Details of the Target

General Information of Target

Target ID LDTP03894
Target Name von Hippel-Lindau disease tumor suppressor (VHL)
Gene Name VHL
Gene ID 7428
Synonyms
von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
VHL family
Subcellular location
Cytoplasm
Function
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
TTD ID
T80423
Uniprot ID
P40337
DrugMap ID
TTEMWSD
Ensemble ID
ENST00000256474.3
HGNC ID
HGNC:12687
ChEMBL ID
CHEMBL3108660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.I180N .
786O Deletion: p.G104AfsTer55 DBIA    Probe Info 
A498 Deletion: p.G144SfsTer14 .
CAMA1 SNV: p.E42Ter .
FADU SNV: p.M1? .
KMRC1 Deletion: p.F76del .
KMRC20 Deletion: p.S168TfsTer5
SNV: p.L169I		 .
OSRC2 Deletion: p.P59RfsTer8 .
VMRCRCW Deletion: p.R161MfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C77(1.49)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		C77(0.00); C162(0.00)  LDD0027  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C77(0.98)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C77(1.01)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C77(1.02)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C77(1.16)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C77(1.00)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C77(1.35)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C77(1.19)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C77(1.26)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C77(1.28)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C77(1.26)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C77(0.96)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C77(1.12)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C77(1.21)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C77(1.02)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C77(1.11)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C77(1.29)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C77(0.93)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C77(1.02)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C77(0.86)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C77(1.03)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C77(1.02)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C77(0.96)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C77(1.30)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C77(1.08)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C77(1.30)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C77(1.15)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C77(1.07)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C77(1.02)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C77(1.05)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C77(1.06)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C77(1.03)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C77(1.04)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C77(0.98)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C77(0.77)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C77(1.18)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C77(1.01)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C77(0.82)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C77(0.92)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C77(1.16)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C77(0.95)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C77(0.96)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C77(0.91)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C77(1.26)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C77(1.32)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C77(1.33)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C77(1.12)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C77(1.04)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C77(0.91)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C77(1.24)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C77(1.69)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C77(1.18)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C77(1.32)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C77(1.52)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C77(1.79)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C77(1.42)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C77(1.32)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C77(1.33)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C77(1.25)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C77(1.59)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C77(1.98)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C77(1.44)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C77(1.30)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C77(1.28)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C77(1.22)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C77(1.25)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C77(1.55)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C77(1.22)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C77(0.95)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C77(1.33)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C77(1.31)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C77(1.15)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C77(1.32)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C77(1.40)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C77(0.76)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C77(1.05)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C77(0.96)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C77(0.90)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C77(0.99)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C77(0.82)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C77(1.12)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C77(0.83)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C77(1.00)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C77(0.94)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C77(1.13)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C77(0.90)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C77(0.81)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C77(0.94)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C77(0.96)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C77(0.92)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C77(0.92)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C77(0.92)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C77(1.26)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C77(1.24)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C77(2.17)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C77(1.16)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C77(1.25)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C77(0.91)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C77(0.97)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C77(0.96)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C77(0.88)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C77(0.96)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C77(0.99)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C77(1.11)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C77(0.98)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C77(1.12)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C77(0.92)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C77(0.97)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C77(0.84)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C77(1.13)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C77(1.14)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C77(1.16)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C77(1.18)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C77(1.12)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C77(0.91)