Details of the Target

General Information of Target

Target ID LDTP03528
Target Name G1/S-specific cyclin-D3 (CCND3)
Gene Name CCND3
Gene ID 896
Synonyms
G1/S-specific cyclin-D3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
Target Type
Literature-reported
Target Bioclass
Other
Family
Cyclin family, Cyclin D subfamily
Subcellular location
Nucleus
Function
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
TTD ID
T72507
Uniprot ID
P30281
DrugMap ID
TT1JXNR
Ensemble ID
ENST00000372988.8
HGNC ID
HGNC:1585
ChEMBL ID
CHEMBL2422

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C47(1.44)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C243(0.00); C47(0.00); C73(0.00); C91(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C243(0.00); C47(0.00); C73(0.00); C91(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C47(0.00); C73(0.00); C125(0.00); C91(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C47(0.96); C91(1.18)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C47(1.07); C91(1.35)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C47(1.02)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C47(1.32)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C47(0.89)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C47(1.25)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C47(1.01)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C47(1.16)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C47(1.46)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C47(1.26)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C47(1.02)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C47(0.82)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C47(0.83); C91(1.18)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C47(2.08)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C47(0.97)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C47(0.93)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C47(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C47(1.06)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C47(1.48)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C47(1.01)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C47(1.03)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C47(0.97)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C47(1.17)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C47(0.98); C91(0.93)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C47(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C47(1.15)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C47(0.96)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C47(0.86)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C47(1.37)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C47(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C47(0.91)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C47(0.81)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C47(1.17)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C47(1.27)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C47(1.05)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C47(1.16)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C47(1.41)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C47(1.25)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C47(1.11)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C47(1.21)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C47(0.93)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C47(1.11)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C47(1.09)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C47(1.31)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C47(1.00); C91(0.97)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C47(1.21)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C47(1.13)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C47(1.35)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C47(1.06)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C47(0.99)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C47(0.98)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C47(0.96)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C47(1.17)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C47(1.02)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C47(1.21)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C91(0.71); C47(0.97)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C47(1.26)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C47(1.21)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C47(1.02)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C47(0.92)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C47(0.86)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C47(1.06)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C47(1.01)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C47(0.88)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C91(1.00); C47(1.02)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C91(1.37); C47(1.98)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C91(0.96); C47(1.00)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C47(1.16); C91(1.19)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C91(0.91); C47(1.19)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C91(1.21); C47(1.23)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C47(1.03); C91(1.05)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C91(0.99); C47(1.20)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C47(0.94); C91(1.16)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C47(0.81); C91(1.14)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C47(1.00); C91(1.45)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C47(1.20); C91(1.28)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C47(0.95); C91(1.22)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C47(1.10); C91(1.23)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C47(1.00); C91(1.25)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C91(1.28); C47(1.53)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C91(1.03); C47(1.21)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C91(1.34); C47(1.41)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C47(0.99); C91(1.22)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C47(0.70); C91(1.21)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C91(0.94)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C91(0.87)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C91(0.96)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C91(1.13)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C91(1.17)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C47(0.64); C91(1.59)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C91(1.14)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C91(0.89)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C91(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C91(1.02)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C91(1.17)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C91(1.07)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C47(1.10)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C47(1.04)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C47(1.18)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C47(1.20)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C47(0.53); C91(1.55)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C47(1.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C47(0.94)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C47(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C47(1.08)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C47(1.09)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C47(1.13)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C47(1.28)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C47(7.69)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C47(3.00)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C47(4.57)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C47(0.96); C91(1.02)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C47(5.62)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C47(9.05)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C47(9.23)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C47(14.99)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C47(5.94)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C47(12.80)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C47(0.91)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C47(6.98)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C91(0.69); C47(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C91(0.62); C47(1.09)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C47(1.21); C91(1.34)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C91(0.79); C47(1.76)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C91(0.55); C47(0.89)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C91(0.70); C47(1.83)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C91(0.80); C47(2.30)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C47(0.51); C91(0.55)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C91(0.70); C47(1.16)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C91(0.77); C47(1.80)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C91(0.60); C47(0.87)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C91(0.70); C47(1.07)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C91(0.56); C47(1.18)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C47(0.95); C91(1.26)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C91(0.45); C47(1.13)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C91(0.68); C47(1.45)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C91(0.46); C47(1.57)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C91(1.26)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C91(1.64)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C91(1.00)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C91(0.93)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C91(0.73)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C91(0.67)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C91(0.98)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C91(0.89)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C91(1.24)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C91(1.26)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C91(0.88)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C91(0.81)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C91(0.86)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C91(0.94)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C91(1.32)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C47(1.03)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C47(1.01)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C47(1.01); C91(0.94)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C47(0.79); C91(1.24)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C91(0.87); C47(1.07)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C47(1.44)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C5(0.68); C47(0.35); C91(0.27)  LDD2227  [4]
