1357(0.94); C882(1.03); C506(1.11)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C517(0.59); C393(0.79); C506(0.81); C882(0.85)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C517(0.72); C393(0.79); C506(0.81); C1241(0.97)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C517(0.67); C1357(0.93); C506(1.02); C334(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C517(0.78); C1357(0.90); C393(0.91); C334(1.02)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C882(0.88); C517(0.91); C1969(0.92); C1241(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C517(0.75); C393(0.83); C506(1.03); C334(1.11)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C1357(0.91); C393(1.08); C506(1.14); C334(1.15)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C1357(0.78); C393(1.15); C517(1.21); C506(1.44)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C517(0.61); C393(0.83); C882(0.88); C1241(1.00)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C517(0.84); C1357(0.90); C393(0.95); C506(1.15)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1241(1.21); C1357(0.81); C1460(1.71); C1471(1.71)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1241(0.91); C1357(0.99); C1460(1.30); C1471(1.30)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1241(1.21); C1357(0.99); C1460(1.51); C1471(1.51)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1241(2.26); C1357(1.08); C1460(1.55); C1471(1.55)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1241(1.36); C1357(0.88); C1460(1.78); C1471(1.78)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1241(1.29); C1357(1.10); C1460(1.18); C1471(1.18)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1241(1.00); C1357(0.91); C1460(1.29); C1471(1.29)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1241(0.87); C1357(0.88); C1460(0.85); C1471(0.85)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1241(1.51); C1357(1.22); C1460(0.83); C1471(0.83)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1241(1.18); C1357(1.06); C1460(0.89); C1471(0.89)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1241(1.05); C1357(0.93); C1460(1.15); C1471(1.15)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1241(1.25); C1357(0.93); C1460(1.46); C1471(1.46)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1241(1.17); C1357(0.74); C1460(1.09); C1471(1.09)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1241(1.35); C1357(0.86); C1460(1.57); C1471(1.57)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1241(1.14); C1357(1.04); C1460(0.98); C1471(0.98)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1241(1.07); C1357(1.01); C1460(1.31); C1471(1.31)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1241(1.31); C1357(0.95); C1460(1.14); C1471(1.14)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1241(1.30); C1357(0.94); C1460(1.23); C1471(1.23)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1241(1.21); C1357(0.73); C1460(1.33); C1471(1.33)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1241(1.11); C1357(0.89); C1460(1.20); C1471(1.20)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1241(1.17); C1357(0.74); C1460(1.07); C1471(1.07)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1241(1.08); C1357(0.72); C1460(1.28); C1471(1.28)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1241(1.07); C1460(1.01); C1471(1.01); C334(0.78)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1241(0.83); C1460(0.84); C1471(0.84); C334(0.48)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1241(1.16); C1460(1.09); C1471(1.09); C334(0.63)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1241(0.93); C1460(1.30); C1471(1.30); C334(1.02)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1241(1.02); C1357(0.91); C1460(1.20); C1471(1.20)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1241(1.06); C1460(1.14); C1471(1.14); C334(0.88)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1241(1.09); C1460(1.25); C1471(1.25); C334(0.75)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1241(0.95); C1460(1.48); C1471(1.48); C334(0.47)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1241(1.18); C1460(1.15); C1471(1.15); C334(0.63)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1241(0.86); C1460(1.23); C1471(1.23); C334(0.89)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1241(0.96); C1460(1.17); C1471(1.17); C334(0.93)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1241(1.15); C1460(1.05); C1471(1.05); C334(0.78)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1241(0.95); C1460(1.01); C1471(1.01); C334(0.77)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1241(0.85); C1460(1.13); C1471(1.13); C334(0.83)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1241(1.02); C1460(1.13); C1471(1.13); C334(0.94)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1241(1.37); C1357(1.09); C1460(1.37); C1471(1.37)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1241(1.01); C1460(1.03); C1471(1.03); C334(0.73)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1241(0.88); C1460(1.32); C1471(1.32); C334(0.94)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1241(1.43); C1460(1.00); C1471(1.00); C334(0.79)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1241(1.34); C1460(1.25); C1471(1.25); C334(0.95)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1241(1.11); C1460(1.50); C1471(1.50); C334(1.05)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1241(0.86); C1460(1.03); C1471(1.03); C334(0.85)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1241(1.07); C1460(1.26); C1471(1.26); C334(1.15