Details of the Target

General Information of Target

Target ID LDTP11961
Target Name rRNA N6-adenosine-methyltransferase ZCCHC4 (ZCCHC4)
Gene Name ZCCHC4
Gene ID 29063
Synonyms
rRNA N6-adenosine-methyltransferase ZCCHC4; EC 2.1.1.-; Zinc finger CCHC domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNP
PRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKV
VALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEA
VPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMAD
PGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQ
MIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDE
KVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR
Target Bioclass
Enzyme
Family
ZCCHC4 family
Subcellular location
Nucleus, nucleolus
Function rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Uniprot ID
Q9H5U6
Ensemble ID
ENST00000302874.9
HGNC ID
HGNC:22917

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FUOV1 Substitution: p.K475_Q476delinsNK .
HCT15 SNV: p.S179T DBIA    Probe Info 
HEC1 SNV: p.C64Y DBIA    Probe Info 
HS936T SNV: p.S158G .
JURKAT SNV: p.S388F .
KO52 Substitution: p.K475_Q476delinsNK .
MOLT4 Insertion: p.Q77SfsTer5 IA-alkyne    Probe Info 
NUGC3 Deletion: p.F320LfsTer19 .
OVKATE Substitution: p.K475_Q476delinsNK DBIA    Probe Info 
P31FUJ SNV: p.K415E DBIA    Probe Info 
RL952 Deletion: p.F320LfsTer19 DBIA    Probe Info 
RPMI8226 Substitution: p.K475_Q476delinsNK DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C107(1.64)  LDD2105  [2]
DBIA
 Probe Info  		C64(0.89); C67(0.89); C19(0.89)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C325(0.00); C180(0.00)  LDD0037  [4]
IPM
 Probe Info  		C98(0.00); C19(0.00)  LDD0147  [5]
TFBX
 Probe Info  		C107(0.00); C67(0.00); C98(0.00)  LDD0148  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C19(0.86); C64(1.22); C98(0.98)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C19(1.31); C445(1.00); C448(1.00); C64(1.09)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C19(1.19); C64(0.86); C67(0.64); C98(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C19(1.30); C64(0.76); C67(0.64); C98(1.09)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C19(1.07); C64(0.68); C67(0.66); C98(1.04)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C19(1.43); C64(0.60); C67(0.55); C98(1.81)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C19(1.05); C64(0.68); C67(0.62); C98(1.10)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C19(1.30); C64(0.71); C67(0.56); C98(1.32)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C19(1.35); C64(0.62); C67(0.56); C98(1.51)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C19(1.26); C64(0.61); C67(0.58); C98(0.95)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C19(1.20); C64(0.86); C67(0.64); C98(1.04)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C19(1.06); C64(0.96); C67(0.72); C98(1.01)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C19(1.04); C445(0.94); C448(0.94); C64(1.00)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C19(1.38); C64(0.84); C67(0.68); C98(1.19)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C19(1.20); C64(0.85); C67(0.70); C98(0.97)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C19(1.25); C64(0.70); C67(0.59); C98(1.08)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C19(0.79); C64(0.96)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C19(1.15); C64(1.04)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C19(1.31); C64(1.07)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C19(1.23); C64(1.07)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C19(1.16); C64(0.94)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C19(1.11); C64(1.01)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C19(1.03); C64(1.00)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C19(0.98); C445(1.01); C448(1.01); C64(1.25)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C19(0.87); C64(0.99)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C19(0.96); C64(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C19(1.01); C64(1.12)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C19(0.76); C64(1.24)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C19(1.05); C64(1.27)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C19(1.00); C64(1.15)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C19(1.31); C64(0.97)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C19(1.14); C64(1.19)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C19(1.59); C445(1.07); C448(1.07); C64(0.90)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C19(1.51); C445(1.10); C448(1.10); C64(1.07)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C19(1.96); C445(1.25); C448(1.25); C64(0.76)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C19(1.27); C445(0.99); C448(0.99); C64(1.00)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C19(1.48); C445(1.21); C448(1.21); C64(1.05)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C19(1.77); C445(1.18); C448(1.18); C64(0.92)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C19(1.94); C445(0.86); C448(0.86); C64(0.81)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C19(2.46); C445(1.15); C448(1.15); C64(0.90)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C19(1.34); C445(1.19); C448(1.19); C64(0.77)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C19(1.11); C445(1.13); C448(1.13); C64(0.97)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C19(1.71); C445(1.02); C448(1.02); C64(0.83)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C19(1.54); C445(1.21); C448(1.21); C64(0.82)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C19(1.21); C445(0.86); C448(0.86); C64(1.16)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