Details of the Target

General Information of Target

Target ID LDTP00825
Target Name Cytoplasmic protein NCK2 (NCK2)
Gene Name NCK2
Gene ID 8440
Synonyms
GRB4; Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKN
SLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKF
AYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFL
SLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNA
RGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN
ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYK
KAPIFTSEHGEKLYLVRALQ
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Uniprot ID
O43639
Ensemble ID
ENST00000233154.9
HGNC ID
HGNC:7665

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y251(1.21); Y50(1.42)  LDD0264  [1]
DBIA
 Probe Info  		C144(1.08); C297(1.10)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C297(0.00); C343(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C144(0.00); C297(0.00); C343(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C297(0.00); C343(0.00)  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C144(1.08); C297(1.10)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C144(1.20); C297(1.01)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C144(1.17)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C144(1.10)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C144(1.04)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C144(1.30)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C144(0.98)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C144(1.29)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C144(1.32)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C144(1.19)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C144(1.01)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C144(0.85)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C144(1.05); C297(1.17)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C144(1.02)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C144(0.96)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C144(1.03)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C144(0.94); C297(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C144(1.09); C297(1.15)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C144(1.18); C297(1.29)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C144(1.01); C297(1.50)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C144(1.16); C297(1.16)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C144(1.05); C297(1.10)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C144(1.16); C297(1.26)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C144(0.99); C297(1.32)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C144(1.01); C297(1.31)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C144(1.20); C297(1.12)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C144(1.07); C297(1.37)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C144(0.97); C297(1.12)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C144(1.18); C297(1.00)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C144(1.02); C297(1.16)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C144(0.96); C297(1.21)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C144(0.99); C297(1.32)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C144(1.52); C297(0.88)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C144(1.21); C297(0.95)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C144(1.55); C297(0.94)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C144(1.13); C297(0.98)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C144(1.38); C297(1.14)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C144(1.50); C297(1.15)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C144(1.63); C297(1.22)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C144(1.71); C297(1.06)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C144(1.27); C297(1.09)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C144(1.20); C297(1.00)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C144(1.75); C297(1.24)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C144(1.54); C297(1.35)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C144(0.93); C297(1.13)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C144(1.85); C297(1.61)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C144(1.65); C297(1.41)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C144(1.35); C297(1.20)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C297(1.12); C144(1.17)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C144(1.10); C297(1.11)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C144(1.04); C297(1.16)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C297(1.02); C144(1.38)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C144(0.91); C297(1.24)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C297(0.94); C144(2.90)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C297(1.52); C144(1.94)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C144(1.04); C297(1.25)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C144(1.14); C297(1.23)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C144(1.00); C297(1.34)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C297(1.03); C144(1.10)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C297(1.32); C144(1.73)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C144(0.85); C297(1.21)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C144(1.12); C297(1.41)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C144(1.20); C297(1.19)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C144(1.11); C297(1.12)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C297(1.03); C144(1.13)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C144(1.16); C297(1.59)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C297(1.10); C144(1.18)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C297(1.11); C144(1.29)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C144(1.08); C297(1.10)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C297(1.00); C144(1.01)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C297(1.01); C144(1.02)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C144(0.99); C297(1.05)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C297(0.99); C144(1.02)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C297(1.06); C144(1.26)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C297(1.19); C144(1.53)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C297(1.18); C144(1.44)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C297(1.18); C144(1.28)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C297(1.08); C144(1.43)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C297(1.03); C144(1.26)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C297(1.25); C144(1.45)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C297(1.20); C144(1.53)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C297(1.26); C144(1.79)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C297(1.33); C144(1.55)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C144(1.37); C297(1.39)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C297(0.83); C144(0.86)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C144(0.95); C297(0.98)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