Details of the Target

General Information of Target

Target ID LDTP03795
Target Name Vascular endothelial growth factor receptor 3 (FLT4)
Gene Name FLT4
Gene ID 2324
Synonyms
VEGFR3; Vascular endothelial growth factor receptor 3; VEGFR-3; EC 2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWA
WPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARI
EGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDG
QEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSL
ELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNV
SQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAA
YPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNV
PPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQ
DLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKV
GQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHD
AHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRS
HDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEE
KSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILV
GTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEF
PRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKIL
IHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF
RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQ
VARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKW
MAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA
TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFS
QVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPM
TPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRR
RPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
Subcellular location
Secreted; Cell membrane
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
TTD ID
T07303
Uniprot ID
P35916
DrugMap ID
TTDCBX5
Ensemble ID
ENST00000261937.11
HGNC ID
HGNC:3767
ChEMBL ID
CHEMBL1955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C8(1.11)  LDD2103  [1]
IPM
 Probe Info  		C8(1.92)  LDD1701  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C1054(0.95)  LDD0078  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C8(1.11)  LDD2103  [1]
 LDCM0214  AC1 HCT 116 C1054(1.11)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1054(1.20)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1054(1.10)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1054(1.02)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1054(1.07)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1054(1.08)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1054(1.07)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1054(1.06)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1054(1.08)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1054(1.21)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1054(1.03)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1054(0.99)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1054(1.14)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1054(1.09)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1054(1.00)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1054(1.05)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1054(1.00)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1054(1.05)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1054(1.05)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1054(0.98)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1054(1.15)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1054(1.09)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1054(1.01)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1054(1.08)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1054(0.98)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1054(1.03)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1054(1.10)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1054(1.06)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1054(1.18)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1054(1.09)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1054(1.12)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1054(0.99)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1054(1.13)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1054(0.96)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1054(0.89)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1054(0.80)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1054(0.98)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1054(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1054(1.04)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1054(1.09)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1054(1.11)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1054(1.07)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1054(1.11)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1054(1.03)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1054(1.14)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1054(1.13)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1054(1.00)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1054(0.91)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1054(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1054(1.33)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1054(1.06)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1054(1.20)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1054(1.37)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1054(1.33)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1054(1.17)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1054(1.18)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C1054(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1054(1.14)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1054(1.31)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1054(1.54)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1054(1.29)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1054(1.28)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1054(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1054(0.96)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1054(1.13)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1054(1.36)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1054(1.07)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1054(1.03)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1054(1.14)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1054(1.17)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1054(1.13)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1054(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1054(1.07)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1054(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1054(1.00)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1054(1.00)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1054(0.98)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1054(1.00)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1054(1.09)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1054(1.04)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1054(0.89)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1054(1.03)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1054(0.97)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1054(1.09)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1054(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1054(0.90)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1054(0.98)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1054(0.93)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1054(1.06)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C1054(1.12)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1054(1.13)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1054(1.01)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1054(1.01)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1054(0.98)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1054(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1054(1.11)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C1054(0.95)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1054(1.15)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1054(0.91)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1054(1.14)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1054(1.18)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1054(1.13)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1054(0.96)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1054(1.11)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1054(1.02)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1054(1.12)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1054(1.09)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1054(1.16)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1054(1.26)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1054(1.17)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1054(1.31)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1054(1.18)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1054(1.17)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1054(1.04)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1054(1.34)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1054(1.20)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1054(1.32)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1054(1.48)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1054(1.50)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1054(1.39)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1054(1.04)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1054(0.99)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1054(1.05)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1054(1.06)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1054(1.03)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1054(1.09)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1054(1.19)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1054(1.07)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1054(1.13)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1054(1.15)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1054(1.16)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1054(0.95)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1054(1.06)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1054(1.20)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1054(1.13)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1054(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1054(1.11)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1054(1.12)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1054(1.06)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1054(1.10)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1054(1.02)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1054(0.93)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1054(1.09)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1054(1.08)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1054(1.05)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1054(1.17)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1054(1.26)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1054(1.20)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1054(0.99)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1054(0.86)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1054(1.01)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1054(1.13)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1054(0.91)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1054(0.96)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1054(1.19)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1054(1.06)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1054(1.25)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1054(0.95)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C1054(0.92)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1054(0.99)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1054(1.12)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C1054(1.10)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1054(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1054(1.00)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1054(0.95)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1054(1.19)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1054(1.16)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1054(1.20)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1054(1.28)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1054(1.12)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C1054(1.27)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C1054(1.14)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1054(1.07)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1054(0.96)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1054(1.08)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1054(0.91)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1054(0.97)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1054(1.06)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1054(1.17)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1054(0.99)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1054(1.04)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C1054(1.26)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1054(1.09)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C1054(1.03)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1054(0.93)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1054(0.92)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1054(1.06)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C1054(1.11)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1054(1.15)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1054(1.12)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1054(1.32)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1054(0.99)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1054(0.93)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1054(1.08)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1054(1.19)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1054(1.17)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1054(0.97)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1054(1.00)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C1054(0.99)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1054(1.19)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1054(1.13)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1054(1.40)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1054(1.17)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1054(1.28)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1054(1.33)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1054(1.25)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1054(1.19)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1054(1.11)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1054(1.28)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1054(1.04)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1054(1.15)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1054(0.95)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1054(0.99)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1054(0.86)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1054(0.95)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1054(1.17)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1054(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1054(1.11)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1054(1.18)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1054(0.98)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1054(0.98)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1054(0.95)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1054(1.17)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1054(1.09)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1054(0.97)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1054(1.02)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1054(1.02)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1054(1.03)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1054(1.14)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1054(1.03)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1054(0.97)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1054(0.93)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1054(1.01)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1054(0.97)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1054(0.96)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1054(1.04)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1054(1.12)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1054(1.13)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1054(0.97)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1054(0.96)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1054(1.00)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1054(0.88)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1054(1.09)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1054(0.98)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1054(1.02)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1054(1.09)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1054(1.12)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1054(1.10)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1054(1.18)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1054(1.13)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1054(1.01)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1054(0.87)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C1054(1.13)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1054(1.01)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1054(1.17)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1054(1.13)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1054(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1054(1.10)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C1054(0.83)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1054(0.93)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1054(1.03)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1054(1.04)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C1054(1.13)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1054(0.88)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1054(1.04)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1054(1.04)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1054(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1054(1.19)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1054(1.13)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1054(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1054(0.99)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1054(1.07)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1054(1.05)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C1054(1.08)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1054(0.84)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1054(1.08)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1054(1.02)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1054(1.03)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1054(0.95)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1054(1.06)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1054(1.08)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1054(1.05)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1054(1.14)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1054(1.09)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C873(0.95); C1054(0.82); C828(1.00); C1151(0.99)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C1054(1.11)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1054(1.16)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C1299(3.87); C1054(1.96)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C1299(1.62); C1054(1.66)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C1299(2.14); C1054(1.39)  LDD0082  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C8(3.79)  LDD2116  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C8(4.86)  LDD2149  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vascular endothelial growth factor receptor 2 (KDR) Tyr protein kinase family P35968
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Vascular endothelial growth factor C (VEGFC) PDGF/VEGF growth factor family P49767

