Details of the Target

General Information of Target

Target ID LDTP03359
Target Name Isovaleryl-CoA dehydrogenase, mitochondrial (IVD)
Gene Name IVD
Gene ID 3712
Synonyms
Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; EC 1.3.8.4; Butyryl-CoA dehydrogenase; EC 1.3.8.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEMATATRLLGWRVASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFL
QEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISR
ASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMK
LKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTS
KKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQA
VLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDC
AGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRA
FNADFH
Target Bioclass
Enzyme
Family
Acyl-CoA dehydrogenase family
Subcellular location
Mitochondrion matrix
Function
Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
Uniprot ID
P26440
Ensemble ID
ENST00000650656.1
HGNC ID
HGNC:6186

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [1]
C-Sul
 Probe Info  		3.42  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K318(5.88)  LDD0277  [4]
IPM
 Probe Info  		C254(0.00); C350(0.00); C261(0.00); C355(0.00)  LDD0241  [5]
m-APA
 Probe Info  		11.38  LDD0403  [6]
BTD
 Probe Info  		C350(0.51)  LDD2100  [7]
HHS-475
 Probe Info  		Y277(2.07)  LDD0264  [8]
DBIA
 Probe Info  		C251(2.69); C258(2.69)  LDD0080  [9]
5E-2FA
 Probe Info  		H354(0.00); H63(0.00); H271(0.00)  LDD2235  [10]
IA-alkyne
 Probe Info  		C350(0.00); C136(0.00)  LDD0162  [11]
Acrolein
 Probe Info  		C355(0.00); H426(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		C350(0.00); C355(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [5]
AOyne
 Probe Info  		9.20  LDD0443  [13]
NAIA_5
 Probe Info  		C355(0.00); C136(0.00); C261(0.00); C254(0.00)  LDD2223  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C355(0.89)  LDD2112  [7]
 LDCM0214  AC1 HCT 116 C251(0.87); C258(0.87); C347(1.08); C352(1.08)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C251(1.13); C258(1.13); C347(0.85); C352(0.85)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C251(0.90); C258(0.90); C347(0.84); C352(0.84)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C251(0.67); C258(0.67); C347(0.73); C352(0.73)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C251(0.67); C258(0.67); C347(0.69); C352(0.69)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C251(0.48); C258(0.48); C347(0.50); C352(0.50)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C251(0.54); C258(0.54); C347(0.69); C352(0.69)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C251(0.62); C258(0.62); C347(0.62); C352(0.62)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C251(0.63); C258(0.63); C347(0.59); C352(0.59)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C251(0.50); C258(0.50); C347(0.50); C352(0.57)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C251(0.65); C258(0.65); C347(0.71); C352(0.67)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C251(0.57); C258(0.57); C347(0.70); C352(0.65)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C251(0.92); C258(0.92); C347(0.93); C352(0.93)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C251(0.64); C258(0.64); C347(0.61); C352(0.60)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C251(0.61); C258(0.61); C347(0.70); C352(0.66)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C251(0.62); C258(0.62); C347(0.67); C352(0.68)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C251(1.01); C258(1.01); C347(0.95); C352(0.95)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C251(1.24); C258(1.03); C347(0.82); C352(0.82)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C251(0.83); C258(1.06); C347(0.78); C352(0.78)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C251(0.81); C258(1.21); C347(0.79); C352(0.79)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C251(0.73); C258(0.86); C347(0.81); C352(0.81)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C251(0.95); C258(0.98); C347(0.90); C352(0.90)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C251(0.92); C258(0.87); C347(0.92); C352(0.92)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C251(1.02); C258(1.02); C347(1.17); C352(1.17)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C251(1.10); C258(1.04); C347(0.96); C352(0.96)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C251(0.71); C258(0.74); C347(0.87); C352(0.87)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C251(0.94); C258(0.83); C347(0.86); C352(0.86)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C251(0.80); C258(0.75); C347(0.86); C352(0.86)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C251(0.75); C258(0.72); C347(0.92); C352(0.92)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C251(0.93); C258(0.95); C347(0.85); C352(0.85)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C251(0.93); C258(0.98); C347(0.81); C352(0.81)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C251(0.83); C258(0.83); C347(0.77); C352(0.77)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C251(0.61); C258(0.61); C347(0.35); C352(0.35)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C251(1.09); C258(1.09); C347(1.01); C352(1.01)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C251(1.05); C258(1.05); C347(0.71); C352(0.71)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C251(1.11); C258(1.11); C347(0.96); C352(0.96)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C251(1.44); C258(1.44); C347(0.98); C352(0.98)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C251(1.19); C258(1.19); C347(0.76); C352(0.76)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C251(1.10); C258(1.10); C347(0.71); C352(0.71)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C251(0.94); C258(0.94); C347(0.70); C352(0.70)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C251(0.99); C258(0.99); C347(0.92); C352(0.92)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C251(1.10); C258(1.10); C347(0.99); C352(0.99)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