Details of the Target

General Information of Target

Target ID LDTP11629
Target Name Actin-related protein 6 (ACTR6)
Gene Name ACTR6
Gene ID 64431
Synonyms
Actin-related protein 6; hArp6; hARPX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGSRELEAELEAQLVQAEQ
RNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLSQTRAIKEQLHKYVRELEQ
ANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQE
LAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPATPVGKGTENTFPSPKAIPNGFG
TSPLTPSARISALNIVGDLLRKVGALESKLAACRNFAKDQASRKSYISGNVNCGVLNGNG
TKFSRSGHTSFFDKGAVNGFDPAPPPPGLGSSRPSSAPGMLPLSV
Target Bioclass
Other
Family
Actin family, ARP6 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z.
Uniprot ID
Q9GZN1
Ensemble ID
ENST00000188312.7
HGNC ID
HGNC:24025

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 Deletion: p.F314LfsTer6 .
TCCSUP SNV: p.E47Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y56(7.15)  LDD0259  [1]
IPM
 Probe Info  		C28(0.91)  LDD1701  [2]
DBIA
 Probe Info  		C210(1.90)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C28(0.00); C210(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C210(0.00); C28(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C210(1.05)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C210(1.00)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C210(1.09)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C210(1.16)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C210(0.86)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C210(0.65)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C210(0.91)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C210(0.72)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C210(0.86)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C210(1.07)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C210(0.78)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C210(1.04)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C210(0.96)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C210(0.82)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C210(0.80)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C210(0.64)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C210(0.94)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C210(0.96)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C210(1.04)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C210(1.03)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C210(1.16)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C210(1.15)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C210(1.09)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C210(1.14)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C210(0.78)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C210(1.36)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C210(1.00)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C210(1.23)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C210(1.45)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C210(1.39)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C210(1.32)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C210(1.46)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C210(0.77)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C210(0.78)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C210(0.81)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C210(0.73)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C210(0.78)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C210(0.95)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C210(0.89)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C210(0.96)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C210(1.17)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C210(0.93)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C210(1.02)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C210(0.88)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C210(1.03)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C210(0.93)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C210(0.95)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C210(0.83)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C210(0.85)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C210(0.99)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C210(0.91)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C210(1.17)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C210(1.16)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C210(1.15)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C210(1.48)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C210(1.03)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C210(1.24)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C210(1.35)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C210(0.91)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C210(1.43)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C210(1.31)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C210(1.22)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C210(1.03)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C210(0.92)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C210(1.12)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C210(1.18)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C210(1.35)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C210(0.75)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C210(1.16)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C210(1.31)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C210(1.00)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C210(1.14)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C210(1.10)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C28(0.90); C339(0.90); C390(0.91)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C28(1.00); C339(0.97); C390(1.00)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C28(0.96); C339(1.02); C390(0.98)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C28(0.99); C339(0.93); C390(0.99); C161(1.09)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C28(1.12); C339(0.94)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C210(0.94)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C28(0.91); C339(1.02); C390(1.01)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C28(0.98); C339(1.01); C390(1.04); C161(0.91)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C28(0.92); C339(0.93); C390(0.98)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C28(0.88); C339(0.86); C390(0.98)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C28(0.88); C339(0.98); C390(1.04)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C28(0.89); C339(1.03); C390(0.79)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C28(0.93); C339(0.97); C390(1.02); C161(0.89)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C28(1.04); C339(1.02)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C28(0.93); C339(0.97); C390(1.12)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C28(0.74); C339(1.05); C390(0.97); C161(1.01)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C210(1.03)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C28(0.92); C339(0.96); C390(0.99)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C28(0.85); C339(0.94); C390(1.00)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C28(1.02); C339(1.04); C390(1.09)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C28(0.96); C339(0.99); C390(0.99)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C28(0.99); C339(1.11); C390(0.99); C161(0.94)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C28(0.89); C339(1.10)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C210(0.51)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C210(0.73)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C210(0.55)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C210(0.54)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C210(0.83)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C210(0.63)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C210(0.57)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C210(0.55)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C210(0.88)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C210(0.62)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C210(1.26)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C210(0.71)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C210(1.12)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C210(1.09)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C210(1.01)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C210(0.86)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C210(0.74)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C210(0.96)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C210(0.94)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C210(0.73)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C210(0.90)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C210(0.97)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C210(0.99)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C210(0.69)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C210(0.64)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C210(0.65)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C210(0.90)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C210(0.74)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C210(0.84)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C210(0.78)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C210(0.58)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C210(0.68)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C210(0.72)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C210(0.64)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C210(0.61)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C210(0.59)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C210(1.01)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C210(1.05)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C210(0.66)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C210(1.29)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C210(0.59)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C210(0.79)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C210(0.76)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C210(0.85)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C210(0.79)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C210(0.76)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C210(0.79)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C210(0.83)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C210(0.76)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C210(0.95)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C210(0.95)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C210(0.80)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C210(1.34)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C210(0.78)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C210(1.28)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C210(0.63)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C210(0.60)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C210(0.82)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C210(1.02)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C210(1.03)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C210(1.08)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C28(1.04)  LDD2171  [3]
