Details of the Target

General Information of Target

Target ID LDTP13706
Target Name Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1)
Gene Name AGAP1
Gene ID 116987
Synonyms
CENTG2; KIAA1099; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; AGAP-1; Centaurin-gamma-2; Cnt-g2; GTP-binding and GTPase-activating protein 1; GGAP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNA
IKPGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKSLDYS
RKLKNVLVTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSGYI
DCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHR
KLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWST
ATSPLGGERPFRYGPRTPVSDDAESTSMFDMRCEEEAAVQPHSRARQEQLQLINNQLREE
DDKWQDDLARWKSRRRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYREIVQEKE
RRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFL
NDPNPMKYLRQQSLPPPKFTATVETTIARASVLDTSMSAGSGSPSKTVTPKAVPMLTPKP
YSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHG
SPLELKQDNGSIEINIKKPNSVPQELAATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQ
HFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKSPE
PEATLTFPFLDKMPEANQLHLPNLNSQVDSPSSEKSPVMTPQFKFWAWDPEEERRRQEKW
QQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSAD
QLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRLEEKGSLT
EGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKT
LPLDKSINHQIESPSERRKKSPREHFQAGPFSPCSPTPPGQSPNRSISGKKLCSSCGLPL
GKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSRSAGQP
TTL
Target Bioclass
Other
Family
Centaurin gamma-like family
Subcellular location
Cytoplasm
Function GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
Uniprot ID
Q9UPQ3
Ensemble ID
ENST00000304032.13
HGNC ID
HGNC:16922

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.C211R DBIA    Probe Info 
KARPAS299 SNV: p.Ter858LextTer27 .
KPNYN SNV: p.L7M DBIA    Probe Info 
LS180 SNV: p.K779E DBIA    Probe Info 
MIAPACA2 SNV: p.E548Ter .
NUGC3 SNV: p.E551G .
PF382 SNV: p.A52T .
SNGM SNV: p.T535I DBIA    Probe Info 
SNU1079 SNV: p.M135I DBIA    Probe Info 
SW1116 SNV: p.A12G .
TE11 SNV: p.A337V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.01  LDD0403  [1]
DBIA
 Probe Info  		C817(0.48); C826(0.48); C243(1.04); C417(1.01)  LDD0531  [2]
IA-alkyne
 Probe Info  		C417(0.00); C727(0.00)  LDD0165  [3]
IPM
 Probe Info  		C417(0.00); C727(0.00); C243(0.00)  LDD0147  [4]
AOyne
 Probe Info  		14.50  LDD0443  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C817(0.48); C826(0.48); C243(1.04); C417(1.01)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C817(0.83); C826(0.83); C417(0.96)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C817(0.74); C826(0.74); C417(0.93); C777(0.47)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C817(0.75); C826(0.75); C417(0.89); C777(0.50)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C817(0.68); C826(0.68); C417(1.00); C777(0.44)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C817(0.58); C826(0.58); C417(1.22); C777(0.46)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C817(0.55); C826(0.55); C417(1.16); C777(0.42)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C817(0.67); C826(0.67); C417(1.09); C777(0.41)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C817(0.65); C826(0.65); C417(1.13); C777(0.44)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C817(0.73); C826(0.52); C417(0.56); C777(0.29)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C817(0.53); C826(0.65); C417(0.60); C777(0.66)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C817(0.78); C826(0.98); C417(0.64); C777(0.68)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C817(0.74); C826(0.74); C417(0.86)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C817(0.52); C826(0.68); C417(0.68); C777(0.76)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C817(0.80); C826(0.82); C417(0.73); C777(0.61)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C817(0.77); C826(0.69); C417(0.59); C777(0.43)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C417(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C417(1.10)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C417(1.19)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C417(1.31)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C417(1.12)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C417(1.12)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C417(1.15)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C817(0.83); C826(0.83); C417(0.95)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C417(1.13)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C417(1.04)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C417(1.06)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C417(1.02)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C417(1.01)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C417(1.08)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C417(1.25)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C417(1.11)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C417(0.91); C826(0.92)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C417(0.94); C826(1.10)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C417(1.20); C826(1.10)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C417(1.14); C826(0.89)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C417(0.90); C826(0.96)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C417(1.33); C826(1.08)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C417(1.24); C826(0.99)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C417(1.07); C826(0.86)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C417(1.13); C826(1.20)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C417(1.23); C826(0.98)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C417(1.24); C826(0.85)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C417(1.12); C826(0.83)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C817(0.77); C826(0.77); C417(0.96)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C417(1.08); C826(1.02)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C417(1.27); C826(1.32)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C417(1.22); C826(1.16)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C817(0.95); C826(0.95); C777(0.82)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C817(0.56); C826(0.56); C777(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C817(0.61); C826(0.61); C777(1.02)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C817(0.50); C826(0.50); C777(1.20)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C817(0.55); C826(0.55); C777(1.02)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C817(0.45); C826(0.45); C777(1.19)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C817(0.48); C826(0.48); C777(1.26)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C817(0.63); C826(0.63); C417(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C817(0.80); C826(0.80); C777(1.02)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C817(0.64); C826(0.64); C777(1.09)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C817(0.36); C826(0.36); C777(1.27)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C817(0.55); C826(0.55); C777(1.14)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C817(0.64); C826(0.64); C777(1.05)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C817(0.55); C826(0.55); C777(1.16)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C817(0.78); C826(0.78); C777(1.11)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C817(0.73); C826(0.73); C777(1.21)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C817(1.27); C826(1.27)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C817(1.14); C826(1.14)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C817(1.18); C826(1.18)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C417(0.93); C817(0.94); C826(0.94); C243(1.06)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C817(1.01); C826(1.01)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C817(1.00); C826(1.00)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C817(1.22); C826(1.22)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C817(1.19); C826(1.19)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C817(1.55); C826(1.55)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C817(0.61); C826(0.61); C777(1.17)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C817(0.55); C826(0.55); C777(0.97)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