C19(1.99); C445(1.23); C448(1.23); C64(0.79)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C19(1.92); C445(1.17); C448(1.17); C64(0.83)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C19(1.37); C445(1.16); C448(1.16); C64(1.16)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C67(0.91); C64(0.96); C19(1.00); C411(1.20)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C67(0.76); C64(0.90); C19(1.03); C411(1.38)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C19(0.89); C64(1.12); C67(1.14); C411(1.98)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C67(0.90); C19(0.98); C64(1.05); C411(1.32)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C67(0.81); C411(0.89); C414(0.89); C64(0.92)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C67(0.78); C19(0.94); C64(0.94); C411(0.95)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C67(0.68); C64(0.91); C411(1.01); C414(1.01)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C98(0.89); C445(0.97); C448(0.97); C19(1.19)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C64(0.97); C67(1.02); C19(1.05); C411(1.19)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C19(1.01); C64(1.34); C67(1.40); C411(1.46)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C67(0.80); C19(0.91); C64(0.93); C411(1.23)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C67(0.86); C19(0.86); C64(1.03); C411(1.04)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C19(0.93); C411(1.07); C414(1.07); C64(0.94)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C19(0.99); C411(0.90); C414(0.90); C64(0.91)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C19(0.97); C411(1.45); C414(1.45); C64(1.00)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C19(1.00); C411(1.28); C414(1.28); C64(1.28)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C67(1.02); C19(1.03); C64(1.03); C98(1.13)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C67(0.50); C64(0.82); C19(0.89); C98(1.17)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C67(0.80); C64(0.89); C19(0.93); C98(1.24)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C64(0.87); C19(0.99); C98(1.11)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C67(0.81); C19(0.88); C64(0.98); C98(1.12)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C19(0.81); C67(0.83); C64(0.92); C98(1.08)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C19(0.91); C98(0.99); C67(1.12); C64(1.14)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C19(0.87); C67(0.87); C64(0.95); C98(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C64(0.83); C19(0.88); C67(0.91); C98(1.05)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C19(0.87); C445(1.02); C448(1.02); C98(1.14)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C19(1.06); C445(1.24); C448(1.24); C98(1.44)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C19(1.06); C445(1.20); C448(1.20); C98(1.33)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C19(0.97); C445(1.17); C448(1.17); C98(1.22)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C445(1.01); C448(1.01); C98(1.39); C19(1.45)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C64(0.79); C19(1.00); C98(1.23)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C445(1.18); C448(1.18); C19(1.33); C98(1.40)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C445(1.09); C448(1.09); C19(1.12); C98(1.55)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C445(1.34); C448(1.34); C19(1.38); C98(1.88)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C19(1.03); C445(1.12); C448(1.12); C98(1.50)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C445(0.91); C448(0.91); C19(1.05); C98(1.61)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C98(0.76); C19(0.85); C64(1.09); C67(1.29)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C98(0.88); C19(0.93); C64(1.16); C67(1.34)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C19(0.81); C64(0.84); C98(1.01); C67(1.10)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C98(1.02); C64(1.11); C19(1.11); C67(1.13)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C64(0.93); C19(1.04); C98(1.12); C67(1.12)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C64(0.92); C19(0.95); C98(1.20)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C64(0.76); C67(0.88); C19(1.06); C98(1.25)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C64(0.84); C19(1.02); C67(1.05); C98(1.10)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C64(0.76); C67(0.90); C19(1.03); C98(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C64(0.83); C67(1.01); C19(1.20); C98(1.24)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C64(0.87); C19(0.91); C67(0.94); C98(1.12)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C64(0.83); C19(0.84); C67(1.00); C98(1.33)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C98(1.00); C19(1.37)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C98(0.90); C19(1.10)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C98(1.12); C19(1.32)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C98(0.98); C19(1.25)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C64(0.88); C19(0.88); C98(1.26)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C98(1.22); C19(1.51)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C98(1.02); C19(1.46)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C98(0.86); C19(1.23)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C98(1.09); C19(1.38)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C98(0.86); C19(1.33)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C19(1.13); C98(1.27)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C98(0.97); C19(1.36)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