)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1241(0.94); C1460(1.31); C1471(1.31); C334(0.98)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1241(0.92); C1460(1.17); C1471(1.17); C334(0.84)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1241(1.77); C1460(1.07); C1471(1.07); C334(0.88)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1241(1.40); C1357(0.88); C1460(1.45); C1471(1.45)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1241(0.96); C1460(1.27); C1471(1.27); C334(0.84)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1241(0.93); C1460(1.21); C1471(1.21); C334(0.80)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1241(1.00); C1460(1.31); C1471(1.31); C334(0.74)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1241(1.05); C1460(1.32); C1471(1.32); C334(0.79)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1241(1.28); C1460(1.38); C1471(1.38); C334(0.84)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1357(0.92); C1460(1.13); C1471(1.13); C1969(1.03)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1357(0.85); C1460(0.91); C1471(0.91); C1969(0.85)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1357(0.91); C1460(1.22); C1471(1.22); C1969(1.01)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1357(0.82); C1460(1.62); C1471(1.62); C1969(1.07)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1241(1.46); C1357(1.45); C1460(1.46); C1471(1.46)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1357(0.77); C1460(1.18); C1471(1.18); C1969(1.09)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1357(0.79); C1460(1.19); C1471(1.19); C1969(1.09)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1357(0.72); C1460(1.53); C1471(1.53); C1969(1.42)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1357(0.76); C1460(1.35); C1471(1.35); C1969(1.18)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1357(0.83); C1460(1.59); C1471(1.59); C1969(1.23)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1357(0.84); C1460(1.11); C1471(1.11); C1969(1.07)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1357(0.89); C1460(0.88); C1471(0.88); C1969(0.97)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1357(0.71); C1460(0.99); C1471(0.99); C1969(1.15)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1357(0.71); C1460(1.26); C1471(1.26); C1969(1.16)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1357(0.69); C1460(1.87); C1471(1.87); C1969(1.44)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1241(2.64); C1357(1.02); C1460(1.20); C1471(1.20)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1357(0.68); C1460(0.99); C1471(0.99); C1969(0.83)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1241(1.21); C1357(0.92); C1460(1.32); C1471(1.31)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1241(1.20); C1357(0.83); C1460(1.20); C1471(1.20)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1241(1.14); C1357(0.70); C1460(1.12); C1471(1.12)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1241(0.89); C1357(0.90); C1460(1.25); C1471(1.25)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1241(1.00); C1357(0.82); C1460(1.23); C1471(1.22)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1241(0.98); C1357(0.70); C1460(1.31); C1471(1.32)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1241(1.06); C1357(0.72); C1460(1.11); C1471(1.11)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1241(1.27); C1357(0.94); C1460(1.17); C1471(1.19)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1241(1.12); C1357(0.86); C1460(1.03); C1471(1.03)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C1357(0.49)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C334(0.91); C940(0.90); C1137(0.92); C1156(1.18)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C445(1.64)  LDD1702  [5]
 LDCM0625  F8 Ramos C940(0.80)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C940(0.61)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C940(20.00)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C940(0.84)  LDD2191  [20]
 LDCM0576  Fragment14 Ramos C940(1.34)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C940(1.04)  LDD2194  [20]
 LDCM0588  Fragment30 Ramos C940(0.76)  LDD2199  [20]
 LDCM0590  Fragment32 Ramos C940(0.84)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C1241(0.97); C1460(1.41); C1471(1.41); C334(1.01)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C1241(1.64); C1357(0.83); C1460(1.89); C1471(1.89)  LDD0744  [8]
 LDCM0614  Fragment56 Ramos C940(1.46)  LDD2205  [20]
 LDCM0571  Fragment9 Ramos C940(0.87)  LDD2188  [20]
 LDCM0022  KB02 HCT 116 C1460(2.79); C1471(2.79); C393(1.42); C1266(1.67)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C1460(1.76); C1471(1.76); C393(2.21); C1266(1.10)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C1460(1.85); C1471(1.85); C393(1.51); C1266(1.35)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C940(0.86)  LDD2093  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C940(0.42)  LDD2109  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C940(0.45)  LDD2125  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C940(0.72)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C940(0.85)  LDD2137  [5]
 LDCM0021  THZ1 HCT 116 C2885(1.06); C1241(1.28); C1460(1.01); C1471(1.01)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable global transcription activator SNF2L1 (SMARCA1) SNF2/RAD54 helicase family P28370
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.2 (H3C15; H3C14; H3C13) Histone H3 family Q71DI3
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578