Details of the Target

General Information of Target

Target ID LDTP01790
Target Name Prothrombin (F2)
Gene Name F2
Gene ID 2147
Synonyms
Prothrombin; EC 3.4.21.5; Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Target Type
Successful
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted, extracellular space
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
TTD ID
T94033
Uniprot ID
P00734
DrugMap ID
TT6L509
Ensemble ID
ENST00000311907.10
HGNC ID
HGNC:3535
ChEMBL ID
CHEMBL204

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y603(11.04)  LDD0260  [1]
STPyne
 Probe Info  		K384(0.54)  LDD0277  [2]
IPM
 Probe Info  		C336(0.00); C90(0.00); C129(0.00); C536(0.00)  LDD0241  [3]
OPA-S-S-alkyne
 Probe Info  		K384(4.42); K599(6.29)  LDD3494  [4]
DBIA
 Probe Info  		C391(1.04); C550(1.75); C564(1.38); C594(0.94)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
2PCA
 Probe Info  		R383(0.00); K599(0.00); K559(0.00)  LDD0034  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
W1
 Probe Info  		C336(0.00); C129(0.00); Y600(0.00)  LDD0236  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C391(1.04); C550(1.75); C564(1.38); C594(0.94)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C391(1.62); C564(1.01); C594(1.56)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C391(1.25); C564(0.95); C594(1.22)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C391(1.19); C564(1.13); C594(1.14)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C391(0.99); C564(1.02); C594(0.96)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C391(1.19); C564(1.09); C594(1.12)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C391(1.14); C564(0.95); C594(0.96)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C391(1.39); C564(1.13); C594(1.12)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C391(1.18); C564(0.73); C594(0.97)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C391(1.38); C564(0.93); C594(1.04)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C391(1.40); C564(0.98); C594(1.13)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C391(1.09); C564(0.81); C594(0.96)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C391(1.58); C564(1.19); C594(1.43)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C391(1.14); C564(0.75); C594(0.90)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C391(1.32); C564(0.78); C594(0.92)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C391(1.05); C564(0.91); C594(1.06)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C391(0.92); C550(1.25); C564(1.05); C594(1.07)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C391(1.04); C550(1.22); C564(1.14); C594(0.83)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C391(0.95); C550(1.26); C564(1.24); C594(1.04)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C391(1.12); C550(1.29); C564(1.11); C594(1.27)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C391(1.05); C550(1.35); C564(1.30); C594(0.98)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C391(0.92); C550(1.50); C564(1.11); C594(1.03)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C391(1.11); C550(1.62); C564(1.10); C594(1.12)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C391(1.23); C564(1.36); C594(1.52)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C391(1.18); C550(1.12); C564(0.98); C594(1.07)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C391(1.02); C550(1.02); C564(1.01); C594(1.17)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C391(1.12); C550(1.52); C564(0.93); C594(1.21)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C391(0.89); C550(1.08); C564(0.84); C594(0.84)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C391(1.04); C550(1.22); C564(1.10); C594(0.69)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C391(1.18); C550(1.40); C564(1.10); C594(0.92)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C391(0.88); C550(1.19); C564(1.14); C594(0.92)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C391(0.90); C550(1.54); C564(0.85); C594(0.86)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C391(0.86); C564(0.79); C594(1.01)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C391(0.95); C564(1.03); C594(0.77)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C391(0.86); C564(1.04); C594(1.05)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C391(0.96); C564(1.09); C594(0.82)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C391(0.88); C564(1.03); C594(1.04)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C391(0.97); C564(1.01); C594(1.19)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C391(1.02); C564(1.24); C594(1.43)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C391(0.84); C564(1.43); C594(1.28)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C391(0.98); C564(1.27); C594(1.80)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C391(1.01); C564(1.00); C594(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C391(1.26); C564(1.42); C594(1.55)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C391(1.27); C564(1.40); C594(1.92)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C391(1.29); C564(0.93); C594(1.30)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C391(1.61); C564(1.49); C594(1.68)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C391(1.49); C564(1.44); C594(1.59)