Details of the Target

General Information of Target

Target ID LDTP11681
Target Name Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)
Gene Name MAF1
Gene ID 84232
Synonyms
Repressor of RNA polymerase III transcription MAF1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ
LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV
TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY
GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD
KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKI
KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP
KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF
FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS
IKVKSEESL
Target Bioclass
Other
Family
MAF1 family
Subcellular location
Nucleus
Function
Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance. Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation. Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP.
Uniprot ID
Q9H063
Ensemble ID
ENST00000322428.10
HGNC ID
HGNC:24966

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C133(2.50)  LDD0168  [1]
DBIA
 Probe Info  		C34(1.38)  LDD0080  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C133(0.00); C88(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C133(0.00); C34(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C133(2.50)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C133(2.01)  LDD0372  [1]
 LDCM0214  AC1 HEK-293T C34(0.91)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C34(1.02)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C34(1.23)  LDD0824  [2]
 LDCM0230  AC113 HCT 116 C34(1.02)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C34(1.05)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C34(0.96)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C34(0.98)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C34(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C34(0.95)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C34(1.02)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C34(1.34)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C34(1.00)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C34(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C34(1.09)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C34(0.86)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C34(1.13)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C34(1.19)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C34(1.01)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C34(0.97)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C34(1.09)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C34(1.20)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C34(1.11)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C34(1.37)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C34(1.47)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C34(1.39)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C34(1.55)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C34(1.46)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C34(1.13)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C34(1.30)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C34(1.32)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C34(1.26)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C34(1.36)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C34(1.14)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C34(1.25)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C34(1.29)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C34(1.25)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C34(1.17)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C34(1.10)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C34(1.28)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C34(0.93)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C34(1.53)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C34(1.19)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C34(1.12)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C34(1.51)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C34(1.18)  LDD0882  [2]
 LDCM0285  AC25 PaTu 8988t C133(0.87); C34(1.93)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C133(0.99); C34(1.29)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C133(1.32); C34(1.43)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C133(1.29); C34(1.76)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C133(1.17); C34(1.17)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C34(1.07)  LDD0888  [2]
 LDCM0291  AC30 PaTu 8988t C133(1.16); C34(1.21)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C133(1.01); C34(1.12)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C133(1.77); C34(1.47)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C133(1.41); C34(1.28)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C133(1.59); C34(1.23)  LDD1174  [2]
 LDCM0296  AC35 HCT 116 C34(0.85)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C34(0.98)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C34(1.04)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C34(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C34(0.94)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C34(0.99)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C34(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C34(1.34)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C34(1.27)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C34(1.07)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C34(1.03)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C34(1.27)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C34(0.97)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C34(0.91)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C34(0.77)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C34(1.10)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C34(0.87)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C34(0.72)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C34(1.03)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C34(0.96)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C34(1.60)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C34(1.45)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C34(1.27)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C34(0.91)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C34(0.96)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C34(0.98)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C34(0.80)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C34(1.23)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C34(1.59)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C34(1.03)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C34(1.02)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C34(1.01)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C34(0.87)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C34(1.22)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C34(1.07)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C34(1.10)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C34(0.98)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C34(0.92)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C34(1.09)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C34(0.94)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C34(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C34(0.92)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C34(1.13)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C34(0.98)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C34(0.87)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C34(0.91)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C34(1.02)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C34(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C34(0.94)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C34(1.22)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C34(1.10)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C34(1.14)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C34(1.12)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C34(1.04)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C34(0.99)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C34(1.13)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C34(1.04)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C34(1.11)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C34(1.15)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C34(1.13)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C34(1.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C34(0.98)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C34(1.07)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C34(1.05)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C34(1.03)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C34(1.09)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C34(1.18)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C34(1.11)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C34(1.07)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C34(1.25)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C34(1.37)  LDD0873  [2]
 LDCM0632  CL-Sc Hep-G2 C34(20.00)  LDD2227  [6]
 LDCM0367  CL1 PaTu 8988t C34(0.97)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C34(1.46)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C34(0.86)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C34(1.20)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C34(1.25)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C34(1.11)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C34(1.16)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C34(0.92)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C34(1.27)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C34(0.85)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C34(1.28)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C34(1.77)  LDD0976  [2]
