Details of the Target

General Information of Target

Target ID LDTP04991
Target Name DNA-directed RNA polymerase II subunit RPB7 (POLR2G)
Gene Name POLR2G
Gene ID 5436
Synonyms
RPB7; DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
Subcellular location
Nucleus
Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA.
TTD ID
T07607
Uniprot ID
P62487
DrugMap ID
TTD4YFP
Ensemble ID
ENST00000301788.12
HGNC ID
HGNC:9194

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K27(8.71)  LDD0277  [1]
BTD
 Probe Info  		C38(1.06)  LDD2099  [2]
HHS-475
 Probe Info  		Y17(0.72)  LDD0264  [3]
HHS-465
 Probe Info  		Y17(1.10)  LDD2237  [4]
DBIA
 Probe Info  		C127(0.63); C38(0.96)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C127(0.00); C38(0.00); C106(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C127(0.00); C38(0.00); C106(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		C38(0.00); C106(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C38(0.95)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C127(0.63); C38(0.96)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C127(1.33); C38(0.96)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C106(0.59); C127(0.85); C38(0.78)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C106(0.86); C127(0.70); C38(0.74)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C106(0.82); C127(0.68); C38(0.79)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C106(0.66); C127(0.64); C38(0.73)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C106(1.32); C127(0.70); C38(0.84)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C106(0.73); C127(0.63); C38(0.73)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C106(0.62); C127(0.62); C38(0.66)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C106(0.74); C127(0.77); C38(0.73)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C106(0.66); C127(0.85); C38(0.76)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C106(0.88); C127(0.73); C38(1.04)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C127(1.08); C38(0.82)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C106(0.75); C127(0.81); C38(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C106(0.73); C127(0.76); C38(0.72)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C106(0.74); C127(0.55); C38(0.72)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C127(1.03); C38(1.17)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C127(0.88); C38(1.05)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C127(0.84); C38(0.96)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C127(0.80); C38(1.06)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C127(0.83); C38(1.01)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C127(0.98); C38(1.12)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C127(0.84); C38(1.13)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C127(1.40); C38(0.97)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C127(0.85); C38(1.03)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C127(1.04); C38(1.33)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C127(0.79); C38(1.16)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C127(0.89); C38(1.33)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C127(1.18); C38(1.24)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C127(0.89); C38(1.21)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C127(0.98); C38(1.15)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C127(0.84); C38(1.12)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C127(1.13); C38(1.37)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C127(1.37); C38(1.33)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C127(1.14); C38(1.10)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C127(1.13); C38(1.10)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C127(1.04); C38(1.18)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C127(1.04); C38(1.26)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C127(0.95); C38(1.06)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C127(1.01); C38(1.19)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C127(1.15); C38(0.98)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C127(1.17); C38(1.16)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C127(1.08); C38(0.99)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C127(0.86); C38(1.01)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C127(1.21); C38(0.80)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C127(1.09); C38(1.09)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C127(1.17); C38(1.06)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C127(0.94); C38(1.16)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C127(0.60)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C127(0.49)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C127(0.69)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C127(0.34)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C127(0.40)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C127(0.39)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C127(0.35)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C38(1.04); C127(1.20)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C127(0.61)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C127(0.66)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C127(0.52)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C127(0.33)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C127(0.53)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C127(0.49)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C127(0.77)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C127(0.77)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C127(0.85); C38(1.17)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C127(0.71); C38(1.73)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C127(0.79); C38(1.62)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C127(0.68); C38(0.86)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C127(1.00); C38(1.03)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C127(0.75); C38(1.20)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C38(1.04); C127(1.16)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C127(0.80); C38(1.36)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C127(1.23); C38(1.24)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C127(0.69); C38(0.99)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C127(0.66); C38(0.95)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C127(0.71); C38(0.90)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C127(0.83); C38(0.91)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C127(0.64); C38(0.78)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C127(0.69); C38(1.01)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C127(0.59); C38(0.81)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C127(0.78); C38(0.86)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C127(0.54); C38(0.85)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C127(0.55); C38(0.88)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C127(0.62); C38(0.82)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C38(1.21); C127(1.34)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C38(0.96); C127(1.25)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C38(1.05); C127(1.05)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C38(1.01); C127(1.04)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C38(1.00); C127(1.15)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C127(0.78); C38(1.08)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C127(1.03); C38(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C38(0.96); C127(1.20)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C127(0.96); C38(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C127(0.80); C38(0.91)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C38(1.02); C127(1.06)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C38(1.03); C127(1.09)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C127(0.82); C38(0.90)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C127(0.99); C38(1.00)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C127(0.65); C38(0.77)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C127(0.86); C38(0.98)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C127(0.73); C38(1.14)