Details of the Target

General Information of Target

Target ID LDTP12822
Target Name Abl interactor 2 (ABI2)
Gene Name ABI2
Gene ID 10152
Synonyms
ARGBPIA; Abl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAE
GYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMG
VGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEV
DTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGF
LLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLP
RSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLC
TSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRIS
VCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRC
KCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGR
CQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLA
GIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAV
LFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL
Target Bioclass
Other
Family
ABI family
Subcellular location
Cytoplasm; Cell projection, lamellipodium
Function
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
Uniprot ID
Q9NYB9
Ensemble ID
ENST00000261017.9
HGNC ID
HGNC:24011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y241(0.80)  LDD0264  [1]
HHS-465
 Probe Info  		Y241(10.00)  LDD2237  [2]
DBIA
 Probe Info  		C33(0.69)  LDD0531  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C33(0.69)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C33(0.72)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C33(0.63)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C33(0.59)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C33(0.56)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C33(0.61)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C33(0.69)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C33(0.57)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C33(0.63)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C33(0.54)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C33(0.72)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C33(0.79)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C33(0.75)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C33(0.68)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C33(0.73)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C33(0.62)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C33(1.02)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C33(0.91)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C33(0.75)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C33(0.90)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C33(0.96)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C33(1.00)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C33(0.87)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C33(0.84)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C33(0.93)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C33(1.13)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C33(1.05)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C33(1.05)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C33(1.24)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C33(1.03)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C33(1.08)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C33(1.09)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C33(1.07)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C33(1.21)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C33(1.24)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C33(1.04)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C33(1.14)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C33(0.93)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C33(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C33(1.03)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C33(0.98)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C33(0.99)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C33(0.98)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C33(1.14)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C33(0.61)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C33(1.21)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C33(1.00)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C33(1.17)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C33(0.73)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C33(0.67)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C33(0.66)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C33(0.75)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C33(0.74)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C33(0.65)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C33(0.67)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C33(0.71)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C33(0.95)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C33(0.71)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C33(0.75)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C33(0.68)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C33(0.89)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C33(0.84)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C33(0.78)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C33(0.81)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C33(0.90)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C33(0.71)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C33(0.79)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C33(0.77)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C33(0.82)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C33(1.00)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C33(1.16)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C33(0.89)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C33(0.92)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C33(0.81)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C33(0.71)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C33(0.74)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C33(0.75)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C33(0.79)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C33(0.78)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C33(0.64)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C33(0.55)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C33(0.59)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C33(0.59)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C33(0.63)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C33(1.21)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C33(1.00)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C33(0.92)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C33(0.88)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C33(1.03)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C33(0.77)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C33(0.83)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C33(0.79)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C33(0.81)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C33(0.87)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C33(0.83)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C33(0.91)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C33(0.89)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C33(0.88)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C33(0.85)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C33(0.92)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C33(0.69)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C33(0.86)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C33(1.04)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C33(0.96)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C33(0.82)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C33(0.90)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C33(0.79)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C33(0.89)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C33(0.55)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C33(0.52)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C33(0.49)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C33(0.78)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C33(0.45)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C33(0.45)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C33(0.42)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C33(0.44)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C33(0.46)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C33(0.29)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C33(0.32)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C33(0.28)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C33(1.10)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C33(1.34)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C33(0.79)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C33(1.24)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C33(1.10)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C33(1.20)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C33(1.21)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C33(1.19)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C33(1.05)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C33(1.36)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C33(1.07)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C33(1.22)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C33(1.12)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C33(0.83)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C33(1.26)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C33(1.16)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C33(1.20)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C33(0.88)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C33(0.90)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C33(0.88)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C33(0.96)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C33(0.97)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C33(0.94)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C33(0.87)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C33(1.09)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C33(0.94)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C33(1.02)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C33(1.09)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C33(0.95)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C33(0.87)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C33(0.84)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C33(0.95)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C33(0.51)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C33(0.67)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C33(0.87)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C33(0.87)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C33(0.63)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C33(0.82)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C33(0.39)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C33(0.66)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C33(0.64)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C33(0.80)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C33(0.98)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C33(0.88)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C33(0.72)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C33(0.63)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C33(0.73)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C33(0.74)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