 LDCM0379  CL11 PaTu 8988t C34(1.34)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C34(1.36)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C34(1.03)  LDD0979  [2]
 LDCM0382  CL112 PaTu 8988t C133(1.06); C34(1.20)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C133(1.19); C34(1.35)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C133(1.72); C34(1.30)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C133(1.14); C34(1.69)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C133(1.30); C34(1.29)  LDD1265  [2]
 LDCM0387  CL117 HCT 116 C34(1.00)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C34(1.01)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C34(1.17)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C34(1.04)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C34(1.07)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C34(1.12)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C34(1.39)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C34(0.76)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C34(0.84)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C34(0.93)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C34(1.24)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C34(1.19)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C34(0.84)  LDD0997  [2]
 LDCM0400  CL13 PaTu 8988t C34(1.52)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C34(1.67)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C34(1.09)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C34(1.03)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C133(0.96); C48(0.78)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C133(1.06); C48(0.98); C34(0.87)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C133(0.99); C48(0.99)  LDD1610  [8]
 LDCM0407  CL2 PaTu 8988t C34(1.08)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C133(1.16); C48(0.96); C34(0.86)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C133(0.94); C48(0.74)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C133(1.24); C48(1.15)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C133(0.98); C48(1.07); C34(1.15)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C133(0.94); C48(1.01)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C133(0.94); C48(1.16)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C133(1.01); C48(1.20)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C133(1.08); C48(1.07)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C133(1.07); C48(1.17)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C133(1.04); C48(1.10)  LDD1621  [8]
 LDCM0418  CL3 PaTu 8988t C34(1.12)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C133(0.98); C48(0.99); C34(1.02)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C34(1.02)  LDD1018  [2]
 LDCM0421  CL32 HCT 116 C34(1.44)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C34(1.34)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C34(1.69)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C34(1.69)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C34(1.71)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C34(1.72)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C34(1.44)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C34(1.00)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C34(1.31)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C34(1.84)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C34(1.61)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C34(1.66)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C34(1.55)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C34(1.84)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C34(1.46)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C34(1.02)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C34(1.05)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C34(1.09)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C34(1.79)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C34(1.41)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C34(1.14)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C34(1.09)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C34(0.97)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C34(1.12)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C34(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C34(1.02)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C34(0.95)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C34(1.13)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C34(1.10)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C34(1.30)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C34(1.36)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C34(0.87)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C34(0.89)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C34(0.91)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C34(0.91)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C34(0.87)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C34(0.98)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C34(0.84)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C34(0.84)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C34(0.87)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C34(1.30)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C34(0.91)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C34(0.88)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C34(0.86)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C34(0.84)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C34(0.82)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C34(0.70)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C34(1.03)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C34(0.75)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C34(0.59)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C34(1.16)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C34(0.54)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C34(0.68)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C34(0.58)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C34(0.49)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C34(0.31)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C34(0.34)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C34(0.38)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C34(0.35)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C34(0.32)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C34(0.46)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C34(1.33)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C34(0.29)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C34(0.91)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C34(1.07)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C34(0.94)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C34(1.05)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C34(0.89)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C34(1.05)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C34(1.06)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C34(0.92)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C34(0.87)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C133(1.01); C48(0.98)  LDD1698  [8]
 LDCM0625  F8 Ramos C88(1.47); C34(1.59); C203(0.60)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C88(1.15); C34(0.86); C203(0.47)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C88(3.85); C203(0.46)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C88(1.66); C34(0.78); C203(0.60)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C88(0.85); C34(0.95); C203(0.92)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C88(1.20); C34(0.79)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C88(0.90); C34(0.80); C203(0.58)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C88(1.01); C34(0.99); C203(0.91)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C88(0.70); C203(3.46)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C88(0.76); C203(0.91)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C88(0.64); C203(4.09)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C88(1.08); C34(1.57); C203(0.91)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C88(0.94); C34(1.09); C203(0.82)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C88(2.27); C34(0.70); C203(0.46)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C34(0.84)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C88(0.95); C34(0.97); C203(0.87)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C88(1.32); C34(0.95); C203(0.63)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C34(1.40)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C88(0.85); C34(1.04); C203(1.01)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C88(1.37); C34(1.57)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C88(1.10); C34(1.12); C203(0.52)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C88(1.24); C34(1.50); C203(0.64)  LDD2188  [9]
 LDCM0022  KB02 HCT 116 C34(1.38)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C34(0.94)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C34(1.49)  LDD0082  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C88(1.24)  LDD2206  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Armadillo repeat-containing X-linked protein 3 (ARMCX3) Eutherian X-chromosome-specific Armcx family Q9UH62
Proliferating cell nuclear antigen (PCNA) PCNA family P12004

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.