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C127(0.74); C38(0.88)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C38(0.93); C127(1.06)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C127(0.99); C38(1.01)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C127(0.80); C38(0.92)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C38(0.95); C127(0.96)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C127(0.79); C38(0.94)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C127(0.69); C38(0.90)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C127(0.65)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C127(0.57)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C127(0.69)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C38(0.95); C127(1.14)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C127(0.52)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C127(0.50)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C127(0.68)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C127(0.62)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C127(0.63)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C127(0.57)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C127(0.56)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C127(0.49)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C127(0.84); C38(0.99)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C127(0.93); C38(0.97)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C38(0.91); C127(0.92)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C127(0.79); C38(1.00)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C127(1.03); C38(1.14)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C127(0.98); C38(1.06)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C127(0.72); C38(0.92)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C127(0.84); C38(0.95)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C127(0.88); C38(0.95)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C127(0.97); C38(1.06)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C127(0.85); C38(0.92)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C127(0.78); C38(0.84)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C127(0.99); C38(1.13)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C127(0.91); C38(0.92)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C38(0.90); C127(1.13)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C127(1.00); C38(1.04)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C127(0.69); C38(0.94)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C127(0.57)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C127(0.53)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C127(0.51)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C127(0.75)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C127(0.90)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C127(0.85)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C127(0.62)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C127(1.14)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C127(0.66)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C127(0.73)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C127(0.78)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C127(0.59)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C127(0.75)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C127(0.56)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C127(0.72)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C127(0.47); C38(0.75); C106(0.76)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C106(0.65); C38(0.80); C127(0.95)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C127(1.18); C38(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C38(0.90); C127(1.01)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C38(0.98); C127(1.20)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C38(0.84); C127(0.97); C106(1.19)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C127(0.55); C106(0.63); C38(0.93)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C127(0.62); C38(1.03)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C38(0.85); C127(0.93)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C38(0.88); C127(1.03)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C38(0.90); C127(1.04)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C38(0.87); C127(0.95)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C127(0.68); C38(1.11)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C127(0.52); C38(1.70)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C127(0.74); C38(1.37)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C127(0.70); C38(1.25)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C127(0.69); C38(1.13)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C106(0.56); C127(0.64); C38(0.94)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C127(0.57); C38(1.29)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C127(0.66); C38(1.12)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C38(0.83); C127(0.87)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C127(0.58); C38(0.76)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C127(0.54); C38(0.69)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C127(0.64); C38(0.82)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C127(0.65); C38(0.83)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C127(0.93); C38(0.98)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C38(0.93); C127(0.98)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C38(0.91); C127(0.95)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C127(0.75); C106(0.83); C38(1.00)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C38(0.99); C127(1.04)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C127(0.69); C38(0.70)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C127(0.65); C38(0.76)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C127(0.76); C38(0.89)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C127(0.74); C38(0.93)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C127(0.82)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C127(0.58)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C127(0.69)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C127(0.68)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C106(0.58); C127(0.66); C38(0.93)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C127(0.76); C106(0.97); C38(1.01)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C106(0.50); C127(0.61); C38(0.98)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C38(0.68); C127(0.72); C106(0.82)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C106(0.51); C127(0.55); C38(0.83)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C106(0.46); C127(0.52); C38(0.79)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C106(0.47); C127(0.64); C38(0.90)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C38(0.77); C127(0.87); C106(0.93)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C106(0.65); C127(0.69); C38(0.86)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C106(0.45); C127(0.56); C38(0.88)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C106(0.44); C127(0.62); C38(0.74)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C38(0.61); C106(0.80); C127(0.91)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C106(0.60); C127(0.71); C38(0.75)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C106(0.52); C127(0.74); C38(0.67)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C106(0.70); C127(0.73); C38(0.65)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C106(0.53); C127(0.72); C38(0.78)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C106(0.44); C127(0.56); C38(0.67)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C106(0.55); C127(0.58); C38(0.78)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C106(0.98); C127(0.90); C38(0.88)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C106(0.65); C127(0.87); C38(0.78)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C106(0.85); C127(0.68); C38(0.86)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C106(0.45); C127(0.53); C38(0.87)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C106(0.65); C127(0.45); C38(0.68)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C106(0.63); C127(0.51); C38(0.91)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C106(0.92); C127(0.62); C38(