C144(0.96); C297(1.01)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C144(0.93); C297(0.97)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C144(0.97); C297(1.17)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C297(1.17); C144(1.31)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C144(1.08); C297(1.18)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C297(1.02); C144(1.06)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C144(1.11); C297(1.20)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C144(1.09); C297(1.14)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C297(1.14); C144(1.21)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C297(1.12); C144(1.20)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C297(1.09); C144(1.29)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C297(1.08); C144(1.22)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C297(1.14); C144(1.36)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C297(1.31); C144(1.50)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C297(1.20); C144(1.30)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C297(1.20); C144(1.51)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C297(0.99); C144(1.12)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C297(1.12); C144(1.31)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C297(1.05); C144(1.11)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C297(1.11); C144(1.23)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C297(1.28); C144(1.36)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C297(1.38); C144(1.77)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C144(1.47); C297(1.52)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C297(1.30); C144(1.68)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C144(1.59); C297(1.61)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C144(1.07); C297(1.07)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C297(1.47); C144(1.61)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C297(1.37); C144(1.57)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C297(1.39); C144(1.92)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C297(1.42); C144(1.49)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C297(1.56); C144(1.71)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C297(1.62); C144(2.04)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C297(1.55); C144(2.01)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C297(1.65); C144(2.33)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C144(0.82); C297(0.97)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C297(0.78); C144(0.93)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C144(1.12); C297(1.13)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C297(1.02); C144(1.13)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C144(0.73); C297(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C297(1.09); C144(1.14)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C297(1.01); C144(1.10)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C144(0.82); C297(0.82)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C297(0.90); C144(1.03)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C297(0.94); C144(0.96)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C297(0.87); C144(0.87)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C297(0.94); C144(0.95)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C144(1.04); C297(1.10)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C297(1.10); C144(1.20)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C297(0.82); C144(0.95)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C144(0.88); C297(0.99)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C144(0.89); C297(0.92)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C297(1.21); C144(1.49)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C297(1.24); C144(1.32)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C144(1.08); C297(1.28)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C297(1.18); C144(1.21)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C144(1.02); C297(1.42)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C144(1.10); C297(1.25)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C297(1.28); C144(1.32)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C144(1.09); C297(1.32)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C297(1.08); C144(1.54)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C297(1.23); C144(1.41)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C144(0.97); C297(1.27)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C144(0.89); C297(1.11)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C144(1.09); C297(1.16)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C297(1.16); C144(1.34)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C144(1.19); C297(1.34)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C144(1.45)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C144(0.97)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C144(1.07); C297(1.26)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C144(1.12); C297(1.41)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C297(1.04); C144(1.24)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C297(0.82); C144(0.85)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C297(1.17); C144(1.39)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C297(1.12); C144(1.25)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C297(0.91); C144(0.97)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C144(0.86); C297(0.93)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C144(0.98); C297(1.15)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C297(1.04); C144(1.13)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C297(1.24); C144(1.25)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C144(1.50); C297(1.54)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C297(1.40); C144(1.59)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C144(1.38); C297(1.48)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C297(1.12); C144(1.20)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C144(1.28); C297(1.74)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C297(1.26); C144(1.34)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C297(1.19); C144(1.23)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C297(1.06); C144(1.12)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C297(1.24); C144(1.39)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C297(0.95); C144(1.38)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C297(1.18); C144(1.26)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C297(1.28); C144(1.45)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C144(1.13); C297(1.57)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C297(1.07); C144(1.08)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C144(0.99); C297(1.16)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C144(1.54); C297(1.87)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C297(1.07); C144(1.08)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C144(1.10); C297(1.15)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C297(1.22); C144(1.28)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