Details of the Target

General Information of Target

Target ID LDTP03979
Target Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)
Gene Name PIK3CB
Gene ID 5291
Synonyms
PIK3C1; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta; Serine/threonine protein kinase PIK3CB; EC 2.7.11.1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family
Subcellular location
Cytoplasm
Function
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation.
TTD ID
T05031
Uniprot ID
P42338
DrugMap ID
TTTHBCA
Ensemble ID
ENST00000289153.6
HGNC ID
HGNC:8976
ChEMBL ID
CHEMBL3145

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y618(6.69); Y888(60.71)  LDD3495  [1]
DBIA
 Probe Info  		C286(0.94); C287(0.94)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C286(1.17); C287(1.17); C626(1.26); C654(1.44)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C116(0.94); C286(1.17); C287(1.14); C626(1.14)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C286(0.92); C287(0.92); C626(1.19); C654(1.02)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C286(0.95); C287(0.95); C626(1.19); C654(0.83)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C286(0.96); C287(0.96); C626(1.11); C654(0.78)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C286(1.02); C287(1.02); C626(1.28); C654(0.82)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C286(0.95); C287(0.95); C626(1.24); C654(0.92)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C286(0.95); C287(0.95); C626(1.24); C654(0.76)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C286(1.02); C287(1.02); C626(1.54); C654(0.88)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C286(0.90); C287(0.70); C626(1.06); C654(0.79)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C286(1.10); C287(0.84); C626(1.31); C654(1.03)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C286(1.06); C287(0.87); C626(1.09); C654(0.93)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C116(0.87); C286(1.32); C287(1.23); C626(1.17)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C286(1.02); C287(0.87); C626(1.11); C654(0.89)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C286(0.96); C287(0.84); C626(1.09); C654(0.81)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C286(1.01); C287(0.75); C626(1.18); C654(0.78)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C286(1.01); C287(0.99); C654(1.50); C745(1.07)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C286(1.01); C287(1.01); C654(0.97); C745(1.33)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C286(1.09); C287(1.14); C654(0.93); C745(1.24)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C286(1.28); C287(1.39); C654(0.75); C745(1.17)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C286(1.09); C287(1.13); C654(0.71); C745(1.13)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C286(1.06); C287(1.10); C654(0.77); C745(1.14)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C286(1.23); C287(1.16); C654(0.82); C745(1.11)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C116(0.91); C286(1.08); C287(1.02); C626(1.03)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C286(1.28); C287(1.24); C654(0.80); C745(1.11)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C286(1.06); C287(1.07); C654(0.79); C745(1.06)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C286(1.07); C287(1.03); C654(0.90); C745(1.11)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C286(0.96); C287(1.03); C654(0.86); C745(1.05)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C286(1.13); C287(1.03); C654(0.85); C745(1.00)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C286(1.05); C287(1.06); C654(0.94); C745(1.20)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C286(1.24); C287(1.17); C654(0.84); C745(1.30)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C286(1.30); C287(1.28); C654(0.96); C745(1.33)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C286(1.36); C287(1.36); C745(1.44)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C286(0.83); C287(0.83); C745(0.81)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C286(1.01); C287(1.01); C745(1.07)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C286(0.84); C287(0.84); C745(0.83)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C286(1.02); C287(1.02); C745(0.98)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C286(1.12); C287(1.12); C745(1.23)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C286(1.09); C287(1.09); C745(1.29)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C286(1.14); C287(1.14); C745(1.03)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C286(1.21); C287(1.21); C745(1.12)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C286(1.15); C287(1.15); C745(1.07)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C286(1.17); C287(1.17); C745(1.09)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C286(1.04); C287(1.04); C745(1.12)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C116(0.90); C286(1.19); C287(1.19); C626(0.81)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C286(1.07); C287(1.07); C745(1.23)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C286(1.15); C287(1.15); C745(1.33)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C286(1.07); C287(1.07); C745(0.96)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C116(0.73); C286(0.93); C287(0.93); C654(0.96)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C116(0.80); C654(0.97); C286(1.04); C287(1.04)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C116(0.76); C654(0.99); C286(1.06); C287(1.06)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C654(0.82); C116(1.09); C286(1.13); C287(1.13)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C116(1.01); C654(1.04); C286(1.20); C287(1.20)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C286(1.14); C287(1.14); C116(1.26); C745(2.00)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C116(0.93); C286(1.02); C287(1.02); C654(1.43)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C626(0.90); C841(0