Details of the Target

General Information of Target

Target ID LDTP11400
Target Name Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1)
Gene Name QTRT1
Gene ID 81890
Synonyms
TGT; TGUT; Queuine tRNA-ribosyltransferase catalytic subunit 1; EC 2.4.2.64; Guanine insertion enzyme; tRNA-guanine transglycosylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLEGERCWLGAKVRRPR
ASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRG
AVEEPAAPWVGDSPIGQSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTL
NEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHSLKHRVKKSPPEESN
QNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQN
NPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQ
PGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFR
GHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEV
LQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNP
IVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPEC
EHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPD
SPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPA
YYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKS
ELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTES
RKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSR
RVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHP
VQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGV
KVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVE
VTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCS
KVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHE
DKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKE
DEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQH
NPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNH
QGQSCIHRPCGKQDSCPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPM
QKEILLTCSSGHWDQNVSCLPVDCGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQ
GLSPWLTCLEDGLWSLPEVYCKLECDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGY
YVAESAEGKVRNKLLKIQCLEGGIWEQGSCIPVVCEPPPPVFEGMYECTNGFSLDSQCVL
NCNQEREKLPILCTKEGLWTQEFKLCENLQGECPPPPSELNSVEYKCEQGYGIGAVCSPL
CVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHCIQSCEPFQADG
WCDTINNRAYCHYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
Target Bioclass
Enzyme
Family
Queuine tRNA-ribosyltransferase family
Subcellular location
Cytoplasm
Function
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product. Modification of cytoplasmic tRNAs with queuosine controls the elongation speed of cognate codons, thereby ensuring the correct folding of nascent proteins to maintain proteome integrity. {|HAMAP-Rule:MF_03218}.
Uniprot ID
Q9BXR0
Ensemble ID
ENST00000250237.10
HGNC ID
HGNC:23797
ChEMBL ID
CHEMBL6004