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C391(1.00); C564(1.57); C594(1.69)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C129(1.88); C391(1.08); C550(1.01); C564(1.02)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C129(0.50); C550(0.90); C564(0.93); C594(1.19)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C564(0.84); C550(1.04); C391(1.13); C129(1.18)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C564(0.80); C129(0.89); C550(1.05); C594(1.22)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C129(0.83); C564(0.97); C550(1.02); C391(1.54)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C564(0.76); C129(0.81); C550(1.08); C391(1.23)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C564(0.79); C129(0.98); C550(1.07); C391(1.48)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C564(1.15); C594(1.31); C391(1.56)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C564(0.96); C550(0.97); C391(1.25); C594(1.32)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C550(0.79); C564(0.89); C129(0.95); C391(1.07)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C129(0.73); C564(0.92); C550(0.96); C391(1.15)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C564(0.73); C129(1.09); C550(1.10); C391(1.39)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C129(1.38); C391(1.34); C550(1.05); C564(0.88)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C129(0.73); C391(0.92); C550(0.97); C564(0.85)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C129(1.51); C391(0.89); C550(1.06); C564(0.91)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C129(1.04); C391(0.86); C550(0.93); C564(0.85)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C594(0.92); C391(1.00); C564(1.06); C550(1.45)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C564(0.66); C391(1.02); C594(1.09); C550(1.24)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C564(0.76); C594(0.77); C391(0.83); C550(1.01)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C594(1.09); C391(1.13); C564(1.47); C550(2.61)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C564(0.63); C594(0.63); C391(0.84); C550(1.02)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C564(0.60); C594(0.70); C391(0.85); C550(0.91)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C594(0.72); C564(0.74); C391(0.83); C550(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C594(0.75); C564(0.81); C550(0.87); C391(0.91)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C594(0.78); C564(0.89); C391(0.90); C550(1.21)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C564(0.73); C594(1.00); C391(1.03)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C564(0.75); C391(1.16); C594(1.17)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C564(0.75); C391(1.12); C594(1.15)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C564(0.78); C391(0.96); C594(1.12)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C564(0.77); C391(0.98); C594(1.02)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C594(1.14); C391(1.15); C564(1.75); C550(2.83)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C564(0.86); C594(1.25); C391(1.36)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C564(0.97); C594(1.24); C391(1.78)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C564(1.23); C594(1.46); C391(1.81)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C564(0.83); C594(1.05); C391(1.27)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C564(0.64); C594(1.08); C391(1.27)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C564(0.64); C550(0.68); C391(0.92); C594(1.12)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C564(0.66); C550(0.68); C391(1.07); C594(1.13)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C564(0.66); C550(0.71); C594(1.04); C391(1.04)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C550(1.05); C594(1.06); C391(1.08); C564(1.10)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C550(0.91); C564(0.95); C391(1.29); C594(1.44)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C391(1.07); C594(1.10); C564(1.69); C550(2.45)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C550(0.80); C564(0.94); C391(0.99); C594(1.01)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C564(0.52); C550(0.84); C391(1.31); C594(1.67)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C564(0.58); C550(0.78); C391(1.42); C594(1.70)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C564(0.55); C550(1.39); C391(1.45); C594(1.67)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C564(0.80); C550(0.88); C391(1.16); C594(1.21)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C564(0.73); C550(0.91); C594(1.29); C391(1.38)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C594(0.87); C564(0.97); C391(1.10)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C564(0.94); C594(0.95); C391(0.98)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C594(1.01); C391(1.03); C564(1.21)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C564(1.01); C391(1.09); C594(1.17)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C391(1.18); C594(1.39); C564(1.62); C550(2.65)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C564(1.10); C594(1.10); C391(1.16)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C594(0.99); C391(1.09); C564(1.16)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