C414(1.03); C411(1.03); C64(1.03); C67(1.03)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C64(0.91); C67(0.91); C411(0.94); C414(0.96)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C411(0.89); C414(0.91); C64(0.91); C67(0.91)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C98(0.82); C445(0.86); C448(0.86); C64(1.14)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C64(0.83); C67(0.83); C411(1.06); C414(1.16)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C64(0.93); C67(0.93); C411(0.98); C414(0.99)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C414(0.74); C411(0.80); C64(0.85); C67(0.85)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C64(0.83); C67(0.83); C414(0.86); C411(0.95)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C414(0.80); C411(0.92); C64(0.95); C67(0.95)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C414(0.93); C411(0.93); C64(0.98); C67(0.98)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C414(0.81); C411(0.83); C64(0.95); C67(0.95)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C414(0.67); C64(0.80); C67(0.80); C411(0.83)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C64(0.59); C67(0.59); C98(0.77); C411(0.77)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C98(0.63); C411(0.64); C414(0.64); C64(0.65)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C98(0.95); C445(1.03); C448(1.03); C19(1.07)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C411(0.51); C414(0.51); C64(0.65); C67(0.65)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C64(0.78); C67(0.78); C411(0.83); C414(0.83)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C411(0.56); C414(0.56); C64(0.58); C67(0.58)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C411(0.49); C414(0.49); C64(0.66); C67(0.66)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C411(0.55); C414(0.55); C64(0.68); C67(0.68)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C411(0.55); C414(0.55); C64(0.83); C67(0.83)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C411(0.56); C414(0.56); C64(0.56); C67(0.56)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C64(0.61); C67(0.61); C411(0.66); C414(0.66)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C411(0.65); C414(0.65); C98(0.93); C64(0.96)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C411(0.60); C414(0.60); C64(0.66); C67(0.66)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C445(1.04); C448(1.04); C19(1.06); C98(1.17)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C64(0.55); C67(0.55); C411(0.56); C414(0.56)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C411(0.82); C414(0.82); C64(0.95); C67(0.95)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C411(0.46); C414(0.46); C98(0.88); C64(1.00)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C411(0.61); C414(0.61); C64(0.69); C67(0.69)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C64(0.59); C67(0.59); C411(0.63); C414(0.63)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C64(0.71); C67(0.71); C411(0.71); C414(0.71)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C64(0.69); C67(0.69); C411(0.78); C414(0.78)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C64(0.76); C67(0.76); C411(0.94); C414(0.94)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C411(0.73); C414(0.73); C64(0.76); C67(0.76)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C411(0.53); C414(0.53); C64(0.63); C67(0.63)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C411(0.89); C414(0.89); C98(1.07); C19(1.13)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C64(0.62); C67(0.62); C411(0.62); C414(0.62)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C411(0.59); C414(0.59); C64(0.64); C67(0.64)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C411(0.66); C414(0.66); C64(0.71); C67(0.71)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C64(0.79); C67(0.79); C411(0.80); C414(0.80)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C411(0.86); C414(0.86); C98(0.97); C64(0.99)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C411(0.63); C414(0.63); C64(0.71); C67(0.71)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C411(0.62); C414(0.62); C64(0.68); C67(0.68)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C67(0.55); C64(0.65); C19(1.52); C98(1.93)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C67(0.71); C64(0.80); C98(0.89); C19(1.28)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C19(1.04); C445(1.08); C448(1.08); C64(1.27)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C98(1.01); C64(1.04); C445(1.05); C448(1.05)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C64(1.09); C445(1.09); C448(1.09); C98(1.09)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.99  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C64(0.89); C67(0.89); C19(0.89)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C98(0.94); C64(1.00); C67(1.00); C19(1.06)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C64(0.64); C67(0.64); C98(1.51); C19(1.84)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C64(0.84); C19(0.93); C98(1.15)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C98(0.69); C445(0.83); C448(0.83); C64(1.15)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C98(0.78); C445(0.86); C448(0.86); C64(1.16)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C445(0.85); C448(0.85); C64(0.96); C98(0.98)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C445(0.84); C448(0.84); C98(1.06); C19(1.17)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C67(0.62); C64(0.83); C19(0.96); C98(1.37)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C67(0.54); C64(0.75); C19(0.83); C98(1.70)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