Details of the Target

General Information of Target

Target ID LDTP01148
Target Name Lysine-specific demethylase 4A (KDM4A)
Gene Name KDM4A
Gene ID 9682
Synonyms
JHDM3A; JMJD2; JMJD2A; KIAA0677; Lysine-specific demethylase 4A; EC 1.14.11.66; EC 1.14.11.69; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYD
DIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERK
YWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRH
KMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYG
KQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDL
SSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEE
QAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPL
SKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNET
MAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSL
RGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRT
AGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEG
EVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSV
ASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
JHDM3 histone demethylase family
Subcellular location
Nucleus
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.; [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
TTD ID
T18904
Uniprot ID
O75164
DrugMap ID
TTZHPB8
Ensemble ID
ENST00000372396.4
HGNC ID
HGNC:22978
ChEMBL ID
CHEMBL5896

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.I405T .
G415 SNV: p.E991Q .
HT1197 SNV: p.Q916R .
KP4 SNV: p.P599S DBIA    Probe Info 
KYSE150 SNV: p.P649S DBIA    Probe Info 
LNCaP clone FGC SNV: p.A435T .
MFE319 SNV: p.L244M .
NCIH1703 SNV: p.S510C .
PANC1 SNV: p.C763R .
SW756 SNV: p.R309T .
TCCSUP SNV: p.P361S .
YSCCC SNV: p.E426K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y456(16.30); Y1059(7.22)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C430(2.34)  LDD0168  [2]
DBIA
 Probe Info  		C560(1.08)  LDD0078  [3]
IA-alkyne
 Probe Info  		C107(0.00); C560(0.00); C763(0.00); C234(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C763(0.00); C560(0.00); C234(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		5.40  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C430(2.34)  LDD0168  [2]
 LDCM0214  AC1 HCT 116 C234(1.02); C763(0.60); C843(1.25); C844(1.45)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C234(1.08); C308(1.13); C763(0.51); C843(0.90)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C234(0.69); C763(0.79); C843(0.70); C844(0.74)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C234(0.75); C763(0.84); C843(0.62); C844(0.77)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C234(0.80); C763(0.71); C843(0.60); C844(0.64)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C234(0.70); C763(0.67); C843(0.58); C844(0.77)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C234(1.00); C763(0.72); C843(0.76); C844(0.76)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C234(0.74); C763(0.69); C843(0.58); C844(0.71)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C234(0.61); C763(0.71); C843(0.54); C844(0.77)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C234(0.64); C763(0.72); C843(0.56); C844(0.60)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C234(0.63); C763(0.66); C843(0.61); C844(0.75)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C234(1.07); C763(0.72); C843(0.70); C844(0.75)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C234(1.41); C308(1.27); C763(0.53); C843(1.12)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C234(0.61); C763(0.65); C843(0.56); C844(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C234(0.68); C763(0.77); C843(0.58); C844(0.92)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C234(0.55); C763(0.72); C843(0.61); C844(0.60)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C234(1.00); C763(1.15); C843(0.86); C844(0.83)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C234(0.78); C763(1.04); C843(0.73); C844(0.73)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C234(0.76); C763(1.06); C843(0.86); C844(0.82)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C234(0.83); C763(1.10); C843(0.82); C844(0.87)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C234(1.06); C763(1.06); C843(0.86); C844(0.78)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C234(0.88); C763(1.09); C843(0.77); C844(0.82)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C234(0.86); C763(1.34); C843(0.84); C844(0.76)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C234(1.49); C308(1.00); C763(0.60); C843(1.08)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C234(0.83); C763(1.07); C843(0.88); C844(1.02)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C234(1.25); C763(1.04); C843(0.84); C844(0.79)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C234(0.87); C763(1.00); C843(0.77); C844(0.78)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C234(0.83); C763(1.01); C843(0.70); C844(0.76)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C234(1.10); C763(1.12); C843(0.77); C844(0.71)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C234(0.92); C763(1.11); C843(0.94); C844(0.96)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C234(0.79); C763(1.22); C843(0.77); C844(0.79)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C234(0.96); C763(1.05); C843(0.79); C844(0.83)