.95); C116(0.96); C287(1.20)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C116(0.77); C286(1.01); C287(1.01); C654(1.05)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C116(1.00); C286(1.06); C287(1.06); C654(1.17)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C116(0.92); C286(1.04); C287(1.04); C654(1.10)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C654(0.99); C116(1.25); C286(1.34); C287(1.34)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C116(0.94); C286(1.06); C287(1.06); C654(0.86)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C116(1.01); C286(1.08); C287(1.08); C654(1.10)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C116(0.75); C286(1.04); C287(1.04); C654(1.01)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C116(0.74); C286(1.00); C287(1.00); C654(0.87)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C841(0.81); C745(0.82); C286(0.94); C287(0.97)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C745(0.69); C654(1.03); C841(1.09); C287(1.32)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C745(0.77); C654(0.90); C287(1.02); C286(1.05)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C626(1.05); C841(1.10); C654(1.11); C286(1.20)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C654(0.81); C745(0.87); C841(0.87); C287(1.05)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C745(0.74); C654(0.85); C841(0.92); C286(0.98)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C745(0.85); C841(0.90); C654(0.97); C286(0.99)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C745(0.72); C841(0.88); C654(0.98); C287(1.14)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C841(0.88); C745(0.95); C654(0.99); C286(1.02)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C654(0.74); C745(0.97); C841(1.06); C287(1.09)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C654(0.76); C841(0.81); C745(1.03); C116(1.18)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C654(0.66); C286(0.93); C841(0.93); C745(1.06)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C654(0.70); C841(0.92); C745(1.04); C286(1.19)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C654(0.81); C841(0.85); C286(0.92); C626(0.93)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C841(1.05); C286(1.21); C287(1.21); C626(1.55)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C654(0.76); C841(0.76); C286(0.90); C626(1.19)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C654(0.73); C286(0.87); C841(0.96); C287(1.06)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C654(0.70); C841(0.87); C286(1.10); C745(1.12)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C654(0.71); C745(0.73); C841(0.84); C286(1.06)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C654(0.54); C745(0.76); C841(0.79); C626(0.89)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C745(0.72); C286(0.85); C287(0.85); C654(0.99)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C286(0.85); C287(0.85); C116(0.91); C654(1.00)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C745(0.72); C286(0.89); C287(0.89); C116(0.89)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C745(0.83); C286(0.85); C287(0.85); C116(0.89)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C745(0.68); C286(0.94); C287(0.94); C116(1.04)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C841(1.20); C626(1.25); C286(1.30); C287(1.30)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C745(0.68); C626(0.95); C654(1.07); C286(1.07)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C745(0.63); C286(0.96); C287(0.96); C626(1.00)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C745(0.63); C286(1.01); C287(1.01); C116(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C745(0.66); C286(0.96); C287(0.96); C116(0.98)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C745(0.50); C626(1.00); C286(1.08); C287(1.08)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C745(0.50); C626(1.01); C654(1.12); C286(1.13)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C116(0.93); C626(1.00); C286(1.00); C287(1.00)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C116(0.93); C286(0.98); C287(0.98); C626(1.04)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C654(0.91); C626(0.92); C286(0.95); C287(0.95)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C626(0.78); C654(0.93); C286(1.21); C287(1.21)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C841(1.26); C286(1.34); C287(1.34); C626(1.43)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C626(0.73); C654(0.83); C286(1.14); C287(1.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C116(0.80); C286(0.85); C287(0.85); C626(1.05)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C116(0.93); C626(1.01); C286(1.01); C287(1.01)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C654(0.91); C626(0.98); C116(1.11); C286(1.19)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C626(0.96); C286(1.09); C287(1.09); C116(1.13)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C626(0.82); C654(0.83); C286(1.11); C287(1.11)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C654(0.84); C626(0.90); C286(1.45); C287(1.45)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C654(0.93); C287(1.07); C286(1.22)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C654(0.91); C287(1.12); C286(1.23)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C654(0.99); C287(1.29); C286(1.43)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C841(1.02); C116(1.09); C287(1.19); C286(1.20)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C654(0.87); C287(1.17); C286(1.19)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C654(0.82); C287(1.05); C286(1.22)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C654(0.81); C287(1.18); C286(1.34)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C654(0.84); C286(1.19); C287(1.20)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C654(0.87); C287(1.34); C286(1.47)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C654(1.21); C287(1.45); C286(1.66)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C654(1.10); C287(1.30); C286(1.51)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C654(0.91); C287(1.45); C286(1.67)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C654(0.77); C286(0.97); C116(0.99); C287(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C654(0.58); C116(0.90); C286(0.93); C287(0.94)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C116(0.87); C841(0.99); C286(1.10); C287(1.10)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C654(0.87); C287(0.98); C286(1.02); C116(1.41)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C287(0.94); C286(0.95); C654(1.06); C116(1.22)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C286(1.04); C287(1.07); C116(1.13); C654(1.20)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C654(0.72); C286(1.22); C287(1.22); C116(1.32)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C654(0.83); C286(1.17); C287(1.20); C116(1.24)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C654(0.85); C286(1.36); C287(1.43); C116(1.47)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C654(0.92); C287(1.04); C286(1.06); C116(1.13)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C654(0.71); C286(0.91); C287(0.94); C116(1.23)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C286(0.84); C287(0.85); C116(0.90); C654(0.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C286(0.91); C287(0.93); C654(1.07); C116(1.11)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C626(0.96); C841(1.04); C116(1.05); C287(1.15)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C654(0.90); C286(0.96); C287(1.02); C116(1.16)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C654(0.80); C287(0.89); C286(0.90); C116(1.21)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C654(0.97); C286(1.38); C287(1.39); C116(1.80)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C654(0.56); C626(0.79); C841(1.00); C286(1.05)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C654(0.53); C626(0.87); C841(0.99); C286(1.09)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C654(0.69); C841(1.00); C626(1.06); C286(1.08)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C654(0.90); C841(0.91); C626(0.97); C287(1.20)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C654(0.76); C745(1.10); C287(1.12); C841(1.18)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C626(0.93); C841(0.96); C654(0.99); C287(1.14)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C654(0.62); C626(0.89); C841(1.03); C287(1.20)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C287(0.94); C654(0.97); C745(0.98); C841(1.10)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C654(0.58); C841(0.82); C626(0.91); C745(1.23)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C654(0.58); C841(1.06); C626(1.13); C286(1.15)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C654(0.68); C626(0.89); C287(0.99); C841(1.08)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C841(0.82); C745(0.96); C654(0.96); C626(1.11)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C654(0.55); C626(0.89); C841(0.95); C745(1.04)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C654(0.62); C841(0.86); C626(0.96); C745(1.06)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C654(0.62); C841(0.86); C626(0.87); C745(1.25)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C654(0.87); C286(1.10); C287(1.10); C626(1.18)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C654(0.79); C286(0.95); C287(0.95); C745(1.00)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C116(0.98); C286(1.07); C287(1.03); C626(1.08)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C116(0.92); C626(1.05); C287(1.13); C841(1.20)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C841(0.91); C626(1.03); C116(1.16); C287(1.40)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C286(0.94); C287(0.94)  LDD0078  [2]
 LDCM0102  BDHI 8 Jurkat C287(13.22)  LDD0204  [5]
 LDCM0632  CL-Sc Hep-G2 C100(0.89)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C654(0.71); C745(0.91); C286(0.97); C116(0.99)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C745(0.69); C626(0.75); C116(0.89); C654(0.91)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C841(0.98); C654(1.13); C626(1.21); C286(1.24)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C116(1.01); C626(1.01); C841(1.10); C287(1.26)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C116(0.84); C745(1.07); C841(1.12); C287(1.13)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C116(0.85); C841(0.99); C745(1.00); C287(1.16)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C116(0.94); C745(1.08); C286(1.10); C626(1.10)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C745(0.76); C841(0.92); C287(1.11); C654(1.11)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C745(0.75); C841(1.10); C287(1.21); C654(1.40)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C745(0.77); C841(1.02); C654(1.14); C287(1.19)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C745(0.84); C841(1.02); C287(1.27); C654(1.33)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C745(0.90); C654(0.91); C841(0.94); C287(1.16)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C745(0.64); C626(0.71); C654(0.92); C116(0.97)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C745(0.83); C841(1.20); C654(1.29); C287(1.33)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C841(0.90); C654(0.98); C745(1.00); C286(1.20)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C654(0.87); C841(0.88); C626(1.03); C286(1.07)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C654(0.75); C841(0.75); C626(0.84); C745(0.94)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C841(0.75); C626(0.76); C654(0.85); C745(1.01)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C841(0.78); C654(0.85); C745(0.87); C626(0.96)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C654(0.79); C745(0.83); C841(0.85); C286(1.07)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