Details of the Target

General Information of Target

Target ID LDTP03862
Target Name DNA-binding protein SMUBP-2 (IGHMBP2)
Gene Name IGHMBP2
Gene ID 3508
Synonyms
SMBP2; SMUBP2; DNA-binding protein SMUBP-2; EC 3.6.4.12; EC 3.6.4.13; ATP-dependent helicase IGHMBP2; Glial factor 1; GF-1; Immunoglobulin mu-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLY
GRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVTVAFDE
SHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPAS
EIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLC
CAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVLARSDSAQIVADIRKDI
DQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLATNTGASADGP
LKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAALAGLSL
SLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAA
TEETGVPLLLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQALVDAGVPARDIAVVSP
YNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRINVA
VTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQGSS
HAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSPEGV
ESQDGVDHFRAMIVEFMASKKMQLEFPPSLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFI
TVSKRAPRPRAALGPPAGTGGPAPLQPVPPTPAQTEQPPREQRGPDQPDLRTLHLERLQR
VRSAQGQPASKEQQASGQQKLPEKKKKKAKGHPATDLPTEEDFEALVSAAVKADNTCGFA
KCTAGVTTLGQFCQLCSRRYCLSHHLPEIHGCGERARAHARQRISREGVLYAGSGTKNGS
LDPAKRAQLQRRLDKKLSELSNQRTSRRKERGT
Target Bioclass
Enzyme
Family
DNA2/NAM7 helicase family
Subcellular location
Nucleus
Function
5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. Specific to 5'-phosphorylated single-stranded guanine-rich sequences. May play a role in RNA metabolism, ribosome biogenesis or initiation of translation. May play a role in regulation of transcription. Interacts with tRNA-Tyr.
Uniprot ID
P38935
Ensemble ID
ENST00000255078.8
HGNC ID
HGNC:5542

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C395(0.43)  LDD2092  [1]
DBIA
 Probe Info  		C612(4.62)  LDD0204  [2]
Acrolein
 Probe Info  		N.A.  LDD0224  [3]
IA-alkyne
 Probe Info  		C612(0.00); C395(0.00); C191(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C395(1.64)  LDD2152  [1]
 LDCM0214  AC1 HCT 116 C395(1.07)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C240(0.68); C241(0.68); C395(0.70)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C240(0.28); C241(0.28); C395(0.98)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C240(0.42); C241(0.42); C395(0.91)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C240(0.35); C241(0.35); C395(0.77)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C240(0.30); C241(0.30); C395(0.74)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C240(0.28); C241(0.28); C395(0.88)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C240(0.26); C241(0.26); C395(0.85)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C240(0.29); C241(0.29); C395(0.79)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C240(0.50); C241(0.33); C395(0.82)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C240(0.31); C241(0.51); C395(0.86)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C240(0.39); C241(0.36); C395(0.86)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C240(0.45); C241(0.45); C395(0.73)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C240(0.30); C241(0.42); C395(0.84)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C240(0.31); C241(0.51); C395(0.82)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C240(0.38); C241(0.32); C395(0.74)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C395(1.37)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C395(1.02)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C395(0.94)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C395(1.18)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C395(0.92)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C395(1.17)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C395(1.18)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C240(0.90); C241(0.90); C395(0.97)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C395(1.16)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C395(0.94)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C395(1.16)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C395(0.91)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C395(1.23)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C395(1.27)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C395(1.12)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C395(1.03)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C240(1.23); C241(1.23)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C240(1.33); C241(1.33)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C240(1.42); C241(1.42)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C240(1.38); C241(1.38)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C240(1.33); C241(1.33)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C240(1.30); C241(1.30)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C240(0.93); C241(0.93)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C240(1.31); C241(1.31)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C240(1.10); C241(1.10)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C240(1.09); C241(1.09)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C240(0.81); C241(0.81)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C240(0.83); C241(0.83)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C240(1.36); C241(1.36); C395(1.04)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C240(0.72); C241(0.72)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C240(0.85); C241(0.85)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C240(1.11); C241(1.11)  LDD0579  [7]
 LDCM0263  AC143 PaTu 8988t C240(0.81); C241(0.81); C395(0.87)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C240(1.01); C241(1.01); C395(0.93)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C240(0.84); C241(0.84); C395(0.92)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C240(0.91); C241(0.91); C395(1.11)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C240(0.83); C241(0.83); C395(0.81)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C240(0.76); C241(0.76); C395(0.93)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C240(0.69); C241(0.69); C395(0.94)  LDD1148  [7]
 LDCM0270  AC15 HCT 116 C240(0.58); C241(0.58); C395(0.84)  LDD0587  [7]
