Details of the Target

General Information of Target

Target ID LDTP01476
Target Name E3 ubiquitin-protein ligase TRIM37 (TRIM37)
Gene Name TRIM37
Gene ID 4591
Synonyms
KIAA0898; MUL; POB1; E3 ubiquitin-protein ligase TRIM37; EC 2.3.2.27; Mulibrey nanism protein; RING-type E3 ubiquitin transferase TRIM37; Tripartite motif-containing protein 37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQL
RELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALW
GGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVR
EIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK
SSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPP
LQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNII
REFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYIT
QLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM
LLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASS
TATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRR
THLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQR
KQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA
LAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDP
GENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVV
AVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGM
SSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE
NSGR
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Chromosome
Function
E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity.
TTD ID
T91605
Uniprot ID
O94972
DrugMap ID
TTAMCSL
Ensemble ID
ENST00000262294.12
HGNC ID
HGNC:7523

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G922C .
HCT15 SNV: p.S587N .
IM95 Deletion: p.N464MfsTer28 .
Ishikawa (Heraklio) 02 ER SNV: p.D465V .
KP4 SNV: p.G585S .
MCC13 Substitution: p.R785C .
MDST8 SNV: p.R751L .
NUGC3 SNV: p.L696V .
OE33 SNV: p.C109S .
SHP77 SNV: p.E187G .
U87MG SNV: p.N144S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K149(0.91)  LDD0274  [1]
AHL-Pu-1
 Probe Info  		C604(5.57)  LDD0171  [2]
DBIA
 Probe Info  		C748(1.30)  LDD0078  [3]
NAIA_5
 Probe Info  		C477(0.00); C790(0.00)  LDD2224  [4]
IPM
 Probe Info  		C477(0.00); C790(0.00); C82(0.00)  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C604(5.57)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C372(1.25); C51(0.77); C54(0.77); C748(0.62)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C51(1.01); C54(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C372(0.84); C51(1.05); C54(1.05)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C372(0.86); C51(1.18); C54(1.18)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C372(0.87); C51(1.12); C54(1.12)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C372(0.91); C51(1.06); C54(1.06)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C372(0.88); C51(0.94); C54(0.94)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C372(0.87); C51(1.18); C54(1.18)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C372(0.95); C51(1.07); C54(1.07)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C372(0.82); C51(0.99); C54(0.99)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C372(0.74); C51(1.06); C54(1.06)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C372(0.83); C51(0.83); C54(0.83)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C51(1.24); C54(1.24)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C372(0.90); C51(1.21); C54(1.21)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C372(0.82); C51(1.27); C54(1.27)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C372(0.75); C51(0.86); C54(0.86)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C372(0.91); C51(0.75); C54(0.75); C748(1.24)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C372(1.14); C51(1.19); C54(0.73); C748(1.12)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C372(1.09); C51(1.44); C54(1.05); C748(0.82)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C372(1.13); C51(1.47); C54(0.84); C748(0.93)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C372(1.06); C51(0.87); C54(1.03); C748(1.05)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C372(0.85); C51(1.11); C54(0.95); C748(0.97)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C372(1.16); C51(0.97); C54(1.18); C748(0.93)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C51(0.87); C54(0.87)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C372(1.20); C51(1.05); C54(1.09); C748(0.97)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C372(0.97); C51(1.29); C54(0.94); C748(1.20)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C372(1.15); C51(1.40); C54(0.84); C748(0.95)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C372(1.30); C51(1.22); C54(1.03); C748(1.42)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C372(0.99); C51(1.12); C54(1.04); C748(0.89)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C372(0.81); C51(1.16); C54(0.91); C748(0.84)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C372(1.31); C51(1.52); C54(1.02); C748(0.89)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C372(1.27); C51(1.13); C54(0.96); C748(1.08)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C372(0.96)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C372(1.67)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C372(1.38)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C372(0.91)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C372(1.19)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C372(1.37)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C372(1.17)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C372(1.31)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C372(1.53)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C372(1.78)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C372(1.79)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C372(1.71)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C51(1.37); C54(1.37)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C372(1.39)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C372(1.86)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C372(1.54)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C372(0.44); C748(1.29)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C372(0.91); C748(1.15)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C372(0.68); C748(1.04)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C372(0.57); C748(1.33)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C372(0.99); C748(1.11)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C372(0.87); C748(1.49)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C372(0.52); C748(1.24)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C51(1.10); C54(1.10)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C372(0.77); C748(0.85)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C372(0.56); C748(1.11)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C372(0.75); C748(1.22)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C372(0.65); C748(2.00)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C372(0.61); C748(1.51)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C372(0.63); C748(1.48)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C372(0.49); C748(1.43)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C372(0.65); C748(1.32)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C307(1.09)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C307(1.00)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C307(1.07)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C372(1.26); C51(0.89); C54(0.89); C748(0.87)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C307(0.94)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C307(1.02)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C307(0.90)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C307(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C307(1.11)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C748(0.83); C372(1.37)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C748(0.69); C372(1.03)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C748(1.15); C372(1.35)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C748(1.01); C372(1.29)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C748(0.89); C372(1.09)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C372(1.17); C51(1.09); C54(1.09); C748(0.92)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