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C763(0.92); C843(0.94); C844(1.19); C847(1.10)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C763(1.10); C843(1.01); C844(1.01); C847(1.05)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C763(1.13); C843(0.81); C844(1.04); C847(0.98)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C763(1.06); C843(0.88); C844(1.00); C847(0.93)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C763(0.86); C843(0.93); C844(1.03); C847(1.00)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C763(1.07); C843(0.83); C844(0.97); C847(0.94)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C763(1.04); C843(1.03); C844(1.16); C847(1.18)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C763(1.01); C843(1.00); C844(0.91); C847(0.99)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C763(1.04); C843(1.06); C844(0.92); C847(1.04)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C763(0.87); C843(0.93); C844(1.00); C847(0.98)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C763(1.14); C843(0.75); C844(0.79); C847(0.80)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C763(1.20); C843(0.92); C844(0.99); C847(0.99)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C234(1.23); C308(1.12); C763(0.50); C843(0.81)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C763(1.03); C843(1.04); C844(1.16); C847(1.17)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C763(1.42); C843(0.94); C844(0.95); C847(1.01)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C763(1.18); C843(0.81); C844(0.86); C847(0.87)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C843(0.77); C763(1.02); C844(1.15); C847(1.53)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C843(0.47); C763(0.57); C844(0.62); C847(0.77)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C847(0.71); C844(0.79); C843(0.88); C763(1.40)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C843(0.59); C763(0.68); C844(0.69); C847(0.79)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C763(0.77); C843(0.86); C844(0.88); C847(0.89)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C763(0.57); C843(0.60); C844(0.80); C847(1.01)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C763(0.70); C843(0.93); C844(1.02); C847(1.10)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C763(0.64); C843(0.88); C234(1.02); C847(1.07)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C763(0.77); C843(0.93); C844(1.25); C847(1.57)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C763(0.68); C843(0.69); C844(0.81); C847(0.93)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C843(0.45); C844(0.75); C763(0.82); C847(1.04)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C763(0.51); C847(0.61); C844(0.66); C843(0.71)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C763(0.77); C843(0.70); C844(0.86); C847(1.02)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C763(1.21); C843(0.52); C844(0.89); C847(1.27)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C763(0.76); C843(0.71); C844(0.77); C847(0.83)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C763(1.11); C843(0.52); C844(0.66); C847(0.80)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C847(0.89); C308(0.89); C844(0.90); C843(0.91)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C847(0.74); C844(0.75); C843(0.78); C763(1.00)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C843(0.91); C844(0.95); C847(1.02); C763(1.24)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C763(0.84); C843(0.96); C234(1.01); C844(1.04)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C308(0.67); C844(0.87); C843(0.99); C847(1.06)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C844(0.75); C847(0.82); C843(0.83); C308(0.93)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C308(0.95); C843(0.96); C844(1.03); C847(1.04)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C843(0.81); C844(0.82); C847(0.85); C763(0.93)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C308(0.93); C847(0.96); C843(0.97); C844(0.97)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C844(0.87); C763(0.88); C847(0.88); C234(1.07)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C847(0.72); C844(0.74); C763(0.76); C843(0.86)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C763(0.76); C847(0.81); C844(0.81); C843(0.81)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C763(0.65); C844(0.65); C847(0.68); C843(0.73)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C763(0.60); C844(0.78); C843(0.82); C847(0.86)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C763(0.47); C234(1.00); C843(1.22); C844(1.50)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C763(0.70); C844(0.79); C847(0.80); C843(1.01)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C847(0.66); C844(0.69); C763(0.74); C843(0.79)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C847(0.63); C763(0.65); C844(0.68); C843(0.80)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C763(0.74); C844(0.84); C847(0.85); C843(0.90)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C763(0.63); C847(0.64); C844(0.68); C843(0.83)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C847(1.08); C763(1.09); C843(1.12); C844(1.19)