Details of the Target

General Information of Target

Target ID LDTP04046
Target Name Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)
Gene Name PTPN9
Gene ID 5780
Synonyms
Tyrosine-protein phosphatase non-receptor type 9; EC 3.1.3.48; Protein-tyrosine phosphatase MEG2; PTPase MEG2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP
ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class 3 subfamily
Subcellular location
Cytoplasm
Function Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Uniprot ID
P43378
Ensemble ID
ENST00000618819.5
HGNC ID
HGNC:9661
ChEMBL ID
CHEMBL6117

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K176(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y304(15.47)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C506(20.00)  LDD0170  [4]
IPM
 Probe Info  		C321(1.59)  LDD1702  [5]
DBIA
 Probe Info  		C412(1.59)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C506(20.00)  LDD0170  [4]
 LDCM0214  AC1 HCT 116 C412(1.35); C567(0.95)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C412(0.79)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C567(0.81)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C567(0.97)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C567(0.88)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C567(0.82)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C567(0.87)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C567(0.83)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C567(0.83)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C567(0.89)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C567(0.86)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C567(0.88)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C412(0.66)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C567(0.97)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C567(0.95)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C567(0.83)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C412(1.26)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C412(1.39)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C412(0.97)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C412(0.76)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C412(1.16)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C412(1.05)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C412(0.97)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C412(0.55)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C412(1.24)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C412(0.90)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C412(0.87)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C412(0.78)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C412(1.09)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C412(0.97)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C412(0.83)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C412(0.63)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C412(0.55)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C412(0.68)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C412(0.69)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C412(0.84)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C412(0.59)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C412(0.55)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C412(0.51)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C412(0.62)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C412(0.49)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C412(0.45)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C412(0.37)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C412(0.52)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C412(0.60)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C412(0.55)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C412(0.44)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C412(0.46)  LDD0860  [6]
 LDCM0263  AC143 PaTu 8988t C567(1.20); C338(0.98)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C567(0.94); C338(1.09)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C567(0.82); C338(0.88)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C567(1.53); C338(2.15)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C567(1.39); C338(1.05)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C567(0.74); C338(0.91)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C567(0.68); C338(0.98)  LDD1148  [6]
 LDCM0270  AC15 HEK-293T C412(0.46)  LDD0868  [6]
 LDCM0271  AC150 PaTu 8988t C567(0.69); C338(1.16)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C567(0.98); C338(1.40)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C567(0.68); C338(1.29)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C567(0.69); C338(1.12)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C567(0.80); C338(1.35)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C567(0.77); C338(1.02)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C567(0.77); C338(1.18)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C567(0.71); C338(1.15)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C567(1.02); C412(0.94)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C567(0.81); C412(1.01)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C567(1.07); C412(1.15)  LDD1157  [6]
 LDCM0279  AC2 HCT 116 C567(0.91); C412(1.41)  LDD0596  [6]
 LDCM0280  AC20 PaTu 8988t C567(0.84); C412(0.99)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C567(0.98); C412(1.09)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C567(0.79); C412(0.98)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C567(0.77); C412(1.15)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C567(0.74); C412(0.93)  LDD1163  [6]
 LDCM0285  AC25 PaTu 8988t C412(0.93)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C412(1.08)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C412(1.21)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C412(1.18)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C412(1.11)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C567(0.95); C412(1.39)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C412(0.94)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C412(1.01)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C412(1.01)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C412(1.14)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C412(0.97)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C412(0.90)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C412(0.82)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C412(0.82)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C412(0.75)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C412(0.78)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C567(0.65); C412(1.16)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C412(0.78)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C412(0.72)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C412(0.76)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C412(0.76)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C412(0.80)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C412(0.77)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C412(0.96)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C412(0.95)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C412(0.88)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C412(1.10)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C567(0.58); C412(1.30)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C412(0.93)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C412(0.82)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C412(0.85)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C412(0.68)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C412(0.94)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C412(0.75)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C412(0.74)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C567(0.78)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C567(0.74)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C567(0.70)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C412(0.73)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C567(0.81)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C567(0.97)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C567(0.78)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C567(0.78)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C567(0.74)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C567(0.83)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C567(0.83)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C567(0.82)  LDD0648  [6]
 LDCM0334  AC7 HEK-293T C412(0.92)  LDD0932  [6]
 LDCM0345  AC8 HEK-293T C412(0.57)  LDD0943  [6]
 LDCM0349  AC83 PaTu 8988t C412(1.17)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C412(1.11)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C412(1.14)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C412(1.25)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C412(1.34)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C412(1.11)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C412(1.22)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C412(0.98)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C412(1.09)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C412(1.19)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C412(1.18)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C412(1.09)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C412(1.13)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C412(1.03)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C412(0.92)  LDD1243  [6]
 LDCM0365  AC98 HCT 116 C567(0.77)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C567(0.91)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C412(0.65)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C412(0.55)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C412(0.58)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 13.02  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C412(1.59)  LDD0078  [6]
 LDCM0102  BDHI 8 Jurkat C567(5.33)  LDD0204  [10]
 LDCM0367  CL1 HCT 116 C412(0.82); C567(1.00)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C567(0.92); C412(1.36)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C567(0.74); C412(1.06)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C412(0.69)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C412(0.73)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C412(0.63)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C412(0.67)  LDD0971  [6]
 LDCM0374  CL105 PaTu 8988t C567(0.85); C412(1.03)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C567(0.89); C412(0.99)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C567(0.98); C412(1.01)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C567(0.93); C412(0.98)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C567(0.87); C412(1.01)  LDD1257  [6]