 LDCM0367  CL1 HEK-293T C28(0.86); C339(0.96)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C28(0.75); C339(0.82); C390(0.96)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C210(1.15)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C210(1.02)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C210(1.01)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C210(1.02)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C210(0.90)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C210(1.17)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C210(1.01)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C210(1.17)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C210(0.97)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C210(1.06)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C28(0.61); C339(1.08); C390(1.01); C161(0.65)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C210(1.02)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C210(1.03)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C28(0.92); C339(0.90); C390(1.07)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C28(0.97); C339(1.06)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C28(0.92); C339(0.89)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C28(1.03); C339(1.05); C390(1.30)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C28(1.06); C339(1.18); C390(0.95)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C28(0.92); C339(0.99)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C28(0.99); C339(0.99)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C28(1.01); C339(0.97); C390(1.22)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C28(0.84); C339(1.00); C390(0.97)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C28(1.04); C339(0.98); C390(1.04)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C210(0.70)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C210(0.61)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C210(0.69)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C210(0.58)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C210(0.99)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C210(0.94)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C210(0.83)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C210(1.06)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C28(0.89); C339(1.02)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C28(1.02); C339(1.18)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C28(0.92); C339(0.88); C390(1.26)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C210(1.04)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C210(0.69)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C210(0.39)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C210(0.65)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C28(1.01); C339(1.09)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C210(0.67)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C210(0.51)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C210(0.50)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C210(0.71)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C210(0.50)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C210(0.59)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C210(0.93)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C210(0.85)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C210(0.55)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C210(0.68)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C28(0.97); C339(1.06); C390(1.07)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C210(0.81)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C210(1.00)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C210(0.44)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C210(0.62)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C210(0.43)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C210(0.54)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C210(0.75)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C210(0.43)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C210(0.44)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C28(0.97); C339(1.04); C390(0.90)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C210(0.66)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C210(0.64)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C210(0.51)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C210(0.42)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C210(0.49)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C210(0.40)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C210(0.83)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C210(0.84)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C210(0.93)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C210(0.94)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C28(0.87); C339(0.91); C390(0.89)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C210(0.99)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C210(1.10)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C210(0.77)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C210(0.86)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C210(0.74)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C210(0.85)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C210(0.75)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C210(1.20)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C210(0.88)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C210(0.87)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C28(0.86); C339(0.89); C390(0.93)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C210(0.77)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C210(0.78)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C210(0.62)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C210(0.52)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C210(0.66)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C210(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C210(0.44)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C210(0.52)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C210(0.40)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C210(0.42)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C28(0.82); C339(1.06); C390(0.93)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C210(0.54)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C210(1.24)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C210(1.17)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C210(0.85)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C210(0.64)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C210(0.54)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C210(2.71)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C210(1.60)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C210(0.50)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C28(0.76); C339(0.91); C390(0.79); C161(0.82)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C210(0.62)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C210(0.79)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C210(0.64)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C210(0.62)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C210(0.52)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C210(0.93)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C210(0.76)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C210(0.85)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C210(0.55)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C210(0.55)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C28(0.89); C339(1.02)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C210(1.08)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C210(1.14)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C210(1.12)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C210(0.91)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C210(0.79)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C210(0.70)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C210(0.95)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C210(0.77)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C210(0.82)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C210(0.90)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C28(0.98); C339(1.14); C390(1.29)  LDD1698  [7]
 LDCM0625  F8 Ramos C28(3.34)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C28(0.91)  LDD2189  [8]
 LDCM0574  Fragment12 Ramos C28(0.58)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C28(0.89)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C28(0.77)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C28(0.53)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C28(1.00)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C28(1.70)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C28(1.00)  LDD2197  [8]
 LDCM0588  Fragment30 Ramos C28(1.00)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C28(0.88)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C28(0.45)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C210(0.60)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C28(0.94)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C28(0.83)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C210(0.35)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C28(0.67)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C28(0.72)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C28(0.68)  LDD2186  [8]
 LDCM0022  KB02 HCT 116 C210(1.90)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C210(1.93)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C210(3.14)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C28(1.04)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2A.Z (H2AZ1) Histone H2A family P0C0S5
Zinc finger HIT domain-containing protein 1 (ZNHIT1) ZNHIT1 family O43257

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578