Details of the Target

General Information of Target

Target ID LDTP04998
Target Name Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)
Gene Name PPP2CB
Gene ID 5516
Synonyms
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A-beta; EC 3.1.3.16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Target Bioclass
Enzyme
Family
PPP phosphatase family, PP-1 subfamily
Subcellular location
Cytoplasm
Function
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Uniprot ID
P62714
Ensemble ID
ENST00000221138.9
HGNC ID
HGNC:9300
ChEMBL ID
CHEMBL2435

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.23  LDD0402  [1]
TH211
 Probe Info  		Y127(17.20); Y267(7.38)  LDD0257  [2]
Probe 1
 Probe Info  		Y80(4.51)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C269(3.37)  LDD0169  [4]
DBIA
 Probe Info  		C196(9.02)  LDD0209  [5]
HHS-482
 Probe Info  		Y127(1.19)  LDD0285  [6]
HHS-475
 Probe Info  		Y218(0.81); Y284(0.81); Y265(0.95); Y267(0.96)  LDD0264  [7]
HHS-465
 Probe Info  		Y127(10.00); Y248(3.23); Y265(10.00); Y267(10.00)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C251(0.00); C269(0.00); C50(0.00); C55(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
JW-RF-010
 Probe Info  		C20(0.00); C266(0.00)  LDD0026  [11]
NAIA_4
 Probe Info  		C196(0.00); C266(0.00)  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		C251(0.00); C196(0.00); C133(0.00)  LDD0217  [16]
W1
 Probe Info  		C266(0.00); C20(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C251(0.00); C196(0.00); C269(0.00); C50(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.60  LDD0475  [18]
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C196(20.00); C133(2.01)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C269(3.37)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C251(1.03); C196(0.97); C133(1.10); C269(0.90)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C251(0.98); C196(1.03); C133(0.95); C269(1.04)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C251(0.90); C196(0.93); C133(1.07); C269(1.16)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C251(0.91); C196(1.01); C133(1.04); C269(1.10)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C251(1.11); C196(0.95); C133(0.99); C269(1.21)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C251(0.94); C196(1.00); C133(0.99); C269(1.12)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C251(1.04); C196(1.00); C133(1.03); C269(0.87)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C251(0.99); C196(1.04); C133(0.97); C269(0.96)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C251(0.82); C196(1.02); C133(0.90); C269(0.53)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C251(1.01); C196(1.12); C133(0.93); C269(0.98)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C251(0.89); C196(0.98); C133(1.04); C269(1.05)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C251(0.97); C196(0.93); C133(1.03); C269(1.03)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C251(1.02); C196(0.93); C133(1.03); C269(1.15)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C251(0.97); C196(0.99); C133(0.89); C269(1.13)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C251(0.92); C196(1.04); C133(1.04); C269(1.10)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C251(1.01); C196(1.01); C133(0.95); C269(0.92)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C251(1.04); C196(0.97); C133(0.97); C269(1.05)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C251(1.08); C196(1.00); C133(1.03); C269(0.99)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C251(0.94); C196(0.95); C133(1.06); C269(1.00)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C251(0.99); C196(0.94); C133(0.97); C269(1.08)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C251(1.15); C196(1.05); C133(1.00); C269(0.99)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C251(1.07); C196(0.97); C133(0.92); C269(1.14)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C251(0.97); C196(0.97); C133(0.92); C269(1.08)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C251(0.92); C196(1.04); C133(0.95); C269(0.98)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C251(1.03); C196(0.97); C133(0.91); C269(0.85)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C251(1.01); C196(1.04); C133(0.90); C269(1.00)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C251(1.03); C196(1.11); C133(0.97); C269(0.97)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C251(0.84); C196(0.96); C133(0.93); C269(0.97)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C251(1.02); C196(1.01); C133(1.00); C269(1.11)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C251(1.09); C196(0.95); C133(0.96); C269(1.07)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C251(0.92); C196(0.95); C133(0.98); C269(1.07)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C251(0.92); C196(1.01); C133(1.04); C269(1.04)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C251(0.94); C196(1.05); C133(0.99); C269(0.97)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C251(1.04); C196(1.04); C133(0.94); C269(0.94)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C251(0.99); C196(1.07); C133(0.92); C269(0.87)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C251(0.92); C196(1.02); C133(1.02); C269(1.03)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C251(0.97); C196(0.98); C133(0.96); C269(1.05)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C251(1.10); C196(1.08); C133(1.01); C269(1.11)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C251(1.16); C196(1.00); C133(1.09); C269(1.11)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C251(0.94); C196(0.99); C133(0.99); C269(1.17)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C251(0.94); C196(1.02); C133(1.01); C269(1.14)