C817(0.56); C826(0.56); C777(1.02)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C817(0.49); C826(0.49); C777(1.06)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C817(0.50); C826(0.50); C777(0.82)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C817(0.66); C826(0.66); C417(0.90); C243(0.93)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C817(0.53); C826(0.53); C777(0.77)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C817(0.41); C826(0.41); C777(0.99)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C817(0.48); C826(0.48); C777(0.88)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C817(0.45); C826(0.45); C777(1.10)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C817(0.50); C826(0.50); C777(1.07)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C817(0.98); C826(0.98)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C817(1.18); C826(1.18)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C817(1.04); C826(1.04)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C817(1.30); C826(1.30)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C817(1.16); C826(1.16)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C817(0.51); C826(0.51); C243(1.01); C417(1.05)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C817(1.07); C826(1.07)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C817(1.27); C826(1.27)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C817(1.04); C826(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C817(0.94); C826(0.94)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C817(0.98); C826(0.98)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C817(0.93); C826(0.93)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C817(1.02); C826(1.02)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C817(0.91); C826(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C817(0.82); C826(0.82)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C817(1.00); C826(1.00)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C817(0.57); C826(0.57); C243(0.86); C417(1.04)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C817(1.08); C826(1.08)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C817(1.36); C826(1.36)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C817(1.05); C826(1.05)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C817(1.05); C826(1.05)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C817(1.03); C826(1.03)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C817(1.01); C826(1.01)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C817(0.95); C826(0.95)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C817(0.62); C826(0.62); C243(0.96)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C817(0.59); C826(0.59); C243(0.96)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C817(0.90); C826(0.90); C243(1.17)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C817(0.60); C826(0.60); C417(1.06)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C817(0.55); C826(0.55); C243(1.24)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C817(0.44); C826(0.44); C243(1.03)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C817(0.70); C826(0.70); C243(1.24)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C817(0.58); C826(0.58); C243(1.32)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C817(0.67); C826(0.67); C243(1.30)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C817(0.65); C826(0.65); C243(1.16)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C817(0.70); C826(0.70); C243(1.01)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C817(0.61); C826(0.61); C243(1.26)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C243(0.89); C817(0.91); C826(0.91)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C817(0.78); C826(0.78); C243(0.79)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C817(0.88); C826(0.88); C417(1.02)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C243(0.88); C817(0.95); C826(0.95)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C243(0.83); C817(0.88); C826(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C243(0.89); C817(1.08); C826(1.08)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C817(0.89); C826(0.89); C243(1.02)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C817(0.84); C826(0.84); C243(0.90)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C243(0.93); C817(1.06); C826(1.06)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C817(0.75); C826(0.75); C243(0.91)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C817(0.77); C826(0.77); C243(1.00)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C817(0.84); C826(0.84); C243(0.96)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C243(0.89); C817(1.10); C826(1.10)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C817(0.76); C826(0.76); C417(1.11)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C817(1.04); C826(1.04); C243(1.04)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C817(0.87); C826(0.87); C243(0.88)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C817(0.85); C826(0.85); C243(1.00)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C817(0.56); C826(0.56); C417(1.73)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C817(0.95); C826(0.95); C417(1.54)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C817(0.71); C826(0.71); C417(1.19)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C417(1.20); C817(1.27); C826(1.27)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C817(0.85); C826(0.85); C417(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C817(0.88); C826(0.88); C417(1.13)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C817(0.89); C826(0.89); C417(1.44)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C417(0.95); C817(1.36); C826(1.36)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C817(0.96); C826(0.96); C417(1.71)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C817(1.16); C826(1.16); C417(1.61)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C817(0.89); C826(0.89); C417(1.24)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C417(1.15); C817(1.32); C826(1.32)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C817(0.79); C826(0.79); C417(1.19)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C817(0.99); C826(0.99); C417(1.38)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C817(0.83); C826(0.83); C417(1.45)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C777(0.30); C817(0.39); C826(0.39); C417(1.35)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C777(0.55); C417(0.91); C817(0.92); C826(0.92)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C817(0.77); C826(0.77); C417(1.01)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C817(0.62); C826(0.62); C417(0.88)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C817(0.66); C826(0.66); C417(1.07)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 13.01  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C417(0.82); C727(0.53)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C826(1.05)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C826(1.57)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C817(0.57); C826(0.57); C243(0.97); C417(1.01)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C817(0.73); C826(0.73); C417(1.12)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C817(0.90); C826(0.90); C417(1.09)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C817(0.70); C826(0.70); C417(0.97)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C817(0.84); C826(0.84); C417(0.95)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C817(0.88); C826(0.88)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C817(0.82); C826(0.82)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C817(0.87); C826(0.87)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C817(0.87); C826(0.87)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C817(0.92); C826(0.92)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C826(2.13)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C817(1.12); C826(1.12)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C817(1.29); C826(1.29)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C817(0.74); C826(0.74); C777(1.06)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C817(0.67); C826(0.67); C777(0.78)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C817(0.58); C826(0.58); C777(0.67)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C817(0.64); C826(0.64); C777(0.79)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C817(0.58); C826(0.58); C777(0.