Details of the Target

General Information of Target

Target ID LDTP13225
Target Name Ubiquitin thioesterase ZRANB1 (ZRANB1)
Gene Name ZRANB1
Gene ID 54764
Synonyms
TRABID; Ubiquitin thioesterase ZRANB1; EC 3.4.19.12; TRAF-binding domain-containing protein; hTrabid; Zinc finger Ran-binding domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIY
TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAV
PFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAIL
SLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLK
YIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSK
KGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAP
WFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIF
VEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFA
SLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLV
TGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMES
YNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG
Target Bioclass
Enzyme
Family
Peptidase C64 family
Subcellular location
Cytoplasm
Function
Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
Uniprot ID
Q9UGI0
Ensemble ID
ENST00000359653.4
HGNC ID
HGNC:18224

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C207(2.42)  LDD1701  [1]
DBIA
 Probe Info  		C104(2.83); C107(2.83)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C342(1.16); C348(1.16)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C342(1.00); C348(1.00)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C207(1.07); C342(0.71); C348(0.71)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C207(1.38); C342(0.70); C348(0.70)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C207(0.80); C342(0.82); C348(0.82)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C207(1.40); C342(0.80); C348(0.80)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C207(1.63); C342(0.77); C348(0.77)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C207(1.26); C342(0.90); C348(0.90)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C207(1.58); C342(0.73); C348(0.73)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C207(1.24); C342(0.70); C348(1.04)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C207(1.18); C342(0.71); C348(0.64)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C207(1.01); C342(0.64); C348(0.76)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C342(1.14); C348(1.14)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C207(1.07); C342(0.69); C348(0.67)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C207(0.90); C342(0.75); C348(0.68)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C207(1.06); C342(0.79); C348(0.83)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C342(0.99); C348(0.99)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C342(1.05); C348(1.05)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C342(1.12); C348(1.12)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C342(1.30); C348(1.30)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C342(0.98); C348(0.98)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C342(1.00); C348(1.00)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C342(1.10); C348(1.10)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C342(0.95); C348(0.95)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C342(0.89); C348(0.89)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C342(1.07); C348(1.07)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C342(1.02); C348(1.02)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C342(0.91); C348(0.91)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C342(1.06); C348(1.06)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C342(1.03); C348(1.03)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C342(1.14); C348(1.14)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C342(1.11); C348(1.11)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C207(1.24); C342(1.09); C348(1.00)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C207(1.26); C342(1.07); C348(0.83)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C207(0.99); C342(0.80); C348(0.80)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C207(1.09); C342(0.85); C348(0.97)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C207(1.10); C342(1.06); C348(0.91)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C207(0.98); C342(0.78); C348(0.77)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C207(1.25); C342(0.79); C348(0.83)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C207(0.99); C342(0.93); C348(0.87)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C207(1.16); C342(0.97); C348(1.00)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C207(0.81); C342(0.81); C348(0.79)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C207(0.80); C342(0.84); C348(0.79)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C207(0.93); C342(0.76); C348(0.78)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C342(1.04); C348(1.04)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C207(0.86); C342(0.92); C348(0.89)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C207(0.96); C342(0.78); C348(0.78)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C207(1.19); C342(0.85); C348(0.77)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C342(0.98); C348(0.98); C207(1.17)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C207(0.91); C348(1.03); C342(1.03)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C348(0.89); C342(0.92); C207(1.08)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C342(0.91); C348(0.93); C207(1.50)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C342(0.84); C348(0.84); C207(1.04)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C348(1.09); C342(1.15); C207(1.29)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C348(1.00); C207(1.02); C342(1.05)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C342(0.98); C348(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C207(0.83); C348(0.88); C342(0.95)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C348(0.83); C342(0.91); C207(1.27)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C348(0.84); C342(0.96); C207(1.09)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C348(0.93); C342(1.04); C207(1.21)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C207(0.96); C342(1.04); C348(0.93)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C207(1.10); C342(1.15); C348(1.00)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C207(1.27); C342(0.91); C348(0.85)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C207(1.36); C342(1.02); C348(0.86)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C342(0.83); C348(0.83)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C342(0.77); C348(0.77)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C342(0.76); C348(0.76)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C342(1.31); C348(1.31)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C342(0.89); C348(0.89)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