Details of the Target

General Information of Target

Target ID LDTP02716
Target Name Hepatocyte growth factor (HGF)
Gene Name HGF
Gene ID 3082
Synonyms
HPTA; Hepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIK
TKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYE
NKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNP
RGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTP
HRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPL
ETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGS
ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME
DLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNL
DHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRD
LKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLP
NYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAG
AEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKII
LTYKVPQS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase S1 family, Plasminogen subfamily
Function
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation.
TTD ID
T83797
Uniprot ID
P14210
DrugMap ID
TT4V2JM
Ensemble ID
ENST00000222390.11
HGNC ID
HGNC:4893
ChEMBL ID
CHEMBL5479

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.V15F DBIA    Probe Info 
A375 SNV: p.D462Y .
CAL27 SNV: p.D224Y .
DU145 SNV: p.R630L .
HT115 SNV: p.R494Ter .
ICC10 SNV: p.N262I .
ICC106 SNV: p.N262I .
ICC108 SNV: p.N262I .
KASUMI2 SNV: p.W415R; p.R424H .
LNCaP clone FGC SNV: p.E217K .
MEWO SNV: p.R702C .
NCIH1944 SNV: p.V529I .
NCIH196 SNV: p.D117N .
NCIH2172 SNV: p.A56S; p.N418I; p.H423Y; p.S577Ter .
NUGC3 SNV: p.R514K .
SHP77 SNV: p.D626N .
SKN SNV: p.S192N .
TCCSUP SNV: p.E227K .
WM115 SNV: p.R197C .
WM2664 SNV: p.R197C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C84(3.87)  LDD2229  [1]
BTD
 Probe Info  		C84(0.86)  LDD2102  [2]
DBIA
 Probe Info  		C177(0.92)  LDD0533  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C84(0.66)  LDD2142  [2]
 LDCM0214  AC1 PaTu 8988t C177(1.31)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C177(1.57)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C177(0.92)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C177(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C177(0.88)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C177(1.09)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C177(1.05)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C177(1.18)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C177(0.91)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C177(0.70)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C177(0.70)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C177(0.99)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C177(1.17)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C177(1.50)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C177(0.71)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C177(0.72)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C177(1.04)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C177(0.95)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C177(1.21)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C177(1.15)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C177(0.89)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C177(1.33)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C177(1.39)  LDD0553  [3]
 LDCM0237  AC12 PaTu 8988t C177(1.09)  LDD1116  [3]
 LDCM0238  AC120 HCT 116 C177(1.72)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C177(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C177(1.12)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C177(0.90)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C177(1.13)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C177(1.37)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C177(1.15)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C177(1.30)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C177(1.08)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C177(0.91)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C177(0.86)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C177(0.78)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C177(0.75)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C177(0.74)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C177(0.74)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C177(1.03)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C177(0.81)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C177(0.92)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C177(0.77)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C177(0.90)  LDD0856  [3]
 LDCM0259  AC14 PaTu 8988t C177(0.90)  LDD1138  [3]
 LDCM0260  AC140 HEK-293T C177(0.67)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C177(0.81)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C177(0.90)  LDD0860  [3]
 LDCM0263  AC143 PaTu 8988t C177(1.21)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C177(1.49)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C177(0.99)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C177(1.29)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C177(1.22)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C177(1.37)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C177(1.24)  LDD1148  [3]
 LDCM0270  AC15 PaTu 8988t C177(1.34)  LDD1149  [3]
 LDCM0271  AC150 PaTu 8988t C177(1.69)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C177(1.81)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C177(1.46)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C177(1.33)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C177(1.81)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C177(1.64)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C177(1.78)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C177(1.52)  LDD2169  [3]
 LDCM0276  AC17 HCT 116 C177(0.73)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C177(0.82)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C177(0.58)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C177(2.41)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C177(0.54)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C177(0.61)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C177(0.61)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C177(0.51)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C177(0.57)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C177(0.47)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C177(0.41)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C177(0.67)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C177(0.67)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C177(0.94)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C177(2.06)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C177(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C177(1.27)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C177(0.79)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C177(0.55)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C177(0.50)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C177(0.64)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C177(0.66)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C177(0.50)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C177(1.31)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C177(1.04)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C177(0.94)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C177(1.40)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C177(0.60)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C177(0.60)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C177(0.55)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C177(0.73)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C177(0.67)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C177(0.83)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C177(0.90)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C177(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C177(1.23)  LDD0628  [3]
 LDCM0312  AC5 PaTu 8988t C177(1.57)  LDD1191  [3]
 LDCM0313  AC50 HCT 116 C177(1.33)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C177(1.02)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C177(0.87)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C177(0.82)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C177(0.72)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C177(1.14)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C177(1.04)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C177(0.84)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C177(0.72)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C177(0.94)  LDD0920  [3]