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C251(1.04); C196(1.01); C133(1.06); C269(1.08)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C251(1.04); C196(1.01); C133(0.97); C269(1.04)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C251(1.04); C196(1.01); C133(1.03); C269(1.10)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C251(0.94); C196(1.05); C133(1.05); C269(1.19)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C251(0.87); C196(1.03); C133(0.90); C269(1.09)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C251(1.03); C196(0.95); C133(1.02); C269(1.16)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C251(1.03); C196(1.05); C133(0.93); C269(1.15)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C251(0.89); C196(1.00); C133(1.08); C269(1.19)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C251(0.95); C196(1.01); C133(1.01); C269(1.09)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C251(1.04); C196(0.99); C133(1.04); C269(0.94)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C251(0.99); C196(1.04); C133(0.99); C269(0.99)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C251(1.06); C196(1.00); C133(1.04); C269(1.09)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C251(1.04); C196(1.04); C133(0.94); C269(1.00)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C251(0.87); C196(1.00); C133(1.05); C269(0.95)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C251(1.03); C196(1.02); C133(1.02); C269(1.00)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C251(1.05); C196(0.97); C133(1.01); C269(1.04)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C251(0.92); C196(1.08); C133(0.96); C269(0.98)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C251(0.97); C196(1.04); C133(1.14); C269(1.01)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C251(0.86); C196(1.06); C133(1.05); C269(1.11)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C251(0.99); C196(1.06); C133(0.97); C269(0.97)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C251(1.08); C196(0.93); C133(0.97); C269(1.12)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C251(1.02); C196(0.99); C133(1.01); C269(0.91)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C251(0.96); C196(0.99); C133(1.04); C269(1.09)  LDD1514  [21]
 LDCM0108  Chloroacetamide HeLa C251(0.00); C196(0.00); C133(0.00); C20(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C251(1.09); C196(1.05); C133(1.02); C269(0.93)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C251(0.81); C196(1.04); C133(1.25); C269(0.91)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C251(0.82); C196(0.99); C133(1.00); C269(1.02)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C251(0.94); C196(0.95); C133(0.96); C269(1.01)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C251(1.00); C196(0.98); C133(1.04); C269(1.01)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C251(0.97); C196(0.99); C133(1.00); C269(1.15)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C251(1.00); C196(1.00); C133(0.96); C269(1.11)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C251(1.09); C196(0.95); C133(0.98); C269(0.96)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C251(1.11); C196(0.96); C133(0.93); C269(1.10)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C251(0.93); C196(1.06); C133(0.99); C269(1.15)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C251(0.92); C196(1.06); C133(0.94); C269(1.07)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C251(1.07); C196(1.05); C133(1.01); C269(1.01)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C251(1.07); C196(1.03); C133(1.38); C269(1.05)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C251(1.01); C196(1.07); C133(0.98); C269(1.13)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C251(0.99); C196(1.05); C133(0.93); C269(1.01)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C251(0.95); C196(1.00); C133(0.95); C269(1.06)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C251(1.00); C196(0.97); C133(0.97); C269(0.98)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C251(0.85); C196(1.00); C133(1.01); C269(0.97)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C251(0.94); C196(1.08); C133(0.95); C269(1.14)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C251(0.98); C196(1.00); C133(0.93); C269(1.10)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C251(1.03); C196(0.98); C133(0.98); C269(1.03)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C251(1.07); C196(1.03); C133(1.18); C269(1.19)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C251(1.08); C196(1.06); C133(1.06); C269(1.15)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C251(1.01); C196(1.00); C133(1.20); C269(1.00)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C251(0.91); C196(0.96); C133(0.99); C269(1.09)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C251(1.12); C196(0.90); C133(0.94); C269(1.05)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C251(1.09); C196(1.04); C133(0.98); C269(1.14)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C251(0.93); C196(1.01); C133(1.00); C269(1.10)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C251(0.93); C196(1.02); C133(1.08); C269(1.25)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C251(0.97); C196(0.96); C133(1.14); C269(1.00)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C251(1.10); C196(0.99); C133(1.08); C269(0.97)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C251(0.98); C196(1.06); C133(1.02); C269(1.03)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C251(0.83); C196(0.97); C133(1.04); C269(1.04)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C251(1.04); C196(0.99); C133(0.88); C269(0.92)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C251(1.09); C196(0.93); C133(1.02); C269(1.