C251(1.31); C258(1.31); C347(0.78); C352(0.78)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C251(1.29); C258(1.29); C347(0.84); C352(0.84)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C251(1.18); C258(1.18); C347(1.04); C352(1.04)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C251(1.17); C258(1.17); C347(0.71); C352(0.71)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C251(1.13); C258(1.13); C347(0.83); C352(0.83)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C251(1.37); C258(1.37); C347(0.98); C352(0.98)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C251(0.98); C258(0.98); C347(1.00); C352(1.00)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C347(0.86); C352(0.86); C251(0.92); C258(0.92)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C251(0.91); C258(0.91); C347(1.08); C352(1.08)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C251(0.85); C258(0.85); C347(1.02); C352(1.02)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C347(0.73); C352(0.73); C251(0.76); C258(0.76)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C347(0.24); C352(0.24); C251(0.54); C258(0.54)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C347(0.60); C352(0.60); C251(0.78); C258(0.78)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C347(0.92); C352(0.92); C251(1.11); C258(1.11)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C251(1.04); C258(1.04); C347(1.20); C352(1.20)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C251(1.20); C258(1.20); C347(1.22); C352(1.22)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C347(0.66); C352(0.66); C251(0.70); C258(0.70)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C347(0.22); C352(0.22); C251(0.55); C258(0.55)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C251(0.83); C258(0.83); C347(0.88); C352(0.88)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C251(0.99); C258(0.99); C347(1.06); C352(1.06)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C251(1.06); C258(1.06); C347(1.02); C352(1.02)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C251(1.18); C258(1.18); C347(1.03); C352(1.03)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C347(0.83); C352(0.83)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C347(0.81); C352(0.81)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C347(0.92); C352(0.92)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C347(0.92); C352(0.92); C251(0.96); C258(0.96)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C347(1.09); C352(1.09)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C347(1.05); C352(1.05)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C347(0.87); C352(0.87)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C347(0.95); C352(0.95)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C347(0.81); C352(0.81)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C347(1.21); C352(1.21)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C347(1.01); C352(1.01)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C347(0.99); C352(0.99)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C347(1.11); C352(1.11)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C347(1.04); C352(1.04)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C347(0.88); C352(0.88); C251(0.89); C258(0.89)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C347(0.91); C352(0.91)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C347(1.05); C352(1.05)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C347(0.65); C352(0.65)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C347(0.82); C352(0.82)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C347(0.70); C352(0.70)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C251(1.03); C258(1.03); C347(1.36); C352(1.36)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C251(0.92); C258(0.92); C347(1.22); C352(1.22)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C251(0.97); C258(0.97); C347(1.17); C352(1.17)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C251(0.93); C258(0.93); C347(1.17); C352(1.17)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C251(0.98); C258(0.98); C347(1.07); C352(1.07)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C347(0.82); C352(0.82); C251(0.87); C258(0.87)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C347(0.71); C352(0.71); C251(0.96); C258(0.96)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C251(0.91); C258(0.91); C347(0.97); C352(0.97)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C347(0.81); C352(0.81); C251(0.91); C258(0.91)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C251(0.94); C258(0.94); C347(1.01); C352(1.01)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C347(0.83); C352(0.83); C251(0.97); C258(0.97)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C347(0.67); C352(0.67); C251(0.95); C258(0.95)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C251(1.11); C258(1.11); C347(1.22); C352(1.22)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C347(0.92); C352(0.92); C251(1.18); C258(1.18)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C251(1.15); C258(1.15); C347(1.23); C352(1.23)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C347(0.37); C352(0.37); C251(0.49); C258(0.49)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C251(0.85); C258(0.85); C347(0.86); C352(0.86)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C347(0.41); C352(0.41); C251(0.60); C258(0.60)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C251(1.01); C258(1.01); C347(1.20); C352(1.20)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C347(0.97); C352(0.97); C251(1.11); C258(1.11)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C347(0.60); C352(0.60); C251(0.84); C258(0.84)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C347(0.66); C352(0.66); C251(0.78); C258(0.78)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C347(0.33); C352(0.33); C251(0.54); C258(0.54)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C347(0.27); C352(0.27); C251(0.43); C258(0.43)