Details of the Target

General Information of Target

Target ID LDTP13371
Target Name Mitochondrial peptide methionine sulfoxide reductase (MSRA)
Gene Name MSRA
Gene ID 4482
Synonyms
Mitochondrial peptide methionine sulfoxide reductase; EC 1.8.4.11; Peptide-methionine; S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQLSKNLGDSSPPAEAPKPPVYSRPTVLMRAPPASSRAPPVPWDPPPIDLQASLAAWQA
PQPAWEAPQGQLPAPVVPMTQPPALGGPIVPAPPLGGPMGKPPTPGVLMVHPPPPGAPMA
QPPTPGVLMVHPSAPGAPMAHPPPPGTPMSHPPPPGTPMAHPPPPGTPMAHPPPPGTPMV
HPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAQPPAPGVLMA
QPLTPGVLMVQPAAPGAPMVQPPPAAMMTQPQPSGAPMAKPPGPGVLMIHPPGARAPMTQ
PPASGAPMAQPAAPPAQPMAPPAQPMASWAPQAQPLILQIQSQVIRAPPQVPQGPQAPPA
QLATPPGWQATSPGWQATQQGWQATPLTWQTTQVTWQAPAVTWQVPPPMRQGPPPIRPGP
PPIRPGPPPVRQAPPLIRQAPPVIRQAPPVIRQAPPVIRQAPAVIRQAPPVIRQAPPVIR
QAPPVIRQAPPLIRQAPPPIRPAPQVLATQPPLWQALPPPPPLRQAPQARLPAPQVQAAP
QVPTAPPATQVPAAPPAGPQVPQPVLPAPLSAPLSAPQAVHCPSIIWQAPKGQPPVPHEI
PTSMEFQEVQQTQALAWQAQKAPTHIWQPLPAQEAQRQAPPLVQLEQPFQGAPPSQKAVQ
IQLPPQQAQASGPQAEVPTLPLQPSWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTPSGE
CRASSIDRRGSSKERRTSSKERRAPSKDRMIFAATFCAPKAVSAARAHLPAAWKNLPATP
ETFAPSSSVFPATSQFQPASLNAFKGPSAASETPKSLPYALQDPFACVEALPAVPWVPQP
NMNASKASQAVPTFLMATAAAPQATATTQEASKTSVEPPRRSGKATRKKKHLEAQEDSRG
HTLAFHDWQGPRPWENLNLSDWEVQSPIQVSGDWEHPNTPRGLSGWEGPSTSRILSGWEG
PSASWALSAWEGPSTSRALGLSESPGSSLPVVVSEVASVSPGSSATQDNSKVEAQPLSPL
DERANALVQFLLVKDQAKVPVQRSEMVKVILREYKDECLDIINRANNKLECAFGYQLKEI
DTKNHAYIIINKLGYHTGNLVASYLDRPKFGLLMVVLSLIFMKGNCVREDLIFNFLFKLG
LDVRETNGLFGNTKKLITEVFVRQKYLEYRRIPYTEPAEYEFLWGPRAFLETSKMLVLRF
LAKLHKKDPQSWPFHYLEALAECEWEDTDEDEPDTGDSAHGPTSRPPPR
Target Bioclass
Enzyme
Family
MsrA Met sulfoxide reductase family
Subcellular location
Cytoplasm; Mitochondrion
Function Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Uniprot ID
Q9UJ68
Ensemble ID
ENST00000317173.9
HGNC ID
HGNC:7377

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P125S .
HT SNV: p.Y207C .
KPNYN SNV: p.E170D .
LS180 SNV: p.E63A .
NALM6 SNV: p.G97R .