C391(0.93); C564(1.08); C594(1.16)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C391(0.95); C564(0.97); C594(0.99)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C391(0.99); C564(1.20); C594(1.31)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C391(1.02); C564(1.25); C594(1.30)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C564(0.82); C391(0.89); C594(1.05)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C564(1.34); C391(1.34); C594(1.37)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C594(1.18); C564(1.19); C391(1.27)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C594(1.19); C391(1.27); C564(1.29)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C564(1.04); C594(1.18); C391(1.29)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C594(1.20); C564(1.22); C391(1.39)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C564(1.15); C594(1.35); C391(1.56)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C564(1.23); C594(1.39); C391(1.50)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C391(1.27); C564(1.28); C594(1.30)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C564(1.08); C391(1.44); C594(1.66)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C564(1.24); C391(2.15); C594(2.34)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C564(1.40); C391(2.22); C594(2.25)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C564(1.49); C594(2.35); C391(2.38)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C564(0.92); C594(1.09); C391(1.22)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C594(0.93); C564(1.07); C391(1.16)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C564(1.11); C391(1.15); C594(1.19)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C594(1.03); C391(1.14); C564(1.39)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C594(1.19); C564(1.29); C391(1.35)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C594(0.92); C391(0.98); C564(1.41)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C594(0.92); C391(1.11); C564(1.43)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C594(1.00); C564(1.11); C391(1.36)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C594(0.94); C564(1.00); C391(1.03)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C594(0.85); C564(0.94); C391(0.98)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C594(0.79); C564(0.90); C391(0.99)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C391(0.91); C594(0.93); C564(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C594(0.93); C564(1.09); C391(1.10)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C391(1.06); C564(1.28); C594(1.52)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C594(0.86); C564(1.03); C391(1.06)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C391(0.86); C594(0.87); C564(1.01)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C564(0.94); C391(1.02); C594(1.13)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C550(1.00); C391(1.10); C564(1.14); C594(1.43)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C550(1.08); C391(1.10); C564(1.32); C594(1.46)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C564(1.01); C391(1.08); C550(1.17); C594(1.38)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C564(0.91); C550(0.94); C391(0.95); C594(1.17)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C391(0.80); C594(0.96); C564(1.03); C550(1.09)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C391(0.81); C564(0.98); C594(1.02); C550(1.09)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C391(0.88); C564(0.89); C550(1.01); C594(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C391(0.78); C594(1.00); C564(1.01); C550(1.52)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C564(0.60); C391(0.92); C550(1.09); C594(1.22)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C564(0.96); C391(0.97); C550(1.22); C594(1.27)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C391(0.84); C594(1.06); C564(1.08); C550(1.19)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C564(0.75); C391(0.94); C594(0.96); C550(1.55)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C564(0.87); C391(0.87); C594(0.89); C550(1.36)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C564(0.74); C391(0.89); C594(0.90); C550(1.34)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C564(0.72); C391(0.93); C594(1.10); C550(1.60)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C594(1.28); C391(1.45); C564(1.49)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C594(1.05); C564(1.25); C391(1.34)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C391(1.34); C564(1.08); C594(1.60)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C564(1.04); C391(1.44); C594(1.48)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C564(1.15); C594(1.47); C391(1.70)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa C391(0.00); C594(0.00); H450(0.00)  