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C847(0.94); C844(0.96); C763(1.04); C843(1.05)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C763(1.20); C847(1.23); C843(1.25); C844(1.28)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C847(1.12); C763(1.14); C843(1.17); C844(1.18)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C847(0.97); C763(0.97); C844(1.04); C843(1.10)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C763(0.83); C234(1.21); C843(1.28); C844(1.85)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C844(0.85); C847(0.87); C763(0.95); C843(1.08)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C763(0.96); C844(0.98); C847(0.99); C843(1.03)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C843(0.87); C844(0.88); C847(0.93); C763(0.99)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C844(0.87); C843(0.91); C763(0.93); C847(0.93)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C763(0.97); C843(1.06); C847(1.20); C844(1.23)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C763(0.93); C844(1.03); C847(1.04); C843(1.04)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C306(0.67); C308(0.89); C843(0.94); C234(1.00)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C306(0.91); C763(0.92); C308(1.02); C843(1.10)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C763(0.80); C306(0.83); C308(0.87); C843(0.87)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C306(0.67); C843(0.72); C763(0.75); C844(0.90)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C763(0.55); C234(1.18); C843(1.46); C844(1.69)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C306(0.75); C843(0.76); C763(0.87); C234(1.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C308(0.81); C306(0.81); C843(0.97); C234(1.07)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C234(0.96); C763(1.06); C306(1.10); C843(1.11)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C763(0.69); C306(0.88); C843(0.91); C308(1.10)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C843(0.77); C763(0.77); C306(0.86); C308(1.11)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C306(0.63); C763(0.78); C843(0.87); C844(0.98)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C763(0.57); C306(0.67); C843(0.68); C847(0.83)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C763(0.40); C844(0.98); C847(1.04); C234(1.05)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C763(0.41); C844(0.81); C847(0.95); C234(1.01)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C763(0.52); C234(0.93); C844(0.95); C847(0.97)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C763(0.45); C847(0.78); C843(0.88); C844(0.97)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C763(0.35); C234(0.87); C844(0.89); C847(0.92)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C763(0.34); C844(0.83); C847(0.86); C234(0.91)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C763(0.34); C844(0.92); C234(0.99); C847(1.05)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C763(0.33); C844(0.83); C847(0.91); C234(0.93)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C763(0.37); C844(0.81); C234(0.95); C847(1.00)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C763(0.40); C844(0.98); C847(1.05); C234(1.13)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C763(0.41); C234(0.90); C844(0.92); C847(0.97)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C763(0.27); C844(0.72); C234(0.78); C847(0.81)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C763(0.72); C843(0.78); C844(0.83); C847(0.83)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C843(0.67); C844(0.75); C847(0.75); C763(0.86)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C763(0.90); C308(0.98); C847(1.03); C843(1.07)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C844(0.91); C847(0.91); C306(0.95); C308(0.95)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C843(0.72); C763(0.88); C844(0.89); C847(0.89)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C843(0.72); C844(0.89); C847(0.89); C306(0.89)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C843(0.57); C763(0.62); C844(0.82); C847(0.82)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C843(0.50); C763(0.58); C844(0.78); C847(0.78)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C843(0.48); C763(0.58); C844(0.65); C847(0.65)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C843(0.69); C763(0.85); C306(0.88); C308(0.88)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C844(0.73); C847(0.73); C843(0.75); C763(0.78)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C843(0.59); C844(0.76); C847(0.76); C763(0.86)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C843(0.70); C844(0.85); C847(0.85); C306(1.06)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C763(0.58); C847(0.72); C843(0.89); C234(0.98)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C843(0.67); C844(0.88); C847(0.88); C763(0.91)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C844(0.78); C847(0.78); C843(0.82); C306(0.86)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C763(0.66); C843(0.67); C844(0.67); C847(0.67)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C763(0.67); C843(1.05); C847(1.07); C308(1.18)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