Details of the Target

General Information of Target

Target ID LDTP01975
Target Name Metallothionein-2 (MT2A)
Gene Name MT2A
Gene ID 4502
Synonyms
CES1; MT2; Metallothionein-2; MT-2; Metallothionein-2A; Metallothionein-II; MT-II
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCC
A
Target Bioclass
Other
Family
Metallothionein superfamily, Type 1 family
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Uniprot ID
P02795
Ensemble ID
ENST00000245185.6
HGNC ID
HGNC:7406

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C48(1.35); C26(0.54)  LDD2099  [1]
IPM
 Probe Info  		C50(1.20); C13(1.02); C48(0.99)  LDD1701  [1]
DBIA
 Probe Info  		C34(1.04); C33(0.97); C15(0.96); C7(0.96)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C44(0.00); C48(0.00); C50(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C44(0.00); C48(0.00); C50(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C44(0.00); C48(0.00); C50(0.00)  LDD0037  [3]
ATP probe
 Probe Info  		N.A.  LDD0035  [4]
Phosphinate-6
 Probe Info  		C21(0.00); C29(0.00); C60(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C48(1.16); C50(1.45); C26(0.58)  LDD2117  [1]
 LDCM0214  AC1 HCT 116 C44(0.78); C50(0.72); C15(0.69); C41(1.03)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C44(0.62); C50(0.66); C13(0.65); C15(0.71)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C44(0.74); C50(0.73); C13(1.02); C15(1.06)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C44(0.71); C50(0.72); C13(1.03); C15(1.06)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C44(0.89); C50(0.83); C13(1.05); C15(1.04)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C44(1.02); C50(0.99); C13(1.35); C15(1.31)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C44(0.88); C50(0.83); C13(1.07); C15(1.07)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C44(1.08); C50(1.03); C13(1.31); C15(1.26)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C44(0.93); C50(0.92); C13(1.13); C15(1.26)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C44(0.95); C50(0.89); C13(1.49); C15(1.29)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C44(0.78); C50(0.78); C13(0.79); C15(1.00)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C44(0.77); C50(0.80); C13(0.94); C15(0.84)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C44(0.60); C50(0.66); C13(0.68); C15(0.66)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C44(0.84); C50(0.82); C13(1.08); C15(1.14)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C44(0.79); C50(0.79); C13(1.02); C15(1.15)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C44(0.94); C50(0.89); C13(1.07); C15(1.13)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C44(1.15); C50(1.15); C13(1.08); C15(1.08)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C44(1.23); C50(1.30); C13(1.47); C15(1.11)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C44(1.54); C50(1.58); C13(1.23); C15(1.09)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C44(1.43); C50(1.46); C13(1.28); C15(1.36)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C44(1.27); C50(1.32); C13(1.47); C15(1.06)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C44(1.17); C50(1.23); C13(1.29); C15(1.10)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C44(1.17); C50(1.22); C13(1.49); C15(1.11)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C44(0.51); C50(0.54); C13(0.54); C15(0.49)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C44(1.28); C50(1.42); C13(1.67); C15(1.15)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C44(1.17); C50(1.20); C13(1.06); C15(1.07)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C44(1.32); C50(1.37); C13(1.33); C15(1.17)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C44(1.05); C50(1.12); C13(1.04); C15(1.05)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C44(1.27); C50(1.29); C13(1.04); C15(1.08)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C44(1.16); C50(1.17); C13(1.34); C15(1.22)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C44(1.41); C50(1.43); C13(1.35); C15(1.42)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C44(1.31); C50(1.35); C13(1.18); C15(1.30)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C44(1.12); C50(1.13); C13(1.35); C15(1.19)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C44(0.67); C50(0.59); C13(0.72); C15(0.65)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C44(0.88); C50(0.85); C13(1.03); C15(0.95)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C44(0.80); C50(0.71); C13(0.92); C15(0.67)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C44(0.67); C50(0.56); C13(0.79); C15(0.71)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C44(0.88); C50(0.80); C13(1.11); C15(0.88)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C44(0.85); C50(0.79); C13(1.01); C15(0.87)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C44(0.87); C50(0.80); C13(1.12); C15(1.05)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C44(0.82); C50(0.69); C13(