Details of the Target

General Information of Target

Target ID LDTP00899
Target Name Exostosin-like 3 (EXTL3)
Gene Name EXTL3
Gene ID 2137
Synonyms
EXTL1L; EXTR1; KIAA0519; Exostosin-like 3; EC 2.4.1.223; EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFPLIAHYYLTTLDEADEA
GKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKIEACKKS
IENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLH
NCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANVYVTENADIACLYVI
LVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQ
STFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIESLRSSLQEA
RSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGERED
RLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWNE
AALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTRIQI
PAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFTLTVTDF
YRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPR
EQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRT
EKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI
PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLV
SHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVD
SVLFKTRLPHDKTKCFKFI
Target Bioclass
Enzyme
Family
Glycosyltransferase 47 family
Subcellular location
Endoplasmic reticulum membrane
Function
Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion.; Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REGA through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REGA and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death.
Uniprot ID
O43909
Ensemble ID
ENST00000220562.9
HGNC ID
HGNC:3518

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C74(20.00)  LDD2227  [1]
DBIA
 Probe Info  		C83(1.22)  LDD0080  [2]
IA-alkyne
 Probe Info  		C879(0.00); C83(0.00)  LDD0165  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C289
 Probe Info  		25.11  LDD1959  [4]
C407
 Probe Info  		11.24  LDD2064  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C83(1.11); C74(1.01)  LDD1507  [5]
 LDCM0215  AC10 HCT 116 C83(1.11)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C83(0.91)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C83(1.00)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C83(0.98)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C83(1.22)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C83(1.01)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C83(0.95)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C83(1.16)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C83(0.75)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C83(0.73)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C83(0.80)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C83(1.22)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C83(0.79)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C83(0.70)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C83(0.73)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C83(1.13)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C83(0.86)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C83(0.80)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C83(0.97)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C83(0.87)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C83(1.09)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C83(0.95)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C83(1.12)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C83(0.89)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C83(1.00)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C83(0.93)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C83(0.91)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C83(1.14)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C83(1.12)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C83(1.19)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C83(1.15)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C83(0.95)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C83(0.85)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C83(0.79)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C83(1.02)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C83(1.01)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C83(0.87)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C83(1.23)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C83(1.00)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C83(1.31)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C83(0.82)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C83(0.88)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C83(0.78)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C83(1.44)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C83(1.18)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C83(0.97)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C83(0.89)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C83(1.04)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C83(1.00); C74(1.08)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C83(1.03); C74(1.10)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C879(0.91); C83(1.44); C74(1.22)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C83(0.96); C74(1.03)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C879(0.97); C83(1.03); C74(1.07)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C74(0.98)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C83(0.90); C74(0.80)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C74(1.00)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C83(1.07); C74(0.97)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C83(1.05)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C83(0.86)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C83(0.98)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C83(0.75)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C83(0.79)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C879(1.25); C83(1.14); C74(1.02)  LDD1529  [5]
 LDCM0291  AC30 HCT 116 C83(0.99)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C83(0.78)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C83(0.83)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C83(0.93)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C83(1.01)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C83(1.04)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C83(0.99)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C83(1.15)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C83(1.07)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C83(1.00)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C879(1.13); C83(0.94); C74(1.13)  LDD1540  [5]
 LDCM0302  AC40 HCT 116 C83(1.05)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C83(1.02)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C83(0.98)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C83(1.08)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C83(1.09)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C83(1.10)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C83(1.09); C74(0.98)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C74(1.11)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C83(1.04); C74(0.90)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C83(1.04); C74(1.05)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C74(1.06)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C83(1.07); C74(1.10)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C879(0.87); C83(1.09); C74(1.01)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C879(1.12); C83(1.00); C74(0.98)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C74(0.99)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C83(1.12); C74(0.84)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C74(0.94)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C83(1.05); C74(1.04)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C83(0.88)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C83(1.16)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C83(1.01)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C83(1.19)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C83(0.43)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C83(0.95)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C83(1.28)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C83(1.35)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C83(1.17)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C83(1.12)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C83(1.12)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C83(1.10)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C83(0.82)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C83(0.75)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C83(1.10)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C83(0.87)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C83(0.78)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C83(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C83(1.02)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C83(0.85)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C83(1.03)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C83(0.93)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C83(0.81)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C83(0.79)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C83(0.83)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C83(1.01)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C83(0.82)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C83(0.82)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C83(0.90)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