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C564(0.81); C594(0.82); C550(0.95); C391(1.03)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C594(1.12); C564(1.13); C391(1.35); C550(2.01)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C594(0.85); C391(0.93); C564(1.43); C550(1.99)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C564(1.00); C391(1.46); C594(1.62)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C564(1.05); C594(1.34); C391(1.62)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C564(1.04); C594(1.08); C391(1.22)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C564(1.17); C594(1.27); C391(1.32)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C594(1.09); C564(1.12); C391(1.21); C550(1.37)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C564(1.00); C594(1.03); C550(1.05); C391(1.05)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C564(1.02); C594(1.06); C391(1.08); C550(1.39)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C391(1.23); C564(1.31); C594(1.51); C550(2.11)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C594(0.85); C564(0.87); C391(1.07); C550(1.12)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C564(1.06); C594(1.16); C391(1.28); C550(1.56)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C594(0.93); C550(0.94); C391(1.12); C564(1.13)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C550(0.87); C564(0.94); C391(0.96); C594(1.02)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C564(0.83); C391(1.07); C594(1.20)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C564(1.02); C594(1.25); C391(1.34)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C564(0.96); C594(1.18); C391(1.45)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C564(0.96); C594(1.24); C391(1.30)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C564(0.98); C391(1.41); C594(1.56)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C550(1.06); C564(1.11); C391(1.61); C594(1.80)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C564(0.48); C550(0.83); C391(1.53); C594(1.92)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C564(0.49); C550(0.99); C391(1.17); C594(1.26)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C564(1.27); C594(1.30); C391(1.57); C550(2.74)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C564(0.57); C550(1.13); C391(1.33); C594(1.40)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C391(1.08); C564(1.11); C594(1.23)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C391(1.14); C594(1.17); C564(1.35)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C391(0.96); C564(1.04); C594(1.20)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C391(0.98); C564(1.06); C594(1.22)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C594(1.20); C564(1.26); C391(1.30)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C594(0.76); C391(0.94); C564(1.35)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C391(1.20); C564(1.20); C594(1.27)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C564(1.10); C594(1.44); C391(1.51)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C594(1.18); C564(1.47); C391(1.48); C550(1.88)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C594(0.97); C391(1.26); C564(1.29); C550(1.67)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C564(0.93); C550(1.12); C594(1.28); C391(1.33)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C550(1.01); C391(1.04); C594(1.07); C564(1.13)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C129(0.73); C564(1.00); C594(1.01); C391(1.11)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C129(0.89); C391(1.05); C594(1.09); C564(1.17)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C550(1.01); C129(1.07); C564(1.14); C594(1.18)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C564(0.74); C594(0.83); C550(0.83); C391(0.92)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C129(0.99); C550(1.05); C564(1.12); C594(1.19)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C129(0.88); C564(1.12); C550(1.24); C594(1.31)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C550(0.73); C129(0.82); C391(1.23); C594(1.47)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C550(0.64); C129(0.97); C564(1.04); C594(1.06)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C129(0.94); C550(1.02); C564(1.05); C391(1.30)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C129(1.06); C391(1.68); C550(1.18); C564(1.31)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C129(1.13); C391(1.18); C550(1.33); C564(1.70)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C129(1.13); C391(1.26); C550(1.37); C564(1.41)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C129(1.12); C391(1.42); C550(1.58); C564(1.07)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C129(1.32); C391(1.27); C550(0.86); C564(1.10)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C391(0.96); C550(0.90); C564(0.76); C594(0.91)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C129(1.24); C391(1.17); C550(1.13); C564(1.24)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C391(1.56); C550(1.29); C564(1.03); C594(1.28)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C391(1.40); C550(1.37); C564(1.07); C594(1.04)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C391(1.13); C550(0.95); C564(0.95); C594(0.89)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C391(1.38); C550(1.29); C564(1.11); C594(1.34)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C391(1.54); C550(1.79); C564(1.18); C594(1.40)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C391(1.47); C550(1.37); C564(1.09); C594(1.19)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C391(1.54); C550(1.95); C564(1.11); C594(1.27)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C