Details of the Target

General Information of Target

Target ID LDTP11702
Target Name Toll-interacting protein (TOLLIP)
Gene Name TOLLIP
Gene ID 54472
Synonyms
Toll-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIH
PCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFR
ASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIAD
RLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLG
LATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGE
FIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAI
DRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKE
KRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSF
TSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQ
SYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMG
VFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRA
ALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQG
KFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAV
LKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVT
YQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQ
NAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN
Target Bioclass
Other
Family
Tollip family
Subcellular location
Cytoplasm
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P).
Uniprot ID
Q9H0E2
Ensemble ID
ENST00000317204.11
HGNC ID
HGNC:16476

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A95T DBIA    Probe Info 
MCC26 SNV: p.S126F .
MDAMB468 SNV: p.Q19R .
MOLT4 SNV: p.A236S IA-alkyne    Probe Info 
RKO SNV: p.P18T .
SNGM SNV: p.R228L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.98  LDD0402  [1]
TH211
 Probe Info  		Y83(5.40)  LDD0260  [2]
STPyne
 Probe Info  		K63(6.37); K66(10.00); K96(5.13)  LDD0277  [3]
Probe 1
 Probe Info  		Y83(12.02)  LDD3495  [4]
BTD
 Probe Info  		C77(1.57)  LDD2097  [5]
HHS-475
 Probe Info  		Y83(1.63)  LDD0264  [6]
DBIA
 Probe Info  		C229(1.38)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
CY-1
 Probe Info  		E247(0.00); Q246(0.00)  LDD0246  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C229(0.00); C106(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C106(0.00); C229(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2225  [11]
IPM
 Probe Info  		N.A.  LDD0147  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
MPP-AC
 Probe Info  		N.A.  LDD0428  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [13]
TPP-AC
 Probe Info  		N.A.  LDD0427  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C77(1.48)  LDD2117  [5]
 LDCM0214  AC1 HCT 116 C229(1.10)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C229(1.04)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C229(1.41)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C229(1.15)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C229(1.09)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C229(1.36)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C229(1.19)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C229(1.20)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C229(1.60)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C229(1.27)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C229(1.19)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C229(1.09)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C229(0.79)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C229(1.17)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C229(1.51)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C229(1.33)  LDD0546  [7]
 LDCM0230  AC113 HEK-293T C229(1.34)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C229(1.00)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C229(1.07)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C229(0.88)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C229(1.13)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C229(0.69)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C229(0.82)  LDD0834  [7]
 LDCM0237  AC12 HCT 116 C229(0.91)  LDD0554  [7]
 LDCM0238  AC120 HEK-293T C229(0.79)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C229(1.00)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C229(1.06)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C229(0.74)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C229(0.81)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C229(0.89)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C229(1.08)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C229(0.83)  LDD0843  [7]
 LDCM0246  AC128 HCT 116 C229(0.61)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C229(0.72)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C229(0.80)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C229(0.73)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C229(0.91)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C229(0.85)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C229(0.68)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C229(0.64)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C229(0.64)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C229(0.54)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C229(0.57)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C229(0.75)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C229(0.82)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C229(0.91)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C229(0.70)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C229(0.73)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C229(1.06)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C229(1.08)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C229(0.87)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C229(0.98)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C229(0.94)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C229(0.94)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C229(1.03)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C229(0.80)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C229(0.85)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C229(1.12)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C229(0.80)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C229(0.86)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C229(0.82)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C229(1.01)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C229(1.02)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C229(0.92)  LDD2161  [7]
 LDCM0276  AC17 PaTu 8988t C229(0.98)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C229(1.12)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C229(1.07)  LDD1157  [7]
 LDCM0279  AC2 HCT 116 C229(1.32)  LDD0596  [7]
 LDCM0280  AC20 PaTu 8988t C229(1.31)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C229(1.35)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C229(1.58)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C229(1.44)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C229(1.27)  LDD1163  [7]
