Details of the Target

General Information of Target

Target ID LDTP12671
Target Name Alpha-parvin (PARVA)
Gene Name PARVA
Gene ID 55742
Synonyms
MXRA2; Alpha-parvin; Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGR
GLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHA
GHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSL
QPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPH
VQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSR
EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKK
VLLGEVISDTNEKTSLDIAQKICYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTE
ELKILRASAETLHSLQTAFT
Target Bioclass
Other
Family
Parvin family
Subcellular location
Cell junction, focal adhesion
Function
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Uniprot ID
Q9NVD7
Ensemble ID
ENST00000334956.15
HGNC ID
HGNC:14652

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDMYZ SNV: p.D353N .
SUPT1 SNV: p.R39Q .
TOV21G SNV: p.P21T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K131(6.11); K156(10.00); K25(1.02); K260(10.00)  LDD0277  [1]
BTD
 Probe Info  		C352(0.77)  LDD2089  [2]
HHS-475
 Probe Info  		Y362(0.89)  LDD0264  [3]
IPM
 Probe Info  		C352(1.10)  LDD1701  [2]
DBIA
 Probe Info  		C352(0.95)  LDD0531  [4]
HHS-465
 Probe Info  		N.A.  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C352(0.72)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C352(0.97)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C352(0.72)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C352(0.73)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C352(1.14)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C352(1.57)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C352(0.85)  LDD2103  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C352(0.69)  LDD2132  [2]
 LDCM0214  AC1 HCT 116 C352(0.95)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C352(0.82)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C352(0.86)  LDD1105  [4]
 LDCM0230  AC113 HCT 116 C352(0.96)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C352(1.10)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C352(1.03)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C352(1.21)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C352(1.21)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C352(1.08)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C352(1.26)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C352(1.03)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C352(1.08)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C352(0.81)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C352(1.00)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C352(0.76)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C352(0.96)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C352(0.89)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C352(0.88)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C352(0.90)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C352(1.55)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C352(1.17)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C352(1.14)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C352(1.31)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C352(0.96)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C352(1.11)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C352(1.10)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C352(1.17)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C352(1.28)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C352(1.30)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C352(1.25)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C352(1.38)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C352(0.81)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C352(1.04)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C352(1.08)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C352(0.96)  LDD1141  [4]
 LDCM0270  AC15 PaTu 8988t C352(0.80)  LDD1149  [4]
 LDCM0276  AC17 HEK-293T C352(1.03)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C352(1.06)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C352(0.93)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C352(0.95)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C352(1.06)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C352(1.06)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C352(1.07)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C352(1.11)  LDD1522  [6]
 LDCM0285  AC25 HEK-293T C352(1.03)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C352(0.98)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C352(1.11)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C352(1.17)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C352(1.10)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C352(0.90)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C352(1.04)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C352(1.30)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C352(1.01)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C352(1.16)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C352(1.04)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C352(1.12)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C352(0.98)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C352(1.14)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C352(1.20)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C352(1.11)  LDD0618  [4]
 LDCM0303  AC41 HEK-293T C352(0.99)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C352(1.07)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C352(0.96)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C352(1.07)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C352(1.06)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C352(1.06)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C352(1.35)  LDD1548  [6]
 LDCM0311  AC49 HEK-293T C352(1.08)  LDD1550  [6]
 LDCM0312  AC5 HCT 116 C352(0.83)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C352(1.10)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C352(0.99)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C352(1.16)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C352(0.98)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C352(1.09)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C352(1.28)  LDD1557  [6]
 LDCM0320  AC57 HEK-293T C352(0.97)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C352(1.09)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C352(0.94)  LDD1561  [6]
 LDCM0323  AC6 PaTu 8988t C352(0.67)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C352(1.01)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C352(1.01)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C352(1.11)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C352(1.25)  LDD1566  [6]
 LDCM0334  AC7 PaTu 8988t C352(0.85)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C352(0.61)  LDD1224  [4]
 LDCM0349  AC83 HCT 116 C352(1.10)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C352(1.34)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C352(1.10)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C352(0.97)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C352(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C352(0.89)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C352(1.02)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C352(0.97)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C352(0.93)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C352(1.10)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C352(1.08)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C352(0.94)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C352(1.04)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C352(1.06)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C352(0.98)  LDD0681  [4]
 LDCM0545  Acetamide MDA-MB-231 C352(0.60)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C352(0.66)  LDD2113  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C352(1.02)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C352(0.72)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C352(0.83)  LDD1154  [4]
 LDCM0498  BS-3668 MDA-MB-231 C352(0.63)  LDD2091  [2]
 LDCM0367  CL1 HCT 116 C352(1.14)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C352(1.41)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C352(1.15)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C352(0.67)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C352(0.98)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C352(1.07)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C352(0.88)  LDD1252  [4]
 LDCM0374  CL105 HEK-293T C352(1.05)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C352(1.08)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C352(1.09)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C352(1.11)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C352(1.01)  LDD1582  [6]
 LDCM0379  CL11 HCT 116 C352(1.20)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C352(1.18)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C352(1.12)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C352(1.02)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C352(0.98)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C352(1.18)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C352(1.19)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C352(1.06)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C352(1.02)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C352(1.24)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C352(1.10)  LDD1593  [6]
