Details of the Target

General Information of Target

Target ID LDTP13995
Target Name Ras-related protein Rap-2c (RAP2C)
Gene Name RAP2C
Gene ID 57826
Synonyms
Ras-related protein Rap-2c; EC 3.6.5.2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQ
SGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLE
RDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHS
HTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRR
SLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMML
LSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLM
TFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTP
SNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGL
FSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPP
RPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPG
TPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNP
AQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Subcellular location
Cytoplasm
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Uniprot ID
Q9Y3L5
Ensemble ID
ENST00000342983.6
HGNC ID
HGNC:21165

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C140(0.65)  LDD0533  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		11.50  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.25  LDD0472  [10]
FFF probe3
 Probe Info  		7.92  LDD0465  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C140(0.72)  LDD1093  [1]
 LDCM0215  AC10 HEK-293T C140(1.07)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C140(0.65)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C140(0.56)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C140(0.63)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C140(0.45)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C140(0.53)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C140(0.34)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C140(0.54)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C140(0.42)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C140(0.59)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C140(0.65)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C140(0.92)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C140(0.62)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C140(0.67)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C140(0.59)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C140(1.36)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C140(1.11)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C140(1.11)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C140(1.10)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C140(1.21)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C140(1.25)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C140(1.12)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C140(1.05)  LDD1510  [11]
 LDCM0238  AC120 HCT 116 C140(1.50)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C140(0.81)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C140(0.85)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C140(0.97)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C140(1.01)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C140(1.04)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C140(1.06)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C140(1.40)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C140(0.64)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C140(1.05)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C140(0.85)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C140(1.43)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C140(1.37)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C140(0.95)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C140(0.89)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C140(0.84)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C140(0.96)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C140(0.89)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C140(0.85)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C140(1.03)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C140(0.90)  LDD1512  [11]
 LDCM0260  AC140 HCT 116 C140(1.00)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C140(1.05)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C140(1.39)  LDD0579  [1]
 LDCM0263  AC143 PaTu 8988t C140(1.06)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C140(0.87)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C140(0.96)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C140(1.12)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C140(0.96)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C140(0.68)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C140(0.57)  LDD1148  [1]
 LDCM0270  AC15 HEK-293T C140(0.95)  LDD1513  [11]
 LDCM0271  AC150 PaTu 8988t C140(0.61)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C140(0.49)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C140(0.46)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C140(0.48)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C140(0.51)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C140(0.53)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C140(0.77)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C140(0.52)  LDD2169  [1]
 LDCM0276  AC17 HCT 116 C140(0.85)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C140(0.57)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C140(0.72)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C140(1.18)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C140(0.90)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C140(0.63)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C140(0.93)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C140(0.87)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C140(0.94)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C140(0.80)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C140(0.78)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C140(0.86)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C140(2.90)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C140(0.83)  LDD0887  [1]
 LDCM0290  AC3 PaTu 8988t C140(0.77)  LDD1169  [1]
 LDCM0291  AC30 HEK-293T C140(0.90)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C140(0.77)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C140(0.71)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C140(0.99)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C140(0.85)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C140(1.02)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C140(0.99)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C140(1.02)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C140(1.02)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C140(0.92)  LDD1539  [11]
 LDCM0301  AC4 PaTu 8988t C140(0.90)  LDD1180  [1]
 LDCM0302  AC40 HEK-293T C140(1.04)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C140(1.04)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C140(1.02)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C140(0.94)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C140(1.08)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C140(0.93)  LDD1546  [11]
 LDCM0308  AC46 HCT 116 C140(1.18)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C140(0.95)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C140(1.43)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C140(0.66)  LDD0628  [1]
 LDCM0312  AC5 PaTu 8988t C140(0.73)  LDD1191  [1]
 LDCM0313  AC50 HCT 116 C140(0.69)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C140(1.27)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C140(1.09)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C140(0.76)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C140(0.82)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C140(0.77)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C140(0.67)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C140(0.66)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C140(0.64)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C140(0.51)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C140(1.02)  LDD1562  [11]
 LDCM0324  AC60 HCT 116 C140(0.71)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C140(1.13)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C140(0.53)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C140(0.70)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C140(0.56)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C140(0.69)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C140(0.83)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C140(0.39)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C140(0.54)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C140(0.69)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C140(1.00)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C140(0.41)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C140(0.95)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C140(0.73)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C140(0.42)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C140(0.42)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C140(0.37)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C140(0.48)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C140(0.51)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C140(0.81)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C140(0.85)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C140(0.98)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C140(0.45)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C140(1.00)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C140(0.26)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C140(1.05)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C140(1.16)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C140(1.15)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C140(1.25)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C140(1.20)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C140(1.42)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C140(1.24)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C140(1.03)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C140(1.17)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C140(1.15)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C140(1.21)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C140(1.37)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C140(1.26)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C140(1.24)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C140(1.13)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C140(0.23)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C140(1.03)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C140(1.02)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C140(1.04)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C140(1.03)  LDD1514  [11]