1.17); C15(0.95)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C44(0.80); C50(0.74); C13(1.05); C15(0.93)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C44(0.81); C50(0.79); C13(1.01); C15(0.91)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C44(0.80); C50(0.70); C13(1.11); C15(0.94)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C44(0.57); C50(0.63); C13(0.67); C15(0.62)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C44(0.91); C50(0.84); C13(1.20); C15(1.05)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C44(0.81); C50(0.73); C13(1.05); C15(0.89)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C44(0.66); C50(0.58); C13(0.85); C15(0.75)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C44(0.90); C50(0.95); C13(1.07); C15(1.19)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C48(1.10); C13(1.14); C50(1.20); C34(1.21)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C48(0.95); C44(1.04); C7(1.04); C50(1.06)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C48(1.06); C50(1.06); C44(1.07); C34(1.28)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C50(1.11); C44(1.12); C48(1.16); C34(1.26)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C44(1.42); C50(1.42); C48(1.49); C34(1.64)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C48(1.19); C44(1.25); C50(1.27); C34(1.35)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C15(0.53); C48(0.54); C19(0.55); C44(0.57)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C48(0.92); C44(0.95); C50(0.98); C34(1.06)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C13(1.00); C7(1.01); C48(1.03); C19(1.04)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C48(1.14); C13(1.22); C50(1.24); C5(1.25)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C48(1.41); C44(1.56); C50(1.60); C41(1.68)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C44(1.15); C50(1.16); C13(1.24); C15(1.42)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C44(1.21); C50(1.25); C13(1.14); C15(1.62)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C44(1.00); C50(1.04); C13(1.08); C15(1.15)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C44(1.16); C50(1.14); C13(0.88); C15(1.06)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C7(0.69); C13(0.73); C48(0.77); C44(0.78)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C15(0.78); C19(0.83); C48(0.84); C13(0.87)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C7(0.97); C36(1.07); C41(1.08); C34(1.09)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C50(0.76); C5(0.79); C44(0.82); C48(0.82)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C13(0.85); C7(0.86); C48(0.87); C44(0.95)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C7(0.99); C13(1.12); C5(1.17); C36(1.22)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C7(0.84); C13(0.87); C15(0.96); C48(0.98)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C7(0.68); C48(0.74); C44(0.79); C19(0.82)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C7(0.65); C13(0.72); C48(0.78); C15(0.84)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C7(0.85); C19(0.87); C13(0.96); C44(0.99)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C19(0.96); C7(0.99); C13(1.08); C44(1.10)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C44(1.12); C13(1.15); C50(1.17); C7(1.18)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C44(1.12); C7(1.15); C19(1.20); C48(1.20)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C19(1.18); C7(1.25); C13(1.32); C33(1.33)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C5(0.71); C50(0.73); C15(0.79); C44(0.80)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C19(1.23); C13(1.23); C7(1.30); C5(1.38)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C19(1.11); C37(1.13); C7(1.13); C33(1.15)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C19(1.21); C5(1.37); C13(1.41); C37(1.42)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C19(1.23); C7(1.25); C13(1.36); C44(1.39)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C44(1.27); C48(1.33); C19(1.41); C7(1.49)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C13(0.62); C19(0.77); C50(0.81); C44(0.87)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C13(0.52); C5(0.69); C19(0.80); C7(0.84)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C5(0.58); C13(0.66); C19(0.73); C7(0.79)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C13(0.73); C5(0.78); C19(0.93); C15(0.93)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C13(0.75); C5(0.87); C19(1.01); C7(1.02)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C15(0.65); C50(0.74); C44(0.80); C48(0.80)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C5(0.86); C13(1.07); C7(1.12); C19(1.15)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C13(0.70); C5(0.77); C19(0.90); C7(0.91)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C13(0.78); C48(0.93); C5(0.95); C44(0.96)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C13(0.80); C5(0.95); C7(0