C33(0.75)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C33(0.41)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C33(0.71)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C33(0.76)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C33(0.83)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C33(0.62)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C33(0.64)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C33(0.71)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C33(0.68)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C33(0.82)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C33(0.88)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C33(1.14)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C33(0.40)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C33(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C33(0.92)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C33(0.75)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C33(0.78)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C33(0.84)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C33(0.69)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C33(0.56)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C33(0.54)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C33(0.51)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C33(0.37)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C33(0.42)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C33(0.49)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C33(0.81)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C33(0.71)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C33(0.73)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C33(0.86)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C33(0.66)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C33(0.71)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C33(0.63)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C33(0.78)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C33(0.67)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C33(0.74)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C33(0.72)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C33(0.68)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C33(0.78)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C33(0.77)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C33(0.67)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C33(0.62)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C33(0.86)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C33(0.92)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C33(0.89)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C33(0.82)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C33(0.82)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C33(0.86)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C33(0.91)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C33(0.98)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C33(1.03)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C33(0.73)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C33(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C33(0.83)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C33(0.93)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C33(0.95)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C33(0.94)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C33(0.81)  LDD0752  [3]
 LDCM0437  CL47 HEK-293T C33(0.97)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C33(1.12)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C33(0.83)  LDD1643  [10]
 LDCM0440  CL5 PaTu 8988t C33(0.58)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C33(1.00)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C33(1.02)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C33(1.08)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C33(0.97)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C33(0.84)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C33(1.03)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C33(1.44)  LDD1651  [10]
 LDCM0450  CL59 HEK-293T C33(0.89)  LDD1653  [10]
 LDCM0451  CL6 PaTu 8988t C33(0.73)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C33(0.84)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C33(1.29)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C33(1.15)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C33(0.98)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C33(1.09)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C33(0.94)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C33(1.01)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C33(1.16)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C33(1.45)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C33(0.81)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C33(0.69)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C33(1.26)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C33(1.11)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C33(1.26)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C33(1.39)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C33(1.17)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C33(0.80)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C33(0.82)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C33(0.93)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C33(0.91)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C33(0.52)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C33(0.94)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C33(0.92)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C33(0.91)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C33(0.89)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C33(0.81)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C33(0.84)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C33(0.85)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C33(0.86)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C33(0.92)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C33(0.87)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C33(0.64)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C33(1.01)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C33(0.83)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C33(0.94)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C33(0.97)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C33(0.73)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C33(0.79)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C33(0.80)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C33(0.60)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C33(0.71)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C33(0.65)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C33(0.99)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C33(1.47)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C33(0.92)  LDD0744  [3]
 LDCM0116  HHS-0101 DM93 Y241(0.80)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y241(0.58)  LDD0265  [1]
 LDCM0119  HHS-0401 DM93 Y241(0.56)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y241(0.76)  LDD0268  [1]
 LDCM0022  KB02 A101D C33(2.51)  LDD2250  [11]
 LDCM0023  KB03 A101D C33(3.69)  LDD2667  [11]
 LDCM0024  KB05 SH-4 C33(3.94)  LDD3419  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Valine--tRNA ligase, mitochondrial (VARS2) Class-I aminoacyl-tRNA synthetase family Q5ST30
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) Cyclophilin-type PPIase family P30405
Dystrobrevin beta (DTNB) Dystrophin family O60941
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Large ribosomal subunit protein mL44 (MRPL44) Ribonuclease III family Q9H9J2
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
PWWP domain-containing protein 2B (PWWP2B) . Q6NUJ5
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Sorting nexin-18 (SNX18) Sorting nexin family Q96RF0
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Syntaxin-4 (STX4) Syntaxin family Q12846
Tripartite motif-containing protein 72 (TRIM72) TRIM/RBCC family Q6ZMU5
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Early growth response protein 4 (EGR4) EGR C2H2-type zinc-finger protein family Q05215
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
PHD finger protein 1 (PHF1) Polycomblike family O43189
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Hematopoietically-expressed homeobox protein HHEX (HHEX) . Q03014
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Myogenin (MYOG) . P15173
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Other
Click To Hide/Show 99 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Abl interactor 2 (ABI2) ABI family Q9NYB9
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Large ribosomal subunit protein bL28m (MRPL28) Bacterial ribosomal protein bL28 family Q13084
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Embryonal Fyn-associated substrate (EFS) CAS family O43281
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Centromere protein Q (CENPQ) CENP-Q/OKP1 family Q7L2Z9
Dynein axonemal intermediate chain 7 (DNAI7) DNAI7 family Q6TDU7
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Vasodilator-stimulated phosphoprotein (VASP) Ena/VASP family P50552
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM9C (FAM9C) FAM9 family Q8IZT9
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Radial spoke head 14 homolog (RSPH14) Flagellar radial spoke RSP14 family Q9UHP6
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Protein INCA1 (INCA1) INCA family Q0VD86
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Oocyte-expressed protein homolog (OOEP) KHDC1 family A6NGQ2
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 10 (MED10) Mediator complex subunit 10 family Q9BTT4
Mediator of RNA polymerase II transcription subunit 11 (MED11) Mediator complex subunit 11 family Q9P086
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Pro-opiomelanocortin (POMC) POMC family P01189
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
Vinculin (VCL) Vinculin/alpha-catenin family P18206
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Actin nucleation-promoting factor WASL (WASL) . O00401
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Bridging integrator 3 (BIN3) . Q9NQY0
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Coiled-coil alpha-helical rod protein 1 (CCHCR1) . Q8TD31
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 115 (CCDC115) . Q96NT0
CUE domain-containing protein 1 (CUEDC1) . Q9NWM3
Cytoplasmic protein NCK2 (NCK2) . O43639
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Galectin-9B (LGALS9B) . Q3B8N2
Gametogenetin (GGN) . Q86UU5
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Heat shock factor 2-binding protein (HSF2BP) . O75031
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
INO80 complex subunit B (INO80B) . Q9C086
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
LIM domain transcription factor LMO4 (LMO4) . P61968
Melanoma-associated antigen 1 (MAGEA1) . P43355
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
PML-RARA-regulated adapter molecule 1 (PRAM1) . Q96QH2
Protein Largen (PRR16) . Q569H4
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
Secretagogin (SCGN) . O76038
SH3 domain-binding protein 1 (SH3BP1) . Q9Y3L3
Small kinetochore-associated protein (KNSTRN) . Q9Y448
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein C20orf202 (C20orf202) . A1L168
Uncharacterized protein C4orf17 (C4orf17) . Q53FE4
Vinexin (SORBS3) . O60504
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840