391(1.46); C550(1.12); C564(1.13); C594(1.54)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C391(1.15); C550(0.82); C564(0.82); C594(0.92)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C391(1.78); C550(1.17); C564(1.09); C594(1.50)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C391(1.55); C550(1.40); C564(1.26); C594(1.56)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C391(2.32); C550(1.65); C564(1.32); C594(2.08)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C391(1.54); C550(1.34); C564(0.97); C594(1.55)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C391(1.64); C550(2.38); C564(1.30); C594(1.71)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C391(1.95); C550(2.25); C564(1.32); C594(1.69)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C129(0.90); C391(1.10); C564(0.90); C594(0.81)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C129(1.25); C391(1.08); C564(0.95); C594(0.86)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C129(1.40); C391(1.13); C564(0.93); C594(0.88)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C129(1.00); C391(1.11); C564(0.91); C594(0.90)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C391(1.04); C550(1.22); C564(0.88); C594(0.99)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C129(1.35); C391(1.09); C564(0.92); C594(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C129(1.16); C391(1.18); C564(0.87); C594(0.89)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C129(1.39); C391(1.19); C564(0.95); C594(0.88)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C129(0.84); C391(1.13); C564(0.77); C594(0.75)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C129(0.93); C391(0.97); C564(0.71); C594(0.68)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C129(1.06); C391(0.95); C564(0.82); C594(0.77)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C129(1.24); C391(1.08); C564(1.02); C594(1.02)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C129(1.41); C391(1.17); C564(0.86); C594(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C129(1.32); C391(1.03); C564(0.91); C594(0.84)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C129(1.12); C391(1.08); C564(1.02); C594(1.09)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C391(1.27); C550(1.32); C564(0.93); C594(1.13)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C129(1.72); C391(1.26); C564(1.00); C594(1.05)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C129(1.31); C391(1.15); C564(1.17); C594(1.11)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C129(1.20); C391(1.21); C564(1.10); C594(1.33)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C129(1.11); C391(1.43); C564(1.41); C594(1.43)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C129(1.11); C391(1.22); C564(2.30); C594(1.39)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C129(1.41); C391(1.18); C564(2.15); C594(1.14)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C129(1.54); C391(1.61); C564(1.70); C594(1.50)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C129(1.41); C391(1.35); C564(1.61); C594(1.47)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C129(1.18); C391(1.17); C564(0.81); C594(1.38)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C129(1.22); C391(1.14); C564(1.09); C594(1.16)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C391(1.58); C550(2.67); C564(1.41); C594(1.41)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C129(1.28); C391(1.15); C564(1.13); C594(1.13)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C129(1.26); C391(1.03); C564(1.21); C594(1.20)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C129(1.73); C391(0.93); C564(1.47); C594(1.14)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C129(1.27); C391(0.96); C564(1.21); C594(1.12)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C129(1.31); C391(1.05); C564(1.72); C594(1.44)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C129(0.91); C391(0.86); C550(0.59); C564(0.96)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C129(1.32); C391(1.09); C550(0.81); C564(1.14)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C129(1.00); C391(1.15); C550(0.85); C564(0.89)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C129(0.74); C391(1.17); C550(0.97); C564(1.15)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C391(1.23); C550(0.96); C564(0.82); C594(0.99)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C129(1.12); C391(0.91); C550(1.20); C564(1.19)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C129(1.21); C391(1.17); C550(1.20); C564(1.20)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C129(0.98); C391(1.39); C550(1.42); C564(1.50)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C129(0.62); C391(1.18); C550(0.65); C564(0.65)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C129(0.91); C391(1.27); C550(0.74); C564(1.15)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C129(0.80); C391(1.09); C550(0.87); C564(0.99)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C129(0.81); C391(1.02); C550(0.80); C564(1.04)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C129(0.92); C391(1.10); C550(1.39); C564(1.20)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C129(0.82); C391(1.05); C550(1.11); C564(1.17)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C129(1.20); C391(1.