 LDCM0271  AC150 PaTu 8988t C240(1.01); C241(1.01); C395(0.88)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C240(0.65); C241(0.65); C395(1.01)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C240(0.74); C241(0.74); C395(0.73)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C240(0.79); C241(0.79); C395(0.89)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C240(0.80); C241(0.80); C395(1.02)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C240(0.94); C241(0.94); C395(0.96)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C240(0.72); C241(0.72); C395(0.94)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C240(1.90); C241(1.90); C395(1.07)  LDD2169  [7]
 LDCM0276  AC17 HCT 116 C395(0.87)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C395(0.46)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C395(0.73)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C395(1.11)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C395(0.83)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C395(0.69)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C395(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C395(0.83)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C395(0.96)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C240(1.02); C241(1.02); C395(1.07)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C395(0.98); C240(1.22); C241(1.22)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C240(0.61); C241(0.61); C395(0.75)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C240(0.57); C241(0.57); C395(0.83)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C395(0.91); C240(0.92); C241(0.92)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C395(1.08)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C395(0.71); C240(0.81); C241(0.81)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C240(0.95); C241(0.95); C395(1.03)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C240(0.50); C241(0.50); C395(0.64)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C240(0.51); C241(0.51); C395(0.75)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C240(0.57); C241(0.57); C395(0.71)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C240(1.26); C241(1.26); C395(1.28)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C395(1.17); C240(3.43); C241(3.43)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C395(1.11); C240(1.34); C241(1.34)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C395(1.03); C240(1.27); C241(1.27)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C395(1.08); C240(1.28); C241(1.28)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C395(1.02)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C240(0.85); C241(0.85); C395(1.20)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C395(1.18); C240(1.24); C241(1.24)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C395(1.02); C240(1.42); C241(1.42)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C395(1.25); C240(1.42); C241(1.42)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C395(1.09); C240(1.53); C241(1.53)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C395(1.08); C240(1.34); C241(1.34)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C240(0.98); C241(0.98); C395(1.03)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C240(0.91); C241(0.91); C395(1.05)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C395(1.63); C240(1.75); C241(1.75)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C240(1.20); C241(1.20); C395(1.34)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C395(0.98)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C240(1.13); C241(1.13); C395(1.21)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C395(1.50); C240(2.09); C241(2.09)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C240(0.86); C241(0.86); C395(1.06)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C240(0.91); C241(0.91); C395(1.16)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C240(0.89); C241(0.89); C395(1.06)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C240(0.89); C241(0.89); C395(1.26)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C240(0.97); C241(0.97); C395(1.57)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C240(0.33); C241(0.33); C395(0.73)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C240(0.29); C241(0.29); C395(0.73)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C240(0.30); C241(0.30); C395(0.68)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C240(0.52); C241(0.52); C395(0.71)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C240(0.29); C241(0.29); C395(0.74)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C240(0.52); C241(0.52); C395(0.97)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C240(0.24); C241(0.24); C395(0.64)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C240(0.32); C241(0.32); C395(0.68)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C240(0.36); C241(0.36); C395(0.76)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C240(0.37); C241(0.37); C395(0.74)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C240(0.35); C241(0.35); C395(0.73)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C240(0.39); C241(0.39); C395(0.73)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C240(1.30); C241(1.30)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C240(0.93); C241(0.93)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C240(0.88); C241(0.88); C395(0.95)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C240(1.29); C241(1.29)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C240(1.02); C241(1.02)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C240(0.98); C241(0.98)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C240(1.16); C241(1.16)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C240(1.12); C241(1.12)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C240(1.16); C241(1.16)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C240(0.98); C241(0.98)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C240(0.99); C241(0.99)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C240(1.49); C241(1.49)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C240(0.87); C241(0.87)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C240(0.50); C241(0.50); C395(0.79)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C240(1.12); C241(1.12)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C240(1.23); C241(1.23)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C240(1.20); C241(1.20)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