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C77(1.11)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C77(1.23)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C77(1.24)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C77(1.13)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C77(1.21)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C77(1.24)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C77(1.18)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C77(0.97)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C77(1.00)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C77(1.24)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C77(1.12)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C77(1.12)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C77(1.42)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C77(1.32)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C77(1.50)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C77(1.02)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C77(1.02)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C77(1.02)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C77(1.04)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C77(1.35)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C77(0.97)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C77(0.84)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C77(1.37)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C77(1.55)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C77(1.48)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C77(1.17)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C77(1.35)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C77(1.08)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C77(1.13)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C77(1.40)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C77(1.02)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C77(1.49)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C77(1.48)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C77(1.22)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C77(1.22)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C77(1.18)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C77(1.34)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C77(1.45)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C77(1.11)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C77(1.11)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C77(0.94)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C77(0.99)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C77(1.33)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C77(1.13)  LDD2171  [1]
 LDCM0632  CL-Sc Hep-G2 C77(20.00)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C77(1.09)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C77(1.05)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C77(1.02)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C77(1.37)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C77(1.00)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C77(1.02)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C77(0.98)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C77(1.27)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C77(1.48)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C77(1.37)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C77(1.52)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C77(1.19)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C77(1.19)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C77(1.40)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C77(1.41)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C77(0.91)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C77(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C77(1.34)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C77(1.15)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C77(0.89)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C77(1.02)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C77(1.10)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C77(1.52)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C77(1.24)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C77(1.43)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C77(0.74)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C77(0.95)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C77(1.05)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C77(0.93)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C77(1.10)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C77(1.09)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C77(1.15)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C77(0.95)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C77(1.31)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C77(1.38)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C77(1.27)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C77(1.01)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C77(1.01)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C77(1.17)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C77(1.09)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C77(1.12)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C77(1.23)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C77(1.41)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C77(1.66)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C77(1.45)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C77(1.30)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C77(1.20)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C77(1.23)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C77(1.03)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C77(1.18)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C77(1.19)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C77(0.99)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C77(1.12)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C77(1.24)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C77(1.33)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C77(1.70)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C77(1.85)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C77(2.08)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C77(1.67)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C77(2.22)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C77(2.04)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C77(1.01)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C77(1.54)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C77(1.52)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C77(2.31)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C77(2.25)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C77(1.98)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C77(2.17)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C77(1.00)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C77(0.91)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C77(1.12)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C77(1.26)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C77(1.09)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C77(1.07)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C77(0.94)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C77(0.92)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C77(1.15)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C77(1.12)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C77(1.06)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C77(1.03)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C77(0.93)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C77(1.05)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C77(1.02)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C77(1.10)