33); C550(1.00); C564(1.34)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C391(1.31); C550(1.35); C564(1.03); C594(1.08)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C129(0.79); C391(0.80); C550(0.97); C564(0.95)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C391(1.09); C550(1.15); C564(1.25); C594(1.01)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C391(0.90); C550(1.01); C564(1.03); C594(0.85)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C391(0.95); C550(2.24); C564(1.14); C594(0.91)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C391(1.04); C550(2.37); C564(1.36); C594(0.95)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C391(1.02); C550(1.60); C564(1.19); C594(0.99)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C391(0.91); C550(2.22); C564(1.38); C594(0.96)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C391(1.12); C550(2.65); C564(1.56); C594(0.90)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C391(0.98); C550(1.18); C564(1.32); C594(0.92)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C391(1.03); C550(1.36); C564(1.28); C594(1.01)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C391(1.19); C594(1.11)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C129(1.32); C391(1.22); C564(1.66); C594(1.49)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C391(2.57); C550(1.07); C564(1.12); C594(1.49)  LDD0744  [5]
 LDCM0107  IAA HeLa H450(0.00); C391(0.00)  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C564(0.87); C391(1.04)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C564(0.97); C391(0.96)  LDD1497  [10]
 LDCM0024  KB05 Hs 936.T C564(1.20)  LDD3313  [11]
 LDCM0109  NEM HeLa N.A.  LDD0224  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thrombomodulin (THBD) . P07204

The Drug(s) Related To This Target

Approved
Click To Hide/Show 31 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Coagulation Factor Ix (Recombinant) BiotechDrug DB00100
Drotrecogin Alfa BiotechDrug DB00055
Human C1-esterase Inhibitor BiotechDrug DB06404
Anisindione Small molecular drug D09WKB
Argatroban Small molecular drug D07UWV
Bivalirudin Small molecular drug D09HVL
Dabigatran Small molecular drug D0M7JT
Dabigatran Etexilate Small molecular drug DB06695
Enoxaparin Small molecular drug DB01225
Kappadione Small molecular drug DB09332
Lepirudin Small molecular drug D09LPN
Menadione Small molecular drug DB00170
Proflavine Small molecular drug DB01123
Pyridoxal Phosphate Small molecular drug D06JGH
Thrombomodulin Alfa Small molecular drug DB05777
Ximelegatran Small molecular drug D0B5LF
Anti-inhibitor Coagulant Complex . DB13151
Antithrombin Alfa . DB11166
Atryn Antithrombin . D0AW9T
Coagulation Factor Ix Human . DB13152
Conestat Alfa . DB09228
Copper . DB09130
Desirudin Recombinant . D03LWO
Human Prothrombin Complex Concentrate . D07KFG
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999
Turoctocog Alfa . DB09109
Turoctocog Alfa Pegol . DB14738
Zinc . DB01593
Zinc Acetate . DB14487
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hirudin Small molecular drug D0F3SZ
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Melagatran Small molecular drug D01MUU
Sr-123781a . D0VL4V
Phase 2
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Efegatran Sulfate Hydrate Small molecular drug D09DFB
Odiparcil Small molecular drug D0N6EA
Ep-217609 . D0UK1L
Lb-30870 . D0I7MX
Nu-172 . D0H9RN
Pegmusirudin . D0K8FI
Recombinant Rgd-hirudin . D0GG5I
Tf0023 . D0PX0N
Phase 1
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd-8165 Small molecular drug D0K4FP
Rwj-671818 Small molecular drug D00LOB
Dp-4088 . D05HAD
Ep-42675 . D0G6UQ
Solulin . D0L2XU
Ssr-128428 . D02UIC
Investigative
Click To Hide/Show 163 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3,4-dichlorophenyl)(1h-pyrazol-1-yl)Methanone Small molecular drug D0X1OY
(3-nitro-1h-pyrazol-1-yl)(P-tolyl)Methanone Small molecular drug D08OCS
(3-nitro-1h-pyrazol-1-yl)(Phenyl)Methanone Small molecular drug D08WQJ
(4-bromo-1h-pyrazol-1-yl)(P-tolyl)Methanone Small molecular drug D05ZIP
(4-nitro-1h-pyrazol-1-yl)(O-tolyl)Methanone Small molecular drug D00WFQ
(4-nitro-1h-pyrazol-1-yl)(Phenyl)Methanone Small molecular drug D06LPR
1,2,3,4,6-penta-o-galloyl-beta-d-glucose Small molecular drug D00QDR
1-(Hydroxymethyleneamino)-8-hydroxy-octane Small molecular drug D0E1NH
1-benzoyl-n-phenyl-1h-pyrazole-3-carboxamide Small molecular drug D0IU5E
2-(2-hydroxy-phenyl)-1h-indole-5-carboxamidine Small molecular drug D08OLP
2-naphthalenesulfonic Acid Small molecular drug D0N0PI
2-naphthalenesulfonic Acid Small molecular drug DB08254
2-nas-phe(3-am)-4-(2-guanidinoethyl)Piperidine Small molecular drug D0SP2I
3-chlorophenyl 2-oxo-2h-chromene-3-carboxylate Small molecular drug D0P3OH
4-(2,5-diamino-5-hydroxy-pentyl)-phenol Small molecular drug D0N1HV
4-(25-diamino-5-hydroxy-pentyl)-phenol Small molecular drug DB07353
4-(3,4-diethoxy-benzylamino)-benzamidine Small molecular drug D0CT8A
4-(4-benzyloxy-3-methoxy-benzylamino)-benzamidine Small molecular drug D02XPB
4-hydroxyphenylpyruvic Acid Small molecular drug D0G6RI
4-hydroxyphenylpyruvic Acid Small molecular drug DB07718
4-iodobenzo[B]Thiophene 2-carboxamidine Small molecular drug D05MJU
4-iodobenzo[B]Thiophene-2-carboxamidine Small molecular drug DB03136
4-tert-butylbenzenesulfonic Acid Small molecular drug D0D9NT
