Details of the Target

General Information of Target

Target ID LDTP00775
Target Name Protein Mis18-beta (OIP5)
Gene Name OIP5
Gene ID 11339
Synonyms
MIS18B; Protein Mis18-beta; Cancer/testis antigen 86; CT86; Opa-interacting protein 5; OIP-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEP
AAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFL
VGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIV
NASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN
Target Bioclass
Other
Family
Mis18 family
Subcellular location
Nucleus
Function Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Uniprot ID
O43482
Ensemble ID
ENST00000220514.8
HGNC ID
HGNC:20300

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C163(0.80)  LDD2109  [1]
DBIA
 Probe Info  		C171(0.85); C21(0.84)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		14.10  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		11.31  LDD1766  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C171(0.85); C21(0.84)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C171(0.87); C21(0.98)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C171(0.87)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C171(0.83)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C171(1.05)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C171(0.86)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C171(0.82)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C171(0.86)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C171(0.77)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C171(0.83)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C171(0.86)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C171(0.87)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C171(0.82); C21(1.04)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C171(0.84)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C171(0.93)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C171(0.84)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C171(0.92)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C171(0.99)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C171(1.01)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C171(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C171(0.90)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C171(0.99)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C171(1.01)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C171(0.87); C21(0.98)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C171(1.23)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C171(1.01)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C171(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C171(1.03)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C171(1.04)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C171(1.09)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C171(1.08)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C171(1.05)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C171(1.33); C21(1.32)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C171(1.06); C21(0.77)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C171(0.99); C21(1.11)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C171(1.19); C21(0.92)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C171(1.01); C21(0.85)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C171(1.07); C21(0.93)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C171(1.15); C21(1.05)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C171(1.07); C21(1.03)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C171(1.04); C21(1.07)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C171(0.98); C21(0.87)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C171(1.27); C21(0.79)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C171(1.05); C21(1.06)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C171(1.03); C21(0.96)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C171(1.17); C21(1.01)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C171(1.18); C21(0.86)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C171(1.06); C21(0.75)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C21(1.13)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C21(0.84)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C21(0.84)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C21(0.97)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C21(0.96)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C21(1.33)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C21(1.17)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C21(0.88); C171(1.06)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C21(0.98)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C21(0.78)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C21(0.92)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C21(0.98)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C21(0.91)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C21(0.80)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C21(0.95)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C21(0.87)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C21(0.80); C171(0.94)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C21(0.97); C171(1.15)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C21(0.81); C171(0.99)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C171(0.70); C21(0.94)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C21(0.57); C171(1.02)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C171(1.00); C21(1.74)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C21(0.97); C171(1.02)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C21(0.74); C171(0.97)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C171(1.04); C21(1.19)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C171(1.00); C21(1.16)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C171(0.79); C21(1.19)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C171(0.88); C21(1.17)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C171(0.85); C21(1.30)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C171(0.98); C21(1.20)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C171(0.80); C21(0.91)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C171(1.06); C21(1.12)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C171(0.88); C21(1.25)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C171(0.87); C21(1.46)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C171(1.04); C21(1.62)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C171(1.57); C21(1.81)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C171(0.79)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C171(0.75)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C171(0.76)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C171(0.81)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C171(0.67)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C171(0.75); C21(0.99)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C171(0.79)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C171(1.14)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C171(1.24)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C171(1.13)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C171(1.12)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C171(0.92)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C171(0.82); C21(1.16)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C171(0.87); C21(1.05)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C171(0.91); C21(1.14)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C171(0.91); C21(1.30)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C171(0.87); C21(0.90)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C21(0.87); C171(1.01)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C171(1.05); C21(1.66)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C171(0.98); C21(1.25)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C171(0.98); C21(1.17)