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C817(1.02); C826(1.02)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C817(0.78); C826(0.78)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C817(0.89); C826(0.89)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C826(1.10)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C817(1.13); C826(1.13)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C817(14.41); C826(14.41)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C817(0.85); C826(0.85)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C817(0.81); C826(0.81)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C817(0.90); C826(0.90)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C817(0.84); C826(0.84); C243(1.12)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C817(0.90); C826(0.90); C243(0.91)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C817(0.74); C826(0.74); C243(1.18)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C817(0.75); C826(0.75); C243(1.12)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C826(1.13)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C826(1.13)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C826(1.51)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C243(1.07)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C417(0.69); C826(1.01)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C417(1.09); C826(1.09)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C417(0.82); C826(1.00)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C826(1.12)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C417(0.77); C826(1.01)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C417(0.92); C826(1.22)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C417(0.68); C826(1.00)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C417(0.83); C826(1.05)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C417(1.17); C826(0.94)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C417(0.84); C826(0.93)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C417(0.93); C826(0.98)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C417(0.79); C826(1.02)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C417(0.50); C826(1.05)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C417(1.05); C826(0.99)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C826(1.15)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C417(1.08); C826(1.30)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C777(0.83)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C243(1.04); C777(0.68)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C243(1.18); C777(0.72)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C243(1.00); C777(0.79)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C243(1.08); C777(0.97)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C243(0.87); C777(1.03)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C243(0.97); C777(0.93)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C243(1.16); C777(0.81)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C826(1.33)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C243(0.97); C777(0.97)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C243(1.06); C777(1.05)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C243(0.83); C777(0.99)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C243(0.98); C777(0.89)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C243(0.95); C777(0.73)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C243(1.03); C777(0.67)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C417(0.85)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C417(0.78)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C417(0.69)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C417(0.66)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C826(1.28)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C417(0.68)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C417(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C417(0.88)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C417(0.73)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C417(0.75)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C417(0.76)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C417(0.63)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C417(0.59)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C417(0.65)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C417(0.73)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C826(1.48)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C417(0.75)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C417(0.77); C826(1.13)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C417(0.53); C826(1.14)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C417(0.71); C826(1.08)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C417(0.70); C826(0.93)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C417(0.78); C826(1.02)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C417(0.39); C826(1.03)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C417(0.81); C826(1.00)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C417(0.47); C826(1.25)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C417(0.50); C826(1.06)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C826(1.73)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C417(0.56); C826(0.96)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C417(0.56); C826(1.18)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C417(0.87); C826(1.04)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C417(0.46); C826(1.14)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C417(0.79); C826(1.55)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C417(0.97)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C417(0.99)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C417(0.95)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C417(1.00)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C243(2.24); C817(0.74); C826(0.74)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C417(1.12)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C417(1.06)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C417(1.02)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C417(1.15)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C417(1.00)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C417(0.95)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C417(0.88)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C417(1.03)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C417(0.95)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C417(0.85)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C243(1.86); C817(0.95); C826(0.95)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C417(1.02)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C817(0.63); C826(0.63); C243(0.98); C417(1.04)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C817(0.46); C826(0.46); C243(0.87); C417(1.09)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C817(0.71); C826(0.71); C243(0.78); C417(1.03)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C817(0.59); C826(0.59); C243(0.93); C417(1.31)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C817(0.83); C826(0.83); C243(1.07); C417(1.24)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C817(0.50); C826(0.50); C243(0.95); C417(1.17)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C817(0.56); C826(0.56); C243(0.95); C417(1.03)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C817(0.64); C826(0.64); C243(1.06); C417(1.07)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C817(0.46); C826(0.46); C243(0.86); C417(0.99)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C417(1.03)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C417(0.54); C826(1.53)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C243(0.88); C777(0.90)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C764(1.10); C417(1.04); C727(1.02)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C764(0.98); C417(0.91); C727(0.94)  LDD1497  [7]
 LDCM0024  KB05 G361 C417(2.51)  LDD3311  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 534 (ZNF534) Krueppel C2H2-type zinc-finger protein family Q76KX8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840