C763(0.70); C843(0.83); C847(0.90); C844(0.97)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C763(0.83); C843(0.95); C847(1.02); C844(1.21)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C763(0.63); C847(1.13); C843(1.17); C844(1.18)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C763(0.68); C847(1.10); C843(1.15); C844(1.18)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C763(0.88); C843(1.02); C847(1.07); C308(1.44)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C763(0.66); C843(0.99); C847(1.02); C844(1.04)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C763(0.67); C847(1.02); C843(1.10); C844(1.19)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C763(0.73); C308(0.98); C847(1.07); C843(1.07)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C763(0.70); C843(0.98); C847(0.99); C844(1.05)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C763(0.72); C308(0.81); C843(0.93); C847(0.93)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C763(0.84); C308(0.89); C847(0.99); C844(1.00)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C763(0.67); C843(0.91); C847(0.96); C844(0.99)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C763(0.89); C847(1.10); C843(1.10); C844(1.11)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C763(0.62); C847(0.89); C843(0.91); C844(0.98)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C843(0.44); C844(0.58); C847(0.58); C763(0.58)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C234(0.67); C763(0.69); C843(0.75); C844(0.84)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C234(1.15); C308(1.09); C763(0.57); C843(0.91)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C763(0.73); C308(0.93); C847(1.08); C234(1.13)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C763(0.50); C847(0.93); C843(0.98); C234(1.02)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C560(1.08)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C843(0.75); C847(0.75); C844(0.89); C763(1.12)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C844(0.54); C843(0.54); C847(0.54); C763(0.80)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C763(0.67); C843(0.96); C844(1.18); C847(1.18)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C763(0.53); C847(0.86); C843(0.86); C234(0.88)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C763(0.71); C843(0.89); C847(0.90); C308(0.98)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C763(0.76); C847(0.76); C843(0.94); C308(0.95)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C847(0.77); C763(0.85); C843(0.88); C234(1.18)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C847(0.75); C843(0.76); C844(0.81); C763(0.86)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C763(0.58); C843(0.68); C847(0.71); C844(0.79)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C847(0.75); C763(0.75); C844(0.78); C843(0.82)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C763(0.76); C844(0.77); C843(0.77); C847(0.78)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C843(0.77); C847(0.80); C844(0.86); C763(1.14)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C844(0.67); C843(0.70); C847(0.70); C763(0.79)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C843(0.77); C847(0.79); C763(0.80); C844(0.85)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C844(0.85); C847(0.85); C234(0.89); C843(0.92)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C847(0.74); C844(0.74); C843(0.83); C763(0.85)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C763(0.59); C844(0.76); C847(0.83); C843(0.89)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C763(0.68); C844(0.79); C847(0.82); C843(0.98)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C763(0.81); C847(0.81); C844(0.83); C843(0.97)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C763(0.72); C847(0.73); C844(0.75); C843(0.83)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C844(0.70); C847(0.77); C763(0.82); C843(0.97)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C847(1.00); C843(1.02); C763(1.03); C844(1.10)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C844(0.78); C843(0.79); C847(0.83); C763(1.02)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C844(0.65); C843(0.73); C847(0.73); C234(0.94)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C843(0.98); C763(1.02); C847(1.07); C844(1.14)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C306(1.31); C763(1.33); C844(1.42); C234(1.43)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C763(0.70); C306(0.77); C843(0.80); C847(1.01)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C306(0.74); C843(0.77); C763(0.77); C847(0.81)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C306(0.70); C763(0.71); C843(0.79); C847(1.12)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C234(0.85); C763(1.18); C844(1.31); C847(1.39)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C763(0.65); C234(1.00); C843(1.01); C847(1.09)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C763(0.51); C234(0.82); C844(0.91); C847(0.96)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C763(0.50); C844(1.05); C843(1.10); C847(1.11)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C843(0.68); C847(0.68); C844(0.74); C763(0.