C67(0.46); C64(0.71); C19(0.96); C98(1.70)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C67(0.45); C64(0.74); C19(1.03); C98(1.56)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C67(0.75); C64(0.82); C19(1.01); C98(1.38)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C64(0.72); C67(0.72); C98(1.01); C19(1.47)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C67(0.54); C64(0.68); C19(1.07); C98(1.39)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C64(0.72); C67(0.72); C19(0.99); C98(1.14)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C445(0.87); C448(0.87); C98(0.95); C19(1.14)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C445(1.01); C448(1.01); C19(1.19); C98(1.40)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C445(0.77); C448(0.77); C98(1.20); C19(1.53)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C445(0.93); C448(0.93); C98(1.30); C19(1.31)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C445(0.94); C448(0.94); C19(1.09); C98(1.34)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C64(0.90); C67(1.05); C19(1.28); C98(1.47)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C64(0.80); C67(0.85); C19(1.04); C98(1.13)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C64(0.81); C67(0.88); C19(1.03); C98(1.22)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C64(0.69); C67(0.69); C98(1.45); C19(1.75)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C64(0.97); C19(1.12); C98(1.14); C67(1.14)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C98(1.07); C19(1.16)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C98(0.92); C19(1.24)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C98(0.81); C19(1.47)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C98(0.97); C19(1.61)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C64(0.84); C67(0.84); C411(1.09); C414(1.27)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C414(0.90); C411(0.92); C64(0.93); C67(0.93)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C64(0.87); C67(0.87); C411(1.24); C98(1.26)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C414(0.88); C411(0.91); C64(0.98); C67(0.98)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C64(0.72); C67(0.72); C98(1.52); C19(1.57)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C64(0.95); C67(0.95); C19(1.18); C98(1.28)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C64(0.85); C67(0.85); C98(0.93); C19(1.45)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C19(0.79); C64(0.87); C445(0.93); C448(0.93)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C445(0.62); C448(0.62); C67(0.73); C64(0.80)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C64(0.76); C67(0.80); C445(0.90); C448(0.90)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C64(0.76); C445(0.78); C448(0.78); C67(0.82)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C64(1.01); C67(1.01); C98(1.02); C19(1.08)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C67(0.70); C64(0.72); C445(0.84); C448(0.84)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C445(0.64); C448(0.64); C67(0.71); C64(0.75)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C445(0.72); C448(0.72); C67(1.03); C64(1.05)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C67(0.61); C64(0.68); C445(0.76); C448(0.76)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C19(1.20); C445(1.08); C448(1.08); C64(0.84)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C19(1.43); C445(1.01); C448(1.01); C64(0.73)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C19(1.03); C445(0.89); C448(0.89); C64(0.78)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C19(1.13); C445(0.91); C448(0.91); C64(0.70)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C19(1.14); C445(1.13); C448(1.13); C64(0.81)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C19(1.12); C445(1.07); C448(1.07); C64(0.68)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C19(0.98); C64(0.96); C67(0.96); C98(1.05)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C19(0.88); C445(1.09); C448(1.09); C64(0.96)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C19(1.03); C64(0.66); C67(0.66)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C19(0.96); C445(0.89); C448(0.89); C64(0.67)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C19(1.59); C445(0.79); C448(0.79); C64(0.68)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C19(1.45); C445(0.87); C448(0.87); C64(0.63)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C19(1.50); C445(1.16); C448(1.16); C64(0.53)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C19(1.45); C445(0.69); C448(0.69); C64(0.56)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C19(1.58); C445(1.03); C448(1.03); C64(0.56)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C19(1.45); C445(0.96); C448(0.96); C64(0.59)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C19(1.58); C64(1.11); C67(1.11); C98(0.97)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C19(1.28); C445(0.84); C448(0.84); C64(0.50)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C19(1.62); C445(0.72); C448(0.72); C64(0.69)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C19(1.92); C445(0.69); C448(0.69); C64(0.67)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C19(2.00); C445(0.91); C448(0.91); C64(0.75)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C19(1.38); C445(0.95); C448(0.95); C64(0.67)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C19(1.66); C445(1.02); C448(1.02); C64(0.69)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C19(1.11); C98(0.96)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C19(1.09); C98(0.99)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C19