Details of the Target

General Information of Target

Target ID LDTP00392
Target Name Segment polarity protein dishevelled homolog DVL-2 (DVL2)
Gene Name DVL2
Gene ID 1856
Synonyms
Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSM
DQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPL
PPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG
GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRR
KQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIM
KGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQ
AYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVH
TDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYAS
GLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLP
GATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGG
AGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRA
HPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQS
FHMAMGNPSEFFVDVM
Target Bioclass
Other
Family
DSH family
Subcellular location
Cell membrane
Function
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Uniprot ID
O14641
Ensemble ID
ENST00000005340.10
HGNC ID
HGNC:3086
ChEMBL ID
CHEMBL1255125

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y362(10.23)  LDD0259  [1]
m-APA
 Probe Info  		11.59  LDD0403  [2]
HHS-475
 Probe Info  		Y362(0.73)  LDD0264  [3]
DBIA
 Probe Info  		C354(1.00)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C354(0.00); C80(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C354(0.00); C80(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
YN-1
 Probe Info  		N.A.  LDD0447  [9]
Ox-W18
 Probe Info  		N.A.  LDD2175  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		10.20  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C412(2.58)  LDD0372  [14]
 LDCM0214  AC1 HCT 116 C80(0.95)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C354(0.72); C80(1.15)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C354(1.18); C80(0.87)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C354(1.37); C80(0.86)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C354(1.36); C80(0.86)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C354(1.36); C80(0.85)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C354(2.06); C80(0.82)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C354(1.20); C80(0.84)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C354(1.40); C80(0.85)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C354(1.68); C80(0.94)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C354(1.18); C80(0.85)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C354(1.83); C80(0.83)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C354(1.21); C80(1.19)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C354(1.67); C80(0.88)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C354(2.63); C80(0.90)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C354(1.67); C80(1.02)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C354(0.85); C80(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C354(0.62); C80(0.85)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C354(0.78); C80(0.92)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C354(0.64); C80(0.92)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C354(0.41); C80(1.13)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C354(0.48); C80(0.86)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C354(0.30); C80(0.96)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C354(0.83); C80(1.17)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C354(1.32); C80(0.85)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C354(2.00); C80(0.87)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C354(1.00); C80(0.88)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C354(1.44); C80(0.82)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C354(0.59); C80(0.97)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C354(1.36); C80(0.80)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C354(1.32); C80(0.84)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C354(0.86); C80(0.90)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C80(0.89)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C80(1.09)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C80(1.31)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C80(1.03)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C80(1.13)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C80(1.38)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C80(1.15)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C80(1.31)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C80(1.23)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C80(1.38)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C80(1.43)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C80(1.43)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C354(1.02); C80(1.15)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C80(1.27)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C80(1.45)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C80(1.29)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C354(1.06); C80(0.90)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C354(0.87); C80(0.89)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C80(0.82); C354(1.28)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C80(0.85); C354(1.54)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C80(0.81); C354(1.36)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C80(0.94); C354(1.26)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C80(0.89); C354(1.55)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C354(0.85); C80(1.14)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C354(0.87); C80(0.90)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C354(0.76); C80(0.86)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C80(0.93); C354(1.09)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C354(0.76); C80(1.09)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C354(0.89); C80(0.88)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C354(0.59); C80(0.97)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C354(0.94); C80(0.99)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C354(1.15); C80(0.84)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C80(0.81); C354(1.54)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C80(0.85); C354(1.24)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C80(0.86); C354(1.38)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C80(0.88)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C80(0.99); C354(1.58)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C80(0.87); C354(1.42)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C80(0.92); C354(1.36)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C80(0.88); C354(1.54)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C80(0.88); C354(1.64)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C80(1.05)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C80(1.22)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C80(1.14)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C80(1.07)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C80(1.21)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C80(0.91)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C80(1.13)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C80(0.93)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C80(1.13)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C80(1.34)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C80(1.25)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C80(0.76)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C80(0.75)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C80(0.84)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C80(0.97)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C80(0.89)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C80(0.92)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C80(1.00)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C80(1.04)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C80(1.03)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C80(1.02)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C80(1.07)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C80(1.21)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C80(1.07)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C80(1.28)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C80(1.17)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C80(1.05)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C80(0.92)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C80(1.13)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C80(1.17)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C80(1.10)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C80(1.23)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C80(1.14)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C80(1.41)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C80(1.56)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C80(0.93)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C80(0.87)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C80(0.91)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C354(0.71); C80(1.17)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C80(0.96)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C80(0.89)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C80(0.92)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C80(0.84)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C80(0.94)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C80(0.86)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C80(0.85)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C80(0.88)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C354(0.70)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C354(0.97)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C354(0.78); C80(0.95)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C354(0.57)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C354(0.72)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C354(1.21)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C354(1.66)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C354(1.21)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C354(1.12)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C354(1.18)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C354(0.99)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C354(0.77)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C354(0.73)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C354(0.92); C80(1.11)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C354(1.03)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C354(0.66)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C354(0.88)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C80(0.84)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C80(0.77)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C80(0.89)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C80(0.88)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C80(0.88)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C80(0.83)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C80(0.96)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C80(0.86)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C80(0.86)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C80(0.87)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C80(0.88)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C80(0.91)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C80(0.72)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C80(0.76)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C80(0.87)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C80(0.94); C354(1.34)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C354(0.83); C80(0.85)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C354(0.73); C80(1.08)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C354(0.71); C80(1.21)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C354(1.04); C80(1.27)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.59  