OE33 SNV: p.G221D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.43  LDD0402  [1]
Probe 1
 Probe Info  		Y99(22.13)  LDD3495  [2]
HHS-475
 Probe Info  		Y211(11.17)  LDD0264  [3]
DBIA
 Probe Info  		C229(4.21); C220(2.60)  LDD0533  [4]
5E-2FA
 Probe Info  		H153(0.00); H186(0.00); H127(0.00)  LDD2235  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
NAIA_5
 Probe Info  		C109(0.00); C229(0.00); C220(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C229(0.17); C220(0.17)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C229(0.51); C220(0.75)  LDD1094  [4]
 LDCM0216  AC100 HCT 116 C229(4.21); C220(2.60)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C229(0.99); C220(1.04)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C229(0.54); C220(0.84)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C229(0.16); C220(0.68)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C229(0.35); C220(0.71)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C229(0.28); C220(0.73)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C229(0.28); C220(0.65)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C229(0.11); C220(0.54)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C229(0.99); C220(1.03)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C229(1.15); C220(1.10)  LDD0542  [4]
 LDCM0226  AC11 PaTu 8988t C229(0.56); C220(0.81)  LDD1105  [4]
 LDCM0227  AC110 HCT 116 C229(0.89); C220(0.98)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C229(0.80); C220(0.97)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C229(0.54); C220(0.92)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C229(1.53); C220(1.28)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C229(0.97); C220(1.06)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C229(0.83); C220(1.20)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C229(0.93); C220(1.30)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C229(1.26); C220(1.12)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C229(1.04); C220(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C229(1.08); C220(1.15)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C229(0.53); C220(0.85)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C229(0.95); C220(1.23)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C229(1.39); C220(1.00)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C229(1.00); C220(1.08)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C229(0.85); C220(0.98)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C229(1.21); C220(0.94)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C229(1.06); C220(1.02)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C229(0.99); C220(1.11)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C229(1.07); C220(1.06)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C229(0.16); C220(0.16)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C229(1.21); C220(1.21)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C229(0.48); C220(0.48)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C229(1.24); C220(1.24)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C229(1.57); C220(1.57)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C229(0.73); C220(0.73)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C229(0.43); C220(0.43)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C229(0.45); C220(0.45)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C229(0.76); C220(0.76)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C229(1.37); C220(1.37)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C229(0.70); C220(0.70)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C229(0.83); C220(0.83)  LDD0575  [4]
 LDCM0259  AC14 PaTu 8988t C229(1.32); C220(1.25)  LDD1138  [4]
 LDCM0260  AC140 HCT 116 C229(0.52); C220(0.52)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C229(0.88); C220(0.88)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C229(1.78); C220(1.78)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C229(0.72); C220(0.72)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C229(0.82); C220(0.82)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C229(0.99); C220(0.99)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C229(0.89); C220(0.89)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C229(0.79); C220(0.79)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C229(0.45); C220(0.45)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C229(0.25); C220(0.25)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C229(0.97); C220(1.04)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C229(0.58); C220(0.58)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C229(0.17); C220(0.17)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C229(0.30); C220(0.30)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C229(0.16); C220(0.16)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C229(0.18); C220(0.18)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C229(0.41); C220(0.41)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C229(0.36); C220(0.36)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C229(0.63); C220(0.63)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C220(1.05); C229(1.17)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C220(0.84); C229(0.85)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C220(0.98); C229(1.03)  LDD0595  [4]
 LDCM0279  AC2 PaTu 8988t C229(0.42); C220(0.42)  LDD1158  [4]
 LDCM0280  AC20 HCT 116 C220(1.10); C229(1.13)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C220(1.00); C229(1.10)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C220(0.97); C229(1.00)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C220(0.85); C229(0.87)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C229(0.92); C220(0.94)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C220(0.91); C229(0.97)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C229(1.08); C220(1.09)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C229(0.90); C220(0.99)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C229(0.94); C220(1.01)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C229(0.96); C220(1.15)  LDD0606  [4]
 LDCM0290  AC3 PaTu 8988t C229(0.50); C220(0.50)  LDD1169  [4]
 LDCM0291  AC30 HCT 116 C229(1.17); C220(1.23)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C229(1.01); C220(1.04)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C229(0.61); C220(0.89)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C229(0.66); C220(0.89)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C229(0.35); C220(0.78)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C220(1.64); C229(1.67)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C229(1.29); C220(1.36)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C229(1.47); C220(1.53)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C229(0.95); C220(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C229(0.86); C220(0.95)  LDD0617  [4]
 LDCM0301  AC4 PaTu 8988t C229(0.56); C220(0.56)  LDD1180  [4]
 LDCM0302  AC40 HCT 116 C229(0.61); C220(0.69)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C229(1.05); C220(1.24)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C229(0.80); C220(0.90)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C229(0.90); C220(1.06)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C229(0.83); C220(0.93)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C229(0.77); C220(0.83)  LDD0624  [4]