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C347(0.79); C352(0.79)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C347(0.91); C352(0.91)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C347(0.76); C352(0.76)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C347(0.84); C352(0.84); C251(1.18); C258(1.18)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C347(0.75); C352(0.75)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C347(0.79); C352(0.79)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C347(0.63); C352(0.63)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C347(0.70); C352(0.70)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C347(0.66); C352(0.66)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C347(0.68); C352(0.68)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C347(0.64); C352(0.64)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C347(0.70); C352(0.70)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C347(0.90); C352(0.90); C251(1.05); C258(1.05)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C251(0.82); C258(0.82); C347(0.84); C352(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C347(0.90); C352(0.90); C251(1.14); C258(1.14)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C347(0.49); C352(0.49); C251(0.59); C258(0.59)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C347(0.94); C352(0.94); C251(0.98); C258(0.98)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C347(0.72); C352(0.72); C251(0.85); C258(0.85)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C347(0.41); C352(0.41); C251(0.49); C258(0.49)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C347(0.42); C352(0.42); C251(0.53); C258(0.53)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C347(0.37); C352(0.37); C251(0.50); C258(0.50)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C347(0.58); C352(0.58); C251(0.71); C258(0.71)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C347(0.50); C352(0.50); C251(0.82); C258(0.82)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C347(0.97); C352(0.97); C251(1.01); C258(1.01)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C347(0.81); C352(0.81); C251(0.94); C258(0.94)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C251(1.04); C258(1.04); C347(1.08); C352(1.08)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C347(0.65); C352(0.65); C251(0.75); C258(0.75)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C251(0.87); C258(0.87); C347(1.00); C352(1.00)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C347(0.39); C352(0.39); C251(0.55); C258(0.55)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C251(0.45); C258(0.45); C347(0.50); C352(0.50)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C251(0.59); C258(0.59); C347(0.72); C352(0.72)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C251(1.04); C258(1.04); C347(1.15); C352(1.15)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C347(0.80); C352(0.80); C251(0.93); C258(0.93)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C347(0.88); C352(0.88); C251(1.24); C258(1.24)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C347(0.93); C352(0.93); C251(1.00); C258(1.00)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C347(0.70); C352(0.70); C251(0.85); C258(0.85)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C347(1.10); C352(1.10); C251(1.90); C258(1.90)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C251(0.35); C258(0.35); C347(0.43); C352(0.43)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C251(0.46); C258(0.46); C347(0.49); C352(0.49)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C251(0.97); C258(0.97); C347(0.98); C352(0.98)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C347(1.02); C352(1.02); C251(1.03); C258(1.03)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C347(0.79); C352(0.79); C251(1.10); C258(1.10)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C347(0.81); C352(0.81); C251(1.03); C258(1.03)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C251(0.60); C258(0.60); C347(0.63); C352(0.63)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C251(0.12); C258(0.12); C347(0.34); C352(0.34)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C251(0.75); C258(0.75); C347(0.78); C352(0.78)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C350(0.92)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C251(1.27); C258(1.27); C347(0.86); C352(0.86)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C347(0.93); C352(0.93); C251(1.17); C258(1.17)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C347(0.40); C352(0.40); C251(0.67); C258(0.67)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [6]
 LDCM0108  Chloroacetamide HeLa C355(0.00); H426(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C136(2.51)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C251(1.16); C258(1.16); C347(1.35); C352(1.35)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C347(0.91); C352(0.91); C251(1.06); C258(1.06)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C251(0.84); C258(0.84); C347(1.10); C352(1.10)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C251(1.19); C258(1.19); C347(1.20); C352(1.20)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C347(0.96); C352(0.96); C251(1.27); C258(1.27)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C251(1.18); C258(1.18); C347(2.39); C352(2.39)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C347(1.00); C352(1.00); C251(1.10); C258(1.10)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C347(1.00); C352(1.00)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C347(0.93); C352(0.93)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C347(0.63); C352(0.63)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C347(0.58); C352(0.58)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C347(0.96); C352(0.96)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C251(0.86); C258(0.86); C347(0.90); C352(0.90)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C347(1.20); C352(1.20)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