 LDCM0323  AC6 PaTu 8988t C177(0.87)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C177(2.05)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C177(0.91)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C177(1.00)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C177(0.88)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C177(0.95)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C177(0.81)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C177(1.54)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C177(0.88)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C177(1.63)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C177(1.01)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C177(1.13)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C177(1.31)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C177(1.13)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C177(0.89)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C177(1.03)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C177(1.06)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C177(1.22)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C177(0.91)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C177(0.82)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C177(1.10)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C177(0.88)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C177(0.86)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C177(0.99)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C177(0.76)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C177(0.73)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C177(1.39)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C177(0.91)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C177(1.39)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C177(1.95)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C177(1.32)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C177(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C177(1.21)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C177(1.90)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C177(1.37)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C177(1.35)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C177(1.09)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C177(1.45)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C177(1.61)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C177(1.65)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C177(1.79)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C177(0.05)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C177(0.59)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C177(0.86)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C177(2.20)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C177(1.68)  LDD1154  [3]
 LDCM0367  CL1 HCT 116 C177(0.80)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C177(0.64)  LDD0685  [3]
 LDCM0369  CL100 PaTu 8988t C177(1.20)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C177(1.15)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C177(1.01)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C177(0.98)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C177(0.87)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C177(1.22)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C177(0.84)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C177(1.27)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C177(1.54)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C177(0.58)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C177(0.61)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C177(0.71)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C177(0.63)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C177(0.79)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C177(0.76)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C177(0.81)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C177(0.74)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C177(0.76)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C177(1.42)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C177(0.55)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C177(0.57)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C177(0.48)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C177(0.57)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C177(0.62)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C177(0.86)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C177(0.50)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C177(0.54)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C177(1.27)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C177(1.06)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C177(1.15)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C177(0.86)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C177(0.75)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C177(0.65)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C177(0.62)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C177(1.71)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C177(0.84)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C177(2.10)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C177(1.41)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C177(0.70)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C177(1.59)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C177(1.06)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C177(1.57)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C177(1.49)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C177(1.49)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C177(20.00)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C177(1.88)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C177(1.77)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C177(1.62)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C177(1.23)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C177(0.60)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C177(1.72)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C177(0.98)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C177(0.82)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C177(0.98)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C177(0.87)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C177(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C177(0.74)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C177(0.81)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C177(0.90)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C177(0.62)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C177(0.76)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C177(0.66)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C177(0.71)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C177(0.74)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C177(1.02)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C177(1.44)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C177(1.19)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C177(1.16)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C177(1.18)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C177(0.96)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C177(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C177(1.21)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C177(1.13)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C177(1.36)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C177(1.73)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C177(1.27)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C177(1.57)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C177(1.07)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C177(1.11)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C177(1.95)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C177(1.71)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C177(0.82)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C177(2.07)  LDD0769  [3]
 LDCM0462  CL7 HCT 116 C177(0.78)  LDD0779  [3]
 LDCM0469  CL76 HCT 116 C177(1.07)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C177(1.28)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C177(1.05)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C177(1.27)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C177(0.91)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C177(1.44)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C177(1.21)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C177(1.49)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C177(0.89)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C177(1.49)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C177(1.46)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C177(1.48)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C177(1.26)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C177(1.46)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C177(1.58)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C177(0.72)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C177(0.89)  LDD0802  [3]
 LDCM0486  CL91 PaTu 8988t C177(1.03)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C177(1.22)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C177(1.44)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C177(1.16)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C177(1.26)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C177(1.13)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C177(1.39)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C177(1.81)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C177(1.45)  LDD1373  [3]
 LDCM0427  Fragment51 HCT 116 C177(0.60)  LDD0744  [3]
 LDCM0022  KB02 A204 C189(2.10); C70(2.07)  LDD2252  [5]
 LDCM0023  KB03 A204 C189(2.82); C70(2.81)  LDD2669  [5]
 LDCM0024  KB05 SKMEL2 C177(2.43)  LDD3322  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C84(0.86)  LDD2102  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C84(1.03)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C84(0.76)  LDD2106  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C84(0.82)  LDD2108  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C84(3.83)  LDD2145  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C84(2.21)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor (HGF) Peptidase S1 family P14210
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Heparin Small molecular drug DB01109
Valproic Acid Small molecular drug DB00313
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Donaperminogene Seltoplasmid Gene therapy D9CI7V
Vm-202 . D0D4OS
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ficlatuzumab Monoclonal antibody D03UBW
Mp0250 . D0ME7Q
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tak-701 Small molecular drug D0H9HT
Abi-011 . D0P4KU
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-510 Small molecular drug DB05434
Foretinib Small molecular drug DB12307
N,O6-disulfo-glucosamine Small molecular drug D0B0SV
No6-disulfo-glucosamine Small molecular drug DB03959
O2-sulfo-glucuronic Acid Small molecular drug D06VYT
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rilotumumab Antibody D07AOO

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840