C745(0.73); C626(1.08); C654(1.13); C116(1.33)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C745(0.69); C286(0.91); C287(0.91); C116(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C745(0.58); C654(0.94); C626(0.97); C116(1.07)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C745(0.72); C626(0.76); C654(0.95); C116(1.04)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C745(0.64); C286(0.99); C287(0.99); C116(1.05)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C654(0.51); C626(1.02); C116(1.28); C286(1.84)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C626(0.97); C286(1.02); C287(1.02); C116(1.12)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C654(0.86); C626(0.98); C116(1.04); C286(1.12)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C626(0.78); C654(0.95); C286(1.12); C287(1.12)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C654(0.97); C287(1.01); C286(1.03)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C287(1.12); C286(1.21); C654(1.46)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C654(0.93); C286(1.03); C287(1.05)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C654(0.82); C287(1.21); C286(1.45)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C745(0.72); C626(0.75); C287(1.06); C654(1.07)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C745(0.71); C626(0.78); C286(0.90); C116(1.01)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C626(0.75); C745(0.76); C287(0.96); C116(0.97)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C654(0.64); C745(0.87); C841(0.97); C286(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C745(0.77); C286(0.93); C287(0.93); C841(0.96)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C841(0.79); C745(0.85); C654(1.04); C286(1.06)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C745(0.71); C654(0.94); C841(1.15); C116(1.26)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C654(0.88); C286(0.91); C116(0.99); C745(1.00)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C841(0.79); C654(0.79); C745(0.83); C286(1.10)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C745(0.80); C841(0.82); C654(1.16); C286(1.24)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C745(0.83); C841(1.01); C654(1.05); C286(1.77)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C654(0.72); C745(0.79); C841(0.85); C286(1.22)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C654(0.81); C745(0.82); C841(0.85); C286(1.14)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C116(1.82); C286(1.33); C287(1.33); C654(0.62)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C116(1.53); C286(1.18); C287(1.18); C654(0.65)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C116(1.33); C286(1.18); C287(1.18); C654(0.76)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C116(1.55); C286(1.14); C287(1.14); C654(0.61)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C116(1.57); C286(1.14); C287(1.14); C654(0.77)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C116(0.91); C286(0.91); C287(0.99); C626(0.80)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C116(1.46); C286(0.89); C287(0.89); C654(0.69)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C286(1.00); C287(1.00); C626(0.93); C745(1.14)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C286(1.04); C287(1.03); C626(0.94); C745(1.02)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C286(1.09); C287(1.09); C626(1.05); C745(0.94)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C286(1.23); C287(1.20); C626(1.10); C745(1.24)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C286(1.17); C287(1.18); C626(1.11); C745(1.11)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C286(1.08); C287(1.07); C626(0.92); C745(1.09)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C286(1.12); C287(1.16); C626(1.10); C745(1.13)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C286(1.15); C287(1.15); C626(1.27); C745(1.16)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C116(0.99); C286(0.92); C287(0.96); C626(0.80)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C286(1.18); C287(1.21); C626(1.14); C745(1.00)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C286(1.05); C287(1.06); C626(1.05); C745(1.16)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C286(1.49); C287(1.49); C626(0.88); C745(1.20)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C286(1.23); C287(1.19); C626(1.42); C745(1.11)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C286(1.19); C287(1.18); C626(1.10); C745(1.09)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C286(1.22); C287(1.20); C626(1.32); C745(1.38)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C116(0.83); C286(1.00); C287(1.00); C654(0.89)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C116(0.77); C286(0.96); C287(0.96); C654(0.82)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C116(0.85); C286(0.87); C287(0.87); C654(0.92)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C116(0.91); C286(0.93); C287(0.93); C654(0.86)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C116(1.03); C286(1.08); C287(1.02); C626(0.93)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C116(0.97); C286(0.87); C287(0.87); C654(0.84)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C116(0.89); C286(0.90); C287(0.90); C654(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C116(0.95); C286(0.96); C287(0.96); C654(1.01)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C116(0.74); C286(0.94); C287(0.94); C654(0.71)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C116(0.85); C286(0.91); C287(0.91); C654(0.91)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C116(0.87); C286(0.89); C287(0.89); C654(0.74)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C116(1.11); C286(1.02); C287(1.02); C654(0.71)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C116(0.83); C286(0.95); C287(0.95); C654(0.75)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C116(0.81); C286(0.95); C287(0.95); C654(0.86)