10)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C251(0.90); C196(0.91); C133(0.94); C269(1.06)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C251(1.00); C196(0.98); C133(1.02); C269(1.11)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C251(0.96); C196(0.99); C133(1.01); C269(0.84)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C251(1.13); C196(0.98); C133(1.10); C269(1.07)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C251(0.99); C196(1.10); C133(1.17); C269(1.19)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C251(1.12); C196(1.03); C133(1.04); C269(1.13)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C251(1.23); C196(1.08); C133(1.16); C269(1.15)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C251(1.09); C196(1.00); C133(1.22); C269(1.04)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C251(0.91); C196(0.75); C133(1.18); C269(1.28)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C251(1.10); C196(0.94); C133(1.15); C269(1.18)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C251(1.02); C196(1.03); C133(1.13); C269(0.98)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C251(1.05); C196(0.83); C133(0.95); C269(0.94)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C251(0.99); C196(0.98); C133(1.00); C269(1.16)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C251(1.08); C196(0.90); C133(0.92); C269(1.16)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C251(1.03); C196(1.06); C133(0.93); C269(1.09)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C251(1.21); C196(0.94); C133(1.00); C269(0.92)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C251(1.07); C196(1.06); C133(1.00); C269(1.01)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C251(1.10); C196(1.00); C133(1.15); C269(1.11)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C251(1.00); C196(1.00); C133(1.09); C269(1.18)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C251(1.13); C196(0.88); C133(1.13); C269(1.12)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C251(1.04); C196(0.99); C133(1.12); C269(0.84)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C251(0.92); C196(0.96); C133(1.14); C269(1.17)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C251(1.07); C196(0.93); C133(1.17); C269(1.20)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C251(1.09); C196(0.94); C133(1.11); C269(1.01)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C251(1.09); C196(1.00); C133(0.94); C269(1.00)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C251(0.90); C196(1.00); C133(1.01); C269(1.04)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C251(0.97); C196(1.04); C133(1.12); C269(1.01)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C251(1.01); C196(0.94); C133(1.00); C269(1.00)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C251(1.07); C196(0.94); C133(0.91); C269(0.83)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C251(1.10); C196(0.96); C133(1.03); C269(1.00)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C251(0.97); C196(1.05); C133(1.11); C269(1.12)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C251(1.12); C196(0.92); C133(1.05); C269(1.05)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C251(1.09); C196(0.98); C133(1.22); C269(1.01)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C251(1.04); C196(1.02); C133(1.19); C269(1.13)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C251(0.95); C196(0.98); C133(1.17); C269(1.09)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C251(1.04); C196(0.93); C133(1.28); C269(0.91)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C251(1.05); C196(0.86); C133(0.92); C269(1.05)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C251(1.12); C196(1.03); C133(0.96); C269(0.85)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C251(1.03); C196(0.95); C133(1.08); C269(1.05)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C251(1.01); C196(0.91); C133(0.99); C269(1.06)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C251(1.10); C196(1.03); C133(0.98); C269(0.79)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C251(1.03); C196(1.14); C133(1.10); C269(0.96)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C251(1.01); C196(0.98); C133(1.16); C269(1.02)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C251(1.19); C196(0.87); C133(1.09); C269(0.97)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C251(1.03); C196(0.93); C133(1.05); C269(1.08)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C251(0.89); C196(0.92); C133(1.20); C269(1.17)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C251(1.00); C196(1.01); C133(1.22); C269(1.10)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C251(1.06); C196(0.98); C133(1.05); C269(0.97)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C251(1.05); C196(0.79); C133(0.94); C269(0.89)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C251(1.08); C196(0.88); C133(0.92); C269(0.95)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C251(1.14); C196(0.99); C133(0.92); C269(1.10)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C251(1.02); C196(1.04); C133(1.02); C269(1.13)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C251(0.92); C196(0.97); C133(1.00); C269(1.03)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C251(1.18); C196(0.88); C133(0.96); C269(0.88)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C251(1.04); C196(1.00); C133(1.03); C269(1.00)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C251(1.03); C196(0.95); C133(1.20); C269(1.03)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C251(1.10); C196(0.95); C133(1.12); C269(1.05)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C251(1.16); C196(0.92); C133(1.16); C269(1.07)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C251(1.17); C196