Details of the Target

General Information of Target

Target ID LDTP01357
Target Name E3 SUMO-protein ligase PIAS2 (PIAS2)
Gene Name PIAS2
Gene ID 9063
Synonyms
PIASX; E3 SUMO-protein ligase PIAS2; EC 2.3.2.-; Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein transferase PIAS2; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIREL
YRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGS
VLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFP
LPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLT
SAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQE
DGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDE
EEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTP
ISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSS
RSETGVITSSGSNIPDIISLD
Target Bioclass
Enzyme
Family
PIAS family
Subcellular location
Nucleus speckle
Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
Uniprot ID
O75928
Ensemble ID
ENST00000324794.11
HGNC ID
HGNC:17311

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.S596I .
AN3CA SNV: p.L305S DBIA    Probe Info 
CAL33 Insertion: p.D155Ter .
HKGZCC SNV: p.S600T .
MEWO SNV: p.P615S DBIA    Probe Info 
OVK18 Deletion: p.F403LfsTer11 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C425(2.39)  LDD0168  [2]
DBIA
 Probe Info  		C220(0.94); C231(0.94)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C425(2.39)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C425(2.15)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C214(0.78); C220(1.14); C231(0.94); C385(1.11)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C441(0.99); C220(1.05); C231(1.05); C385(1.07)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C441(1.32); C214(0.37); C220(0.60); C231(0.60)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C441(1.63); C214(0.82); C220(0.83); C231(0.83)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C441(1.25); C214(0.46); C220(0.67); C231(0.67)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C441(1.89); C214(0.45); C220(0.67); C231(0.67)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C441(1.19); C214(0.54); C220(0.67); C231(0.67)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C441(1.53); C214(0.80); C220(0.93); C231(0.93)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C441(1.36); C214(0.45); C220(0.72); C231(0.72)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C441(1.38); C214(0.44); C220(0.71); C231(0.71)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C441(1.45); C214(0.68); C220(0.90); C231(0.90)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C441(1.05); C214(0.65); C220(0.87); C231(0.87)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C441(1.10); C220(1.02); C231(1.02); C385(1.05)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C441(1.47); C214(0.46); C220(0.75); C231(0.75)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C441(1.26); C214(0.65); C220(0.74); C231(0.74)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C441(1.59); C214(0.43); C220(0.76); C231(0.76)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C441(1.41); C220(0.98); C231(0.98); C425(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C441(1.47); C220(0.88); C231(0.88); C425(0.82)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C441(1.74); C220(1.06); C231(1.06); C425(0.83)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C441(1.85); C220(1.07); C231(1.07); C425(0.89)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C441(1.28); C220(0.96); C231(0.96); C425(0.81)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C441(1.47); C220(0.79); C231(0.79); C425(0.84)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C441(1.40); C220(0.98); C231(0.98); C425(0.79)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C441(1.07); C220(0.91); C231(0.91); C385(0.97)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C441(1.25); C220(0.96); C231(0.96); C425(0.89)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C441(1.88); C220(0.80); C231(0.80); C425(0.85)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C441(1.39); C220(0.93); C231(0.93); C425(0.85)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C441(1.22); C220(0.98); C231(0.98); C425(0.77)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C441(1.16); C220(0.93); C231(0.93); C425(0.87)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C441(1.24); C220(0.89); C231(0.89); C425(0.79)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C441(1.69); C220(0.85); C231(0.85); C425(1.04)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C441(1.56); C220(0.88); C231(0.88); C425(0.86)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C441(1.66); C220(0.88); C231(0.88); C385(1.44)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C441(0.94); C220(0.88); C231(0.88); C385(1.15)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C441(1.01); C220(0.99); C231(0.99); C385(0.97)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C441(0.60); C220(0.91); C231(0.91); C385(1.15)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C441(0.95); C220(1.02); C231(1.02); C385(0.94)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C441(0.96); C220(0.92); C231(0.92); C385(1.20)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C441(0.94); C220(1.15); C231(1.15); C385(1.04)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C441(1.07); C220(0.91); C231