Details of the Target

General Information of Target

Target ID LDTP00707
Target Name PHD finger protein 1 (PHF1)
Gene Name PHF1
Gene ID 5252
Synonyms
PCL1; PHD finger protein 1; Protein PHF1; hPHF1; Polycomb-like protein 1; hPCl1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREV
CLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHV
PRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGH
LSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGG
PEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGE
RSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGG
VSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPS
PSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIG
FPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGD
PVRVLARRVRPDGSVQYLVEWGGGGIF
Target Bioclass
Transcription factor
Family
Polycomblike family
Subcellular location
Nucleus
Function
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Uniprot ID
O43189
Ensemble ID
ENST00000374512.7
HGNC ID
HGNC:8919

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 Deletion: p.W75Ter DBIA    Probe Info 
CHL1 SNV: p.P155L DBIA    Probe Info 
DU145 Deletion: p.R6GfsTer2
SNV: .		 DBIA    Probe Info 
HCT116 SNV: p.P84S DBIA    Probe Info 
HCT15 SNV: p.G192D .
HEC1 SNV: p.V98M; p.R137C DBIA    Probe Info 
JURKAT SNV: p.P126L .
LS180 Deletion: p.R6GfsTer2; p.G240AfsTer137 DBIA    Probe Info 
MCC13 Substitution: p.P5L DBIA    Probe Info 
MOLT4 Deletion: p.P342LfsTer35
SNV: p.D67V		 .
SKMEL30 SNV: p.C139W DBIA    Probe Info 
T24 SNV: p.D274N DBIA    Probe Info 
YSCCC SNV: p.E321Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K109(0.55)  LDD0277  [1]
IA-alkyne
 Probe Info  		C327(3.33)  LDD0372  [2]
IPM
 Probe Info  		C518(2.11)  LDD1701  [3]
DBIA
 Probe Info  		C327(1.13)  LDD0078  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C327(3.33)  LDD0372  [2]
 LDCM0214  AC1 HCT 116 C327(1.32)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C327(1.16)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C189(0.38); C191(0.38); C327(1.17)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C189(0.44); C191(0.44); C327(1.04)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C189(0.39); C191(0.39); C327(0.97)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C189(0.26); C191(0.26); C327(1.04)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C189(0.30); C191(0.30); C327(1.04)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C189(0.26); C191(0.26); C327(1.07)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C189(0.22); C191(0.22); C327(1.23)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C189(0.39); C191(0.39); C327(1.05)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C189(0.34); C191(0.34); C327(1.03)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C189(0.36); C191(0.36); C327(0.98)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C327(1.25)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C189(0.34); C191(0.34); C327(1.09)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C189(0.35); C191(0.35); C327(1.13)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C189(0.33); C191(0.33); C327(1.09)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C189(1.36); C191(1.36); C327(1.03)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C189(0.85); C191(0.85); C327(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C189(0.56); C191(0.56); C327(0.98)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C189(0.54); C191(0.54); C327(1.03)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C189(1.09); C191(1.09); C327(0.92)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C189(0.96); C191(0.96); C327(1.06)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C189(0.80); C191(0.80); C327(1.02)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C327(1.06)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C189(0.81); C191(0.81); C327(1.04)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C189(0.92); C191(0.92); C327(0.89)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C189(1.33); C191(1.33); C327(0.96)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C189(1.06); C191(1.06); C327(0.84)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C189(1.23); C191(1.23); C327(0.97)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C189(0.97); C191(0.97); C327(0.93)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C189(0.55); C191(0.55); C327(1.08)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C189(0.66); C191(0.66); C327(1.05)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C327(0.77)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C327(0.89)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C327(0.98)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C327(0.87)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C327(1.15)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C327(1.15)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C327(0.96)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C327(0.95)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C327(1.07)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C327(1.02)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C327(1.06)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C327(1.31)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C327(1.15)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C327(1.22)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C327(1.31)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C327(1.27)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C327(1.13); C189(1.14); C191(1.14)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C327(1.09); C189(1.76); C191(1.76)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C327(0.96); C189(1.15); C191(1.15)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C327(1.04); C189(1.31); C191(1.31)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C189(0.95); C191(0.95); C327(1.10)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C327(0.99); C189(1.18); C191(1.18)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C189(0.88); C191(0.88); C327(1.16)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C327(1.20)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C189(1.06); C191(1.06); C327(1.32)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C189(1.13); C191(1.13); C327(1.36)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C327(0.97); C189(1.01); C191(1.01)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C327(0.96); C189(1.16); C191(1.16)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C189(1.32); C191(1.32); C327(0.97)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C189(1.28); C191(1.28); C327(1.23)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C