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C171(1.00); C21(1.26)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C171(0.80); C21(1.74)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C171(1.07); C21(1.93)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C171(0.75)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C171(1.10)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C171(0.85)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C171(0.94); C21(1.15)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C171(0.75)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C171(0.86)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C171(0.68)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C171(0.70)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C171(0.73)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C171(0.65)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C171(0.83)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C171(0.71)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C171(1.20)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C171(1.25)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C21(0.84); C171(0.90)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C171(0.93)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C171(1.19)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C171(0.92)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C171(0.89)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C171(1.07)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C171(0.91)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C171(0.94)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C171(1.16)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C171(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C171(0.98)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C21(0.95); C171(0.98)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C171(1.03)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C171(1.04)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C171(1.05)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C171(1.11)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C171(0.97)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C171(0.85)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C171(1.17)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C171(1.09)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C171(1.04)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C171(1.04)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C171(0.93)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C171(1.03)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C171(0.95)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C171(0.88)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C171(0.89)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C171(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C171(0.77)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C171(0.96)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C171(0.83)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C171(0.76)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C171(0.90); C21(1.07)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C171(0.85); C21(1.13)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C171(1.02); C21(1.27)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C21(1.04)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C171(0.98)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C171(1.13)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C171(0.74); C21(1.03)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C171(1.04); C21(1.11)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C21(0.97); C171(1.07)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C21(0.85); C171(0.92)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C21(0.91); C171(1.00)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C171(0.98); C21(1.04)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C21(0.70); C171(1.13)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C21(0.99); C171(1.00)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C171(1.06); C21(1.40)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C171(0.93); C21(1.48)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C171(1.00)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C21(0.76); C171(0.98)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C171(0.90); C21(1.03)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C171(0.97); C21(1.16)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C171(1.13); C21(1.25)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C21(1.07); C171(1.25)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C171(1.16); C21(1.32)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C171(1.06); C21(1.31)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C171(1.13)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C171(0.88)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C171(0.80)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C171(1.22)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C171(0.84)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C171(0.91); C21(1.41)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C171(1.07); C21(1.23)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C171(1.10); C21(1.78)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C171(0.85); C21(3.12)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C171(0.75)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C171(1.09)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C171(0.74)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C171(0.78)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C171(1.17)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C171(1.08)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C171(1.07)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C171(0.88); C21(1.09)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C21(0.81); C171(0.90)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C171(0.85); C21(1.06)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C21(0.96); C171(0.98)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C171(0.96)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C171(0.85); C21(0.97)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C171(0.83); C21(0.95)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C21(0.95); C171(1.53)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C21(0.99); C171(1.09)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C171(0.82); C21(1.23)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C171(0.81); C21(1.31)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C171(0.90); C21(1.13)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C171(0.85); C21(1.14)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C171(0.77); C21(1.22)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C171(0.96); C21(1.09)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C171(1.01)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C171(0.99); C21(0.98)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C171(0.98); C21(0.93)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C171(1.01); C21(1.38)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C171(1.18); C21(0.99)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C171(1.47); C21(1.30)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C171(0.72); C21(1.53)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C171(2.11); C21(1.35)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C171(0.95); C21(1.24)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C171(0.86); C21(0.97)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C171(1.05)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C171(1.02); C21(1.15)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C171(1.77); C21(1.19)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C171(2.07); C21(1.43)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C171(1.30); C21(1.21)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C171(0.85); C21(1.50)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C171(0.85); C21(1.60)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C171(0.85); C21(1.00)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C171(0.91); C21(1.14)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C171(0.90); C21(0.96)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C171(0.94); C21(1.05)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C171(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C171(0.85); C21(1.12)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C171(0.82); C21(1.15)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C171(0.81); C21(1.05)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C171(1.48); C21(0.98)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C171(0.92); C21(1.47)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C171(0.92); C21(0.99)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C171(1.13); C21(1.19)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C171(1.12); C21(0.79)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C171(0.97); C21(1.10)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C171(0.94); C21(1.03)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C171(0.87)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C171(0.89); C21(1.06)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C171(0.93); C21(0.63)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C171(0.89); C21(1.09)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C171(0.87); C21(0.73)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C171(0.91); C21(0.77)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C171(0.96); C21(0.73)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C171(0.97); C21(0.83)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C171(1.14); C21(0.93)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C171(1.26); C21(0.67)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C171(1.00); C21(0.80)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C171(1.01)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C171(1.06); C21(1.33)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C171(0.95); C21(0.81)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C171(0.97); C21(0.82)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C171(1.17); C21(1.00)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C171(1.10); C21(1.04)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C171(1.16); C21(1.37)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C171(1.53); C21(0.88)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C171(1.05); C21(1.45)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C171(0.94); C21(1.85)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C171(1.29)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C171(1.04); C21(1.35)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C171(1.01); C21(1.27)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C171(1.16); C21(1.88)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C171(1.00); C21(1.26)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C171(1.03); C21(1.96)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C171(1.09); C21(1.12)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C171(1.43); C21(0.98)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C171(1.08); C21(1.09)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C171(1.55); C21(1.45)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C171(1.21); C21(1.84)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C171(1.15)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C171(1.66); C21(1.04)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C171(1.20); C21(0.95)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C171(0.95); C21(0.86)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C171(0.83); C21(0.98)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C171(0.75); C21(1.37)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C171(0.68); C21(1.07)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C171(0.86); C21(1.30)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C171(0.80); C21(0.95)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C171(0.67); C21(0.87)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C171(0.77); C21(1.03)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C171(0.84); C163(1.26)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C171(1.02); C21(0.82)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C171(1.07); C21(1.21)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C21(0.97); C171(1.09)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C21(1.03); C171(1.00)  LDD1497  [6]
 LDCM0024  KB05 MOLM-13 C171(2.50)  LDD3333  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C163(0.80)  LDD2109  [1]
 LDCM0021  THZ1 HCT 116 C21(1.04)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB11-a (POLR2J) Archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family P52435
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Dual specificity protein phosphatase 21 (DUSP21) Protein-tyrosine phosphatase family Q9H596
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ras-related protein Rab-26 (RAB26) Rab family Q9ULW5
GTPase HRas (HRAS) Ras family P01112
GTP-binding protein GEM (GEM) RGK family P55040
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Ceramide kinase (CERK) . Q8TCT0
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B9 (HOXB9) Abd-B homeobox family P17482
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Other
Click To Hide/Show 73 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Acyl carrier protein, mitochondrial (NDUFAB1) Acyl carrier protein (ACP) family O14561
Protein BEX2 (BEX2) BEX family Q9BXY8
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cep170-like protein (CEP170P1) CEP170 family Q96L14
Dysbindin (DTNBP1) Dysbindin family Q96EV8
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Splicing factor ESS-2 homolog (ESS2) ESS2 family Q96DF8
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cuticular Hb1 (KRT81) Intermediate filament family Q14533
Keratin, type II cuticular Hb3 (KRT83) Intermediate filament family P78385
Keratin, type II cuticular Hb6 (KRT86) Intermediate filament family O43790
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Keratin, type II cytoskeletal 6B (KRT6B) Intermediate filament family P04259
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Phakinin (BFSP2) Intermediate filament family Q13515
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
Protein S100-Z (S100Z) S-100 family Q8WXG8
Ski-like protein (SKIL) SKI family P12757
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Tektin-3 (TEKT3) Tektin family Q9BXF9
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Tropomyosin alpha-3 chain (TPM3) Tropomyosin family P06753
YTH domain-containing family protein 1 (YTHDF1) YTHDF family Q9BYJ9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
APOBEC1 complementation factor (A1CF) . Q9NQ94
Ciliary microtubule inner protein 1 (CIMIP1) . Q9H1P6
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) . Q9Y6H1
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
G protein pathway suppressor 2 (GPS2) . Q13227
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Kelch-like protein 42 (KLHL42) . Q9P2K6
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Mis18-binding protein 1 (MIS18BP1) . Q6P0N0
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Proline-rich protein 35 (PRR35) . P0CG20
Rab effector MyRIP (MYRIP) . Q8NFW9
Small kinetochore-associated protein (KNSTRN) . Q9Y448
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Sterile alpha motif domain-containing protein 7 (SAMD7) . Q7Z3H4
Tastin (TROAP) . Q12815
Testis-expressed protein 12 (TEX12) . Q9BXU0
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) . Q9BV90
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Vinexin (SORBS3) . O60504

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840