C240(0.67); C241(0.67); C395(0.90)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C240(0.51); C241(0.51); C395(0.81)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C240(0.74); C241(0.74); C395(0.89)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C240(0.70); C241(0.70); C395(0.81)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C240(0.76); C241(0.76); C395(0.98)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C240(0.61); C241(0.61); C395(0.77)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C240(0.59); C241(0.59); C395(0.71)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C240(0.79); C241(0.79); C395(1.03)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C240(0.67); C241(0.67); C395(0.83)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C240(0.69); C241(0.69); C395(0.84)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C240(0.54); C241(0.54); C395(0.72)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C240(0.72); C241(0.72); C395(0.97)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C240(0.76); C241(0.76); C395(1.04)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C240(0.66); C241(0.66); C395(0.84)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C240(0.67); C241(0.67); C395(0.69)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C240(0.28); C241(0.28); C395(0.89)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C240(0.54); C241(0.54); C395(0.92)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C240(1.08); C241(1.08); C395(1.34)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C240(0.64); C241(0.64); C395(0.95)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C240(0.39); C241(0.39); C395(0.69)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C395(1.13); C902(1.21); C913(1.21); C916(1.21)  LDD2171  [7]
 LDCM0102  BDHI 8 Jurkat C612(4.62)  LDD0204  [2]
 LDCM0367  CL1 HCT 116 C240(1.28); C241(1.28)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C240(0.60); C241(0.60)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C395(0.92)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C240(0.40); C241(0.40); C395(0.66)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C240(0.92); C241(0.92); C395(1.04)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C395(0.93); C240(1.48); C241(1.48)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C240(0.94); C241(0.94); C395(1.03)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C395(0.51)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C395(0.52)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C395(0.43)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C395(0.51)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C395(0.59)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C240(0.94); C241(0.94)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C395(0.44)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C395(0.68)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C240(0.89); C241(0.89); C395(1.03)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C240(0.60); C241(0.60); C395(0.65)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C240(0.91); C241(0.91); C395(1.03)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C240(0.69); C241(0.69); C395(0.95)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C240(0.78); C241(0.78); C395(1.07)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C240(1.43); C241(1.43); C395(1.54)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C395(1.05); C240(1.08); C241(1.08)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C240(0.95); C241(0.95); C395(1.11)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C240(0.70); C241(0.70)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C240(0.93); C241(0.93); C395(1.23)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C395(0.62); C240(1.36); C241(1.36)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C240(0.85); C241(0.85); C395(1.19)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C240(0.86); C241(0.86); C395(1.03)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C240(0.87); C241(0.87); C395(1.18)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C240(0.64); C241(0.64); C395(0.93)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C240(0.54); C241(0.54); C395(0.74)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C240(0.50); C241(0.50); C395(0.83)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C240(0.24); C241(0.24); C395(0.67)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C240(0.83); C241(0.83)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C240(0.86); C241(0.86)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C240(1.18); C241(1.18)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C240(0.85); C241(0.85)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C240(0.97); C241(0.97)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C240(1.23); C241(1.23)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C240(0.70); C241(0.70)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C240(1.61); C241(1.61)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C240(0.45); C241(0.45)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C240(0.49); C241(0.49)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C240(0.76); C241(0.76)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C240(0.46); C241(0.46)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C240(0.48); C241(0.48)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C240(0.45); C241(0.45)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C240(0.51); C241(0.51)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C240(0.49); C241(0.49)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C240(0.52); C241(0.52)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C240(0.48); C241(0.48)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C240(0.89); C241(0.89)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C240(0.78); C241(0.78)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C240(0.87); C241(0.87); C395(0.65)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C240(0.88); C241(0.88); C395(0.88)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C240(0.68); C241(0.68); C395(0.88)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C240(0.49); C241(0.49); C395(0.52)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C240(0.46); C241(0.46); C395(0.46)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C240(0.44); C241(0.44); C395(0.52)