(0.91); C385(1.33)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C441(0.91); C220(0.93); C231(0.93); C385(0.90)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C441(0.83); C220(1.00); C231(1.00); C385(1.23)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C441(0.88); C220(1.21); C231(1.21); C385(1.20)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C441(0.89); C220(1.13); C231(1.13); C385(1.37)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C441(0.93); C220(1.00); C231(1.00); C385(1.04)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C441(1.03); C220(1.24); C231(1.24); C385(1.07)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C441(0.92); C220(1.08); C231(1.08); C385(1.07)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C441(0.81); C220(1.13); C231(1.13); C385(0.94)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C441(1.14); C220(0.85); C231(0.85); C425(0.95)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C220(0.91); C231(0.91); C385(0.98); C388(0.98)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C220(0.85); C231(0.85); C425(0.92); C441(1.01)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C425(0.86); C220(0.87); C231(0.87); C385(1.30)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C220(1.06); C231(1.06); C385(1.11); C388(1.11)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C425(0.78); C220(1.05); C231(1.05); C385(1.22)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C425(0.73); C220(0.96); C231(0.96); C385(0.98)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C385(0.93); C388(0.93); C441(1.00); C220(1.13)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C441(0.90); C220(0.93); C231(0.93); C425(0.98)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C385(0.63); C388(0.63); C220(0.92); C231(0.92)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C425(1.05); C220(1.05); C231(1.05); C385(1.05)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C220(0.89); C231(0.89); C425(0.94); C385(1.03)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C441(1.23); C220(0.79); C231(0.79); C385(1.05)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C441(1.15); C220(0.93); C231(0.93); C385(0.80)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C441(1.17); C220(0.88); C231(0.88); C385(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C441(1.18); C220(0.92); C231(0.92); C385(1.15)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C385(0.96); C388(0.96); C425(1.04); C220(1.06)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C214(0.98); C220(0.98); C231(0.98); C385(0.99)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C385(0.91); C388(0.91); C425(1.03); C441(1.06)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C214(0.94); C231(1.02); C385(1.04); C388(1.05)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C385(0.95); C388(0.95); C220(0.98); C231(0.98)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C385(0.90); C388(0.90); C425(0.93); C220(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C425(0.98); C385(0.99); C388(0.99); C220(1.10)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C385(0.97); C388(0.97); C425(0.99); C220(1.08)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C425(0.82); C385(0.95); C388(0.95); C441(1.15)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C214(0.82); C220(0.82); C231(0.82); C441(0.91)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C214(0.99); C220(0.99); C231(0.99); C385(1.00)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C385(0.98); C388(0.98); C214(1.07); C220(1.07)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C425(1.12); C441(1.14); C214(1.15); C220(1.15)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C214(0.90); C220(0.90); C231(0.90); C385(0.94)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C231(0.93); C214(0.94); C220(1.00); C388(1.06)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C214(0.79); C220(0.79); C231(0.79); C385(0.97)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C214(0.81); C220(0.81); C231(0.81); C385(0.94)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C214(0.84); C220(0.84); C231(0.84); C385(1.04)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C214(0.89); C220(0.89); C231(0.89); C385(0.95)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C385(0.85); C388(0.85); C214(0.89); C220(0.89)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C214(0.71); C220(0.75); C231(0.79); C441(0.91)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C214(0.87); C220(0.93); C385(0.98); C388(0.98)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C214(0.88); C441(0.89); C220(1.12); C425(1.16)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C231(0.72); C220(0.76); C214(0.80); C425(0.96)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C214(0.86); C220(0.92); C231(0.97); C441(1.10)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C214(0.90); C231(1.06); C388(1.10); C385(1.14)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C214(0.62); C220(0.73); C231(0.83); C441(1.05)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C231(0.68); C220(0.82); C441(0.93); C214(0.97)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C214(0.85); C385(0.96); C388(0.96); C441(0.99)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C214(0.69); C220(0.75); C231(0.80); C385(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