(1.03); C133(1.19); C269(1.05)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C251(1.02); C196(0.92); C133(1.15); C269(1.20)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C251(1.02); C196(0.96); C133(1.06); C269(1.15)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C251(1.04); C196(0.94); C133(1.03); C269(1.05)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C251(0.98); C196(1.00); C133(0.88); C269(1.02)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C251(1.08); C196(1.01); C133(1.05); C269(1.27)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C251(0.93); C196(0.96); C133(1.01); C269(1.15)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C251(1.09); C196(0.99); C133(0.93); C269(0.87)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C251(1.04); C196(1.03); C133(1.16); C269(1.09)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C251(1.01); C196(1.07); C133(1.16); C269(1.13)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C251(1.03); C196(0.94); C133(1.06); C269(0.82)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C251(1.16); C196(1.03); C133(1.09); C269(1.16)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C251(1.14); C196(0.97); C133(1.23); C269(1.21)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C251(1.06); C196(1.01); C133(1.05); C269(1.23)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C251(1.01); C196(0.96); C133(1.16); C269(1.13)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C251(0.92); C196(0.98); C133(1.15); C269(0.91)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C251(1.12); C196(0.88); C133(1.06); C269(0.97)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C251(1.19); C196(0.81); C133(1.03); C269(1.04)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C251(1.06); C196(0.98); C133(1.02); C269(1.01)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C251(0.97); C196(0.99); C133(1.04); C269(1.03)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C251(1.01); C196(0.88); C133(1.00); C269(0.87)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C251(1.25); C196(1.07); C133(1.37); C269(1.04)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C251(0.93); C196(1.12); C133(1.05); C269(0.87)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C251(1.02); C196(0.88); C133(1.12); C269(1.08)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C251(0.92); C196(0.94); C133(1.08); C269(0.99)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C251(1.07); C196(0.94); C133(1.06); C269(1.06)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C251(1.07); C196(0.96); C133(1.07); C269(1.00)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C251(0.87); C196(1.07); C133(1.09); C269(0.95)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C251(0.95); C196(1.04); C133(1.04); C269(0.88)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C251(0.99); C196(1.04); C133(0.94); C269(0.88)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C251(1.19); C196(0.99); C133(0.96); C269(0.97)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C251(1.00); C196(0.96); C133(1.03); C269(1.01)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C251(0.93); C196(0.99); C133(0.93); C269(1.04)  LDD1698  [21]
 LDCM0572  Fragment10 Ramos C20(0.82)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C20(20.00)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C20(0.87)  LDD2191  [22]
 LDCM0576  Fragment14 Ramos C20(0.82)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C20(0.75)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C20(0.19)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C20(1.17)  LDD2196  [22]
 LDCM0588  Fragment30 Ramos C20(1.66)  LDD2199  [22]
 LDCM0590  Fragment32 Ramos C20(0.69)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C251(1.06); C196(1.03); C133(0.99); C269(1.13)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C20(0.30)  LDD2203  [22]
 LDCM0427  Fragment51 HEK-293T C251(1.15); C196(0.90); C133(0.96); C269(1.10)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C20(0.17)  LDD2204  [22]
 LDCM0571  Fragment9 Ramos C20(0.80)  LDD2188  [22]
 LDCM0116  HHS-0101 DM93 Y218(0.81); Y284(0.81); Y265(0.95); Y267(0.96)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y284(0.67); Y248(0.80); Y267(0.82); Y265(0.82)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y218(0.61); Y130(0.67); Y284(0.71); Y267(0.78)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y284(0.62); Y265(0.87); Y267(0.88); Y130(0.94)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y284(0.76); Y265(0.89); Y267(0.90); Y248(1.33)  LDD0268  [7]
 LDCM0107  IAA HeLa C196(0.00); C133(0.00); H191(0.00); C20(0.00)  LDD0221  [16]
 LDCM0123  JWB131 DM93 Y127(1.19)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y127(0.50)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y127(1.49)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y127(1.73)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y127(1.45)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y127(1.08)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y127(0.47)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y127(0.88)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C251(1.01); C196(1.08); C133(1.04); C269(0.98)  LDD1492  [21]
 LDCM0023  KB03 Jurkat C196(9.02)  LDD0209  [5]
 LDCM0024  KB05 G361 C251(0.99); C269(1.08)  LDD3311  [23]
 LDCM0109  NEM HeLa C196(0.00); H191(0.00)  LDD0224  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Immunoglobulin-binding protein 1 (IGBP1) IGBP1/TAP42 family P78318
Striatin-interacting protein 1 (STRIP1) STRIP family Q5VSL9
TIP41-like protein (TIPRL) TIP41 family O75663
Axin-2 (AXIN2) . Q9Y2T1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin E Small molecular drug DB00163

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840