C347(1.20); C352(1.20)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C347(1.33); C352(1.33)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C347(0.76); C352(0.76)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C347(1.09); C352(1.09)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C347(0.89); C352(0.89)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C347(0.96); C352(0.96)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C347(0.59); C352(0.59); C251(0.85); C258(0.85)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C347(0.97); C352(0.97); C251(0.98); C258(0.98)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C347(0.92); C352(0.92); C251(0.93); C258(0.93)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C347(0.57); C352(0.57); C251(0.78); C258(0.78)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C251(0.94); C258(0.94); C347(1.01); C352(1.01)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C251(0.93); C258(0.93); C347(1.75); C352(1.75)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C347(1.00); C352(1.00); C251(1.08); C258(1.08)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C347(0.54); C352(0.54); C251(0.84); C258(0.84)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C347(0.46); C352(0.46); C251(0.69); C258(0.69)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C347(0.96); C352(0.96)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C347(1.27); C352(1.27)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C347(0.93); C352(0.93)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C347(1.07); C352(1.07)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C347(0.89); C352(0.89); C251(0.89); C258(0.89)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C347(0.79); C352(0.79); C251(1.13); C258(1.13)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C251(1.36); C258(1.36); C347(1.57); C352(1.57)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C347(0.94); C352(0.94); C251(0.97); C258(0.97)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C251(1.10); C258(1.10); C347(1.41); C352(1.41)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C347(0.96); C352(0.96); C251(0.99); C258(0.99)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C347(0.95); C352(0.95); C251(1.09); C258(1.09)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C347(1.07); C352(1.07); C251(1.20); C258(1.20)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C347(0.62); C352(0.62); C251(0.75); C258(0.75)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C251(0.74); C258(0.74); C347(0.83); C352(0.83)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C251(0.45); C258(0.45); C347(0.49); C352(0.49)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C347(0.74); C352(0.74); C251(0.88); C258(0.88)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C347(0.51); C352(0.51); C251(0.65); C258(0.65)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C251(0.76); C258(0.76); C347(0.75); C352(0.75)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C251(0.82); C258(0.82); C347(0.98); C352(0.98)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C251(1.08); C258(1.08); C347(0.88); C352(0.88)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C251(0.89); C258(0.89); C347(0.88); C352(0.88)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C251(0.88); C258(0.88); C347(0.71); C352(0.71)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C251(1.05); C258(1.05); C347(1.06); C352(1.06)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C251(0.90); C258(0.90); C347(0.88); C352(0.88)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C251(0.80); C258(0.80); C347(1.03); C352(1.03)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C251(0.87); C258(0.87); C347(0.88); C352(0.88)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C251(1.16); C258(1.16); C347(1.42); C352(1.42)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C251(0.73); C258(0.73); C347(0.74); C352(0.74)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C251(0.62); C258(0.62); C347(0.44); C352(0.44)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C251(0.73); C258(0.73); C347(0.61); C352(0.61)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C251(0.56); C258(0.56); C347(0.39); C352(0.39)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C251(0.66); C258(0.66); C347(0.47); C352(0.47)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C251(1.15); C258(1.15); C347(1.52); C352(1.52)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C251(0.76); C258(0.76); C347(0.65); C352(0.65)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C251(0.76); C258(0.76); C347(0.74); C352(0.74)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C251(0.44); C258(0.44); C347(0.33); C352(0.33)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C251(0.48); C258(0.48); C347(0.38); C352(0.38)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C251(0.83); C258(0.83); C347(0.66); C352(0.66)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C251(0.85); C258(0.85); C347(0.58); C352(0.58)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C251(1.08); C258(1.08); C347(1.28); C352(1.28)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C251(0.94); C258(0.94); C347(1.17); C352(1.17)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C251(0.95); C258(0.95); C347(1.04); C352(1.04)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C251(1.03); C258(1.03); C347(0.97); C352(0.97)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C251(1.00); C258(1.00); C347(0.78); C352(0.78)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C251(1.02); C258(1.02); C347(1.19); C352(1.19)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C251(0.92); C258(0.92); C347(0.98); C352(0.98)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C251(1.05); C258(1.05); C347(1.23); C352(1.23)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C251(1.00); C258(1.00); C347(1.12); C352(1.12)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C251(1.14); C258(1.14); C347(1.26); C352(1.26)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