C214(0.83); C441(0.91); C220(0.92); C231(1.00)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C214(0.70); C220(0.83); C441(0.84); C231(0.97)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C214(0.89); C220(0.93); C231(0.93); C385(0.96)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C214(0.85); C441(0.97); C220(1.00); C231(1.00)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C425(0.98); C214(0.99); C385(0.99); C388(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C214(0.81); C220(0.92); C231(0.92); C385(1.08)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C214(0.92); C231(1.07); C388(1.12); C385(1.13)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C214(0.83); C220(0.93); C231(0.93); C441(0.96)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C214(0.89); C441(0.90); C220(0.90); C231(0.90)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C214(0.77); C220(0.88); C231(0.88); C425(0.89)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C214(0.65); C220(0.82); C231(0.82); C425(0.98)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C214(1.01); C385(1.05); C388(1.05); C220(1.06)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C220(0.94); C231(0.94); C214(1.10); C385(1.15)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C214(0.86); C220(0.90); C231(0.90); C385(1.19)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C220(0.83); C231(0.88); C385(0.90); C388(0.90)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C220(0.85); C385(0.88); C388(0.88); C231(0.88)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C385(0.88); C388(0.88); C425(0.89); C220(0.96)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C385(0.93); C388(0.93); C425(1.03); C441(1.05)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C385(0.85); C388(0.85); C425(0.91); C231(0.92)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C385(0.74); C388(0.74); C220(0.83); C231(0.88)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C385(0.83); C388(0.83); C220(0.87); C214(0.89)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C214(0.87); C220(0.91); C231(0.91); C425(1.06)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C231(0.96); C220(0.98); C425(1.08); C214(1.15)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C385(0.82); C388(0.82); C220(0.89); C214(0.99)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C425(0.82); C385(0.85); C388(0.85); C220(0.94)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C220(0.81); C385(0.91); C388(0.91); C214(0.92)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C214(0.87); C425(0.94); C385(0.95); C388(0.95)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C425(0.88); C214(0.88); C231(1.00); C220(1.06)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C425(0.91); C385(0.99); C388(0.99); C441(1.04)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C425(0.77); C214(0.96); C385(0.99); C388(0.99)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C425(0.74); C214(0.88); C441(0.95); C385(1.17)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C425(0.68); C214(0.93); C385(0.97); C388(0.97)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C425(0.74); C214(0.83); C385(0.95); C388(0.95)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C425(0.67); C214(0.85); C385(0.90); C388(0.90)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C425(0.70); C214(0.87); C385(0.96); C388(0.96)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C425(0.66); C441(0.97); C214(0.99); C231(1.03)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C425(0.94); C214(0.94); C385(0.95); C388(0.95)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C214(0.82); C425(0.85); C220(0.96); C441(0.97)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C425(0.79); C214(0.86); C385(0.92); C388(0.92)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C441(0.88); C385(0.98); C388(0.98); C425(1.03)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C441(0.68); C425(0.75); C214(1.02); C385(1.06)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C425(0.72); C214(0.92); C385(0.97); C388(0.97)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C425(0.82); C214(0.93); C385(0.94); C388(0.94)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C425(0.90); C385(0.98); C388(0.98); C220(1.00)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C425(0.92); C385(1.09); C388(1.09); C220(1.17)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C425(0.89); C385(0.93); C388(0.93); C220(0.94)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C425(0.86); C220(0.96); C231(0.96); C385(0.97)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C425(0.83); C441(0.91); C385(0.94); C388(0.94)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C425(0.81); C385(1.02); C388(1.02); C220(1.12)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C220(0.96); C231(0.96); C425(1.01); C385(1.01)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C220(0.93); C231(0.93); C441(1.01); C425(1.08)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C220(0.94); C231(0.94); C385(1.11); C388(1.11)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C220(1.02); C231(1.02); C385(1.09); C388(1.09)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C220(0.84); C231(0.84); C385(1.03); C388(1.03)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C441(0.77