(1.19); C98(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C19(1.09); C98(1.01)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C19(1.11); C64(0.77); C67(0.77); C98(1.04)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C19(1.14); C98(0.96)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C19(1.29); C98(1.14)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C19(1.12); C98(1.03)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C19(1.13); C98(0.91)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C19(1.06); C98(0.91)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C19(1.05); C98(0.83)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C19(1.20); C98(0.84)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C19(1.05); C98(0.97)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C19(1.03); C98(0.99)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C19(1.02); C98(1.00)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C19(1.17); C64(0.97); C67(0.97); C98(1.00)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C19(1.13); C98(1.09)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C19(1.20); C445(0.89); C448(0.89); C64(0.92)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C19(1.17); C445(0.89); C448(0.89); C64(0.65)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C19(1.52); C445(0.96); C448(0.96); C64(0.70)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C19(1.29); C445(1.15); C448(1.15); C64(0.62)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C19(1.18); C445(0.92); C448(0.92); C64(0.73)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C19(1.40); C445(0.99); C448(0.99); C64(0.44)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C19(1.20); C445(1.07); C448(1.07); C64(0.74)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C19(1.06); C445(1.17); C448(1.17); C64(0.86)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C19(1.21); C445(0.68); C448(0.68); C64(0.93)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C19(1.32); C64(0.68); C67(0.68); C98(1.30)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C19(1.01); C445(0.99); C448(0.99); C64(0.75)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C19(1.30); C445(0.97); C448(0.97); C64(0.71)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C19(1.30); C445(0.86); C448(0.86); C64(0.75)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C19(1.41); C445(0.94); C448(0.94); C64(0.58)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C19(1.15); C445(1.09); C448(1.09); C64(0.67)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C19(1.13); C64(0.97); C67(0.97); C98(1.00)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C19(1.07); C64(1.00); C67(1.00); C98(1.04)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C19(1.25); C64(0.92); C67(0.92); C98(1.60)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C19(1.45); C64(1.16); C67(1.16); C98(0.99)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C19(1.42); C64(0.64); C67(0.64); C98(1.30)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C19(0.93); C64(0.92); C67(0.92); C98(1.41)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C19(1.22); C64(1.05); C67(1.05); C98(1.26)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C19(1.25); C64(1.09); C67(1.09); C98(0.94)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C19(1.41); C64(0.92); C67(0.92); C98(1.10)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C19(1.60); C64(0.97); C67(0.97); C98(1.29)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C19(1.21); C64(0.98); C67(0.98); C98(0.81)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C19(0.98); C64(0.96); C67(0.96); C98(1.09)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C19(1.16); C64(0.99); C67(0.99); C98(1.18)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C19(1.27); C64(1.08); C67(1.08); C98(1.56)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C19(1.47); C64(1.01); C67(1.01); C98(1.50)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C19(1.23); C64(0.69); C67(0.69); C98(1.15)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C19(1.20); C64(0.99); C67(0.99); C98(1.04)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C19(1.00); C64(0.91); C98(0.82)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C19(0.98); C64(0.72); C98(0.96)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C19(0.85); C64(0.84); C98(1.10)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C19(1.00); C64(0.62); C98(1.03)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C19(1.23); C64(0.69); C98(1.01)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C19(1.07); C64(0.74); C98(1.20)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C19(1.08); C64(0.77); C98(1.10)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C19(0.97); C64(1.11); C98(0.99)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C19(1.01); C64(0.81); C98(0.98)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C98(0.91); C40(1.32); C197(1.19)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C197(4.27); C64(2.27); C98(1.04); C259(0.71)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C19(1.31); C445(0.94); C448(0.94); C64(0.81)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C19(1.71); C445(0.71); C448(0.71); C64(0.71)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C98(1.14)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C98(1.40)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C98(7.83)  LDD0082  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C107(1.64)  LDD2105  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C107(0.95)  LDD2141  [2]
 LDCM0021  THZ1 HCT 116 C411(1.63); C414(1.63)  LDD2173  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402