.97); C19(1.03)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C7(0.92); C44(0.93); C48(0.95); C15(1.06)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C13(0.87); C7(0.97); C5(1.05); C15(1.09)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C13(0.95); C44(1.02); C48(1.02); C33(1.07)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C33(0.95); C44(0.97); C5(0.98); C50(0.98)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C33(1.00); C13(1.03); C7(1.06); C36(1.08)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C33(1.89); C5(1.89); C13(1.92); C34(2.04)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C15(0.56); C50(0.72); C44(0.76); C48(0.76)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C19(1.20); C7(1.20); C5(1.21); C34(1.35)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C13(0.80); C33(0.95); C7(0.99); C37(1.02)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C13(0.98); C37(1.06); C33(1.06); C19(1.13)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C33(1.13); C5(1.20); C13(1.20); C34(1.20)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C5(1.25); C19(1.29); C13(1.30); C33(1.31)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C5(1.41); C33(1.46); C15(1.55); C34(1.55)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C5(1.60); C33(2.11); C19(2.14); C7(2.22)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C41(0.97); C37(1.11); C7(1.14); C36(1.14)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C41(1.02); C7(1.05); C37(1.18); C48(1.22)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C44(1.04); C50(1.06); C7(1.12); C48(1.14)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C19(0.61); C15(0.65); C48(0.66); C44(0.66)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C41(1.15); C37(1.17); C50(1.21); C44(1.23)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C41(0.97); C37(0.98); C7(1.04); C34(1.06)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C41(0.99); C37(1.03); C34(1.10); C50(1.10)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C50(0.97); C41(0.97); C37(1.00); C44(1.03)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C37(1.08); C50(1.10); C41(1.10); C34(1.12)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C50(0.72); C44(0.74); C37(0.76); C34(0.80)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C50(0.65); C44(0.69); C37(0.72); C48(0.73)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C50(0.80); C44(0.90); C37(0.93); C34(0.95)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C13(1.26); C5(1.30); C34(1.30); C37(1.31)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C5(1.21); C13(1.21); C37(1.26); C19(1.26)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C15(0.53); C44(0.54); C48(0.54); C19(0.58)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C37(1.98); C41(2.40); C34(2.54); C33(2.59)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C13(1.02); C37(1.11); C34(1.12); C41(1.15)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C13(1.24); C7(1.33); C41(1.34); C37(1.34)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C37(1.50); C50(1.55); C44(1.57); C34(1.58)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C44(1.35); C50(1.38); C41(1.42); C36(1.48)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C37(1.59); C7(1.64); C34(1.68); C41(1.72)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C37(1.14); C7(1.17); C36(1.19); C41(1.22)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C13(1.32); C19(1.35); C7(1.37); C37(1.38)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C7(1.02); C37(1.04); C19(1.06); C5(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C37(1.11); C7(1.15); C13(1.21); C34(1.23)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C44(0.56); C48(0.56); C19(0.58); C50(0.63)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C37(1.05); C41(1.18); C34(1.18); C7(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C37(0.95); C13(1.03); C7(1.08); C50(1.14)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C50(1.48); C44(1.49); C41(1.62); C37(1.65)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C37(1.48); C50(1.49); C48(1.50); C44(1.53)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C48(1.25); C41(1.31); C44(1.32); C50(1.33)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C7(1.00); C48(1.11); C50(1.12); C44(1.16)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C7(0.90); C34(1.05); C48(1.07); C37(1.07)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C7(0.84); C48(0.92); C41(0.95); C44(0.95)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C7(0.86); C5(0.99); C37(1.00); C41(1.01)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C7(1.11); C37(1.15); C41(1.18); C34(1.19)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C13(0.70); C7(0.76); C19(0.81); C5(0.84)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C37(1.26); C41(1.30); C7(1.30); C34(1.39)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C7(0.89); C37(1.15); C41(1.17); C5(1.18