C297(1.08); C144(1.10)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C297(1.16); C144(1.45)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C297(1.13); C144(1.20)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C144(1.10); C297(1.12)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C297(1.22); C144(1.30)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C297(1.35); C144(1.53)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C144(1.20); C297(1.27)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C144(1.09); C297(1.18)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C297(0.99); C144(1.24)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C297(1.10); C144(1.25)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C297(1.04); C144(1.11)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C297(1.14); C144(1.28)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C297(0.89); C144(1.22)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C297(0.91); C144(0.93)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C297(0.99); C144(1.31)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C297(0.89); C144(1.11)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C297(1.06); C144(1.18)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C297(1.09); C144(1.21)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C297(1.11); C144(1.33)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C144(1.16); C297(1.28)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C144(1.17); C297(1.18)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C144(1.15); C297(1.07)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C144(1.26); C297(1.19)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C144(1.32); C297(0.94)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C144(1.01); C297(0.81)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C144(1.15); C297(1.05)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C144(1.02); C297(0.92)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C144(1.20); C297(1.04)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C144(1.16); C297(0.90)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C144(1.20); C297(1.07)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C144(1.38); C297(1.23)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C144(1.06); C297(0.97)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C144(1.28); C297(1.03)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C144(1.19); C297(1.01)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C144(0.98); C297(0.85)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C144(1.15); C297(0.91)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C144(0.93); C297(0.94)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C144(1.03); C297(0.88)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C144(1.16); C297(0.90)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C144(1.37); C297(1.10)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C144(1.38); C297(0.96)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C144(1.01); C297(1.15)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C144(1.08); C297(1.11)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C144(1.16); C297(1.08)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C144(1.01); C297(0.99)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C144(1.06); C297(1.00)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C144(0.96); C297(1.03)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C144(1.08); C297(1.05)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C144(1.03); C297(1.20)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C144(0.95); C297(0.97)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C144(0.98); C297(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C144(1.00); C297(0.99)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C144(1.01); C297(0.96)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C144(0.91); C297(0.97)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C144(1.00); C297(1.01)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C144(1.04); C297(0.95)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C144(1.04); C297(1.22)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C144(1.04); C297(0.97)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C144(1.14); C297(1.07)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C144(1.12); C297(1.01)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C144(0.98); C297(1.10)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C144(1.01); C297(1.11)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C144(0.95); C297(1.04)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C144(1.25); C297(1.48)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C144(0.86); C297(1.24)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C144(1.05); C297(1.17)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C144(1.05); C297(1.02)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C144(1.14); C297(1.25)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C144(1.16); C297(1.08)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C144(1.08); C297(1.14)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C144(1.10); C297(1.00)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C144(0.90); C297(1.12)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C144(0.95); C297(1.14)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C144(1.19); C297(1.14)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C144(0.99); C297(1.01)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C144(1.38); C297(1.08)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C144(1.38); C297(1.24)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C144(1.38); C297(1.32)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C144(1.03); C297(1.02)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C144(1.19); C297(1.04)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C144(1.65); C297(1.56)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C144(1.57); C297(1.34)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C144(1.90); C297(1.42)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C144(1.32); C297(1.15)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C144(1.08); C297(1.05)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C144(1.28); C297(1.18)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C144(1.49); C297(1.43)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C144(1.90); C297(1.74)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C144(1.16); C297(1.05)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C144(0.92); C297(0.89)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C144(1.11); C297(1.11)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C144(0.97); C297(1.00)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C144(1.14); C297(0.99)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C144(1.13); C297(1.11)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C144(1.13); C297(1.06)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C144(1.16); C297(1.13)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C144(1.17); C297(1.07)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C144(1.25); C297(1.20)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C144(1.24); C297(1.16)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C297(0.94); C144(1.06)  LDD1698  [7]