 LDCM0367  CL1 PaTu 8988t C47(1.34); C91(0.98)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C47(2.11); C91(1.35)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C47(0.88); C91(1.20)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C91(0.91); C47(1.08)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C91(1.29); C47(1.43)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C91(0.84); C47(0.89)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C47(0.96); C91(1.03)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C47(1.12); C91(1.35)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C91(1.43); C47(2.33)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C91(1.30); C47(1.46)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C91(1.55); C47(1.68)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C91(1.09); C47(1.97)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C47(1.70); C91(0.99)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C47(1.89); C91(2.18)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C91(1.03); C47(1.81)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C47(0.83); C91(1.11)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C47(1.05); C91(1.21)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C47(1.07); C91(1.10)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C91(0.96); C47(1.00)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C47(1.15); C91(1.18)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C91(1.33)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C91(0.89)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C91(1.01)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C47(1.09); C91(1.05)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C91(1.24)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C47(0.83)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C47(1.14)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C47(1.31)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C47(1.19)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C47(3.61)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C47(20.00)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C47(3.89)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C47(5.43)  LDD0716  [2]
 LDCM0400  CL13 PaTu 8988t C47(2.11); C91(1.23)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C47(1.23); C91(1.20)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C47(20.00); C91(0.87)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C91(1.04)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C91(0.97); C47(1.20)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C47(0.68); C91(1.01)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C47(0.78); C91(0.97)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C47(1.48); C91(1.08)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C47(0.56); C91(0.92)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C47(0.59); C91(1.53)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C47(0.45); C91(1.14)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C47(0.65); C91(0.90)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C47(0.47); C91(0.96)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C47(0.52); C91(1.22)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C47(0.43); C91(0.87)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C47(0.55); C91(1.07)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C47(0.51); C91(0.96)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C47(0.48); C91(1.03)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C47(1.68); C91(1.08)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C47(0.46); C91(1.22)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C47(0.74); C91(1.12)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C47(0.71); C91(0.95)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C47(0.92); C91(1.11)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C47(0.93); C91(1.27)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C47(0.96); C91(0.88)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C47(0.96); C91(1.23)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C47(0.95); C91(0.79)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C47(0.94); C91(0.96)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C47(1.04); C91(0.99)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C47(0.92); C91(0.89)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C47(1.11); C91(0.91)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C47(0.98); C91(0.68)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C47(0.88); C91(0.81)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C47(1.00); C91(1.02)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C47(1.61); C91(1.63)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C91(0.97)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C91(0.88)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C91(0.93)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C91(1.06)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C47(1.34); C91(1.13)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C91(0.98)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C91(1.08)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C91(1.09)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C91(0.81)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C91(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C91(0.87)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C91(0.85)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C91(0.83)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C91(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C91(0.97)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C47(1.57); C91(0.95)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C91(0.98)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C91(1.05)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C91(1.10)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C91(1.25)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C91(1.33)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C91(1.39)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C91(1.59)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C91(1.33)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C91(1.34)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C91(1.19)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C47(1.44); C91(1.11)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C91(1.16)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C91(1.02)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C91(0.97)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C91(1.19)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C91(1.16)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C47(1.15)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C47(1.06)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C47(1.30)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C47(0.94)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C47(4.50); C91(1.91)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C47(0.93)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C47(0.91)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C47(0.89)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C47(0.94)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C47(1.08)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C47(0.99)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C47(0.88)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C47(0.95)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C47(0.95)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C47(0.93)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C47(1.26); C91(1.13)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C47(1.85)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C47(1.07); C91(1.12)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C47(0.91); C91(3.27)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C47(0.96); C91(1.61)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C47(0.88); C91(1.60)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C47(1.03); C91(1.32)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C47(1.22); C91(1.14)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C47(0.92); C91(1.36)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C47(1.05); C91(1.51)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C47(1.21); C91(1.40)  LDD0811  [2]
 LDCM0634  CY-0357 Hep-G2 C91(0.91); C47(0.17)  LDD2228  [4]
 LDCM0625  F8 Ramos C47(0.52)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C125(0.58)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C47(0.26)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C47(1.50)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C125(0.88)  LDD2192  [6]
 LDCM0579  Fragment20 Ramos C47(1.10)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C47(1.32); C125(1.23)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C47(0.95)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C47(0.73); C125(0.67)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C47(0.61); C125(0.95)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C47(1.17); C125(0.97)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C47(0.85)  LDD2200  [6]
 LDCM0468  Fragment33 HCT 116 C91(1.28)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C47(0.95)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C47(0.88)  LDD2184  [6]
 LDCM0427  Fragment51 HCT 116 C47(0.85); C91(1.04)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C47(0.79); C125(0.68)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C125(0.81)  LDD2205  [6]
 LDCM0022  KB02 697 C47(2.60)  LDD2245  [7]
 LDCM0023  KB03 Jurkat C47(18.94)  LDD0209  [8]
 LDCM0024  KB05 NALM-6 C47(5.37)  LDD3339  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase III subunit RPC7-like (POLR3GL) Eukaryotic RPC7 RNA polymerase subunit family Q9BT43
Cyclin-dependent kinase 14 (CDK14) CMGC Ser/Thr protein kinase family O94921
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 5 (CDK5) CMGC Ser/Thr protein kinase family Q00535
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular retinoic acid-binding protein 2 (CRABP2) Fatty-acid binding protein (FABP) family P29373
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.