)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C5(1.03); C41(1.03); C19(1.04); C37(1.12)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C7(0.77); C36(1.05); C5(1.07); C48(1.08)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C48(1.04); C36(1.05); C34(1.05); C37(1.07)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C7(1.01); C37(1.06); C41(1.12); C48(1.21)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C7(1.11); C37(1.25); C34(1.26); C41(1.32)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C44(1.27); C48(1.32); C50(1.46); C37(1.58)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C50(0.67); C44(0.67); C7(0.69); C48(0.71)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C44(0.55); C50(0.55); C13(0.59); C15(0.58)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C19(0.63); C44(0.63); C48(0.63); C15(0.64)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C15(0.66); C5(0.74); C19(0.80); C48(0.80)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C34(1.04); C33(0.97); C15(0.96); C7(0.96)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C44(0.78); C50(0.78); C48(0.91); C33(0.94)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C37(1.25); C41(1.26); C7(1.34); C34(1.39)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C15(0.65); C44(0.70); C48(0.70); C50(0.71)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C19(0.59); C15(0.61); C44(0.64); C48(0.64)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C19(0.54); C48(0.54); C33(0.56); C44(0.57)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C19(0.50); C15(0.53); C48(0.53); C44(0.54)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C15(0.45); C19(0.49); C44(0.51); C48(0.51)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C48(0.85); C44(0.86); C7(0.94); C50(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C5(1.24); C48(1.26); C44(1.29); C7(1.32)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C48(0.92); C7(0.97); C44(0.97); C34(1.07)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C44(0.92); C7(0.93); C48(0.99); C13(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C7(0.97); C48(0.99); C13(0.99); C44(1.03)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C37(1.48); C41(1.60); C5(1.69); C36(1.69)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C44(0.88); C48(0.90); C7(0.92); C34(0.98)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C48(0.77); C44(0.78); C7(0.78); C13(0.88)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C44(0.89); C48(0.92); C50(0.98); C5(1.00)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C44(1.32); C37(1.34); C19(1.37); C48(1.39)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C44(0.97); C48(1.01); C13(1.12); C7(1.18)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C48(1.12); C44(1.12); C19(1.16); C50(1.18)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C44(1.11); C48(1.19); C19(1.22); C7(1.27)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C19(1.59); C15(1.62); C7(1.65); C13(1.78)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C13(0.82); C5(0.96); C19(0.96); C7(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C5(0.90); C13(0.94); C19(1.01); C7(1.02)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C5(1.39); C37(1.48); C7(1.55); C33(1.64)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C13(0.62); C5(0.83); C19(0.87); C7(0.91)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C13(0.55); C15(0.86); C7(1.38); C5(1.46)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C33(1.14); C13(1.18); C34(1.23); C44(1.27)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C33(0.92); C34(1.04); C44(1.12); C50(1.13)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C33(1.24); C34(1.36); C50(1.42); C37(1.43)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C44(0.79); C48(0.80); C50(0.83); C37(0.84)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C50(0.90); C44(0.97); C41(1.02); C48(1.03)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C41(0.87); C48(0.92); C50(0.93); C44(0.94)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C7(0.85); C50(1.18); C33(1.18); C34(1.19)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C19(1.41); C7(1.46); C5(1.52); C36(1.52)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C37(1.05); C33(1.05); C34(1.07); C36(1.09)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C37(1.18); C33(1.32); C34(1.33); C41(1.33)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C13(0.98); C5(0.99); C19(1.01); C37(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C37(0.94); C41(0.97); C34(0.99); C13(1.03)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C13(0.84); C15(1.15); C7(1.19); C37(1.20)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C13(0.83); C5(1.07); C33(1.08); C37(1.09)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C44(0.93); C48(0.96); C50(0.97); C37(1.01)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C13(0.84); C5(1.15); C19(1.20); C7(1.22)