C251(1.05); C258(1.05); C347(1.15); C352(1.15)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C251(1.04); C258(1.04); C347(1.03); C352(1.03)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C251(1.22); C258(1.22); C347(1.27); C352(1.27)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C251(0.97); C258(0.97); C347(1.26); C352(1.26)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C251(1.06); C258(1.06); C347(0.92); C352(0.92)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C251(1.15); C258(1.15); C347(1.06); C352(1.06)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C251(0.98); C258(0.98); C347(1.09); C352(1.09)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C251(0.91); C258(0.91); C347(0.84); C352(0.84)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C251(0.91); C258(0.91); C347(0.89); C352(0.89)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C251(0.88); C258(0.88); C347(1.09); C352(1.09)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C251(0.86); C258(0.86); C347(1.03); C352(1.03)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C251(0.91); C258(0.91); C347(0.80); C352(0.80)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C251(0.80); C258(0.80); C347(0.61); C352(0.61)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C251(0.78); C258(0.78); C347(0.68); C352(0.68)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C251(0.98); C258(0.98); C347(1.16); C352(1.16)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C251(1.01); C258(1.01); C347(1.13); C352(1.13)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C251(0.86); C258(0.86); C347(0.84); C352(0.84)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C251(0.92); C258(0.92); C347(0.76); C352(0.76)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C251(1.03); C258(1.03); C347(0.88); C352(0.88)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C251(0.98); C258(0.98); C347(0.80); C352(0.80)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C251(0.94); C258(0.94); C347(0.97); C352(0.97)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C251(0.94); C258(0.94); C347(0.83); C352(0.83)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C251(0.96); C258(0.96); C347(0.85); C352(0.85)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C251(1.06); C258(1.06); C347(1.62); C352(1.62)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C251(0.94); C258(0.94); C347(0.90); C352(0.90)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C251(0.85); C258(0.85); C347(0.69); C352(0.69)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C251(1.44); C258(1.44); C347(0.58); C352(0.58)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C251(0.91); C258(0.91); C347(1.02); C352(1.02)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C251(0.91); C258(0.91); C347(0.82); C352(0.82)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C251(0.68); C258(0.68); C347(0.60); C352(0.60)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C251(0.81); C258(0.81); C347(1.02); C352(1.02)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C251(0.72); C258(0.72); C347(0.81); C352(0.81)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C251(1.06); C258(1.06); C347(1.06); C352(1.06)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C251(1.01); C258(1.01); C347(0.97); C352(0.97)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C251(1.25); C258(1.25); C347(1.11); C352(1.11)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C251(0.83); C258(0.83); C347(0.77); C352(0.77)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C251(0.66); C258(0.66); C347(0.57); C352(0.57)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C251(0.81); C258(0.81); C347(0.96); C352(0.96)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C251(1.33); C258(1.33); C347(1.45); C352(1.45)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C251(0.90); C258(0.90); C347(1.03); C352(1.03)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C251(1.18); C258(1.18); C347(1.58); C352(1.58)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C251(1.00); C258(1.00); C347(0.96); C352(0.96)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C251(0.96); C258(0.96); C347(1.19); C352(1.19)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C251(0.90); C258(0.90); C347(1.30); C352(1.30)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C251(0.98); C258(0.98); C347(1.37); C352(1.37)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C251(0.95); C258(0.95); C347(1.14); C352(1.14)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C251(0.86); C258(0.86); C347(1.24); C352(1.24)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C251(0.93); C258(0.93); C347(0.91); C352(0.91)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C136(1.08); C261(1.10); C254(1.21)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C251(0.96); C258(0.96); C347(0.89); C352(0.89)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C251(0.54); C258(0.54); C347(0.46); C352(0.46)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y277(2.07)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y277(1.99)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y277(1.35)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y277(2.09)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y277(2.02)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C251(2.69); C258(2.69)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C251(3.92); C258(3.92)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C251(1.15); C258(1.15)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C350(0.51)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C350(1.06)  LDD2101  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C350(0.89)  LDD2134  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C350(1.65)  LDD2141  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavin Adenine Dinucleotide Small molecular drug DB03147
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coenzyme A Persulfide . DB04036

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402