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C240(0.47); C241(0.47); C395(0.50)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C240(0.41); C241(0.41); C395(0.51)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C240(0.94); C241(0.94)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C240(0.40); C241(0.40); C395(0.46)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C240(0.42); C241(0.42); C395(0.62)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C240(0.75); C241(0.75); C395(0.58)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C240(0.54); C241(0.54); C395(0.49)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C240(0.51); C241(0.51); C395(0.66)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C240(0.63); C241(0.63); C395(0.59)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C240(2.24); C241(2.24)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C240(2.00); C241(2.00)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C240(1.77); C241(1.77)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C240(0.88); C241(0.88)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C240(0.75); C241(0.75)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C240(1.72); C241(1.72)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C240(1.49); C241(1.49)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C240(1.38); C241(1.38)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C240(1.28); C241(1.28)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C240(1.96); C241(1.96)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C240(1.59); C241(1.59)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C240(0.92); C241(0.92)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C240(1.55); C241(1.55)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C240(2.45); C241(2.45)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C240(1.22); C241(1.22)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C240(1.23); C241(1.23)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C240(1.11); C241(1.11)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C240(0.70); C241(0.70)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C240(0.69); C241(0.69)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C240(0.48); C241(0.48)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C240(0.41); C241(0.41)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C240(0.73); C241(0.73)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C240(0.49); C241(0.49)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C240(0.47); C241(0.47)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C240(0.66); C241(0.66)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C240(1.09); C241(1.09)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C240(0.64); C241(0.64)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C240(0.76); C241(0.76)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C240(0.51); C241(0.51)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C240(1.18); C241(1.18)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C240(0.48); C241(0.48)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C240(0.42); C241(0.42)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C240(0.93); C241(0.93)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C240(0.96); C241(0.96)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C240(0.66); C241(0.66)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C240(0.62); C241(0.62)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C240(0.60); C241(0.60)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C240(1.19); C241(1.19)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C240(0.59); C241(0.59)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C240(0.63); C241(0.63)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C240(0.72); C241(0.72)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C240(0.72); C241(0.72)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C240(0.51); C241(0.51)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C240(0.82); C241(0.82)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C240(0.59); C241(0.59)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C240(0.61); C241(0.61)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C240(0.80); C241(0.80)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C240(0.55); C241(0.55)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C240(1.06); C241(1.06)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C395(1.21)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C395(1.04)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C395(1.09)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C395(1.04)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C395(1.01)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C395(1.21)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C395(0.99)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C395(0.91)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C395(0.86)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C612(1.12); C395(1.22); C191(1.04); C241(1.04)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C395(10.84)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C240(0.47); C241(0.47)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C240(0.63); C241(0.63); C395(0.58)  LDD0744  [7]
 LDCM0022  KB02 HEK-293T C395(0.84); C191(1.07); C612(1.01)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C46(14.64); C395(8.84); C240(5.28); C241(5.28)  LDD0209  [2]
 LDCM0024  KB05 OCUG-1 C897(1.59)  LDD3373  [9]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C395(0.43)  LDD2092  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C395(1.28)  LDD2093  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C395(0.85)  LDD2094  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C395(1.04)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C395(1.16)  LDD2107  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C395(0.90)  LDD2109  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C395(1.11)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C395(0.81)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C395(1.04)  LDD2127  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C395(0.98)  LDD2135  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C395(0.86)  LDD2140  [1]
 LDCM0021  THZ1 HCT 116 C395(1.13); C902(1.21); C913(1.21); C916(1.21)  LDD2173  [7]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840