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C13(0.92); C37(1.41); C5(1.46); C33(1.48)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C13(0.75); C33(1.96); C5(2.10); C41(2.15)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C5(1.03); C15(1.09); C37(1.13); C33(1.14)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C13(0.80); C5(1.24); C15(1.40); C37(1.41)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C44(2.38); C50(2.90); C13(0.80); C15(1.25)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C44(1.93); C50(1.80); C13(0.99); C15(1.10)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C44(1.81); C50(1.94); C13(0.87); C15(1.10)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C44(2.17); C50(2.17); C13(0.87); C15(1.31)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C44(2.36); C50(2.36); C13(0.78); C15(1.29)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C44(1.21); C50(1.19); C15(1.22); C41(0.98)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C44(1.71); C50(1.74); C13(0.89); C15(1.04)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C44(0.91); C50(0.92); C13(1.20); C15(1.11)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C44(0.99); C50(1.03); C13(1.35); C15(1.26)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C44(0.98); C50(1.08); C13(1.17); C15(1.26)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C44(1.22); C50(1.32); C13(1.63); C15(1.53)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C44(1.35); C50(1.36); C13(1.31); C15(1.33)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C44(0.91); C50(1.06); C13(1.28); C15(1.29)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C44(1.26); C50(1.38); C13(1.92); C15(1.51)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C44(1.65); C50(1.57); C13(1.70); C15(1.63)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C44(1.48); C50(1.39); C15(1.29); C41(1.16)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C44(1.19); C50(1.32); C13(1.38); C15(1.48)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C44(1.07); C50(1.15); C13(1.27); C15(1.28)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C44(1.84); C50(2.04); C13(2.92); C15(2.00)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C44(1.57); C50(1.64); C13(1.60); C15(1.80)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C44(1.14); C50(1.27); C13(1.86); C15(1.61)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C44(1.42); C50(1.47); C13(1.69); C15(1.72)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C44(0.88); C50(0.95); C13(1.17); C15(1.09)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C44(0.77); C50(0.88); C13(1.02); C15(0.97)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C44(0.84); C50(0.95); C13(1.13); C15(1.08)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C44(0.97); C50(0.94); C13(0.97); C15(1.03)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C44(1.22); C50(1.26); C15(1.33); C41(1.27)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C44(0.84); C50(1.05); C13(1.13); C15(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C44(0.90); C50(1.07); C13(1.02); C15(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C44(1.02); C50(1.04); C13(1.25); C15(1.24)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C44(1.01); C50(1.09); C13(1.14); C15(1.02)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C44(1.13); C50(1.35); C13(0.95); C15(0.96)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C44(1.00); C50(1.08); C13(0.93); C15(0.93)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C44(0.93); C50(1.06); C13(0.91); C15(1.14)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C44(0.99); C50(1.07); C13(0.93); C15(1.08)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C44(0.96); C50(1.13); C13(0.99); C15(1.11)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C44(1.09); C50(1.11); C13(0.97); C15(1.01)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C44(1.46); C50(1.39); C15(1.52); C41(1.34)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C44(0.99); C50(1.02); C13(1.04); C15(1.09)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C44(1.10); C50(1.10); C13(0.90); C15(1.09)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C44(1.03); C50(1.01); C13(0.98); C15(1.10)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C44(1.01); C50(1.00); C13(1.07); C15(1.30)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C44(1.10); C50(1.04); C13(1.11); C15(1.39)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C44(0.89); C50(0.91); C13(1.02); C15(1.18)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C44(1.21); C50(1.19); C13(1.22); C15(1.74)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C44(1.42); C50(1.32); C13(1.28); C15(1.49)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C44(0.99); C50(1.05); C13(1.12); C15(1.50)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C44(1.19); C50(1.12); C13(1.16); C15(1.69)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C44(1.51); C50(1.55); C15(1.40); C41(1.43