189(1.08); C191(1.08); C327(1.01)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C189(1.25); C191(1.25); C327(0.96)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C235(0.71); C189(0.83); C191(0.83); C327(0.93)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C235(0.28); C189(0.77); C191(0.77); C327(1.12)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C235(0.55); C189(0.78); C191(0.78); C327(1.24)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C327(1.25)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C235(0.71); C327(0.87); C189(0.92); C191(0.92)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C235(0.56); C189(0.93); C191(0.93); C327(0.99)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C235(0.49); C189(0.86); C191(0.86); C327(1.15)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C235(0.46); C189(0.89); C191(0.89); C327(0.97)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C235(0.72); C189(0.93); C191(0.93); C327(1.08)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C189(0.97); C191(0.97); C327(0.97)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C189(0.83); C191(0.83); C327(1.32)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C189(0.69); C191(0.69); C327(1.36)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C189(0.71); C191(0.71); C327(1.45)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C189(0.73); C191(0.73); C327(1.41)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C327(1.27)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C189(0.69); C191(0.69); C327(1.51)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C189(0.73); C191(0.73); C327(1.28)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C189(0.51); C191(0.51); C327(1.75)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C189(0.51); C191(0.51); C327(1.37)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C189(0.53); C191(0.53); C327(1.12)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C327(0.72); C189(1.49); C191(1.49)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C327(0.66); C189(0.94); C191(0.94)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C327(0.72); C189(1.23); C191(1.23)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C327(0.79); C189(1.19); C191(1.19)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C327(0.82); C189(0.86); C191(0.86)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C327(1.53)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C327(0.84); C189(0.85); C191(0.85)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C327(0.74); C189(1.05); C191(1.05)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C327(0.81); C189(1.18); C191(1.18)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C327(0.76); C189(1.17); C191(1.17)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C327(0.74); C189(0.89); C191(0.89)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C327(0.83); C189(0.97); C191(0.97)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C327(1.41)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C327(1.46)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C327(1.43)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C327(1.20)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C327(1.46)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C327(1.64)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C327(1.08)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C327(1.05)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C327(1.14)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C327(1.41)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C327(1.37)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C327(1.19)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C235(0.71); C327(1.04)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C235(0.68); C327(1.12)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C235(0.60); C327(1.13)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C327(1.28)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C235(0.77); C327(1.42)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C235(1.03); C327(1.09)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C235(0.84); C327(1.40)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C235(0.62); C327(1.28)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C235(0.77); C327(1.27)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C235(0.76); C327(1.26)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C235(0.81); C327(0.96)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C235(0.95); C327(1.01)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C327(0.83); C189(1.53); C191(1.53)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C327(0.90); C189(1.36); C191(1.36)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C327(1.06)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C189(1.13); C191(1.13); C327(1.18)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C327(1.18); C189(1.24); C191(1.24)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C327(1.47); C189(1.48); C191(1.48)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C189(1.11); C191(1.11); C327(1.48)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C327(1.45); C189(2.06); C191(2.06)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C327(1.10); C189(1.34); C191(1.34)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C327(1.01); C189(1.21); C191(1.21)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C327(0.84); C189(1.35); C191(1.35)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C327(0.98); C189(1.09); C191(1.09)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C327(1.08); C189(1.18); C191(1.18)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C327(1.05)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C327(1.17); C189(1.22); C191(1.22)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C327(1.01); C189(1.41); C191(1.41)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C327(1.01); C189(1.46); C191(1.46)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C189(0.53); C191(0.53); C327(1.20)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C189(0.55); C191(0.55); C327(1.31)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C189(0.64); C191(0.64); C327(1.37)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C189(0.47); C191(0.47); C327(1.21)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C189(0.80); C191(0.80); C327(1.29)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C189(0.57); C191(0.57); C327(1.36)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C189(0.46); C191(0.46); C327(1.16)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C189(0.82); C191(0.82); C327(1.51)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C189(0.43); C191(0