 LDCM0308  AC46 PaTu 8988t C229(1.10); C220(1.10)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C229(0.88); C220(0.88)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C229(0.93); C220(0.93)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C229(0.33); C220(0.33)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C229(0.19); C220(0.19)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C229(0.21); C220(0.21)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C229(0.25); C220(0.25)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C229(1.20); C220(1.20)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C229(0.19); C220(0.19)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C229(0.16); C220(0.16)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C229(1.27); C220(1.27)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C229(0.70); C220(0.70)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C229(0.49); C220(0.79)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C229(0.43); C220(0.69)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C229(0.23); C220(0.49)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C229(1.10); C220(1.07)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C229(0.68); C220(0.73)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C229(0.75); C220(0.77)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C229(0.19); C220(0.48)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C229(0.77); C220(0.79)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C229(0.19); C220(0.46)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C229(0.22); C220(0.57)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C229(0.39); C220(0.59)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C229(0.07); C220(0.44)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C229(0.37); C220(0.37)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C229(0.33); C220(0.33)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C229(1.13); C220(1.05)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C229(0.10); C220(0.10)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C229(0.92); C220(0.92)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C229(0.25); C220(0.25)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C229(0.10); C220(0.10)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C229(0.10); C220(0.10)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C229(0.11); C220(0.11)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C229(0.12); C220(0.12)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C229(0.12); C220(0.12)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C229(0.71); C220(0.71)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C229(0.43); C220(0.43)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C229(1.11); C220(1.04)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C229(0.20); C220(0.20)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C229(0.57); C220(0.57)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C229(0.11); C220(0.11)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C229(0.11); C220(0.88)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C229(0.17); C220(1.01)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C220(1.46); C229(1.62)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C229(1.02); C220(1.13)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C220(1.30); C229(1.72)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C220(1.08); C229(1.15)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C229(0.40); C220(0.92)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C220(1.24); C229(1.68)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C229(0.10); C220(0.85)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C229(0.13); C220(0.83)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C220(1.21); C229(1.53)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C220(1.65); C229(2.55)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C220(1.22); C229(1.23)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C229(0.81); C220(1.26)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C229(0.21); C220(0.91)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C229(0.06); C220(0.63)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C229(0.58); C220(0.80)  LDD0683  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C229(1.61); C220(1.46)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C229(0.24); C220(0.72)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C229(0.37); C220(0.63)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 11.65  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C220(0.99); C229(1.13)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C229(0.29); C220(0.52)  LDD0685  [4]
 LDCM0369  CL100 PaTu 8988t C229(0.74); C220(0.74)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C229(0.87); C220(0.96)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C229(0.67); C220(0.88)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C229(0.60); C220(0.78)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C229(0.92); C220(1.10)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C220(0.90); C229(0.92)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C229(0.49); C220(0.57)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C229(0.41); C220(0.54)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C229(0.20); C220(0.41)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C220(0.97); C229(0.99)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C229(0.15); C220(0.48)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C229(0.61); C220(0.68)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C220(0.83); C229(0.84)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C220(1.22); C229(1.31)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C229(0.74); C220(1.06)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C229(1.04); C220(1.29)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C229(0.93); C220(1.13)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C229(1.00); C220(1.02)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C229(0.55); C220(0.60)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C229(0.77); C220(0.85)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C229(0.82); C220(0.85)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C229(0.14); C220(0.53)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C229(1.02); C220(1.08)  LDD0708  [4]