); C385(1.07); C388(1.07); C220(1.17)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C441(0.72); C385(0.88); C388(0.88); C220(0.98)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C220(0.82); C231(0.82); C441(1.15); C385(1.17)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C385(1.02); C388(1.02); C220(1.14); C231(1.14)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C214(0.69); C385(0.77); C388(0.77); C220(0.89)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C214(0.57); C385(0.66); C388(0.66); C220(0.75)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C441(0.83); C220(1.01); C231(1.01); C385(1.07)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C385(0.90); C388(0.90); C425(0.93); C441(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C385(1.04); C388(1.04); C220(1.20); C231(1.20)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C220(0.94); C231(0.94)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C385(0.91); C388(0.91); C425(0.95); C441(0.96)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C425(1.07); C385(1.27); C388(1.27); C231(1.35)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C214(0.78); C231(0.87); C425(1.02); C220(1.02)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C385(1.10); C388(1.10); C220(1.11); C231(1.11)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C385(0.90); C388(0.90); C425(0.93); C441(1.02)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C441(0.87); C425(0.94); C385(1.05); C388(1.05)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C425(0.91); C441(0.91); C385(0.93); C388(0.93)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C385(0.90); C388(0.90); C425(1.08); C220(1.10)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C385(0.98); C388(0.98); C220(1.17); C231(1.17)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C385(0.93); C388(0.93); C425(1.09); C214(1.12)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C385(1.00); C388(1.00); C220(1.29); C231(1.29)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C385(0.90); C388(0.90); C425(1.04); C220(1.15)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C214(1.08); C441(1.12); C385(1.13); C388(1.13)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C385(0.95); C388(0.95); C425(1.14); C220(1.39)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C385(0.76); C388(0.76); C425(1.01); C220(1.08)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C385(0.83); C388(0.83); C214(0.94); C220(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C214(0.80); C220(0.80); C231(0.80); C385(0.86)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C385(0.76); C388(0.76); C214(0.90); C220(0.90)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C385(0.81); C388(0.81); C214(0.86); C220(0.86)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C214(0.79); C220(0.79); C231(0.79); C385(0.93)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C214(0.91); C220(1.06); C231(1.21); C385(1.23)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C214(0.85); C220(0.92); C231(0.99); C385(1.13)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C231(0.72); C220(0.85); C385(0.96); C388(0.96)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C425(0.99); C214(1.05); C220(1.08); C231(1.09)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C231(0.63); C220(0.72); C214(0.80); C441(0.88)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C425(0.75); C441(0.76); C214(0.88); C220(0.93)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C214(0.78); C441(0.83); C220(0.84); C231(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C214(0.70); C220(0.96); C231(0.96); C441(0.98)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C214(0.78); C220(0.88); C231(0.88); C385(1.00)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C385(0.75); C388(0.75); C441(0.78); C231(0.98)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C441(0.75); C385(0.85); C388(0.85); C214(0.86)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C385(0.73); C388(0.73); C425(0.92); C441(0.93)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C220(0.85); C425(0.87); C385(0.89); C388(0.89)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C425(0.75); C214(0.78); C385(0.95); C388(0.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C425(0.86); C441(0.90); C385(0.91); C388(0.91)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C425(0.88); C385(1.00); C388(1.00); C231(1.11)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C425(1.03); C385(1.11); C388(1.11); C441(1.26)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C214(0.74); C385(0.88); C388(0.88); C425(0.88)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C214(0.67); C385(0.76); C388(0.76); C425(0.94)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C214(0.77); C385(0.84); C388(0.84); C441(1.04)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C441(0.83); C425(0.90); C385(0.91); C388(0.91)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C214(0.75); C385(0.92); C388(0.92); C441(1.22)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C214(0.86); C385(1.01); C388(1.01); C220(1.22)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C214(0.96); C425(1.25); C385(1.30); C388(1.30)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C425(0.73); C214(0.86); C385(0.93); C388(0.93)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