)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C44(1.14); C50(1.17); C13(1.22); C15(1.37)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C44(0.91); C50(1.05); C13(1.10); C15(1.33)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C44(1.04); C50(1.06); C13(0.91); C15(1.26)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C44(0.88); C50(0.95); C13(0.96); C15(1.22)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C44(1.18); C50(1.22); C13(1.05); C15(1.50)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C44(1.15); C50(1.17); C13(0.81); C15(1.23)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C44(0.72); C50(0.81); C13(0.72); C15(1.03)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C44(1.11); C50(1.24); C13(0.88); C15(1.18)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C44(1.61); C50(1.62); C13(0.81); C15(1.48)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C44(2.00); C50(2.05); C15(3.14); C41(1.77)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C44(1.02); C50(1.04); C13(0.76); C15(1.17)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C44(1.09); C50(1.17); C13(0.77); C15(1.19)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C44(1.89); C50(1.94); C13(0.77); C15(2.10)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C44(1.14); C50(1.22); C13(0.73); C15(1.43)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C44(1.47); C50(1.70); C13(0.70); C15(1.85)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C44(0.78); C50(0.95); C13(1.00); C15(1.03)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C44(0.65); C50(0.76); C13(0.93); C15(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C44(0.85); C50(0.96); C13(1.02); C15(1.26)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C44(1.26); C50(1.40); C13(0.88); C15(1.37)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C44(2.06); C50(2.33); C13(0.76); C15(2.79)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C44(1.36); C50(1.39); C15(1.27); C41(1.27)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C44(0.54); C50(0.75); C13(0.90); C15(1.27)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C44(0.90); C50(0.81); C15(0.81); C41(1.09)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C44(0.74); C50(0.67); C15(0.88); C41(0.95)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C44(0.80); C50(0.73); C15(0.61); C41(0.86)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C44(0.92); C50(0.85); C15(0.76); C41(1.09)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C44(0.96); C50(0.80); C15(0.77); C41(1.03)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C44(1.07); C50(0.93); C15(0.74); C41(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C44(1.06); C50(0.92); C15(0.75); C41(1.07)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C44(0.88); C50(0.77); C15(1.01); C41(1.04)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C44(0.97); C50(0.84); C15(0.74); C41(1.06)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(1.92); C44(1.18); C48(1.02); C50(0.86)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C44(1.09); C50(1.14); C13(1.25); C15(1.54)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C44(3.22); C50(3.52); C13(2.70); C15(2.33)  LDD0744  [2]
 LDCM0022  KB02 769-P C391(1.06)  LDD2246  [6]
 LDCM0023  KB03 MDA-MB-231 C50(1.20); C13(1.02); C48(0.99)  LDD1701  [1]
 LDCM0024  KB05 HMCB C391(1.28)  LDD3312  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C48(1.35); C26(0.54)  LDD2099  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C50(0.84)  LDD2109  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C50(0.71)  LDD2123  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C50(0.22); C26(0.80)  LDD2124  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C50(0.80)  LDD2127  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C48(0.78); C50(0.67)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C50(0.68)  LDD2134  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C50(1.22)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C50(0.67)  LDD2137  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C48(0.63); C50(0.63)  LDD2148  [1]
 LDCM0021  THZ1 HCT 116 C19(1.83); C5(1.83); C44(2.05); C48(2.05)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine synthase isoform type-2 (MAT2A) AdoMet synthase family P31153
Serine/threonine-protein kinase D1 (PRKD1) CAMK Ser/Thr protein kinase family Q15139
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Huntingtin (HTT) Huntingtin family P42858
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Alpha-synuclein (SNCA) Synuclein family P37840
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein EOLA1 (EOLA1) EOLA family Q8TE69
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Serine protease inhibitor Kazal-type 7 (SPINK7) . P58062

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cisplatin Small molecular drug DB00515
Copper . DB09130
Silver . DB12965
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840