 LDCM0285  AC25 HCT 116 C229(1.24)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C229(1.44)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C229(1.85)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C229(1.29)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C229(1.51)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C229(1.24)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C229(1.35)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C229(1.63)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C229(1.92)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C229(1.58)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C229(1.77)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C229(0.80)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C229(0.89)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C229(1.01)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C229(0.93)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C229(1.07)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C229(1.11)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C229(1.24)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C229(1.04)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C229(1.15)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C229(1.02)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C229(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C229(1.37)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C229(0.92)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C229(0.82)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C229(0.85)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C229(0.89)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C229(1.08)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C229(1.00)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C229(0.85)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C229(0.77)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C229(0.80)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C229(0.75)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C229(0.81)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C229(0.47)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C229(1.33)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C229(1.40)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C229(1.44)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C229(1.18)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C229(1.29)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C229(1.33)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C229(1.57)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C229(1.52)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C229(1.57)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C229(1.57)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C229(1.24)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C229(1.48)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C229(1.10)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C229(1.13)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C229(0.93)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C229(1.13)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C229(1.01)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C229(0.97)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C229(1.83)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C229(1.45)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C229(1.50)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C229(1.28)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C229(1.34)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C229(1.07)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C229(1.08)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C229(0.84)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C229(1.21)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C229(0.86)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C229(1.44)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C229(1.21)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C229(1.12)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C229(1.22)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C229(2.06)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C229(1.22)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C229(1.41)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C229(1.53)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C229(1.77)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C229(1.14)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C229(1.14)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C229(1.17)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C229(1.16)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C229(1.65)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C229(0.96)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C229(1.45)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C229(1.41)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C229(1.28)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C229(1.04)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C229(0.82)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C229(1.10)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 10.16  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C229(1.00)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C229(1.41)  LDD1247  [7]
 LDCM0369  CL100 HCT 116 C229(1.09)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C229(0.98)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C229(0.82)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C229(0.66)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C229(0.85)  LDD0690  [7]
 LDCM0374  CL105 PaTu 8988t C229(1.13)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C229(0.99)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C229(0.97)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C229(1.01)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C229(1.13)  LDD1257  [7]
 LDCM0379  CL11 PaTu 8988t C229(0.96)  LDD1258  [7]
 LDCM0380  CL110 PaTu 8988t C229(1.34)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C229(1.50)  LDD1260  [7]
 LDCM0382  CL112 HCT 116 C229(1.07)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C229(1.23)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C229(1.39)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C229(1.21)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C229(1.43)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C229(1.54)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C229(0.86)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C229(0.99)  LDD0706  [7]
 LDCM0390  CL12 PaTu 8988t C229(1.09)  LDD1269  [7]
 LDCM0391  CL120 HCT 116 C229(1.07)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C229(1.18)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C229(0.89)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C229(0.65)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C229(0.46)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C229(1.15)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C229(1.05)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C229(1.05)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C229(1.50)  LDD0716  [7]
 LDCM0400  CL13 PaTu 8988t C229(1.46)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C229(1.61)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C229(0.94)  LDD1281  [7]
 LDCM0403  CL16 HCT 116 C229(0.81)  LDD0720  [7]
 LDCM0404  CL17 PaTu 8988t C229(1.82)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C229(1.34)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C229(1.37)  LDD1285  [7]
 LDCM0407  CL2 PaTu 8988t C229(1.09)  LDD1286  [7]
 LDCM0408  CL20 PaTu 8988t C229(1.67)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C229(1.56)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C229(1.54)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C229(2.06)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C229(1.87)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C229(1.31)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C229(1.39)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C229(1.40)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C229(2.08)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C229(1.91)  LDD1296  [7]
 LDCM0418  CL3 PaTu 8988t C229(1.62)  LDD1297  [7]