 LDCM0390  CL12 HCT 116 C352(1.40)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C352(1.08)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C352(1.00)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C352(1.14)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C352(1.30)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C352(1.11)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C352(0.93)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C352(1.11)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C352(1.10)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C352(1.04)  LDD1603  [6]
 LDCM0400  CL13 HCT 116 C352(1.26)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C352(1.35)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C352(1.14)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C352(1.24)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C352(1.34)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C352(1.31)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C352(1.30)  LDD1610  [6]
 LDCM0407  CL2 HCT 116 C352(0.99)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C352(1.38)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C352(1.50)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C352(1.73)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C352(1.73)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C352(1.07)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C352(1.18)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C352(1.18)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C352(1.09)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C352(1.13)  LDD1621  [6]
 LDCM0418  CL3 HCT 116 C352(1.00)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C352(1.09)  LDD1623  [6]
 LDCM0420  CL31 HCT 116 C352(1.11)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C352(1.01)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C352(0.90)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C352(1.20)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C352(1.27)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C352(1.20)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C352(1.20)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C352(0.90)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C352(0.98)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C352(1.29)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C352(1.07)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C352(1.13)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C352(0.91)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C352(0.93)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C352(1.35)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C352(0.94)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C352(1.20)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C352(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C352(1.16)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C352(0.93)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C352(0.98)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C352(1.09)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C352(0.99)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C352(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C352(0.79)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C352(0.96)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C352(0.84)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C352(0.87)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C352(0.92)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C352(1.02)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C352(1.11)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C352(1.03)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C352(1.03)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C352(1.27)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C352(0.91)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C352(1.08)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C352(1.12)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C352(0.90)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C352(0.97)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C352(0.93)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C352(0.80)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C352(1.37)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C352(0.89)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C352(0.91)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C352(1.06)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C352(1.06)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C352(0.99)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C352(0.92)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C352(1.07)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C352(1.09)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C352(0.83)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C352(0.92)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C352(0.94)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C352(0.97)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C352(0.91)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C352(0.78)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C352(0.84)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C352(0.83)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C352(0.82)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C352(0.76)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C352(0.84)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C352(0.78)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C352(1.16)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C352(1.02)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C352(1.04)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C352(0.83)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C352(0.82)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C352(0.86)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C352(0.79)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C352(0.92)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C352(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C352(0.99)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C352(0.87)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C352(1.18)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C352(9.79)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C352(1.05)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C352(2.15)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y362(0.89)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y362(0.87)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y362(0.82)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y362(0.80)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y362(0.93)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C352(1.11)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C352(1.07)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C352(0.93)  LDD1502  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C352(0.83)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C352(0.77)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C352(1.08)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C352(0.95)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C352(1.21)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C352(0.96)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C352(0.97)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C352(1.21)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C352(1.21)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C352(0.95)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C352(0.77)  LDD2104  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C352(0.99)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C352(0.99)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C352(0.98)  LDD2109  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C352(3.09)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C352(0.82)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C352(0.55)  LDD2115  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C352(0.91)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C352(1.08)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C352(0.91)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C352(1.13)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C352(1.39)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C352(1.15)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C352(0.50)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C352(0.52)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C352(1.47)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C352(1.23)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C352(0.85)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C352(0.90)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C352(0.75)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C352(1.04)  LDD2143  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C352(0.61)  LDD2145  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C352(1.42)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Molybdenum cofactor sulfurase (MOCOS) Class-V pyridoxal-phosphate-dependent aminotransferase family Q96EN8
Integrin-linked protein kinase (ILK) TKL Ser/Thr protein kinase family Q13418
Ataxin-3 (ATXN3) . P54252
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402