C748(1.03); C372(1.17)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C748(0.93); C372(1.18)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C748(1.26); C372(1.35)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C748(1.26); C372(1.31)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C372(1.19); C748(1.26)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C307(0.96)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C307(0.94)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C307(0.94)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C307(0.91)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C307(0.90)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C372(1.09); C51(0.82); C54(0.82); C748(1.07)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C307(0.91)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C307(1.09)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C307(0.87)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C307(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C307(1.04)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C307(1.12)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C18(1.06); C372(1.03); C51(0.91); C54(0.91)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C18(1.24); C372(1.14); C51(0.90); C54(0.90)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C18(1.37); C372(1.09); C51(1.00); C54(1.00)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C18(1.19); C372(1.19); C51(0.76); C54(0.76)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C372(1.24); C51(0.96); C54(0.96); C748(0.93)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C18(1.12); C372(1.36); C51(0.98); C54(0.98)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C18(1.23); C372(1.65); C51(0.90); C54(0.90)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C18(1.27); C372(1.40); C51(1.10); C54(1.10)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C18(1.12); C372(1.20); C51(1.14); C54(1.14)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C18(1.24); C372(1.46); C51(1.27); C54(1.27)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C18(1.32); C372(1.37); C51(1.10); C54(1.10)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C18(0.99); C372(1.08); C51(1.16); C54(1.16)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C748(1.01); C307(1.19)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C307(0.86); C748(1.26)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C307(1.12); C748(1.33)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C51(0.98); C54(0.98)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C748(0.98); C307(1.48)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C307(1.19); C748(1.55)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C307(1.40); C748(1.93)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C748(0.79); C307(1.01)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C748(1.11); C307(1.49)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C748(0.68); C307(1.53)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C748(0.86); C307(1.43)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C748(0.77); C307(1.53)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C372(0.93)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C372(0.79)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C51(1.27); C54(1.27)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C372(0.83)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C372(1.09)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C372(1.08)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C372(1.09)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C372(0.92)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C372(0.97)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C372(0.74)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C372(0.76)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C372(1.17)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C372(0.93)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C51(1.25); C54(1.25)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C372(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C372(0.98)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C372(1.00)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C307(0.74)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C307(0.90)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C307(0.79)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C307(0.80)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C307(0.59)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C307(0.65)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C307(0.62)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C307(0.66)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C307(0.62)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C307(0.57)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C307(0.56)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C307(0.63)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C307(0.56)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C307(0.65)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C307(0.61)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C372(0.85); C51(1.18); C54(1.18)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C372(0.71); C51(1.05); C54(1.05)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C51(1.03); C54(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C51(1.17); C54(1.17)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C51(1.24); C54(1.24)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C748(1.30)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C790(1.01)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C372(1.24)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C372(0.79)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C372(1.69); C51(0.84); C54(0.84); C748(0.66)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C51(1.75); C54(1.75)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C51(1.49); C54(1.49)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C51(1.53); C54(1.53)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C51(1.66); C54(1.66)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C307(1.04)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C307(1.17)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C307(1.12)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C307(1.26)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C307(1.14)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C372(0.78)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C307(1.13)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C307(0.99)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C748(0.80); C372(1.10)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C372(1.29); C748(1.33)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C748(0.81); C372(1.12)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C748(0.96); C372(1.09)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C748(1.08); C372(1.20)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C307(0.93)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C307(1.10)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C307(1.03)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C372(0.80)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C307(1.11)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C18(1.13); C372(1.40); C51(1.06); C54(1.06)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C18(1.12); C372(1.23); C51(0.78); C54(0.78)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C18(1.05); C372(0.99); C51(0.70); C54(0.70)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C18(1.15); C372(1.07); C51(0.91); C54(0.91)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C748(1.16); C307(1.23)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C307(0.96); C748(1.45)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C748(0.97); C307(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C307(1.01); C748(1.27)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C372(0.77)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C372(0.97)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C372(0.95)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C51(0.99); C54(0.99)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C51(1.13); C54(1.13)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C51(0.98); C54(0.98)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C51(1.08); C54(1.08)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C372(0.91)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C51(1.21); C54(1.21)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C51(1.02); C54(1.02)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C51(1.81); C54(1.81)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C51(1.15); C54(1.15)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C51(0.59); C54(0.59)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C51(0.68); C54(0.68)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C51(1.32); C54(1.32)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C51(0.67); C54(0.67)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C51(0.71); C54(0.71)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C51(0.61); C54(0.61)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C372(0.80)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C51(0.74); C54(0.74)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C307(1.08); C372(1.37)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C307(1.05); C372(0.88)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C307(1.35); C372(1.56)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C307(1.22); C372(0.97)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C307(1.72); C372(1.15)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C307(1.20); C372(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C307(1.33); C372(1.27)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C307(1.17); C372(1.01)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C372(1.08)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C307(1.18); C372(1.08)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C307(1.07); C372(0.93)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C307(1.70); C372(0.91)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C307(1.26); C372(1.25)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C307(1.38); C372(1.33)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C307(1.37); C372(1.12)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C51(0.76); C54(0.76); C748(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C51(0.93); C54(0.93); C748(1.68)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C51(1.37); C54(1.37); C748(1.09)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C51(0.99); C54(0.99); C748(0.90)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C372(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C51(1.36); C54(1.36); C748(1.11)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C51(0.96); C54(0.96); C748(0.94)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C51(1.07); C54(1.07); C748(1.04)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C51(1.94); C54(1.94); C748(1.20)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C51(1.35); C54(1.35); C748(0.73)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C51(1.02); C54(1.02); C748(0.73)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C51(1.39); C54(1.39); C748(0.83)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C51(1.27); C54(1.27); C748(0.89)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C51(0.94); C54(0.94); C748(1.02)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C51(1.07); C54(1.07); C748(1.03)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C372(0.94)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C51(1.36); C54(1.36); C748(1.35)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C372(1.26); C748(1.11)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C372(0.86); C748(0.86)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C372(1.22); C748(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C372(1.37); C748(1.80)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C372(1.00); C748(0.75)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C372(1.37); C748(0.78)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C372(1.57); C748(0.95)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C372(1.08); C748(0.71)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C372(0.98); C748(0.74)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C372(0.99)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C372(1.17); C748(0.93)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C372(1.09); C748(0.80)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C372(1.20); C748(0.67)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C372(1.01); C748(0.59)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C372(1.11); C748(0.65)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C307(0.72); C51(0.93); C54(0.93)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C307(0.93); C51(0.89); C54(0.89)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C307(0.86); C51(0.77); C54(0.77)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C307(0.88); C51(0.94); C54(0.94)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C372(0.82)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C307(0.91); C51(0.84); C54(0.84)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C307(1.19); C51(0.68); C54(0.68)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C307(1.18); C51(0.69); C54(0.69)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C307(0.95); C51(0.83); C54(0.83)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C307(0.79); C51(1.01); C54(1.01)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C307(0.80); C51(0.99); C54(0.99)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C307(0.61); C51(0.87); C54(0.87)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C307(0.76); C51(0.69); C54(0.69)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C307(0.91); C51(0.67); C54(0.67)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C307(0.95); C51(0.81); C54(0.81)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C372(0.94)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C307(0.78); C51(0.72); C54(0.72)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C372(1.03); C51(1.08); C54(1.08); C748(1.05)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C372(1.14); C51(0.74); C54(0.74); C748(0.76)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C372(1.08); C51(1.01); C54(1.01); C748(0.58)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C372(1.45); C51(0.87); C54(0.87); C748(0.67)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C372(1.61); C51(0.74); C54(0.74); C748(0.47)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C372(1.11); C51(1.46); C54(1.46); C748(0.72)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C372(1.13); C51(1.28); C54(1.28); C748(0.62)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C372(1.29); C51(0.85); C54(0.85); C748(0.99)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C372(1.22); C51(0.95); C54(0.95); C748(0.77)  LDD1092  [3]
 LDCM0634  CY-0357 Hep-G2 C352(0.57)  LDD2228  [4]
 LDCM0468  Fragment33 HCT 116 C372(0.82); C748(0.71)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C307(2.10); C372(0.96)  LDD0744  [3]
 LDCM0022  KB02 A2058 C95(1.47)  LDD2253  [7]
 LDCM0023  KB03 A2058 C95(1.92)  LDD2670  [7]
 LDCM0024  KB05 NCI-H1650 C95(1.63)  LDD3345  [7]
 LDCM0021  THZ1 HCT 116 C748(0.97)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Protein regulator of cytokinesis 1 (PRC1) MAP65/ASE1 family O43663
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Cell division cycle 7-related protein kinase (CDC7) Ser/Thr protein kinase family O00311
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Cell division cycle protein 20 homolog B (CDC20B) WD repeat CDC20/Fizzy family Q86Y33
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Bystin (BYSL) Bystin family Q13895
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cilium assembly protein DZIP1L (DZIP1L) DZIP C2H2-type zinc-finger protein family Q8IYY4
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Axin-1 (AXIN1) . O15169
Coatomer subunit beta (COPB1) . P53618
Elongin-A (ELOA) . Q14241
Microspherule protein 1 (MCRS1) . Q96EZ8
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) . P57075
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840