Details of the Target

General Information of Target

Target ID LDTP14048
Target Name Probable E3 ubiquitin-protein ligase HECTD4 (HECTD4)
Gene Name HECTD4
Synonyms
C12orf51; KIAA0614; Probable E3 ubiquitin-protein ligase HECTD4; EC 2.3.2.26; HECT domain-containing protein 4; HECT-type E3 ubiquitin transferase HECTD4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRAAGGAPLSARAAAASPPPFQTPPRCPVPLLLLLLLGAARAGALEIQRRFPSPTPTN
NFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRL
TDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSML
NVAANHPNASTVGLVLPPAAGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPEIAI
RSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAYLA
LNSEARAGDKESQARSLLARICLPHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVS
VFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLD
SVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVN
NYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSGYLYLMTSHQ
MARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEGPSRC
PAMTVLPSEIDVRQEYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAY
CNLLPRDQFPPFPPNQDHVTVEMSVRVNGRNIVKANFTIYDCSRTAQVYPHTACTSCLSA
QWPCFWCSQQHSCVSNQSRCEASPNPTSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAF
FQGAALECSFGLEEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPE
PMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSDGCRLRGPLQPMAGTCPAPEIHAIEPLS
GPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSG
VVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTD
PCTELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLTFWYMQNPVITAISPRRSP
VSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPGALSNASAPVDFF
INGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIH
KEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFNQTI
ATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIRE
EIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNS
QGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRD
RCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSI
CMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNV
SFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYIL
RDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPT
DELAEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYF
FDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQ
AFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEE
SRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMEDNIYE
CYSEA
Target Bioclass
Enzyme
Subcellular location
Membrane
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Uniprot ID
Q9Y4D8
HGNC ID
HGNC:26611