4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]Piperidine Small molecular drug D09CVG
5-desgalloylstachyurin Small molecular drug D07HWB
6-(2-hydroxy-cyclopentyl)-7-oxo-heptanamidine Small molecular drug D06KCW
Ac-(D)Phe-pro-borohomolys-oh Small molecular drug D09QZJ
Ac-(D)Phe-pro-borohomoornithine-oh Small molecular drug D0E9ON
Ac-(D)Phe-pro-borolys-oh Small molecular drug D0R4AV
Ac-(D)Phe-pro-borolys-oh Small molecular drug DB07658
Benzothiazole Small molecular drug D07NYX
Beta-(2-naphthyl)-alanine Small molecular drug D0N0YX
Beta-phenyl-d-phenylalanyl-n-propyl-l-prolinamide Small molecular drug D03LGM
Beta-phenyl-d-phenylalanyl-n-propyl-l-prolinamide Small molecular drug DB07083
Bms-344577 Small molecular drug D0J1QT
Bms-740808 Small molecular drug D0JU9N
Casuariin Small molecular drug D0I1UF
Chlorodysinosin A Small molecular drug D01NEZ
Cochinchinenene B Small molecular drug D0X0IF
Cochinchinenin B Small molecular drug D0U4HG
Cra_8696 Small molecular drug D0K7YL
Cvs-1578 Small molecular drug D0Y8QU
Cyclotheonamide E Small molecular drug D0D8AK
Cyclotheonamide E4 Small molecular drug D0M1AC
Cyclotheonamide E5 Small molecular drug D0CF3B
D-leucyl-n-(3-chlorobenzyl)-l-prolinamide Small molecular drug D0P1JQ
D-leucyl-n-(4-carbamimidoylbenzyl)-l-prolinamide Small molecular drug D05BMA
D-phenylalanyl-n-(3-chlorobenzyl)-l-prolinamide Small molecular drug D0O1DU
D-phenylalanyl-n-(3-fluorobenzyl)-l-prolinamide Small molecular drug D07YNF
D-phenylalanyl-n-(3-methylbenzyl)-l-prolinamide Small molecular drug D0K3JC
D-phenylalanyl-n-benzyl-l-prolinamide Small molecular drug D08EUH
D-pro-phe-arg Chloromethyl Ketone Small molecular drug D0M4VZ
Dysinosin A Small molecular drug D0V7RD
Gabexate Small molecular drug DB12831
Gamma-carboxy-glutamic Acid Small molecular drug D06UUK
Gamma-carboxy-l-glutamic Acid Small molecular drug DB03847
Hemi-babim Small molecular drug D02KKL
Heparin-cantithrombin Iii Small molecular drug D04CQG
L-370,518 Small molecular drug D0I0NY
L-375378 Small molecular drug D02NHS
Lb30812 Small molecular drug D0QQ4Z
Lysophosphotidylserine Small molecular drug D03MYL
Macrocyclic Tripeptide Motif Small molecular drug D0RQ2T
Methyl L-phenylalaninate Small molecular drug D0I8WD
Methyl L-phenylalaninate Small molecular drug DB06838
Methyl-phe-pro-amino-cyclohexylglycine Small molecular drug D01RTU
N-methylphenylalanyl-n-[(Trans-4-aminocyclohexyl)Methyl]-l-prolinamide Small molecular drug DB08187
Nafamostat Small molecular drug DB12598
Oscillarin Small molecular drug D0H5WV
Pedunculagin Small molecular drug D0Z2TG
Razaxaban Small molecular drug D0ON2Z
Rwj-50353 Small molecular drug D09OBJ
S-2238 Small molecular drug D01WDB
Sc-79407 Small molecular drug D0W5AW
Suramin Small molecular drug DB04786
Tellimagrandin Ii Small molecular drug D0E6SO
Vitamin K Small molecular drug D07QPA
(2r)-2-(5-chloro-2-thienyl)-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}Propene-1-sulfonamide . DB07211
(3asr4rs8asr8brs)-4-(2-(4-fluorobenzyl)-13-dioxodeacahydropyrrolo[34-a] Pyrrolizin-4-yl)Benzamidine . DB07796
(3r)-8-(Dioxidosulfanyl)-3-methyl-1234-tetrahydroquinoline . DB07016
(3z6s)-6-chloro-1-(2-{[(5-chloro-1-benzothiophen-3-yl)Methyl]Amino}Ethyl)-3-({2-[(2r)-2-piperidinyl]Ethyl}Imino)-2-piperazinol . DB07521
(S)-n-(4-carbamimidoylbenzyl)-1-(2-(Cyclohexylamino)Ethanoyl)Pyrrolidine-2-carboxamide . DB06850
(S)-n-(4-carbamimidoylbenzyl)-1-(2-(Cyclohexyloxy)Ethanoyl)Pyrrolidine-2-carboxamide . DB07091
(S)-n-(4-carbamimidoylbenzyl)-1-(2-(Cyclopentylamino)Ethanoyl)Pyrrolidine-2-carboxamide . DB06845
(S)-n-(4-carbamimidoylbenzyl)-1-(2-(Cyclopentyloxy)Ethanoyl)Pyrrolidine-2-carboxamide . DB07088
(S)-n-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)Pyrrolidine-2-carboxamide . DB07131
(S)-n-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)Pyrrolidine-2-carboxamide . DB07095
1-(2-{[(6-amino-2-methylpyridin-3-yl)Methyl]Amino}Ethyl)-6-chloro-3-[(22-difluoro-2-pyridin-2-ylethyl)Amino]-14-dihydropyrazin-2-ol . DB07515
1-butanoyl-n-(4-carbamimidoylbenzyl)-l-prolinamide . DB06929
1-ethoxycarbonyl-d-phe-pro-2(4-aminobutyl)Hydrazine . DB07400
1-guanidino-4-(N-nitro-benzoylamino-l-leucyl-l-prolylamino)Butane . DB04771
1-guanidino-4-(N-phenylmethanesulfonyl-l-leucyl-l-prolylamino)Butane . DB04772
1-[(2r)-2-aminobutanoyl]-n-(3-chlorobenzyl)-l-prolinamide . DB06878
1-[(2r)-2-aminobutanoyl]-n-(4-carbamimidoylbenzyl)-l-prolinamide . DB06947
1-[(4s)-4-amino-5-(13-benzothiazol-2-yl)-5-oxopentyl]Guanidine . DB08624
1-[2-amino-2-cyclohexyl-acetyl]-pyrrolidine-3-carboxylic Acid 5-chloro-2-(2-ethylcarbamoyl-ethoxy)-benzylamide . DB06869
2-(2-hydroxy-phenyl)-3h-benzoimidazole-5-carboxamidine . DB02287
2-(5-chloro-2-thienyl)-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}Ethanesulfonamide . DB07277
2-(6-chloro-3-{[22-difluoro-2-(1-oxido-2-pyridinyl)Ethyl]Amino}-2-oxo-1(2h)-pyrazinyl)-n-[(2-fluorophenyl)Methyl]Acetamide . DB07550
2-(6-chloro-3-{[22-difluoro-2-(2-pyridinyl)Ethyl]Amino}-2-oxo-1(2h)-pyrazinyl)-n-[(2-fluoro-3-methyl-6-pyridinyl)Methyl]Acetamide . DB07549
2-(6-chloro-3-{[22-difluoro-2-(2-pyridinyl)Ethyl]Amino}-2-oxo-1(2h)-pyrazinyl)-n-[(2-fluoro-6-pyridinyl)Methyl]Acetamide . DB07548
2-[2-(4-chloro-phenylsulfanyl)-acetylamino]-3-(4-guanidino-phenyl)-propionamide . DB07105
2-[3-chloro-6-[22-difluoro-2-(1-oxidopyridin-1-ium-2-yl)Ethyl]Imino-1-hydroxypyridin-2-yl]-n-[(1r)-1-(3-chlorophenyl)Ethyl]Acetamide . DB04722