 LDCM0367  CL1 PaTu 8988t C140(0.56)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C140(0.37)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C140(0.98)  LDD1248  [1]
 LDCM0370  CL101 HEK-293T C140(1.00)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C140(1.20)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C140(0.96)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C140(1.05)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C140(0.58)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C140(0.49)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C140(0.49)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C140(0.43)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C140(0.55)  LDD0695  [1]
 LDCM0379  CL11 PaTu 8988t C140(0.64)  LDD1258  [1]
 LDCM0380  CL110 HCT 116 C140(0.42)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C140(0.69)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C140(0.88)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C140(0.80)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C140(0.77)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C140(1.02)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C140(0.87)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C140(1.02)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C140(0.93)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C140(1.03)  LDD1593  [11]
 LDCM0390  CL12 PaTu 8988t C140(0.49)  LDD1269  [1]
 LDCM0391  CL120 HEK-293T C140(1.11)  LDD1595  [11]
 LDCM0392  CL121 HCT 116 C140(0.47)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C140(1.20)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C140(0.74)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C140(0.77)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C140(1.00)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C140(0.73)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C140(0.87)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C140(0.59)  LDD0716  [1]
 LDCM0400  CL13 PaTu 8988t C140(0.40)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C140(0.42)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C140(0.47)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C140(1.09)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C140(1.73)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C140(0.98)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C140(1.08)  LDD1610  [11]
 LDCM0407  CL2 PaTu 8988t C140(0.50)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C140(1.01)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C140(1.37)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C140(0.89)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C140(0.91)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C140(1.05)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C140(1.19)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C140(1.01)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C140(1.04)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C140(1.15)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C140(1.01)  LDD1621  [11]
 LDCM0418  CL3 PaTu 8988t C140(0.86)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C140(0.95)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C140(0.74)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C140(0.87)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C140(0.68)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C140(0.51)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C140(0.47)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C140(0.53)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C140(0.46)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C140(0.52)  LDD0745  [1]
 LDCM0429  CL4 PaTu 8988t C140(1.12)  LDD1308  [1]
 LDCM0430  CL40 HCT 116 C140(0.48)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C140(0.63)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C140(0.42)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C140(0.50)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C140(0.69)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C140(0.56)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C140(1.08)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C140(1.00)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C140(1.00)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C140(1.10)  LDD1643  [11]
 LDCM0440  CL5 PaTu 8988t C140(0.37)  LDD1319  [1]
 LDCM0441  CL50 HEK-293T C140(1.32)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C140(1.15)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C140(1.78)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C140(1.43)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C140(1.02)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C140(1.02)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C140(1.28)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C140(1.03)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C140(0.99)  LDD1653  [11]
 LDCM0451  CL6 PaTu 8988t C140(0.34)  LDD1330  [1]
 LDCM0452  CL60 HEK-293T C140(1.06)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C140(0.98)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C140(1.05)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C140(0.91)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C140(1.37)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C140(1.09)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C140(1.13)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C140(1.05)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C140(1.13)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C140(1.17)  LDD1664  [11]
 LDCM0462  CL7 PaTu 8988t C140(0.37)  LDD1341  [1]
 LDCM0463  CL70 HEK-293T C140(0.96)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C140(1.00)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C140(0.92)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C140(1.28)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C140(0.97)  LDD1670  [11]
 LDCM0469  CL76 PaTu 8988t C140(1.15)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C140(0.85)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C140(0.92)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C140(0.84)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C140(0.44)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C140(1.53)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C140(0.66)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C140(0.80)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C140(0.74)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C140(0.71)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C140(1.00)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C140(1.16)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C140(0.78)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C140(0.77)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C140(0.68)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C140(0.36)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C140(0.77)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C140(1.09)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C140(1.08)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C140(0.98)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C140(1.16)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C140(1.04)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C140(0.92)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C140(0.88)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C140(0.88)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C140(0.90)  LDD1373  [1]
 LDCM0495  E2913 HEK-293T C140(1.11)  LDD1698  [11]
 LDCM0625  F8 Ramos C140(1.02)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C140(2.13)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C140(3.36)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C140(4.00)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C140(1.27)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C140(1.95)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C140(3.96)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C140(1.24)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C140(0.75)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C140(0.86)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C140(1.22)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C140(2.37)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C140(1.23)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C140(3.26)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C140(1.08)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C140(1.21)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C140(2.43)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C140(0.44)  LDD0744  [1]
 LDCM0610  Fragment52 Ramos C140(2.10)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C140(0.95)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C140(1.73)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C140(3.00)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C140(0.60)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C140(0.85)  LDD1497  [11]
 LDCM0024  KB05 HMCB C140(2.86)  LDD3312  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C140(0.91)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C140(0.66)  LDD2207  [14]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.