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C116(0.86); C286(0.98); C287(0.98); C654(0.91)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C116(1.01); C286(1.02); C287(1.08); C626(0.79)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C116(0.86); C286(1.00); C287(1.00); C654(0.92)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C116(1.03); C287(1.07); C626(0.96); C654(1.17)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C116(1.02); C287(1.22); C626(1.00); C654(1.27)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C116(1.27); C287(1.05); C626(0.86); C654(1.15)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C116(1.22); C287(1.04); C626(0.88); C654(1.16)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C116(1.19); C287(0.88); C626(1.07); C654(1.22)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C116(1.62); C287(0.95); C626(0.84); C654(1.17)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C116(1.29); C287(0.89); C626(0.85); C654(0.89)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C116(1.30); C287(0.97); C626(0.70); C654(0.91)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C116(0.98); C287(0.95); C626(0.84); C654(1.02)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C116(0.97); C286(1.14); C287(1.05); C626(0.79)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C116(1.16); C287(0.85); C626(1.02); C654(0.93)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C116(1.11); C287(1.08); C626(0.85); C654(0.94)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C116(1.10); C287(0.99); C626(0.98); C654(0.83)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C116(1.21); C287(1.01); C626(0.82); C654(0.77)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C116(1.38); C287(0.95); C626(0.81); C654(0.98)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C286(1.10); C287(1.10); C626(0.66); C654(0.88)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C286(1.12); C287(1.12); C626(0.63); C654(0.90)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C286(1.24); C287(1.24); C626(0.63); C654(0.90)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C286(1.15); C287(1.15); C626(0.65); C654(0.89)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C116(0.96); C286(1.39); C287(1.21); C626(0.73)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C286(1.12); C287(1.12); C626(0.68); C654(0.84)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C286(1.18); C287(1.18); C626(0.80); C654(0.90)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C286(1.51); C287(1.51); C626(0.62); C654(0.78)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C286(1.45); C287(1.45); C626(0.60); C654(0.80)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C286(1.61); C287(1.61); C626(0.72); C654(0.84)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C286(1.18); C287(1.18); C626(0.59); C654(0.82)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C286(1.28); C287(1.28); C626(0.67); C654(0.92)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C286(1.17); C287(1.17); C626(0.64); C654(0.85)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C286(1.40); C287(1.40); C626(0.55); C654(0.72)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C286(1.74); C287(1.74); C626(0.69); C654(0.85)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C116(1.06); C286(1.06); C287(1.01); C626(0.77)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C286(1.19); C287(1.19); C626(0.83); C654(0.96)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C286(1.27); C287(1.27); C626(1.08); C654(0.97)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C286(1.30); C287(1.30); C626(0.80); C654(0.86)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C286(1.06); C287(1.06); C626(0.74); C654(1.06)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C286(1.32); C287(1.32); C626(1.25); C654(0.99)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C286(1.44); C287(1.44); C626(1.06); C654(1.10)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C286(1.29); C287(1.29); C626(1.18); C654(1.11)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C286(1.34); C287(1.34); C626(1.10); C654(1.05)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C286(1.26); C287(1.26); C626(1.15); C654(1.43)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C286(1.38); C287(1.38); C626(1.23); C654(1.77)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C654(1.16); C551(1.03); C765(1.12); C116(1.02)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C116(1.35); C287(1.12); C626(0.86); C654(0.97)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C286(1.22); C287(1.30); C626(1.03); C745(1.18)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C286(1.88); C287(1.88)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C286(1.56); C287(1.56)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C286(1.34); C287(1.34)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C286(1.19); C287(1.19)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caffeine Small molecular drug DB00201
Investigative
Click To Hide/Show 23 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 31963 Antisense drug D0D9PL
Isis 31982 Antisense drug D0C1NA
Isis 31996 Antisense drug D0Z4LP
Isis 32000 Antisense drug D04PYV
Isis 32002 Antisense drug D0U8DY
Isis 32003 Antisense drug D06FJE
Isis 32004 Antisense drug D0QH9X
Isis 32005 Antisense drug D08SMF
Isis 32006 Antisense drug D0A5LZ
Isis 32008 Antisense drug D09WIW
Isis 32010 Antisense drug D0W3RP
Isis 32014 Antisense drug D00TQI
Isis 32015 Antisense drug D0V9MH
Isis 32020 Antisense drug D0H7CG
Isis 32021 Antisense drug D05YJU
Isis 32024 Antisense drug D01DFK
Isis 32028 Antisense drug D06IZU
Isis 32035 Antisense drug D02IBE
Isis 32039 Antisense drug D07NAT
3-(4-morpholinothieno[3,2-d]Pyrimidin-2-yl)Phenol Small molecular drug D05BPX
Ethyl 1-[(1h-benzimidazol-2(3h)One-5-yl)Sulfonyl]-1h-pyrrole-2-carboxylate Small molecular drug D0W1ST
Ly-292223 Small molecular drug D07APP
Xl765 . DB05241

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402