C214(0.72); C385(0.99); C388(0.99); C425(1.07)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C441(1.46); C214(0.71); C220(1.24); C231(1.32)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C441(1.12); C214(1.06); C220(1.08); C231(1.09)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C441(1.20); C214(0.79); C220(1.26); C231(1.38)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C441(1.14); C214(0.80); C220(1.36); C231(1.57)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C441(1.21); C214(0.71); C220(1.20); C231(1.33)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C441(0.85); C214(0.91); C220(0.95); C231(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C441(1.21); C214(1.57); C220(1.41); C231(1.36)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C441(1.06); C214(1.24); C220(1.30); C231(1.30)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C441(1.05); C220(1.35); C231(1.35); C385(1.01)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C441(1.64); C220(1.84); C231(1.84); C385(1.87)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C441(1.31); C220(1.60); C231(1.60); C385(0.97)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C441(1.15); C220(1.40); C231(1.40); C385(1.25)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C441(1.16); C220(1.37); C231(1.37); C385(1.15)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C441(1.38); C220(1.42); C231(1.42); C385(1.24)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C441(1.41); C220(1.27); C231(1.27); C385(0.89)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C441(1.13); C214(1.35); C220(1.25); C231(1.19)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C441(1.38); C220(1.51); C231(1.51); C385(1.00)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C441(1.21); C220(1.24); C231(1.24); C385(0.86)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C441(1.78); C220(1.58); C231(1.58); C385(1.12)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C441(1.33); C220(1.42); C231(1.42); C385(0.90)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C441(1.42); C220(1.34); C231(1.34); C385(1.02)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C441(1.67); C220(1.64); C231(1.64); C385(0.98)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C441(0.63); C214(0.93); C220(0.95); C231(0.95)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C441(1.07); C214(1.19); C220(1.00); C231(1.00)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C441(0.68); C214(1.22); C220(0.98); C231(0.98)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C441(0.94); C214(0.94); C220(0.95); C231(0.95)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C441(1.00); C214(0.75); C220(0.95); C231(1.05)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C441(0.85); C214(0.81); C220(0.85); C231(0.85)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C441(0.68); C214(0.76); C220(0.86); C231(0.86)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C441(0.95); C214(1.17); C220(1.06); C231(1.06)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C441(0.75); C214(1.05); C220(1.04); C231(1.04)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C441(0.92); C214(1.10); C220(0.97); C231(0.97)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C441(0.66); C214(0.93); C220(1.00); C231(1.00)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C441(0.91); C214(1.18); C220(1.06); C231(1.06)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C441(0.99); C214(1.12); C220(0.99); C231(0.99)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C441(0.50); C214(0.97); C220(0.92); C231(0.92)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C441(1.02); C214(1.19); C220(1.01); C231(1.01)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C441(0.85); C214(1.04); C220(1.01); C231(1.00)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C441(0.58); C214(0.94); C220(1.22); C231(1.22)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C441(1.08); C214(0.96); C220(0.97); C231(0.97)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C441(1.26); C214(0.87); C220(0.81); C231(0.81)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C441(1.37); C214(0.85); C220(0.82); C231(0.82)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C441(1.21); C214(0.94); C220(0.93); C231(0.93)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C441(1.18); C214(1.11); C220(1.11); C231(1.11)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C441(1.55); C214(1.11); C220(1.09); C231(1.09)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C441(1.44); C214(0.95); C220(0.95); C231(0.95)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C441(1.60); C214(0.87); C220(0.87); C231(0.87)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C441(1.39); C214(0.83); C220(0.88); C231(0.88)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C441(0.99); C214(0.80); C220(0.99); C231(1.08)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C441(1.38); C214(0.79); C220(0.79); C231(0.79)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C441(1.32); C214(0.94); C220(0.94); C231(0.94)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C441(1.36); C214(1.02); C220(0.96); C231(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C441(1.59); C214(1.02); C220(0.98); C231(0.98)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C441(1.40); C214(0.91); C220(0.91); C231(0.91)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C441(1.78); C214(1.31); C220(1.16); C231(1.00)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C441(1.46); C214(1.06); C220(1.09); C231(1.13)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C441(1.24); C214(1.27); C220(1.19); C231(1.10)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C441(1.64); C214(1.11); C220(1.08); C231(1.05)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C441(2.35); C214(2.32); C220(2.03); C231(1.89)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C441(1.19); C214(1.10); C220(1.09); C231(1.08)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C441(1.65); C214(1.13); C220(1.00); C231(0.87)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C441(2.07); C214(1.34); C220(1.11); C231(0.89)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C441(1.91); C214(1.15); C220(0.99); C231(0.84)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C441(2.25); C214(1.14); C220(1.14); C231(1.14)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C441(1.87); C214(1.03); C220(1.02); C231(1.00)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C441(1.58); C214(0.99); C220(0.97); C231(0.95)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C441(1.59); C214(0.95); C220(0.90); C231(0.85)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C441(2.17); C214(0.89); C220(0.83); C231(0.77)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C441(3.37); C214(1.30); C220(1.17); C231(1.03)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C441(1.09); C214(1.06); C220(1.02); C231(1.00)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C441(1.96); C214(1.94); C220(1.78); C231(1.62)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C214(0.93); C220(1.00); C231(0.96); C385(0.93)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C214(1.06); C220(0.99); C231(1.02); C385(0.91)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C214(1.07); C220(1.13); C231(1.09); C385(0.99)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C214(0.86); C220(0.92); C231(0.89); C385(1.00)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C214(0.93); C220(1.18); C231(1.09); C385(0.93)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C214(0.95); C220(0.97); C231(0.91); C385(0.97)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C214(1.04); C220(1.30); C231(1.08); C385(1.00)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C214(0.98); C220(1.00); C231(1.02); C385(1.02)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C214(0.88); C220(1.05); C231(0.94); C385(1.10)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C49(1.00); C454(1.01); C231(0.94)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C441(1.56); C214(1.11); C220(1.11); C231(1.11)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C441(1.92); C220(2.12); C231(2.12); C385(1.23)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C385(1.53); C388(1.53); C220(1.11); C231(1.11)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C385(4.07); C388(4.07); C220(1.33); C231(1.33)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C385(1.76); C388(1.76); C220(1.43); C231(1.43)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C441(1.06)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (ACY3) AspA/AstE family Q96HD9
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Neuron navigator 2 (NAV2) Nav/unc-53 family Q8IVL1
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) SAICAR synthetase family; AIR carboxylase family P22234
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
Interferon-induced GTP-binding protein Mx1 (MX1) Dynamin/Fzo/YdjA family P20591
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon-induced GTP-binding protein Mx2 (MX2) Dynamin/Fzo/YdjA family P20592
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Grainyhead-like protein 2 homolog (GRHL2) Grh/CP2 family Q6ISB3
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 319 (ZNF319) Krueppel C2H2-type zinc-finger protein family Q9P2F9
Zinc finger protein 42 homolog (ZFP42) Krueppel C2H2-type zinc-finger protein family Q96MM3
DNA-binding protein RFX2 (RFX2) RFX family P48378
High mobility group protein 20A (HMG20A) . Q9NP66
HMG domain-containing protein 4 (HMGXB4) . Q9UGU5
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Myc proto-oncogene protein (MYC) . P01106
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Enhancer of mRNA-decapping protein 3 (EDC3) EDC3 family Q96F86
Protein FAM118B (FAM118B) FAM118 family Q9BPY3
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Peripherin (PRPH) Intermediate filament family P41219
Late cornified envelope protein 1E (LCE1E) LCE family Q5T753
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) PRKRA family O75569
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) RRM HNRPC family O60812
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Alpha-taxilin (TXLNA) Taxilin family P40222
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
UPF0461 protein C5orf24 (C5orf24) UPF0461 family Q7Z6I8
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
Protein ZNRD2 (ZNRD2) . O60232
RUN and FYVE domain-containing protein 1 (RUFY1) . Q96T51
Spindlin interactor and repressor of chromatin-binding protein (SPINDOC) . Q9BUA3
Ubiquilin-1 (UBQLN1) . Q9UMX0
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402