 LDCM0379  CL11 HCT 116 C412(1.10); C567(1.19)  LDD0696  [6]
 LDCM0380  CL110 PaTu 8988t C567(0.79); C412(1.06)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C567(0.77); C412(1.07)  LDD1260  [6]
 LDCM0382  CL112 PaTu 8988t C412(1.00)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C412(0.90)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C412(0.95)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C412(0.83)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C412(1.24)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C412(0.78)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C412(1.10)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C412(0.74)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C567(0.97); C412(1.39)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C412(0.79)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C412(0.84)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C412(0.79)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C412(0.60)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C412(0.80)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C567(0.94)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C567(1.00)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C567(0.92)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C567(0.73)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C567(0.92); C412(1.37)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C567(1.00); C412(1.21)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C567(1.25); C412(1.36)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C567(0.86)  LDD0720  [6]
 LDCM0404  CL17 HEK-293T C412(1.54)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C412(0.75)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C412(0.70)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C412(0.72); C567(0.91)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C412(1.00)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C412(0.62)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C412(0.85)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C412(0.79)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C412(1.16)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C412(0.56)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C412(0.63)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C412(0.63)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C412(0.58)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C412(0.82)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C412(1.05); C567(1.04)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C412(0.43)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C412(0.81); C567(0.46)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C412(0.88); C567(0.71)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C412(0.91); C567(0.83)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C412(0.96); C567(0.89)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C412(0.74); C567(0.58)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C412(0.83); C567(0.76)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C412(0.93); C567(0.76)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C412(0.82); C567(0.63)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C412(0.99); C567(1.13)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C412(0.74); C567(0.63)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C412(0.85); C567(0.63)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C412(1.01); C567(0.95)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C412(0.93); C567(0.74)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C412(0.76); C567(0.60)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C412(0.79); C567(0.81)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C412(1.27); C567(1.26)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C412(1.21); C567(1.20)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C412(1.14); C567(1.38)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C412(0.95); C567(1.25)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C412(0.83); C567(0.85)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C412(1.16); C567(1.22)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C412(1.20); C567(1.18)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C412(1.21); C567(0.95)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C412(1.13); C567(1.17)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C412(0.90); C567(1.14)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C412(1.23); C567(1.42)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C412(0.99); C567(1.12)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C412(1.08); C567(1.16)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C412(1.18); C567(1.29)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C412(1.03); C567(1.16)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C412(1.14); C567(0.94)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C412(1.01); C567(1.13)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C412(1.06)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C412(1.16)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C412(1.23)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C412(1.11)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C412(1.16)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C412(1.31)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C412(1.37)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C412(1.09)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C412(1.19)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C412(1.31); C567(1.16)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C412(1.13)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C412(1.12)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C412(0.93)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C412(1.11)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C412(1.21)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C412(0.98); C567(1.25)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C412(0.87); C567(1.18)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C412(0.94); C567(0.74)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C412(0.95); C567(0.93)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C412(1.26); C567(0.85)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C412(1.06); C567(1.22)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C412(1.00); C567(1.04)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C412(1.00); C567(1.06)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C412(1.16); C567(1.01)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C412(1.26); C567(1.04)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C412(0.90); C567(1.00)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C412(1.08); C567(0.86)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C412(0.92); C567(1.13)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C412(1.02); C567(1.39)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C412(1.17); C567(0.98)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C412(1.08); C567(1.07)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C412(0.75); C567(1.13)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C412(0.93); C567(0.60)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C412(0.94); C567(0.67)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C412(1.10); C567(0.70)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C412(1.07); C567(0.57)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C412(1.06); C567(0.54)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C412(1.01); C567(0.64)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C412(1.06); C567(0.71)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C412(1.05); C567(0.59)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C412(1.05); C567(0.67)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C321(1.27); C230(0.96); C567(1.24); C338(0.96)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C321(1.59)  LDD1702  [5]
 LDCM0625  F8 Ramos C567(0.69); C321(1.03)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C567(0.48); C321(1.16)  LDD2189  [12]
 LDCM0574  Fragment12 Ramos C567(0.45); C321(0.96)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C321(1.31)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C321(0.89)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C567(0.51); C321(0.83)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C567(0.41); C321(1.13)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C567(0.35); C321(0.80)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C567(0.33); C321(1.35)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C567(0.64); C321(0.48)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C567(0.48); C321(1.51)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C321(1.15)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C321(0.85)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C412(1.11)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C321(1.18)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C567(0.32); C321(0.57)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C412(1.08); C567(1.41)  LDD0744  [6]
 LDCM0614  Fragment56 Ramos C567(0.42)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C567(0.65); C321(0.55)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C567(0.41); C321(1.12)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C412(1.17)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C412(1.10)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C412(1.16)  LDD0082  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-fusing ATPase (NSF) AAA ATPase family P46459
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) UbiG/COQ3 family Q9NZJ6
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Ceramide synthase 4 (CERS4) . Q9HA82
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Gap junction beta-1 protein (GJB1) Connexin family P08034
Derlin-2 (DERL2) Derlin family Q9GZP9
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Monocarboxylate transporter 13 (SLC16A13) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY0
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Barttin (BSND) . Q8WZ55
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Growth hormone receptor (GHR) Type I cytokine receptor family P10912
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Protein FAM114A2 (FAM114A2) FAM114 family Q9NRY5
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein MAL2 (MAL2) MAL family Q969L2
Perilipin-3 (PLIN3) Perilipin family O60664
Protein YIF1A (YIF1A) YIF1 family O95070
Cerebellar degeneration-related antigen 1 (CDR1) . P51861
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Reticulon-3 (RTN3) . O95197
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6
Transmembrane and coiled-coil domain-containing protein 2 (TMCO2) . Q7Z6W1
Transmembrane protein 80 (TMEM80) . Q96HE8
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578