The Drug(s) Related To This Target

Approved
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Axitinib Small molecular drug DB06626
Fostamatinib Small molecular drug DB12010
Lenvatinib Small molecular drug DB09078
Nintedanib Small molecular drug DB09079
Pazopanib Small molecular drug DB06589
Regorafenib Small molecular drug DB08896
Sorafenib Small molecular drug DB00398
Sunitinib Small molecular drug DB01268
Tivozanib Small molecular drug D0W7JZ
Selpercatinib . DB15685
Phase 3
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-869 Small molecular drug D0M9QZ
E-3810 Small molecular drug D02WVT
Pi-88 Small molecular drug D04ZJG
Fruquintinib . D03JTG
Mgcd516 . D05BLN
Sulfatinib . D05PWX
Taberminogene Vadenovec . D0GY4H
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Famitinib Small molecular drug D0Z6MT
Mk-2461 Small molecular drug D00DRL
Vatalanib Small molecular drug D0P6DJ
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imc-3c5 . D09JSM
Jnj-26483327 . D0U3XL
Investigative
Click To Hide/Show 25 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imc-1c11 Antibody DB06101
Anti-vegfr 3 Mab Monoclonal antibody D07VCG
(2-methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine Small molecular drug D06GJO
(5-phenyl-oxazol-2-yl)-m-tolyl-amine Small molecular drug D0D3YL
2-(5-phenyl-oxazol-2-ylamino)-benzonitrile Small molecular drug D03HQK
3,6-di-pyridin-4-yl-pyrazolo[1,5-a]Pyrimidine Small molecular drug D0YN1E
3-(5-phenyl-oxazol-2-ylamino)-benzonitrile Small molecular drug D0J2XD
4-(5-phenyl-oxazol-2-ylamino)-benzenesulfonamide Small molecular drug D09LEK
4-chloro-n-(2-chloro-benzoyl)-benzenesulfonamide Small molecular drug D0UZ5W
4-chloro-n-(2-methyl-benzoyl)-benzenesulfonamide Small molecular drug D0V4BR
4-chloro-n-(3-chloro-benzoyl)-benzenesulfonamide Small molecular drug D05THI
4-chloro-n-(4-chloro-benzoyl)-benzenesulfonamide Small molecular drug D09MSA
4-chloro-n-(4-nitro-benzoyl)-benzenesulfonamide Small molecular drug D0C6OD
Cb-676475 Small molecular drug D0C6KI
Cep-6331 Small molecular drug D07IHM
Denibulin Small molecular drug DB05932
N-(2,4-dichloro-benzoyl)-benzenesulfonamide Small molecular drug D07XBW
N-(3-bromo-benzoyl)-4-chloro-benzenesulfonamide Small molecular drug D0M2QA
Phenyl-(5-phenyl-oxazol-2-yl)-amine Small molecular drug D0BM4F
Pmid22765894c8h Small molecular drug D0C2GE
Sar-131675 Small molecular drug D08GBT
Tg-100801 Small molecular drug DB05075
Vatalanib Small molecular drug DB04879
[3-(5-phenyl-oxazol-2-ylamino)-phenyl]-methanol Small molecular drug D0V9DQ
Linifanib . DB06080
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyrimidine Derivative 15 Small molecular drug D07DJR

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402