 LDCM0392  CL121 PaTu 8988t C229(1.35); C220(1.35)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C229(0.87); C220(0.87)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C229(0.67); C220(0.67)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C229(0.33); C220(0.33)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C220(0.98); C229(1.02)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C220(0.99); C229(1.16)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C220(1.00); C229(1.20)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C229(0.30); C220(0.61)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C229(0.49); C220(0.78)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C220(1.11); C229(1.22)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C229(0.62); C220(0.74)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C229(1.23); C220(1.23)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C229(1.06); C220(1.17)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C229(1.14); C220(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C229(0.79); C220(0.90)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C220(0.95); C229(1.41)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C229(0.47); C220(0.70)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C229(0.24); C220(0.76)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C229(0.18); C220(0.37)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C229(0.72); C220(0.96)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C229(0.24); C220(0.60)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C229(0.22); C220(0.73)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C229(0.81); C220(0.95)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C229(0.84); C220(0.99)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C229(0.51); C220(1.07)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C229(0.59); C220(0.63)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C229(1.02); C220(0.95)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C229(1.17); C220(1.07)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C220(1.05)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C220(0.98)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C220(1.09)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C220(1.15)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C220(1.11)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C220(1.05)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C220(1.11)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C220(0.96)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C229(0.98); C220(0.89)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C220(1.00)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C220(1.08)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C220(0.94)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C220(1.15)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C220(1.01)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C220(0.95)  LDD0752  [4]
 LDCM0436  CL46 PaTu 8988t C229(0.86); C220(0.86)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C229(0.97); C220(0.97)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C229(1.17); C220(1.17)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C229(0.74); C220(0.74)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C229(0.97); C220(0.89)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C229(0.68); C220(0.68)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C229(0.87); C220(0.87)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C229(0.99); C220(0.99)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C229(0.48); C220(0.48)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C229(0.81); C220(0.81)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C229(0.76); C220(0.76)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C229(0.20); C220(0.20)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C229(0.13); C220(0.13)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C229(0.38); C220(0.38)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C229(0.13); C220(0.13)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C229(0.88); C220(0.91)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C229(0.12); C220(0.12)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C220(0.99)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C220(1.06)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C220(1.13)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C220(1.10)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C220(0.96)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C220(1.10)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C220(0.97)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C220(1.20)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C220(1.04)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C229(0.24); C220(0.55)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C220(0.85)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C220(1.06)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C220(1.22)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C220(0.91)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C220(1.04)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C229(0.85); C220(0.85)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C229(0.70); C220(0.70)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C229(0.97); C220(0.97)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C229(0.38); C220(0.38)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C229(0.13); C220(0.59)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C229(0.95); C220(0.95)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C229(0.63); C220(0.63)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C229(0.20); C220(0.20)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C229(0.24); C220(0.24)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C229(0.19); C220(0.19)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C229(0.99); C220(0.99)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C229(1.18); C220(1.18)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C229(0.54); C220(0.54)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C229(0.26); C220(0.26)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C229(0.21); C220(0.21)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C229(0.54); C220(0.76)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C229(0.72); C220(0.72)  LDD0802  [4]
 LDCM0486  CL91 PaTu 8988t C229(0.57); C220(0.57)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C229(0.40); C220(0.40)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C229(0.45); C220(0.45)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C229(0.36); C220(0.36)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C229(0.28); C220(0.28)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C229(0.58); C220(0.58)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C229(0.50); C220(0.50)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C229(0.24); C220(0.24)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C229(0.46); C220(0.46)  LDD1373  [4]
 LDCM0468  Fragment33 HCT 116 C220(1.13)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C220(1.08)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y211(11.17)  LDD0264  [3]
 LDCM0118  HHS-0301 DM93 Y211(0.95)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y211(6.41)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y211(10.03)  LDD0268  [3]
 LDCM0022  KB02 A2058 C87(1.15)  LDD2253  [8]
 LDCM0023  KB03 A2780 C87(1.72)  LDD2671  [8]
 LDCM0024  KB05 COLO792 C87(1.08)  LDD3310  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Methanethiol oxidase (SELENBP1) Selenium-binding protein family Q13228
F-box/LRR-repeat protein 3 (FBXL3) . Q9UKT7
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hippocalcin-like protein 4 (HPCAL4) Recoverin family Q9UM19
EF-hand calcium-binding domain-containing protein 11 (EFCAB11) . Q9BUY7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Methionine Small molecular drug DB00134
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
14-dithiothreitol Small molecular drug DB04447

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840