Details of the Target

General Information of Target

Target ID LDTP15100
Target Name Nucleolus and neural progenitor protein (NEPRO)
Gene Name NEPRO
Gene ID 25871
Synonyms
C3orf17; Nucleolus and neural progenitor protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASHVECRPLGVFECELCTLTAPYSYVGQKPPNTQSMVLLEESYVMKDPFTSDKDRFLVL
GSCCSLCSRLVCVGPECSLFYSKRFCLPCVRENINAFPQEIRQDLEKRKAPSKRTPSQPG
SRT
Target Bioclass
Other
Family
Nepro family
Subcellular location
Nucleus
Function
May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.
Uniprot ID
Q6NW34
Ensemble ID
ENST00000314400.10
HGNC ID
HGNC:24496

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.V348M .
HCT15 Substitution: p.M522_I523delinsIF .
KMS27 SNV: p.H524Y .
LS123 SNV: p.F472L .
MFE319 SNV: p.R94H .
RH30 SNV: p.K279N .
SW620 SNV: p.M76R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.70  LDD0402  [1]
STPyne
 Probe Info  		K257(9.13)  LDD0277  [2]
BTD
 Probe Info  		C419(11.21)  LDD1699  [3]
AHL-Pu-1
 Probe Info  		C492(2.23)  LDD0169  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C316(1.05)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C425(0.00); C492(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C492(0.00); C91(0.00)  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		C425(0.00); C46(0.00); C492(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		C492(0.00); C425(0.00)  LDD2224  [9]
IPM
 Probe Info  		C419(0.00); C316(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C492(0.00); C419(0.00); C425(0.00); C316(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		C425(0.00); C492(0.00)  LDD0218  [5]
AOyne
 Probe Info  		15.00  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C492(2.23)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C316(1.13)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C316(1.29)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C316(1.17)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C316(1.07)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C316(0.92)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C316(1.31)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C316(1.70)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C316(0.95)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C316(0.82)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C316(0.89)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C316(1.16)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C316(0.95)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C316(1.06)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C316(0.71)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C316(1.06)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C316(0.94)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C316(0.98)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C316(1.11)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C316(1.11)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C316(1.15)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C316(1.03)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C316(1.15)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C316(1.24)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C316(0.94)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C316(1.14)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C316(1.03)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C316(1.05)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C316(1.07)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C316(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C316(1.21)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C316(1.18)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C316(1.20)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C316(0.96)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C316(0.80)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C316(0.91)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C316(0.99)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C316(0.98)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C316(1.21)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C316(1.14)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C316(1.11)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C316(1.32)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C316(1.14)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C316(0.92)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C316(1.07)  LDD1137  [6]
 LDCM0259  AC14 HCT 116 C316(0.94)  LDD0576  [6]
 LDCM0260  AC140 PaTu 8988t C316(0.93)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C316(1.15)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C316(0.98)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C316(1.27)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C316(1.27)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C316(1.10)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C316(1.07)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C316(1.23)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C316(1.78)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C316(1.25)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C316(1.01)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C316(1.05)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C316(0.97)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C316(1.35)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C316(1.58)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C316(1.34)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C316(1.18)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C316(1.01)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C316(1.12)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C316(0.69)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C316(0.77)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C316(0.71)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C316(1.02)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C316(0.72)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C316(0.80)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C316(0.82)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C316(0.74)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C316(0.66)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C316(1.63)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C316(1.62)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C316(1.92)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C316(2.20)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C316(1.90)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C316(1.04)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C316(1.74)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C316(1.52)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C316(1.52)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C316(1.96)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C316(2.12)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C316(0.96); C46(0.98); C124(0.98); C492(1.22)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C316(0.97); C46(0.97); C124(1.05); C492(1.06)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C316(0.95); C46(0.97); C124(1.02); C492(0.89)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C316(0.99); C46(0.99); C124(1.02); C492(0.99)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C316(0.98); C46(1.00); C124(0.90); C492(1.14)  LDD1539  [14]
 LDCM0301  AC4 HCT 116 C316(0.93)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C316(0.94); C46(1.04); C124(1.01); C492(0.98)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C316(1.04); C124(1.11); C492(1.25); C91(1.04)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C316(0.98); C46(1.00); C124(1.03); C492(1.05)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C316(0.97); C46(0.85); C124(1.07); C492(1.40)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C316(1.05); C46(0.99); C124(1.06); C492(0.82)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C316(0.98); C46(0.94); C124(0.99); C492(1.03)  LDD1546  [14]
 LDCM0308  AC46 PaTu 8988t C316(0.95)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C316(0.98)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C316(1.24)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C316(1.15)  LDD1190  [6]
 LDCM0312  AC5 HCT 116 C316(0.91)  LDD0629  [6]
 LDCM0313  AC50 PaTu 8988t C316(1.09)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C316(0.52)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C316(0.87)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C316(1.08)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C316(1.36)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C316(0.95)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C316(1.17)  LDD1198  [6]
 LDCM0320  AC57 HCT 116 C316(1.01)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C316(1.05)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C316(1.15)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C316(0.91)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C316(1.15)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C316(0.94)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C316(1.03)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C316(1.16)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C316(1.09)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C316(0.98)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C316(0.90)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C316(1.06)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C316(1.15)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C316(1.19)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C316(1.03)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C316(1.08)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C316(1.15)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C316(1.37)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C316(1.58)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C316(1.55)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C316(1.83)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C316(1.27)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C316(1.29)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C316(1.13)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C316(1.20)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C316(0.91)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C316(1.18)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C316(1.20)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C316(1.70)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C316(1.19)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C316(1.43)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C316(1.49)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C316(1.40)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C316(1.29)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C316(1.25)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C316(1.25)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C316(1.19)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C316(1.37)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C316(1.39)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C316(1.38)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C316(1.40)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C316(1.53)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C316(1.41)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C316(1.43)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C316(1.01)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C316(1.37)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C419(0.41)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C316(0.98)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C316(0.99)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C316(1.25)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 9.89  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C316(1.05)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C492(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C316(1.04); C46(1.11); C124(1.21); C492(1.30)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C316(1.24); C46(1.19); C124(1.27); C492(1.15)  LDD1572  [14]