0.92)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C106(0.82); C127(0.60); C38(0.77)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C106(0.68); C127(0.64); C38(0.95)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C106(0.67); C127(0.66); C38(0.93)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C106(0.90); C127(0.73); C38(0.85)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C106(0.80); C127(0.58); C38(0.84)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C106(0.88); C127(0.69); C38(0.74)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C106(0.70); C127(0.55); C38(0.83)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C106(0.79); C127(0.55); C38(0.97)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C106(0.54); C127(0.52); C38(0.89)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C106(0.45); C127(0.46); C38(0.88)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C106(0.49); C127(1.25); C38(0.74)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C106(0.74); C127(1.18); C38(0.72)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C106(0.55); C127(1.20); C38(0.81)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C106(0.69); C127(1.16); C38(1.01)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C106(0.91); C127(0.85); C38(1.03)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C106(0.76); C127(1.12); C38(0.98)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C106(0.59); C127(1.29); C38(0.86)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C106(0.52); C127(1.19); C38(0.94)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C106(0.82); C127(1.18); C38(0.70)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C106(0.57); C127(1.07); C38(0.78)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C106(0.61); C127(1.20); C38(0.89)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C106(0.72); C127(1.04); C38(0.76)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C106(0.69); C127(1.03); C38(0.73)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C106(0.80); C127(1.25); C38(0.88)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C106(0.71); C127(1.16); C38(0.87)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C106(0.42); C127(0.54); C38(0.82)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C106(0.58); C127(1.07); C38(0.83)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C127(0.97); C38(1.18)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C127(0.83); C38(0.87)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C127(0.79); C38(1.10)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C127(0.84); C38(0.96)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C127(1.06); C38(0.93)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C127(0.84); C38(0.90)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C127(0.95); C38(0.94)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C127(0.69); C38(0.78)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C127(0.59); C38(0.69)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C106(0.64); C127(0.68); C38(1.01)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C127(0.63); C38(0.74)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C127(0.90); C38(1.02)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C127(1.03); C38(1.00)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C127(0.84); C38(1.06)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C127(0.96); C38(0.94)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C127(0.89); C38(0.94)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C127(0.76); C38(0.86)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C127(0.73); C38(1.08)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C127(0.97); C38(0.88)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C106(0.85); C127(0.68); C38(0.94)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C127(0.82); C38(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C127(1.06); C38(0.95)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C127(0.84); C38(1.09)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C127(0.62); C38(0.85)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C127(0.69); C38(0.85)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C127(0.65); C38(0.92)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C127(0.72); C38(0.91)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C127(0.70); C38(0.68)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C127(0.79); C38(0.83)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C127(0.51); C38(1.08)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C106(0.89); C127(0.67); C38(0.86)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C127(0.86); C38(0.91)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C127(0.74); C38(0.83)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C127(0.84); C38(0.79)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C127(0.83); C38(0.91)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C127(0.64); C38(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C127(0.78); C38(0.84)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C127(0.62); C38(0.83)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C127(0.56); C38(0.82)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C127(0.61); C38(0.95)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C127(0.67); C38(0.94)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C38(1.08); C106(1.15)  LDD1698  [12]
 LDCM0625  F8 Ramos C38(1.77); C127(1.72)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C38(0.66)  LDD2189  [13]
 LDCM0574  Fragment12 Ramos C38(0.85)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C38(0.91)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C38(0.79)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C38(0.65)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C38(4.67)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C38(1.41)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C38(0.83)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C38(0.32); C127(1.56)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C38(0.99)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C38(0.84)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C38(0.65)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C127(0.73); C38(0.95)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C38(0.89)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C38(0.69); C127(0.71)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C106(0.60); C127(0.54); C38(0.87)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C38(1.01)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C38(1.15)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C38(0.72); C127(0.63)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C38(0.75)  LDD2188  [13]
 LDCM0116  HHS-0101 DM93 Y17(0.72)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y17(1.01)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y17(0.57)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y17(0.60)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y17(0.55)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C38(0.91); C106(0.98)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C38(0.93); C106(0.96)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C38(1.10); C106(1.88)  LDD3310  [14]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C38(1.06)  LDD2099  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C38(0.94)  LDD2123  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C38(0.90)  LDD2136  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C38(2.32)  LDD2144  [2]
 LDCM0131  RA190 MM1.R C106(1.42)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
E3 ubiquitin-protein ligase TRIM68 (TRIM68) TRIM/RBCC family Q6AZZ1
Uracil phosphoribosyltransferase homolog (UPRT) UPRTase family Q96BW1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Fos-related antigen 2 (FOSL2) BZIP family P15408
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Desmin (DES) Intermediate filament family P17661
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Contactin-associated protein-like 2 (CNTNAP2) Neurexin family Q9UHC6
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
Gamma-parvin (PARVG) Parvin family Q9HBI0
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Bcl-2-like protein 15 (BCL2L15) . Q5TBC7
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.