C342(0.74); C348(0.74)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C342(1.42); C348(1.42)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C342(0.79); C348(0.79)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C342(0.97); C348(0.97)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C342(1.14); C348(1.14)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C342(1.21); C348(1.21)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C342(1.13); C348(1.13)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C342(1.29); C348(1.29)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C342(1.05); C348(1.05)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C342(1.19); C348(1.19)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C342(1.10); C348(1.10)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C342(1.04); C348(1.04)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C342(1.15); C348(1.15)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C342(1.11); C348(1.11)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C342(1.05); C348(1.05)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C342(0.71); C348(0.71)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C342(0.98); C348(0.98)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C342(0.82); C348(0.82)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C342(1.16); C348(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C342(1.07); C348(1.07)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C342(1.27); C348(1.27)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C342(1.02); C348(1.02)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C342(0.88); C348(0.88)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C342(0.99); C348(0.99)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C342(0.96); C348(0.96)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C342(0.97); C348(0.97)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C342(1.02); C348(1.02)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C342(1.08); C348(1.08); C207(1.08)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C207(0.70); C342(0.95); C348(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C207(0.72); C342(1.03); C348(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C342(1.02); C348(1.02); C207(1.24)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C342(1.21); C348(1.21)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C342(1.01); C348(1.01); C207(1.68)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C207(0.93); C342(0.98); C348(0.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C207(0.82); C342(0.98); C348(0.98)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C342(1.09); C348(1.09); C207(1.22)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C207(0.95); C342(1.04); C348(1.04)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C342(1.05); C348(1.05); C207(1.07)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C342(1.08); C348(1.08); C207(1.55)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C342(0.99); C348(0.99)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C342(1.04); C348(1.04)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C342(1.12); C348(1.12)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C342(0.96); C348(0.96)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C342(0.90); C348(0.90)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C342(0.80); C348(0.80)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C342(1.27); C348(1.27)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C342(1.11); C348(1.11)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C342(1.26); C348(1.26)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C342(1.22); C348(1.22)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C342(1.12); C348(1.12)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C342(1.01); C348(1.01)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C342(1.14); C348(1.14)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C342(1.14); C348(1.14)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C342(0.88); C348(0.88)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C342(1.27); C348(1.27)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C342(1.20); C348(1.20)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C342(1.23); C348(1.23)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C342(1.28); C348(1.28)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C342(1.12); C348(1.12)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C342(1.18); C348(1.18)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C342(1.25); C348(1.25)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C342(1.28); C348(1.28)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C342(1.07); C348(1.07)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C342(1.23); C348(1.23)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C342(0.93); C348(0.93)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C342(1.44); C348(1.44)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C342(1.09); C348(1.09)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C342(1.30); C348(1.30)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C342(1.42); C348(1.42); C207(2.80)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C342(1.05); C348(1.05); C207(1.50)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C342(0.99); C348(0.99); C207(1.59)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C342(1.39); C348(1.39); C207(1.74)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C342(1.07); C348(1.07); C207(1.33)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C342(1.27); C348(1.27); C207(2.30)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C342(1.29); C348(1.29); C207(1.51)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C342(1.29); C348(1.29); C207(2.90)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C342(1.39); C348(1.39); C207(1.44)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C207(1.39); C342(1.43); C348(1.43)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C342(0.97); C348(0.97); C207(1.52)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C207(0.85); C342(0.91); C348(0.91)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C342(0.98); C348(0.98); C207(1.64)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C207(0.98); C342(1.07); C348(1.07)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C342(1.29); C348(1.29); C207(2.42)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C342(0.66); C348(0.66); C207(1.86)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C342(0.66); C348(0.66); C207(1.07)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C342(0.98); C348(0.98)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C342(1.06); C348(1.06)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C342(1.12); C348(1.12)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C207(1.00)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