 LDCM0369  CL100 HCT 116 C316(1.13)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C316(1.05)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C316(0.91)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C316(1.01)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C316(1.13)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C316(0.72)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C316(0.82)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C316(0.75)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C316(0.82)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C316(0.82)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C316(1.11); C46(1.23); C124(1.23); C492(1.20)  LDD1583  [14]
 LDCM0380  CL110 HCT 116 C316(0.66)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C316(0.71)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C316(1.36)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C316(1.52)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C316(2.03)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C316(2.05)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C316(2.10)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C316(1.01); C46(0.99); C124(1.01); C492(1.14)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C316(0.99); C46(0.93); C124(0.96); C492(0.83)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C316(0.96); C46(1.01); C124(0.92); C492(1.09)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C316(0.99); C46(1.23); C124(1.25); C492(0.99)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C316(1.05); C46(1.17); C124(0.94); C492(1.08)  LDD1595  [14]
 LDCM0392  CL121 PaTu 8988t C316(0.96)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C316(1.00)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C316(1.12)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C316(1.04)  LDD1274  [6]
 LDCM0396  CL125 HCT 116 C316(0.93)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C316(0.99)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C316(0.96)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C316(1.03)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C316(1.07); C46(1.12); C124(1.05); C492(1.11)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C316(0.92); C46(1.01); C124(0.94); C492(0.91)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C316(1.07); C46(1.09); C124(1.23); C492(1.18)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C316(0.86)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C316(0.60)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C316(0.77)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C316(1.07)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C316(0.88); C46(1.06); C124(1.06); C492(0.90)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C316(0.69)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C316(0.63)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C316(0.70)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C316(0.76)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C316(0.63)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C316(0.75)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C316(0.57)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C316(0.71)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C316(0.85)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C316(0.81)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C316(1.03); C46(1.10); C124(1.02); C492(1.15)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C316(0.59)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C316(0.97)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C316(1.07)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C316(0.98)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C316(1.16)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C316(1.07)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C316(1.15)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C316(1.10)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C316(1.19)  LDD0745  [6]
 LDCM0429  CL4 HEK-293T C316(0.97); C46(1.15); C124(1.04); C492(0.86)  LDD1633  [14]
 LDCM0430  CL40 HCT 116 C316(1.00)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C316(1.10)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C316(1.55)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C316(1.23)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C316(1.20)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C316(1.22)  LDD0752  [6]
 LDCM0436  CL46 PaTu 8988t C316(0.90)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C316(0.97)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C316(1.00)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C316(1.08)  LDD1318  [6]
 LDCM0440  CL5 HEK-293T C316(1.01); C124(1.10); C492(0.96); C91(0.97)  LDD1644  [14]
 LDCM0441  CL50 PaTu 8988t C316(1.00)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C316(1.11)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C316(1.09)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C316(1.17)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C316(0.99)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C316(1.00)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C316(0.92)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C316(1.04)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C316(0.94)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C316(0.96)  LDD1329  [6]
 LDCM0451  CL6 HEK-293T C316(1.06); C46(1.32); C124(1.19); C492(1.00)  LDD1654  [14]
 LDCM0452  CL60 PaTu 8988t C316(0.96)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C316(1.02)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C316(0.81)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C316(0.91)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C316(0.88)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C316(1.04)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C316(0.98)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C316(1.13)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C316(1.21)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C316(1.12)  LDD1340  [6]
 LDCM0462  CL7 HEK-293T C316(1.04); C46(0.98); C124(1.18); C492(1.19)  LDD1665  [14]
 LDCM0463  CL70 PaTu 8988t C316(1.05)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C316(0.88)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C316(0.85)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C316(1.25)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C316(1.18)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C316(1.00)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C316(0.78)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C316(1.00)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C316(1.05)  LDD1351  [6]
 LDCM0473  CL8 HEK-293T C316(1.40); C46(1.63); C124(1.74); C492(1.00)  LDD1676  [14]
 LDCM0474  CL80 PaTu 8988t C316(0.77)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C316(0.84)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C316(1.06)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C316(1.15)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C316(0.99)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C316(0.85)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C316(0.72)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C316(0.99)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C316(1.05)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C316(0.70)  LDD1362  [6]
 LDCM0484  CL9 HEK-293T C316(1.04); C46(1.10); C124(1.35); C492(0.84)  LDD1687  [14]
 LDCM0485  CL90 PaTu 8988t C316(0.93)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C316(1.01)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C316(0.94)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C316(0.94)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C316(1.03)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C316(1.10)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C316(0.94)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C316(1.04)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C316(1.16)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C316(0.96)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C316(0.96); C46(0.94); C124(0.94); C492(1.27)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C425(1.31)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C316(0.93)  LDD1347  [6]
 LDCM0427  Fragment51 HCT 116 C316(1.47)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C316(2.57)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C316(2.86)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C316(4.11)  LDD0082  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C419(0.78)  LDD2097  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C419(0.47)  LDD2116  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C419(1.02)  LDD2128  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C91(1.19)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C425(1.02)  LDD2140  [3]
 LDCM0021  THZ1 HCT 116 C316(0.98)  LDD2173  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402