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C354(1.00)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C80(1.09)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C80(1.22)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C80(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C354(0.87); C80(1.15)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C354(0.86); C80(1.34)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C354(0.75); C80(1.04)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C80(1.10); C354(1.15)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C80(0.94); C354(1.77)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C80(0.95); C354(2.18)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C80(0.89); C354(1.44)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C80(0.89); C354(2.25)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C80(0.80); C354(1.49)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C80(0.95)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C80(0.86); C354(1.77)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C80(0.96); C354(1.64)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C80(0.95)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C80(1.07)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C80(1.16)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C80(1.32)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C80(1.30)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C80(1.12)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C80(0.90)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C80(0.85)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C80(0.99)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C80(1.00)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C80(1.27)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C80(1.28)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C80(1.39)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C80(1.42)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C80(0.91)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C80(0.95)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C80(1.02)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C80(0.98)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C80(1.13)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C80(1.07)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C80(0.85)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C80(1.20)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C354(0.27); C80(0.96)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C354(0.39); C80(0.94)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C354(0.50); C80(0.97)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C80(1.10)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C80(0.97); C354(1.39)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C354(0.43); C80(0.91)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C80(1.17); C354(1.30)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C354(0.52); C80(0.96)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C354(0.82); C80(0.97)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C354(0.31); C80(0.98)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C354(0.46); C80(0.98)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C354(0.64); C80(1.10)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C354(0.26); C80(1.07)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C354(1.00); C80(0.99)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C80(0.94)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C354(0.28); C80(1.04)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C354(0.36); C80(0.96)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C80(1.20)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C80(1.32)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C80(1.21)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C80(0.99)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C80(1.07)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C80(1.10)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C80(1.13)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C80(1.03)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C80(1.31)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C80(1.05)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C80(1.08)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C80(1.06)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C80(1.13)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C80(1.03)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C354(0.56); C80(0.94)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C354(0.58); C80(1.09)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C354(0.90); C80(1.15)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C354(0.52); C80(0.95)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C80(0.91)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C354(0.99); C80(0.87)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C354(0.47); C80(1.01)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C354(1.03); C80(1.01)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C354(3.21); C80(0.77)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C354(1.86); C80(0.80)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C354(1.21); C80(0.92)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C354(2.46); C80(1.06)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C354(1.02); C80(1.01)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C354(7.03); C80(0.99)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C354(1.00); C80(0.94)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C80(0.84)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C354(1.16); C80(0.94)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C80(0.95)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C80(0.82)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C80(0.99)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C80(1.55)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C80(0.93)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C80(1.07)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C80(0.91)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C80(0.91)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C80(0.72)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C80(0.93)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C80(0.74)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C80(1.13)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C80(1.13)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C80(0.76)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C80(0.80)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C354(1.61); C80(0.98)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C354(0.72); C80(1.01)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C354(0.59); C80(0.95)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C354(0.89); C80(1.04)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C80(1.00)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C354(0.78); C80(0.97)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C354(0.57); C80(0.98)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C354(0.50); C80(0.96)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C354(1.19); C80(1.06)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C354(1.13); C80(1.07)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C354(1.28); C80(1.08)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C354(0.86); C80(1.05)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C354(0.97); C80(1.07)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C354(1.16); C80(0.97)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C354(1.77); C80(1.09)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C80(1.02)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C354(1.11); C80(1.05)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C80(1.00)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C80(1.08)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C80(1.11)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C80(1.20)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C80(0.92)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C80(0.95)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C80(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C80(1.05)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C80(1.22)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C80(1.07); C354(1.25)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C80(1.23)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C80(1.00)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y362(0.73)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y362(0.70)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y362(1.11)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y362(1.57)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y362(1.72)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C354(1.29)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C354(1.51)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C354(1.65)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0224  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Receptor-interacting serine/threonine-protein kinase 4 (RIPK4) TKL Ser/Thr protein kinase family P57078
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Dapper homolog 1 (DACT1) Dapper family Q9NYF0
Dixin (DIXDC1) DIXDC1 family Q155Q3
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
BRCA1-A complex subunit RAP80 (UIMC1) RAP80 family Q96RL1
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
Axin-1 (AXIN1) . O15169
WW domain-containing transcription regulator protein 1 (WWTR1) . Q9GZV5

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
10 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402