2-[N'-(4-amino-butyl)-hydrazinocarbonyl]-pyrrolidine-1-carboxylic Acid Benzyl Ester . DB07366
2-{2-hydroxy-[11'-biphenyl]-3-yl}-1h-13-benzodiazole-5-carboximidamide . DB01725
3-(4-chlorophenyl)-5-(Methylthio)-4h-124-triazole . DB08062
3-(7-diaminomethyl-naphthalen-2-yl)-propionic Acid Ethyl Ester . DB07639
3-amino-3-benzyl-9-carboxamide[4.3.0]Bicyclo-16-diazanonan-2-one . DB07461
3-carbamimidamido-11-diphenylurea . DB07120
3-cyclohexyl-d-alanyl-n-(3-chlorobenzyl)-l-prolinamide . DB07190
4-(1r3as4r8as8br)-[1-difluoromethyl-2-(4-fluorobenzyl)-3-oxodecahydropyrrolo[34-a]Pyrrolizin-4-yl]Benzamidine . DB07741
4-(5-benzenesulfonylamino-1-methyl-1h-benzoimidazol-2-ylmethyl)-benzamidine . DB07508
4-({[4-(3-methylbenzoyl)Pyridin-2-yl]Amino}Methyl)Benzenecarboximidamide . DB07809
4-oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[12-a]Pyrazine-6-carboxylic Acid [1-(N-hydroxycarbamimidoyl)-piperidin-4-ylmethyl]-amide . DB02723
4-[(3as4r7r8as8br)-2-(13-benzodioxol-5-ylmethyl)-7-hydroxy-13-dioxodecahydropyrrolo[34-a]Pyrrolizin-4-yl]Benzenecarboximidamide . DB08546
5-(Dimethylamino)-1-naphthalenesulfonic Acid(Dansyl Acid) . DB07376
6-carbamimidoyl-2-[2-hydroxy-5-(3-methoxy-phenyl)-indan-1-yl]-hexanoic Acid . DB06866
6-carbamimidoyl-2-[2-hydroxy-6-(4-hydroxy-phenyl)-indan-1-yl]-hexanoic Acid . DB06865
6-chloro-2-(2-hydroxy-biphenyl-3-yl)-1h-indole-5-carboxamidine . DB03865
Bbs-arg-(D-pip)-gly-(Eqkliseedl)-gly-hir . D0T5WR
Bbs-arg-(D-pip)-gly-(Sph(Py)Ekvs)-gly-hir . D0KQ1K
Bbs-arg-(D-pip)-gly-(Sphyekvs)-gly-hir . D0P0LG
Bbs-arg-(D-pip)-gly-s-(Gs)1-gly-hir . D0CV4F
Bbs-arg-(D-pip)-gly-s-(Gs)11-gly-hir . D07BJZ
Bbs-arg-(D-pip)-gly-s-(Gs)13-gly-hir . D09HFC
Bbs-arg-(D-pip)-gly-s-(Gs)3-gly-hir . D01ARY
Bbs-arg-(D-pip)-gly-s-(Gs)5-gly-hir . D07BMA
Bbs-arg-(D-pip)-gly-s-(Gs)7-gly-hir . D04VYT
Bbs-arg-(D-pip)-gly-s-(Gs)9-gly-hir . D0WF2C
Bufrudin . D0I6DO
D-phenylalanyl-n-{4-[Amino(Iminio)Methyl]Benzyl}-l-prolinamide . DB07005
Desirudine . D0H8OB
Enoxaprin . D06YJX
Flovagatran . DB05714
Gr-133686 . D07IBU
Gw-813893 . DB07278
Haempatch . D08YGD
Melogatran . D08MEC
N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-l-prolinamide . DB06868
N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-l-prolinamide . DB06942
N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-l-prolinamide . DB06936
N-(5-chloro-benzo[B]Thiophen-3-ylmethyl)-2-[6-chloro-oxo-3-(2-pyridin-2-yl-ethylamino)-2h-pyrazin-1-yl]-acetamide . DB07165
N-allyl-5-amidinoaminooxy-propyloxy-3-chloro-n-cyclopentylbenzamide . DB06859
N-cycloheptylglycyl-n-(4-carbamimidoylbenzyl)-l-prolinamide . DB06853
N-cyclooctylglycyl-n-(4-carbamimidoylbenzyl)-l-prolinamide . DB06858
N-ethyl-n-isopropyl-3-methyl-5-{[(2s)-2-(Pyridin-4-ylamino)Propyl]Oxy}Benzamide . DB07279
N-[(2r3s)-3-amino-2-hydroxy-4-phenylbutyl]-4-methoxy-236-trimethylbenzenesulfonamide . DB07527
N-[(2r3s)-3-amino-2-hydroxy-4-phenylbutyl]Naphthalene-2-sulfonamide . DB07522
N-[2-(Carbamimidamidooxy)Ethyl]-2-{6-cyano-3-[(22-difluoro-2-pyridin-2-ylethyl)Amino]-2-fluorophenyl}Acetamide . DB07665
N-[2-({[Amino(Imino)Methyl]Amino}Oxy)Ethyl]-2-{6-chloro-3-[(22-difluoro-2-phenylethyl)Amino]-2-fluorophenyl}Acetamide . DB07946
N-{22-difluoro-2-[(2r)-piperidin-2-yl]Ethyl}-2-[2-(1h-124-triazol-1-yl)Benzyl][13]Oxazolo[45-c]Pyridin-4-amine . DB04591
N-{3-methyl-5-[2-(Pyridin-4-ylamino)-ethoxy]-phenyl}-benzenesulfonamide . DB07944
N4-(N,N-diphenylcarbamoyl)-aminoguanidine . D05NRZ
N7-butyl-n2-(5-chloro-2-methylphenyl)-5-methyl[124]Triazolo[15-a]Pyrimidine-27-diamine . DB07128
Tb-101 . D0F4VK
Tb-102 . D03KFJ
Trans-4-(Guanidinomethyl)-cyclohexane-l-yl-d-3-cyclohexylalanyl-l-azetidine-2-yl-d-tyrosinyl-l-homoargininamide . DB04697
Tumor Vascular Thrombogen . D05RFC
Ve-04051645 . D04PPE
[(2r)-1-[(2s)-2-[[(2s3s)-1-chloro-6-(Diaminomethylideneamino)-2-hydroxyhexan-3-yl]Carbamoyl]Pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]Azanium . DB06841
[Phenylalaninyl-prolinyl]-[2-(Pyridin-4-ylamino)-ethyl]-amine . DB08422
[[Cyclohexanesulfonyl-glycyl]-3[Pyridin-4-yl-aminomethyl]Alanyl]Piperidine . DB07934
{(2s)-1-[N-(Tert-butoxycarbonyl)Glycyl]Pyrrolidin-2-yl}Methyl (3-chlorophenyl)Acetate . DB08152
Withdrawn from market
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ximelagatran Small molecular drug D0JQ7Y
Discontinued
Click To Hide/Show 28 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arc-183 Aptamer D0W5XT
Azd0837 Small molecular drug D0B1KK
Bch-2763 Small molecular drug D06ALB
Bcx-1470 Small molecular drug D01IBO
Bms-189664 Small molecular drug D0G7YZ
Dermolastin Small molecular drug D0B9EH
Dup 714 Small molecular drug D0Y5EX
Efegatran Small molecular drug D02QTV
Inogatran Small molecular drug D0H4UJ
Lb30057 Small molecular drug D0S2JG
Licostinel Small molecular drug D09CKF
Napsagatran Small molecular drug D0Q3WN
Ppack Small molecular drug D0RP8F
Uk-156406 Small molecular drug D0G0XN
Cjc-1004 . D05KTK
Cvs-1123 . D02MHE
Cvs-995 . D0J6VU
Gs-522 . D0S6XJ
Gw-473178 . D05MXK
Hementin . D0WL1C
L-373890 . D05WYW
L-374,087 . D0L6UZ
Mpc-0920 . D0UF5I
Org-34092 . D0SF5F
S-18326 . D0H2ZQ
Sr-80027a . D02ZWG
Ssr-182289 . D06DUO
Vasoflux . D07MZC

References

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Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD013019
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840