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K3307(10.00); K3454(4.05)  LDD0277  [1]
DBIA
 Probe Info  		C1084(2.25)  LDD0080  [2]
CY4
 Probe Info  		M3567(0.00); T3565(0.00)  LDD0247  [3]
IA-alkyne
 Probe Info  		C1334(0.00); C1299(0.00); C3607(0.00); C3504(0.00)  LDD0165  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		C1636(0.00); C1488(0.00); C1084(0.00); C330(0.00)  LDD2156  [6]
NHS
 Probe Info  		N.A.  LDD0010  [5]
NAIA_5
 Probe Info  		C1334(0.00); C1431(0.00); C757(0.00); C120(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1636(1.12)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C1636(1.17)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C1636(1.18)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C1636(1.50)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C1636(1.43)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C1636(1.47)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C1636(1.26)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C1636(1.18)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C1636(1.53)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C1636(1.20)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C1636(1.40)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C1636(1.25)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C1636(1.09)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C1636(1.35)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C1636(1.40)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C1636(1.46)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C1636(0.93)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C1636(0.77)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C1636(0.86)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C1636(0.78)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C1636(1.04)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C1636(1.10)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C1636(1.04)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C1636(0.84)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C1636(1.33)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C1636(1.11)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C1636(1.15)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C1636(1.59)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C1636(1.38)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C1636(1.33)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C1636(1.10)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C1636(1.31)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C1636(0.68)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C1636(0.90)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C1636(0.95)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C1636(0.64)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C1636(0.83)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C1636(0.72)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C1636(0.87)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C1636(0.68)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C1636(0.70)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C1636(0.80)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C1636(0.79)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C1636(0.90)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C1636(1.01)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C1636(1.04)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C1636(0.97)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C1636(0.85)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C1636(1.10)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C1636(0.88)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C1636(0.75)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C1636(0.85)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C1636(0.80)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C1636(0.95)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C1636(0.88)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C1636(0.87)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C1636(0.82)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C1636(0.79)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C1636(0.88)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C1636(0.85)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C1636(0.81)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C1636(0.81)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C1636(0.77)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C1636(0.75)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C1636(0.95)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C1636(0.92)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C1636(0.91)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C1636(1.44)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C1636(0.77)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C1636(0.77)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C1636(0.84)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C1636(0.76)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C1636(0.92)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C586(0.88); C597(0.88)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C586(1.10); C597(1.10)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C586(1.02); C597(1.02)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C586(1.04); C597(1.04)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C586(1.02); C597(1.02)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C1636(1.03)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C586(1.35); C597(1.35)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C586(0.99); C597(0.99)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C586(1.10); C597(1.10)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C586(0.91); C597(0.91)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C586(1.06); C597(1.06)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C586(0.92); C597(1.12)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C586(0.85); C597(0.86)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C586(0.79); C597(0.86)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C586(1.00); C597(1.21)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C586(1.12); C597(1.18)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C1636(1.02)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C586(1.02); C597(1.07)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C586(1.05); C597(1.06)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C586(1.24); C597(1.07)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C586(1.04); C597(1.18)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C586(1.21); C597(1.14)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C586(1.17); C597(1.12)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C586(1.02); C597(1.02)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C586(0.90); C597(0.90)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C586(1.01); C597(1.01)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C586(0.92); C597(0.92)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C1636(0.93)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C586(1.02); C597(1.02)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C586(1.12); C597(1.12)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C586(1.26); C597(1.26)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C586(1.62); C597(1.62)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C586(1.07); C597(1.07)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C586(1.12); C597(1.12)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C586(0.93); C597(0.93)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C1636(0.96); C586(1.25); C597(1.25)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C1636(1.40); C586(1.04); C597(1.04)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C1636(1.32); C586(1.23); C597(1.23)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C1636(1.80)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C1636(0.83); C586(1.24); C597(1.24)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C1636(1.11); C586(1.05); C597(1.05)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C1636(0.91); C586(1.21); C597(1.21)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C1636(0.99); C586(1.25); C597(1.25)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C1636(1.47); C586(1.20); C597(1.20)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C1636(0.78); C586(1.14); C597(1.14)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C1636(1.22); C586(1.07); C597(1.07)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C1636(1.44); C586(1.06); C597(1.06)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C1636(0.83); C586(0.90); C597(0.90)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C1636(0.77); C586(0.92); C597(0.92)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C1636(1.13)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C1636(0.67); C586(0.82); C597(0.82)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C1636(0.73); C586(0.85); C597(0.85)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C1636(0.77); C586(1.05); C597(1.05)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C1636(0.87); C586(1.07); C597(1.07)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C1636(0.76); C586(0.75); C597(0.75)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C1636(0.72); C586(0.98); C597(0.98)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C1636(0.65); C586(0.91); C597(0.91)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C1636(0.80); C586(0.96); C597(0.96)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C1636(0.75); C586(0.91); C597(0.91)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C1636(0.81); C586(0.97); C597(0.97)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C1636(0.88)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C1636(0.82); C586(1.03); C597(1.03)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C1636(0.81); C586(0.89); C597(0.89)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C1636(0.99); C586(1.07); C597(1.07)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C1636(1.56)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C1636(2.92)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C1636(2.21)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C1636(1.60)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C1636(1.47)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C1636(1.61)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C1636(1.42)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C1636(1.36)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C1636(1.62)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C1636(1.11)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C1636(1.46)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C1636(1.74)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C1636(1.70)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C1636(1.21)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C1636(2.48)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C1636(1.36)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C1636(1.29)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C1636(0.80)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C1636(0.91)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C1636(0.93)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C1636(0.89)  LDD2171  [2]
 LDCM0369  CL100 HCT 116 C1636(0.84)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C1636(0.78)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C1636(0.66)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C1636(0.73)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C1636(0.85)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C1636(0.72)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C1636(0.84)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C1636(0.87)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C1636(0.77)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C1636(1.04)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C1636(0.82)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C1636(0.74)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C586(1.57); C597(1.57)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C586(1.17); C597(1.17)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C586(1.56); C597(1.56)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C586(1.40); C597(1.40)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C586(1.14); C597(1.14)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C586(1.46); C597(1.60)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C586(0.88); C597(0.87)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C586(1.02); C597(0.98)  LDD0987  [2]
 LDCM0391  CL120 HEK-293T C586(1.07); C597(1.16)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C586(1.32); C597(1.32)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C586(1.29); C597(1.29)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C586(2.33); C597(2.33)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C586(1.19); C597(1.19)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C1636(1.34); C586(1.01); C597(1.01)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C1636(1.12); C586(1.77); C597(1.77)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C1636(1.60); C586(1.06); C597(1.06)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C1636(1.00); C586(1.34); C597(1.34)  LDD0997  [2]
 LDCM0403  CL16 HCT 116 C1636(1.19)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C1636(0.88)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C1636(0.61)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C1636(0.93)  LDD1004  [2]
 LDCM0408  CL20 HEK-293T C1636(0.95)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C1636(0.69)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C1636(1.04)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C1636(1.02)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C1636(0.62)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C1636(0.76)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C1636(0.81)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C1636(0.85)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C1636(0.55)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C1636(0.96)  LDD1015  [2]
 LDCM0419  CL30 HEK-293T C1636(0.87)  LDD1017  [2]
 LDCM0421  CL32 HCT 116 C1636(1.27)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C1636(1.16)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C1636(1.46)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C1636(1.48)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C1636(1.55)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C1636(1.74)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C1636(1.24)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C1636(0.98)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C1636(1.29)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C1636(1.20)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C1636(1.44)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C1636(1.40)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C1636(1.43)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C1636(0.64); C586(1.20); C597(1.20)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C1636(0.57); C586(1.10); C597(1.10)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C1636(0.83); C586(1.39); C597(1.39)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C1636(0.75); C586(0.90); C597(0.90)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C1636(0.47); C586(1.05); C597(1.05)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C1636(0.51); C586(1.46); C597(1.46)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C1636(0.47); C586(1.00); C597(1.00)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C1636(0.71); C586(1.46); C597(1.46)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C1636(0.71); C586(1.50); C597(1.50)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C1636(0.71); C586(1.02); C597(1.02)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C1636(1.06); C586(1.03); C597(1.03)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C1636(0.65); C586(3.45); C597(3.45)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C1636(1.03); C586(1.05); C597(1.05)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C1636(0.91); C586(1.52); C597(1.52)  LDD1048  [2]
 LDCM0452  CL60 HEK-293T C1636(1.05); C586(1.14); C597(1.14)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C1636(0.60)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C1636(0.48)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C1636(0.67)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C1636(0.23)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C1636(0.44)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C1636(0.35)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C1636(0.26)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C1636(0.45)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C1636(0.23)  LDD1059  [2]
 LDCM0463  CL70 HEK-293T C1636(0.39)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C1636(0.30)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C1636(0.24)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C1636(0.30)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C1636(0.27)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C1636(1.02)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C1636(0.82)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C1636(0.46)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C1636(0.71)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C1636(0.99)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C1636(1.07)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C1636(1.16)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C1636(1.00)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C1636(1.07)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C1636(0.90)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C1636(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C1636(1.10)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C1636(1.55)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C1636(1.51)  LDD0800  [2]
 LDCM0485  CL90 HCT 116 C1636(0.92)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C1636(0.83)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C1636(0.84)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C1636(1.02)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C1636(0.80)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C1636(0.96)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C1636(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C1636(0.77)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C1636(0.80)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C1636(0.74)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C1636(0.17)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C1636(1.12)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C1084(2.25)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1084(1.27)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1084(2.03)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C1636(0.89)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264