 LDCM0419  CL30 PaTu 8988t C229(1.60)  LDD1298  [7]
 LDCM0420  CL31 HEK-293T C229(0.76)  LDD1018  [7]
 LDCM0421  CL32 HCT 116 C229(1.15)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C229(0.83)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C229(0.95)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C229(1.36)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C229(0.82)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C229(1.08)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C229(1.27)  LDD0745  [7]
 LDCM0429  CL4 PaTu 8988t C229(1.12)  LDD1308  [7]
 LDCM0430  CL40 HCT 116 C229(0.89)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C229(1.05)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C229(0.71)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C229(0.92)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C229(1.08)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C229(1.02)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C229(0.89)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C229(0.70)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C229(0.77)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C229(0.99)  LDD0756  [7]
 LDCM0440  CL5 PaTu 8988t C229(1.59)  LDD1319  [7]
 LDCM0441  CL50 HCT 116 C229(0.67)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C229(0.73)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C229(0.85)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C229(0.75)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C229(0.63)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C229(0.63)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C229(0.57)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C229(0.58)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C229(0.88)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C229(1.01)  LDD0767  [7]
 LDCM0451  CL6 PaTu 8988t C229(1.27)  LDD1330  [7]
 LDCM0452  CL60 HCT 116 C229(0.74)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C229(0.96)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C229(0.98)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C229(1.16)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C229(1.15)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C229(0.94)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C229(1.26)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C229(1.09)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C229(1.17)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C229(1.06)  LDD0778  [7]
 LDCM0462  CL7 PaTu 8988t C229(1.36)  LDD1341  [7]
 LDCM0463  CL70 HCT 116 C229(1.10)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C229(1.08)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C229(1.04)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C229(1.10)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C229(1.16)  LDD0784  [7]
 LDCM0469  CL76 HEK-293T C229(1.61)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C229(1.38)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C229(0.97)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C229(1.28)  LDD1070  [7]
 LDCM0473  CL8 PaTu 8988t C229(1.18)  LDD1352  [7]
 LDCM0474  CL80 HEK-293T C229(1.09)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C229(1.69)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C229(1.15)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C229(0.90)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C229(0.66)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C229(0.78)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C229(1.21)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C229(0.70)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C229(1.01)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C229(1.01)  LDD1081  [7]
 LDCM0484  CL9 PaTu 8988t C229(1.27)  LDD1363  [7]
 LDCM0485  CL90 HEK-293T C229(0.70)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C229(1.41)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C229(1.22)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C229(1.14)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C229(0.83)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C229(1.23)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C229(1.19)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C229(1.19)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C229(1.31)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C229(1.21)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C229(1.15)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C229(1.04)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C229(1.24)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C229(0.77)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y83(1.63)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y83(1.54)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y83(1.43)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y83(1.47)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y83(2.36)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C229(1.38)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C229(1.28)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C229(1.41)  LDD0082  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C77(1.57)  LDD2097  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C77(0.56)  LDD2100  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C77(0.31)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C77(1.20)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C77(0.86)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C77(1.61)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C77(1.56)  LDD2119  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C77(1.36)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C77(1.49)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C77(1.55)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C77(1.12)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C77(1.24)  LDD2140  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C77(0.43)  LDD2148  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase WRNIP1 (WRNIP1) AAA ATPase family Q96S55
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) Ser/Thr protein kinase family P19525
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) TKL Ser/Thr protein kinase family O43187
E3 ubiquitin-protein ligase DZIP3 (DZIP3) . Q86Y13
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Alpha-synuclein (SNCA) Synuclein family P37840
Target of Myb1 membrane trafficking protein (TOM1) TOM1 family O60784
Major vault protein (MVP) . Q14764
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Ataxin-1 (ATXN1) ATXN1 family P54253
Cell death-inducing p53-target protein 1 (CDIP1) CDIP1/LITAF family Q9H305
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Phagosome assembly factor 1 (PHAF1) PHAF1 family Q9BSU1
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Pre-mRNA-processing factor 39 (PRPF39) PRP39 family Q86UA1
Proline-rich protein 20D (PRR20D) PRR20 family P86480
CST complex subunit STN1 (STN1) STN1 family Q9H668
TOM1-like protein 1 (TOM1L1) TOM1 family O75674
Tetratricopeptide repeat protein 9C (TTC9C) TTC9 family Q8N5M4
Cleavage stimulation factor subunit 1 (CSTF1) . Q05048
DAZ-associated protein 2 (DAZAP2) . Q15038
Disabled homolog 1 (DAB1) . O75553
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
Mesenteric estrogen-dependent adipogenesis protein (MEDAG) . Q5VYS4
Putative protein MSS51 homolog, mitochondrial (MSS51) . Q4VC12
Retrotransposon-derived protein PEG10 (PEG10) . Q86TG7
RING finger protein 11 (RNF11) . Q9Y3C5
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402