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C77(1.09)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C77(1.01)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C77(1.14)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C77(1.04)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C77(1.04)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C77(1.39)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C77(0.97)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C77(0.97)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C77(1.27)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C77(1.22)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C77(1.01)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C77(1.05)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C77(1.11)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C77(1.26)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C77(1.30)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C77(1.15)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C77(1.04)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C77(1.11)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C77(1.04)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C77(1.03)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C77(2.62)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C77(0.84)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C77(0.98)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C77(0.89)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C77(0.93)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C77(1.01)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C77(1.11)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C77(1.02)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C77(0.95)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C77(1.08)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C77(1.02)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C77(1.26)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C77(1.14)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C77(0.90)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C77(1.18)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C77(1.07)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C77(1.10)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C77(1.05)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C77(0.89)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C77(0.99)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C77(0.90)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C77(0.98)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C77(0.97)  LDD1698  [8]
 LDCM0625  F8 Ramos C77(1.02)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C77(0.98)  LDD2189  [9]
 LDCM0574  Fragment12 Ramos C77(0.50)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C77(0.84)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C77(0.78)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C77(0.59)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C77(0.76)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C77(0.91)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C77(0.79)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C77(1.21)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C77(0.99)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C77(0.68)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C77(0.83)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C77(1.09)  LDD0785  [1]
 LDCM0596  Fragment38 Ramos C77(0.70)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C77(0.83)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C77(2.41)  LDD0744  [1]
 LDCM0610  Fragment52 Ramos C77(1.76)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C77(1.00)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C77(0.87)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C77(0.84)  LDD2188  [9]
 LDCM0022  KB02 HCT 116 C77(1.49)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C77(1.27)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C77(1.50)  LDD0082  [1]
 LDCM0627  NUDT7-COV-1 HEK-293T C77(0.83)  LDD2206  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C77(0.70)  LDD2207  [10]
 LDCM0131  RA190 MM1.R C77(1.14)  LDD0304  [11]
 LDCM0021  THZ1 HCT 116 C77(1.13)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 1 (PRMT1) Protein arginine N-methyltransferase family Q99873
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Cullin-2 (CUL2) Cullin family Q13617
Diacylglycerol kinase iota (DGKI) Eukaryotic diacylglycerol kinase family O75912
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) PHOSPHO family Q8TCD6
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) L-isoaspartyl/D-aspartyl protein methyltransferase family Q9NV79
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
Protein kinase C zeta type (PRKCZ) AGC Ser/Thr protein kinase family Q05513
Ribonuclease SLFN12 (SLFN12) Schlafen family Q8IYM2
SPRY domain-containing SOCS box protein 4 (SPSB4) SPSB family Q96A44
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) Transglutaminase family P21980
(E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) Ubiquitin-conjugating enzyme family Q9C0C9
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Ubiquitin-conjugating enzyme E2 S (UBE2S) Ubiquitin-conjugating enzyme family Q16763
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) VKOR family Q8N0U8
Fizzy-related protein homolog (FZR1) WD repeat CDC20/Fizzy family Q9UM11
E3 ubiquitin-protein ligase RNF139 (RNF139) . Q8WU17
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
MyoD family inhibitor (MDFI) MDFI family Q99750
Alpha-synuclein (SNCA) Synuclein family P37840
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH1 (BACH1) BZIP family O14867
Zinc finger protein GLI1 (GLI1) GLI C2H2-type zinc-finger protein family P08151
Zinc finger and BTB domain-containing protein 49 (ZBTB49) Krueppel C2H2-type zinc-finger protein family Q6ZSB9
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Nucleus accumbens-associated protein 2 (NACC2) . Q96BF6
Zinc finger and BTB domain-containing protein 6 (ZBTB6) . Q15916
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 13 (ASB13) Ankyrin SOCS box (ASB) family Q8WXK3
Ankyrin repeat and SOCS box protein 8 (ASB8) Ankyrin SOCS box (ASB) family Q9H765
Cyclin-C (CCNC) Cyclin family P24863
DNA damage-inducible transcript 4 protein (DDIT4) DDIT4 family Q9NX09
Translation initiation factor eIF2B subunit delta (EIF2B4) EIF-2B alpha/beta/delta subunits family Q9UI10
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Splicing factor 3B subunit 3 (SF3B3) RSE1 family Q15393
Transmembrane protein 185A (TMEM185A) TMEM185 family Q8NFB2
Denticleless protein homolog (DTL) WD repeat cdt2 family Q9NZJ0
DNA damage-binding protein 2 (DDB2) WD repeat DDB2/WDR76 family Q92466
Katanin p80 WD40 repeat-containing subunit B1 (KATNB1) WD repeat KATNB1 family Q9BVA0
Ribosome biogenesis protein WDR12 (WDR12) WD repeat WDR12/YTM1 family Q9GZL7
Calicin (CCIN) . Q13939
Elongin-A2 (ELOA2) . Q8IYF1
Fibronectin (FN1) . P02751
Galectin-3-binding protein (LGALS3BP) . Q08380
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Gigaxonin (GAN) . Q9H2C0
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) . P14866
Kelch-like protein 1 (KLHL1) . Q9NR64
Kelch-like protein 12 (KLHL12) . Q53G59
Kelch-like protein 17 (KLHL17) . Q6TDP4
Kelch-like protein 23 (KLHL23) . Q8NBE8
Kelch-like protein 41 (KLHL41) . O60662
PH-interacting protein (PHIP) . Q8WWQ0
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Superkiller complex protein 8 (SKIC8) . Q9GZS3
Suppressor of cytokine signaling 2 (SOCS2) . O14508
TAR DNA-binding protein 43 (TARDBP) . Q13148
WD repeat and SOCS box-containing protein 1 (WSB1) . Q9Y6I7

The Drug(s) Related To This Target

Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyrrolidine Carboxamide Derivative 1 Small molecular drug D0Q2SE

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.