84)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C844(0.64); C843(0.72); C847(0.72); C234(1.13)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C844(0.70); C843(0.78); C847(0.78); C763(0.90)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C763(0.87); C847(0.91); C308(0.92); C306(0.94)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C763(0.61); C306(0.81); C847(0.87); C843(0.91)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C763(0.43); C234(0.74); C847(0.83); C843(0.87)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C763(0.51); C234(0.89); C847(0.95); C843(0.99)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C844(0.63); C843(0.77); C847(0.77); C234(1.49)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C763(0.66); C234(0.91); C847(0.95); C843(0.99)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C763(0.50); C847(0.90); C843(0.93); C234(0.97)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C763(0.43); C234(0.78); C847(0.86); C306(0.97)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C763(0.78); C847(0.78); C843(0.87); C844(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C763(0.57); C847(0.93); C844(0.99); C843(1.00)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C234(1.08); C306(1.04); C308(1.11); C763(0.52)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C234(0.77); C306(1.05); C308(1.09); C763(0.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C234(1.03); C306(1.14); C308(1.20); C763(0.75)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C234(0.79); C306(1.12); C308(1.11); C763(0.64)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C234(0.90); C306(1.24); C308(1.34); C763(0.59)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C234(1.08); C763(1.25); C843(0.55); C844(0.57)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C234(0.94); C306(1.17); C308(1.08); C763(0.67)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C234(1.25); C763(0.63); C843(1.26); C844(1.26)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C234(0.63); C763(0.46); C843(1.08); C844(1.17)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C234(0.50); C763(0.31); C843(0.83); C844(0.73)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C234(0.51); C763(0.31); C843(1.11); C844(1.13)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C234(0.58); C763(0.42); C843(1.27); C844(1.22)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C234(0.79); C763(0.55); C843(1.09); C844(1.03)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C234(0.50); C763(0.37); C843(1.03); C844(1.05)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C234(0.60); C763(0.42); C843(1.12); C844(1.10)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C234(1.09); C763(1.25); C843(0.75); C844(0.84)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C234(0.73); C763(0.55); C843(1.57); C844(1.50)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C234(0.54); C763(0.55); C843(1.02); C844(1.09)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C234(0.41); C763(0.38); C843(1.07); C844(0.89)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C234(0.64); C763(0.39); C843(1.09); C844(1.13)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C234(0.84); C763(0.33); C843(1.18); C844(1.21)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C234(0.79); C763(0.43); C843(1.25); C844(1.23)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C843(1.28); C844(1.05); C847(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C843(0.99); C844(1.02); C847(1.02)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C843(1.08); C844(1.09); C847(1.09)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C843(1.61); C844(1.60); C847(1.60)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C234(1.00); C763(0.97); C843(0.76); C844(0.60)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C843(1.31); C844(1.17); C847(1.17)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C843(1.14); C844(1.05); C847(1.05)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C843(1.08); C844(1.02); C847(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C843(0.99); C844(1.18); C847(1.18)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C843(0.86); C844(0.90); C847(0.90)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C843(0.83); C844(0.95); C847(0.95)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C843(0.74); C844(0.96); C847(0.96)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C843(1.11); C844(1.29); C847(1.29)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C843(1.38); C844(1.19); C847(1.19)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C843(0.97); C844(1.02); C847(1.02)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C234(1.05); C763(0.73); C843(0.69); C844(0.51)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C843(1.17); C844(1.07); C847(1.07)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C306(1.05); C308(1.12); C763(0.86); C843(0.99)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C306(1.23); C308(1.01); C763(1.04); C843(0.89)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C306(0.83); C308(1.01); C763(0.80); C843(1.15)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C306(0.96); C308(1.16); C763(0.73); C843(0.82)