C83(1.64)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C83(2.00)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C83(1.52)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C83(1.49)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C83(1.56)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C83(1.40)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C83(1.87)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C83(1.41)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C83(1.54)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C83(2.06)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C83(1.62)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C83(1.55)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C83(1.96)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C83(1.25)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C83(1.55)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C83(1.24)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C83(1.02)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C83(1.14)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C83(1.16)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C83(1.09)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C74(20.00)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C83(0.93)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C83(1.11)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C83(0.95); C74(1.01)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C83(0.88)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C83(0.85)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C83(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C83(1.16)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C83(0.97); C74(1.05)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C83(1.06); C74(1.12)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C83(1.18); C74(0.99)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C83(1.03); C74(1.12)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C83(0.90); C74(1.06)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C83(0.67)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C83(1.06); C74(1.15)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C83(1.45); C74(1.04)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C83(0.77)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C83(0.80)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C83(0.75)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C83(0.85)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C83(0.86)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C83(1.01)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C83(0.72)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C83(0.95)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C83(0.73)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C83(1.03)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C83(0.93); C74(1.00)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C83(0.90); C74(1.12)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C83(1.11); C74(1.14)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C83(1.06); C74(1.12)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C83(0.78)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C83(0.68)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C83(1.10)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C83(0.92)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C83(0.85)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C83(0.83)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C83(0.93)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C83(1.08)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C83(0.95)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C83(1.06)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C83(1.17)  LDD1004  [2]
 LDCM0407  CL2 HCT 116 C83(0.83)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C83(1.10)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C83(0.84)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C83(0.91)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C83(0.97)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C83(0.93)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C83(1.00)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C83(1.00)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C83(1.07)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C83(1.15)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C83(1.07)  LDD1015  [2]
 LDCM0418  CL3 HCT 116 C83(0.73)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C83(1.06)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C879(0.78); C83(1.06); C74(1.08)  LDD1624  [5]
 LDCM0421  CL32 HCT 116 C83(0.99)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C83(0.85)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C83(0.97)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C83(0.98)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C83(1.17)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C83(1.18)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C83(0.99)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C83(0.77)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C83(0.97)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C83(1.03)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C83(1.14)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C83(1.09)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C83(1.17)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C83(1.00)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C83(0.95)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C83(1.07)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C83(0.98)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C83(0.91)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C83(1.07)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C83(1.05)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C83(1.02)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C83(1.26)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C83(0.82)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C83(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C83(0.83)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C83(0.96)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C83(0.92)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C83(1.11)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C83(1.01)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C83(0.88)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C83(1.21)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C83(1.20)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C83(1.26)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C83(1.16)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C83(1.20)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C83(0.89)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C83(0.96)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C83(1.12)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C83(1.02)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C83(1.29)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C83(1.07)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C83(1.09)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C83(1.14)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C83(1.23)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C83(1.04)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C83(1.16)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C83(0.88)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C83(0.84)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C83(0.87)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C83(0.93)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C83(1.07)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C83(0.99)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C83(0.96)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C83(0.88)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C83(0.86)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C83(0.86)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C83(0.85)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C83(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C83(0.97)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C83(0.81)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C83(0.87)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C83(1.08)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C83(0.84)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C879(1.05); C83(1.31); C74(1.07)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C879(1.14); C83(1.01); C74(1.79)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C74(1.23)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C83(1.11); C74(0.95)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C74(1.61)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C83(1.07); C74(1.06)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C83(0.92); C74(1.18)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C83(1.10); C74(1.00)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C83(1.19); C74(1.04)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C83(1.06); C74(1.06)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C83(1.21)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C83(1.04)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C83(1.22)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C83(1.64)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C83(1.33)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402