.43); C327(1.28)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C189(0.42); C191(0.42); C327(1.27)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C189(0.46); C191(0.46); C327(1.19)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C189(0.76); C191(0.76); C327(1.44)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C189(1.04); C191(1.04); C327(1.23)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C189(0.51); C191(0.51); C327(1.33)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C189(0.45); C191(0.45); C327(1.37)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C189(0.32); C191(0.32); C327(1.19)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C189(0.53); C191(0.53); C327(0.98)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C327(1.12)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C327(1.20)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C327(1.64)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C327(1.13)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C235(1.00); C327(1.02); C189(1.22); C191(1.22)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C189(0.66); C191(0.66); C235(1.05); C327(1.11)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C327(1.37)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C327(1.06)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C327(1.03)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C327(1.24)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C327(1.06)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C235(0.51); C189(0.77); C191(0.77); C327(1.01)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C235(0.33); C189(0.68); C191(0.68); C327(1.15)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C235(0.41); C189(0.49); C191(0.49); C327(1.39)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C235(0.37); C189(0.57); C191(0.57); C327(1.07)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C235(0.38); C189(0.70); C191(0.70); C327(1.07)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C189(0.69); C191(0.69); C235(0.77); C327(0.90)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C235(0.45); C189(0.59); C191(0.59); C327(0.89)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C235(0.47); C189(0.78); C191(0.78); C327(1.26)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C327(1.06); C189(1.08); C191(1.08)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C189(0.58); C191(0.58); C327(1.28)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C189(0.85); C191(0.85); C327(1.12)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C189(0.81); C191(0.81); C327(1.25)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C189(0.74); C191(0.74); C327(1.12)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C327(0.78); C189(1.52); C191(1.52)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C327(0.86); C189(1.03); C191(1.03)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C327(0.85); C189(1.00); C191(1.00)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C189(0.73); C191(0.73); C235(0.82); C327(1.14)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C327(0.86); C189(0.99); C191(0.99)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C327(1.18)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C327(0.94)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C327(1.09)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C327(1.47)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C327(1.08); C235(1.50)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C235(0.98); C327(1.21)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C235(0.82); C327(1.18)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C235(0.72); C327(1.04)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C189(0.79); C191(0.79); C327(1.06); C235(1.07)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C189(0.73); C191(0.73); C235(0.87); C327(1.32)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C327(0.85); C235(1.06); C189(1.07); C191(1.07)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C191(0.90); C189(0.96); C327(1.07)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C189(0.83); C327(0.88); C191(0.89)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C327(1.03); C191(1.13); C189(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C191(0.92); C189(1.09); C327(1.15)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C235(0.80); C327(0.83); C189(1.09); C191(1.09)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C189(0.49); C191(0.71); C327(1.17)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C191(0.69); C189(0.72); C327(1.19)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C189(0.67); C191(0.79); C327(1.41)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C189(0.41); C191(0.64); C327(1.17)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C189(0.65); C191(0.78); C327(1.20)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C189(0.51); C191(0.62); C327(1.27)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C189(0.58); C191(0.70); C327(1.07)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C189(0.52); C191(0.67); C327(1.27)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C189(0.71); C191(0.80); C327(1.34)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C189(0.66); C191(0.71); C327(1.24)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C189(0.90); C191(0.90); C235(0.80); C327(1.16)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C189(0.92); C191(0.91); C327(1.16)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C189(0.76); C191(0.85); C235(0.74); C327(1.16)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C189(0.89); C191(1.11); C235(0.85); C327(1.35)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C189(0.94); C191(0.87); C235(0.68); C327(1.10)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C189(0.80); C191(0.79); C235(0.68); C327(1.65)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C189(0.65); C191(0.68); C235(0.59); C327(1.57)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C189(0.81); C191(0.76); C235(0.58); C327(1.42)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C189(0.55); C191(0.67); C235(0.72); C327(1.80)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C189(0.67); C191(0.72); C235(0.65); C327(1.63)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C189(0.86); C191(0.86); C235(0.83); C327(1.10)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C189(0.56); C191(0.59); C235(0.59); C327(1.25)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C189(0.65); C191(0.75); C235(0.67); C327(1.59)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C189(0.74); C191(0.86); C235(0.80); C327(1.71)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C189(0.73); C191(0.88); C235(0