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C306(1.05); C308(1.07); C763(0.96); C843(1.06)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C306(0.81); C308(1.33); C763(0.67); C843(0.95)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C306(0.95); C308(1.28); C763(0.85); C843(0.91)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C306(1.22); C308(1.19); C763(0.74); C843(0.93)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C306(1.01); C308(1.09); C763(0.81); C843(0.81)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C234(1.09); C763(0.95); C843(0.86); C844(0.83)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C306(1.05); C308(1.24); C763(0.72); C843(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C306(0.94); C308(1.03); C763(0.86); C843(1.03)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C306(0.90); C308(1.11); C763(0.96); C843(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C306(1.03); C308(1.30); C763(0.78); C843(0.95)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C306(1.02); C308(1.16); C763(0.72); C843(1.17)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C234(0.76); C763(0.37); C843(1.13); C844(1.21)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C234(0.82); C763(0.39); C843(0.95); C844(1.03)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C234(0.94); C763(0.62); C843(1.06); C844(1.14)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C234(0.70); C763(0.49); C843(1.30); C844(1.33)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C234(1.02); C763(0.94); C843(0.72); C844(0.66)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C234(0.71); C763(0.48); C843(1.31); C844(1.33)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C234(0.76); C763(0.41); C843(1.35); C844(1.26)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C234(0.59); C763(0.39); C843(1.34); C844(1.14)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C234(0.64); C763(0.27); C843(1.12); C844(1.10)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C234(0.59); C763(0.25); C843(1.11); C844(1.22)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C234(0.84); C763(0.54); C843(1.13); C844(1.08)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C234(1.23); C763(0.46); C843(1.24); C844(1.16)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C234(0.89); C763(0.43); C843(1.26); C844(1.22)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C234(0.59); C763(0.28); C843(1.30); C844(1.21)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C234(0.50); C763(0.27); C843(1.21); C844(1.07)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C234(1.36); C763(0.95); C843(0.70); C844(0.53)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C234(1.02); C763(0.34); C843(1.27); C844(1.12)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C234(0.81); C763(0.81); C843(0.96); C844(1.27)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C234(0.96); C763(0.70); C843(0.80); C844(0.84)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C234(1.05); C763(0.75); C843(0.85); C844(0.76)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C234(1.12); C763(0.58); C843(1.03); C844(0.83)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C234(0.93); C763(0.49); C843(0.87); C844(0.93)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C234(0.86); C763(0.86); C843(0.93); C844(0.93)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C234(1.00); C763(0.63); C843(0.90); C844(0.94)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C234(0.97); C763(0.81); C843(1.23); C844(1.94)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C234(1.12); C763(0.46); C843(1.15); C844(1.62)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C234(0.80); C402(1.09); C560(1.01); C716(1.17)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C306(1.00); C308(1.29); C763(0.70); C843(1.00)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C234(0.54); C763(0.40); C843(1.37); C844(1.26)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C306(1.81); C308(1.81); C763(1.18)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C306(2.03); C308(2.03); C763(1.58)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C306(1.66); C308(1.66); C763(1.07)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C306(1.06); C308(1.06)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional regulator ERG (ERG) ETS family P11308
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H3.1t (H3-4) Histone H3 family Q16695
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805

The Drug(s) Related To This Target

Patented
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Disulfiram Analog 1 Small molecular drug D05PXW
Disulfiram Analog 2 Small molecular drug D0JQ9Z
Heteroaryl-cyclopropylamine Derivative 4 Small molecular drug D01CIK
Hydroxamate Analog 1 Small molecular drug D0MJ4L
N-(2-phenylcyclopropyl) Amino Acid Derivative 1 Small molecular drug D0UL9U
Pmid25468267-compound-46 Small molecular drug D09NCT
Pmid27019002-compound-21b Small molecular drug D07MQD
Pmid27019002-compound-21c Small molecular drug D0UE4K
Selenium Compound 1 Small molecular drug D0X2AU
Selenium Compound 2 Small molecular drug D09YFD
Selenium Compound 3 Small molecular drug D0X6SJ

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402