 LDCM0625  F8 Ramos C297(1.54)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C297(1.01)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C297(2.53)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C297(0.57); C144(0.65)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C297(0.80); C144(1.13)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C297(0.73)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C297(0.49); C144(1.10)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C297(0.75); C144(0.94)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C297(0.78); C144(1.10)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C297(1.07); C144(1.13)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C297(0.91); C144(0.59)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C297(0.98); C144(1.77)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C297(0.64); C144(1.10)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C297(0.92); C144(0.86)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C144(1.29); C297(1.05)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C297(0.85); C144(0.80)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C297(0.67); C144(0.77)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C144(1.05); C297(0.87)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C297(0.85)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C297(2.15)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C297(0.83); C144(0.76)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C297(0.62)  LDD2188  [8]
 LDCM0116  HHS-0101 DM93 Y251(1.21); Y50(1.42)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y251(0.89); Y50(1.37)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y251(0.44); Y50(1.13)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y251(1.06); Y50(1.43)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y50(0.87); Y251(1.51)  LDD0268  [1]
 LDCM0022  KB02 HEK-293T C297(1.02); C144(0.98); C343(1.04)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C297(0.99); C144(1.07); C343(1.17)  LDD1497  [7]
 LDCM0024  KB05 G361 C297(0.95)  LDD3311  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C297(0.75)  LDD2207  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Valine--tRNA ligase, mitochondrial (VARS2) Class-I aminoacyl-tRNA synthetase family Q5ST30
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Epithelial discoidin domain-containing receptor 1 (DDR1) Tyr protein kinase family Q08345
Tyrosine-protein kinase Srms (SRMS) Tyr protein kinase family Q9H3Y6
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Protein phosphatase Slingshot homolog 3 (SSH3) Protein-tyrosine phosphatase family Q8TE77
Rho-related GTP-binding protein RhoU (RHOU) Rho family Q7L0Q8
Rho-related GTP-binding protein RhoV (RHOV) Rho family Q96L33
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transport and Golgi organization protein 1 homolog (MIA3) MIA/OTOR family Q5JRA6
Calcium and integrin-binding protein 1 (CIB1) . Q99828
T-cell surface glycoprotein CD3 epsilon chain (CD3E) . P07766
Transcription factor
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D8 (HOXD8) Antp homeobox family P13378
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Protein FosB (FOSB) BZIP family P53539
One cut domain family member 3 (ONECUT3) CUT homeobox family O60422
Zinc finger protein 341 (ZNF341) Krueppel C2H2-type zinc-finger protein family Q9BYN7
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Steroidogenic factor 1 (NR5A1) Nuclear hormone receptor family Q13285
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Zinc finger C2HC domain-containing protein 1A (ZC2HC1A) ZC2HC1 family Q96GY0
Zinc finger C2HC domain-containing protein 1B (ZC2HC1B) ZC2HC1 family Q5TFG8
Basic helix-loop-helix transcription factor scleraxis (SCX) . Q7RTU7
Homeobox protein MOX-2 (MEOX2) . P50222
Max-binding protein MNT (MNT) . Q99583
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Neuronal PAS domain-containing protein 2 (NPAS2) . Q99743
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Zinc finger and BTB domain-containing protein 12 (ZBTB12) . Q9Y330
Zinc finger and BTB domain-containing protein 7B (ZBTB7B) . O15156
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fc receptor-like protein 2 (FCRL2) . Q96LA5
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Other
Click To Hide/Show 70 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Abl interactor 2 (ABI2) ABI family Q9NYB9
Beta-defensin 124 (DEFB124) Beta-defensin family Q8NES8
Protein BTG1 (BTG1) BTG family P62324
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372
Ephrin-B2 (EFNB2) Ephrin family P52799
Protein FAM124A (FAM124A) FAM124 family Q86V42
Protein FAM47A (FAM47A) FAM47 family Q5JRC9
Protein FAM53C (FAM53C) FAM53 family Q9NYF3
Protein FAM83A (FAM83A) FAM83 family Q86UY5
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
GRB2-associated and regulator of MAPK protein 1 (GAREM1) GAREM family Q9H706
Protein INCA1 (INCA1) INCA family Q0VD86
Integrator complex subunit 2 (INTS2) Integrator subunit 2 family Q9H0H0
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Negative elongation factor A (NELFA) NELF-A family Q9H3P2
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) RRM CPSF6/7 family Q8N684
Actin-binding protein WASF1 (WASF1) SCAR/WAVE family Q92558
Sex comb on midleg-like protein 2 (SCML2) SCM family Q9UQR0
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
26S proteasome non-ATPase regulatory subunit 10 (PSMD10) . O75832
Actin nucleation-promoting factor WAS (WAS) . P42768
Actin nucleation-promoting factor WASL (WASL) . O00401
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
Beta-chimaerin (CHN2) . P52757
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
C-type lectin domain family 17, member A (CLEC17A) . Q6ZS10
CLOCK-interacting pacemaker (CIPC) . Q9C0C6
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
CUE domain-containing protein 1 (CUEDC1) . Q9NWM3
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
FYN-binding protein 1 (FYB1) . O15117
Gametogenetin (GGN) . Q86UU5
Heat shock factor 2-binding protein (HSF2BP) . O75031
Kelch-like protein 24 (KLHL24) . Q6TFL4
Kelch-like protein 35 (KLHL35) . Q6PF15
Keratinocyte proline-rich protein (KPRP) . Q5T749
Leucine-rich repeat and IQ domain-containing protein 3 (LRRIQ3) . A6PVS8
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) . P48059
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
Melanoma-associated antigen 6 (MAGEA6) . P43360
Methyl-CpG-binding domain protein 6 (MBD6) . Q96DN6
N-chimaerin (CHN1) . P15882
Neuroepithelial cell-transforming gene 1 protein (NET1) . Q7Z628
Protein Largen (PRR16) . Q569H4
Ras association domain-containing protein 7 (RASSF7) . Q02833
Ras/Rap GTPase-activating protein SynGAP (SYNGAP1) . Q96PV0
RBBP8 N-terminal-like protein (RBBP8NL) . Q8NC74
Reticulon-4 (RTN4) . Q9NQC3
RNA-binding protein 26 (RBM26) . Q5T8P6
SH2 domain-containing adapter protein D (SHD) . Q96IW2
Sorbin and SH3 domain-containing protein 2 (SORBS2) . O94875
Suppressor of cytokine signaling 7 (SOCS7) . O14512
Uncharacterized protein C4orf17 (C4orf17) . Q53FE4
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.