.87); C327(1.52)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C189(0.88); C191(0.83); C235(0.66); C327(1.59)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C189(0.58); C191(0.66); C235(0.67); C327(1.66)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C189(1.07); C191(1.07); C327(1.07)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C189(1.10); C191(1.10); C327(1.04)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C189(1.15); C191(1.15); C327(1.09)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C189(0.82); C191(0.82); C327(1.10)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C189(0.78); C191(0.78); C235(1.01); C327(0.86)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C189(1.07); C191(1.07); C327(1.14)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C189(1.11); C191(1.11); C327(1.22)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C189(1.09); C191(1.09); C327(1.31)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C189(1.03); C191(1.03); C327(1.06)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C189(1.43); C191(1.43); C327(1.07)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C189(1.51); C191(1.51); C327(1.05)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C189(0.87); C191(0.87); C327(1.13)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C189(0.98); C191(0.98); C327(1.10)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C189(1.14); C191(1.14); C327(1.10)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C189(0.98); C191(0.98); C327(1.14)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C189(0.94); C191(0.94); C235(1.16); C327(1.02)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C189(0.92); C191(0.92); C327(1.28)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C189(0.81); C191(0.81); C327(1.16)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C189(0.80); C191(0.80); C327(1.11)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C189(0.63); C191(0.63); C327(0.98)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C189(0.56); C191(0.56); C327(1.10)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C189(0.76); C191(0.76); C327(1.10)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C189(0.55); C191(0.55); C327(1.10)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C189(0.60); C191(0.60); C327(1.00)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C189(0.69); C191(0.69); C327(1.03)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C189(1.08); C191(1.08); C327(1.32)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C189(0.68); C191(0.68); C235(0.82); C327(1.22)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C189(0.89); C191(0.89); C327(1.01)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C189(0.60); C191(0.60); C327(1.12)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C189(0.94); C191(0.94); C327(1.00)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C189(0.69); C191(0.69); C327(1.10)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C189(0.57); C191(0.57); C327(1.08)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C189(0.95); C191(1.08); C327(1.08)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C189(0.78); C191(0.88); C327(0.92)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C189(0.78); C191(0.70); C327(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C189(0.54); C191(0.64); C327(1.70)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C189(0.62); C191(0.62); C235(0.87); C327(0.81)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C189(0.79); C191(1.01); C327(1.08)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C189(0.60); C191(0.63); C327(1.30)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C189(0.72); C191(0.74); C327(1.62)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C189(0.73); C191(0.90); C327(1.44)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C189(0.79); C191(0.79); C327(1.53)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C189(0.64); C191(0.66); C327(1.11)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C189(0.82); C191(0.78); C327(1.08)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C189(0.58); C191(0.70); C327(1.30)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C189(0.52); C191(0.58); C327(1.37)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C189(1.06); C191(0.94); C327(1.66)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C189(0.64); C191(0.64); C235(0.66); C327(1.00)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C189(1.23); C191(0.93); C327(0.88)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C327(1.08)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C327(0.93)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C327(0.88)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C327(1.04)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C327(1.11)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C327(1.29)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C327(1.20)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C327(1.47)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C327(1.38)  LDD0811  [4]
 LDCM0468  Fragment33 HCT 116 C189(0.65); C191(0.65); C327(1.31)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C189(0.69); C191(0.73); C235(0.73); C327(1.95)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C136(1.03); C327(1.00)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C136(0.96); C327(1.03)  LDD1497  [6]
 LDCM0024  KB05 G361 C136(1.01); C327(3.21)  LDD3311  [7]
 LDCM0021  THZ1 HCT 116 C327(1.31); C518(0.99); C90(1.17); C91(1.17)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
Baculoviral IAP repeat-containing protein 7 (BIRC7) IAP family Q96CA5
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FosB (FOSB) BZIP family P53539
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger imprinted 2 (ZIM2) Krueppel C2H2-type zinc-finger protein family Q9NZV7
Zinc finger protein 500 (ZNF500) Krueppel C2H2-type zinc-finger protein family O60304
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Transcription factor LBX1 (LBX1) . P52954
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1) IRAK1BP1 family Q5VVH5
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Arginine vasopressin-induced protein 1 (AVPI1) . Q5T686
Ataxin-7-like protein 1 (ATXN7L1) . Q9ULK2
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Four and a half LIM domains protein 2 (FHL2) . Q14192
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
MORN repeat-containing protein 3 (MORN3) . Q6PF18
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
RBBP8 N-terminal-like protein (RBBP8NL) . Q8NC74
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52
Vinexin (SORBS3) . O60504

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840