C207(0.68); C342(1.11); C348(1.11)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C342(1.37); C348(1.37); C207(2.08)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C342(1.18); C348(1.18)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C342(1.12); C348(1.12)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C342(0.97); C348(0.97)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C342(0.97); C348(0.97)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C342(1.05); C348(1.05)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C342(0.89); C348(0.89)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C342(0.78); C348(0.78)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C342(0.69); C348(0.69)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C342(1.41); C348(1.41)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C342(0.97); C348(0.97)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C207(1.20); C342(1.33); C348(1.33)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C342(1.00); C348(1.00)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C342(0.96); C348(0.96)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C342(1.09); C348(1.09)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C342(0.95); C348(0.95)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C342(1.09); C348(1.09)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C342(1.08); C348(1.08)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C342(1.16); C348(1.16)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C342(1.08); C348(1.08)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C342(1.04); C348(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C342(0.89); C348(0.89)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C342(1.14); C348(1.14); C207(2.08)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C342(1.31); C348(1.31)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C207(0.85); C342(0.98); C348(0.98)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C342(0.91); C348(0.91); C207(0.98)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C207(1.09); C342(1.26); C348(1.26)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C342(0.99); C348(0.99); C207(1.56)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C342(1.06); C348(1.06)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C342(0.95); C348(0.95)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C342(0.92); C348(0.92)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C342(1.20); C348(1.20)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C342(1.02); C348(1.02); C207(1.10)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C207(1.14); C342(1.17); C348(1.17)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C207(1.02); C342(1.09); C348(1.09)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C207(0.95); C342(1.04); C348(1.04)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C207(0.80); C342(1.17); C348(1.17)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C207(0.62); C342(0.77); C348(0.77)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C207(0.66); C342(0.97); C348(0.97)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C342(0.97); C348(0.97); C207(1.30)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C207(0.92); C342(0.99); C348(0.99)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C207(1.01); C342(1.30); C348(1.30)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C342(1.18); C348(1.18); C207(1.33)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C207(0.79); C342(1.05); C348(1.05)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C207(0.88); C342(1.04); C348(1.04)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C207(0.97); C342(1.09); C348(1.09)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C207(0.61); C342(1.04); C348(1.04)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C207(0.54); C342(1.08); C348(1.08)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C207(0.71); C342(1.01); C348(1.01)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C207(0.85); C342(1.14); C348(1.14)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C207(0.71); C342(0.96); C348(0.96)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C207(0.49); C342(0.97); C348(0.97)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C207(0.76); C342(1.19); C348(1.19)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C207(0.80); C342(0.98); C348(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C207(1.74); C342(0.98); C348(0.98)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C207(1.07); C342(1.05); C348(1.05)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C207(1.77); C342(0.95); C348(0.95)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C207(1.05); C342(1.21); C348(1.21)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C207(1.37); C342(0.91); C348(0.91)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C207(1.42); C342(1.07); C348(1.07)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C207(0.72); C342(1.00); C348(1.00)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C207(1.29); C342(2.24); C348(2.24)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C207(1.03); C342(1.04); C348(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C207(1.82); C342(1.06); C348(1.06)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C207(1.39); C342(1.21); C348(1.21)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C207(1.34); C342(1.22); C348(1.22)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C207(1.38); C342(1.24); C348(1.24)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C342(1.32); C348(1.32)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C342(1.13); C348(1.13)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C342(0.92); C348(0.92)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C342(1.27); C348(1.27)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C207(1.13); C342(1.01); C348(1.01)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C342(1.12); C348(1.12)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C342(1.13); C348(1.13)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C342(1.17); C348(1.17)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C342(1.27); C348(1.27)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C342(1.13); C348(1.13)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C342(1.08); C348(1.08)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C342(1.02); C348(1.02)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C342(1.16); C348(1.16)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C342(1.23); C348(1.23)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C342(1.01); C348(1.01)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C207(1.28); C342(1.04); C348(1.04)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C342(1.03); C348(1.03)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C207(1.57); C342(0.96); C348(1.06)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C207(0.90); C342(1.02); C348(1.11)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C207(1.09); C342(0.95); C348(1.10)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C207(1.15); C342(1.09); C348(1.13)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C207(0.97); C342(1.00); C348(1.10)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C207(1.02); C342(1.12); C348(1.26)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C207(1.03); C342(1.08); C348(1.19)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C207(0.85); C342(1.18); C348(1.35)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C207(0.99); C342(1.08); C348(1.22)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C207(1.26); C342(1.11); C348(1.11)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C207(0.91); C342(1.14); C348(1.41)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C207(0.82); C342(1.09); C348(1.38)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C207(1.11); C342(1.00); C348(0.97)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C207(0.72); C342(1.00); C348(1.18)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C207(0.72); C342(0.89); C348(1.16)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C342(0.82); C348(0.82)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C342(0.81); C348(0.81)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C342(0.86); C348(0.86)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C342(0.97); C348(0.97)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C207(2.65); C342(1.85); C348(1.85)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C342(0.67); C348(0.67)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C342(0.88); C348(0.88)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C342(1.27); C348(1.27)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C342(0.83); C348(0.83)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C342(0.89); C348(0.89)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C342(0.79); C348(0.79)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C342(0.81); C348(0.81)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C342(0.95); C348(0.95)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C342(0.85); C348(0.85)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C342(0.98); C348(0.98)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C207(0.79); C342(0.95); C348(0.95)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C342(1.36); C348(1.36)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C342(1.25); C348(1.25)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C342(1.15); C348(1.15)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C342(1.20); C348(1.20)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C342(1.36); C348(1.36)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C342(1.10); C348(1.10)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C342(1.39); C348(1.39)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C342(1.14); C348(1.14)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C342(1.07); C348(1.07)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C342(1.15); C348(1.15)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C207(1.61)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C207(1.09); C342(1.04); C348(1.20)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C207(2.05); C342(1.50); C348(1.50)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C104(2.83); C107(2.83)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C104(2.64); C107(2.64)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C104(1.34); C107(1.34)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C207(1.00)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Arrestin domain-containing protein 2 (ARRDC2) Arrestin family Q8TBH0
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Protein N-lysine methyltransferase METTL21A (METTL21A) METTL21 family Q8WXB1
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Tudor-interacting repair regulator protein (NUDT16L1) Nudix hydrolase family Q9BRJ7
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Methionine aminopeptidase 1 (METAP1) Peptidase M24A family P53582
AMSH-like protease (STAMBPL1) Peptidase M67C family Q96FJ0
Phenazine biosynthesis-like domain-containing protein (PBLD) PhzF family P30039
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Tyrosine-protein kinase receptor Tie-1 (TIE1) Tyr protein kinase family P35590
Dual specificity protein phosphatase 13B (DUSP13B) Protein-tyrosine phosphatase family Q9UII6
Tensin-4 (TNS4) PTEN phosphatase protein family Q8IZW8
GTP-binding protein GEM (GEM) RGK family P55040
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Rho-related BTB domain-containing protein 3 (RHOBTB3) . O94955
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
ETS domain-containing transcription factor ERF (ERF) ETS family P50548
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and BTB domain-containing protein 47 (ZBTB47) Krueppel C2H2-type zinc-finger protein family Q9UFB7
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 17 (ZNF17) Krueppel C2H2-type zinc-finger protein family P17021
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 490 (ZNF490) Krueppel C2H2-type zinc-finger protein family Q9ULM2
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 599 (ZNF599) Krueppel C2H2-type zinc-finger protein family Q96NL3
Zinc finger protein 629 (ZNF629) Krueppel C2H2-type zinc-finger protein family Q9UEG4
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 775 (ZNF775) Krueppel C2H2-type zinc-finger protein family Q96BV0
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
PHD finger protein 1 (PHF1) Polycomblike family O43189
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
Bromodomain-containing protein 1 (BRD1) . O95696
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger protein 408 (ZNF408) . Q9H9D4
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 47 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Bystin (BYSL) Bystin family Q13895
Cell division control protein 45 homolog (CDC45) CDC45 family O75419
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Testis-specific Y-encoded-like protein 4 (TSPYL4) Nucleosome assembly protein (NAP) family Q9UJ04
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Chromobox protein homolog 7 (CBX7) . O95931
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Guanine nucleotide exchange factor VAV3 (VAV3) . Q9UKW4
INO80 complex subunit B (INO80B) . Q9C086
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Melanoma-associated antigen B4 (MAGEB4) . O15481
Microspherule protein 1 (MCRS1) . Q96EZ8
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Phostensin (PPP1R18) . Q6NYC8
RAS protein activator like-3 (RASAL3) . Q86YV0
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
TBC1 domain family member 3F (TBC1D3F) . A6NER0
TBC1 domain family member 3G (TBC1D3G) . Q6DHY5
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060