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.I313R DBIA    Probe Info 
MOLT4 SNV: p.M175I IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.31  LDD0402  [1]
STPyne
 Probe Info  		K55(20.00)  LDD2217  [2]
BTD
 Probe Info  		C213(1.00)  LDD2126  [3]
HHS-482
 Probe Info  		Y131(1.90)  LDD0285  [4]
HHS-465
 Probe Info  		Y75(10.00)  LDD2237  [5]
DBIA
 Probe Info  		C317(0.28); C319(0.28); C322(0.28)  LDD0533  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C213(0.00); C67(0.00); C70(0.00); C23(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C213(0.00); C67(0.00); C185(0.00); C70(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C213(0.00); C67(0.00); C70(0.00); C185(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		C67(0.00); C23(0.00)  LDD0027  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
NAIA_5
 Probe Info  		C213(0.00); C70(0.00); C23(0.00)  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C67(0.99)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C319(0.69); C322(0.69); C67(1.32)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C317(0.28); C319(0.28); C322(0.28)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C317(0.36); C319(0.36); C322(0.36)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C317(0.44); C319(0.44); C322(0.44)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C317(0.32); C319(0.32); C322(0.32)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C317(0.69); C319(0.69); C322(0.69)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C317(0.31); C319(0.31); C322(0.31)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C317(0.31); C319(0.31); C322(0.31)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C317(0.33); C319(0.33); C322(0.33)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C317(0.35); C319(0.35); C322(0.35)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C317(0.97); C319(0.97); C322(0.97)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C319(0.57); C322(0.57); C67(1.09)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C317(0.32); C319(0.32); C322(0.32)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C317(0.39); C319(0.39); C322(0.39)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C317(0.45); C319(0.45); C322(0.45)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C319(1.05); C322(1.05)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C319(1.02); C322(1.02)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C319(1.29); C322(1.29)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C319(1.02); C322(1.02)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C319(0.95); C322(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C319(1.02); C322(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C319(0.90); C322(0.90)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C319(0.60); C322(0.60); C67(1.04)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C319(0.88); C322(0.88)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C319(0.86); C322(0.86)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C319(1.19); C322(1.19)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C319(0.92); C322(0.92)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C319(1.11); C322(1.11)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C319(0.86); C322(0.86)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C319(1.13); C322(1.13)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C319(0.95); C322(0.95)  LDD0562  [6]
 LDCM0259  AC14 HEK-293T C319(0.52); C322(0.52); C67(1.34)  LDD0857  [6]
 LDCM0263  AC143 HEK-293T C317(0.77); C319(0.77); C322(0.77)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C317(0.91); C319(0.91); C322(0.91)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C317(0.80); C319(0.80); C322(0.80)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C317(0.68); C319(0.68); C322(0.68)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C317(0.92); C319(0.92); C322(0.92)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C317(0.87); C319(0.87); C322(0.87)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C317(0.83); C319(0.83); C322(0.83)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C319(0.50); C322(0.50); C67(1.56)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C317(0.93); C319(0.93); C322(0.93)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C317(0.82); C319(0.82); C322(0.82)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C317(0.83); C319(0.83); C322(0.83)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C317(0.90); C319(0.90); C322(0.90)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C317(1.00); C319(1.00); C322(1.00)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C317(0.68); C319(0.68); C322(0.68)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C317(0.81); C319(0.81); C322(0.81)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C317(0.79); C319(0.79); C322(0.79)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C317(0.78); C319(0.45); C322(0.62)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C317(0.75); C319(0.52); C322(0.64)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C317(0.83); C319(0.73); C322(0.83)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C67(0.85)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C317(0.85); C319(0.71); C322(0.84)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C317(0.78); C319(0.78); C322(0.78)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C317(0.85); C319(0.79); C322(0.91)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C317(0.92); C319(0.67); C322(0.80)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C317(0.78); C319(0.70); C322(0.84)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C317(1.22); C319(1.36); C322(1.36); C67(1.11)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C317(1.35); C319(1.44); C322(1.44); C67(1.15)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C317(1.37); C319(1.41); C322(1.41); C67(1.51)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C317(1.34); C319(1.43); C322(1.43); C67(3.86)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C317(1.44); C319(1.49); C322(1.49); C67(1.89)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C67(0.88)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C317(1.46); C319(1.64); C322(1.64); C67(1.17)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C317(1.24); C319(1.63); C322(1.63); C67(0.85)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C317(1.15); C319(1.28); C322(1.28); C67(1.96)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C317(1.26); C319(1.29); C322(1.29); C67(1.34)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C317(1.20); C319(1.40); C322(1.40); C67(1.01)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C317(0.77); C319(0.91); C322(0.91)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C317(1.20); C319(1.09); C322(1.09)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C317(0.88); C319(1.07); C322(1.07)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C317(0.85); C319(0.93); C322(0.93)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C317(0.60); C319(0.59); C322(0.59)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C67(1.23)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C317(0.95); C319(0.96); C322(0.96)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C317(1.03); C319(1.07); C322(1.07)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C317(1.07); C319(0.95); C322(0.95)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C317(0.67); C319(0.63); C322(0.63)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C317(0.88); C319(0.86); C322(0.86)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C317(0.78); C319(0.83); C322(0.83)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C317(1.15); C319(1.15); C322(1.15); C67(1.02)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C317(0.93); C319(0.93); C322(0.93); C67(1.10)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C317(0.94); C319(0.94); C322(0.94); C67(1.06)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C317(1.00); C319(1.00); C322(1.00); C67(1.15)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C67(1.08)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C317(1.02); C319(1.02); C322(1.02); C67(1.22)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C317(0.73); C319(0.73); C322(0.73); C67(1.14)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C317(0.80); C319(0.80); C322(0.80); C67(1.34)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C317(0.89); C319(0.89); C322(0.89); C67(1.17)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C317(0.67); C319(0.67); C322(0.67); C67(1.37)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C317(0.53); C319(0.53); C322(0.53); C67(1.27)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C317(1.05); C319(1.05); C322(1.05); C67(1.07)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C317(0.66); C319(0.66); C322(0.66)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C317(0.80); C319(0.80); C322(0.80)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C317(1.40); C319(1.40); C322(1.40)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C319(0.66); C322(0.66); C67(0.80)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C317(0.77); C319(0.77); C322(0.77)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C317(0.67); C319(0.67); C322(0.67)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C317(0.87); C319(0.87); C322(0.87)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C317(0.65); C319(0.65); C322(0.65)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C317(0.82); C319(0.82); C322(0.82)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C317(1.29); C319(1.29); C322(1.29)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C317(1.12); C319(1.12); C322(1.12)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C317(0.63); C319(0.63); C322(0.63)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C317(0.83); C67(1.24)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C317(0.86); C67(1.13)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C319(0.83); C322(0.83); C67(0.91)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C317(0.97); C67(1.36)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C317(0.95); C67(1.25)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C317(1.03); C67(1.44)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C317(1.08); C67(1.43)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C317(1.00); C67(1.46)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C317(1.08); C67(1.51)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C317(1.09); C67(1.44)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C317(1.14); C67(1.32)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C317(0.96); C67(1.33)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C317(0.97); C67(1.21)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C319(0.53); C322(0.53); C67(1.16)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C317(1.09); C67(1.42)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C317(1.11); C67(1.53)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C317(1.09); C67(1.79)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C317(1.29); C319(1.29)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C317(1.33); C319(1.33)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C317(1.41); C319(1.41)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C317(1.09); C319(1.09)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C317(0.92); C319(0.92)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C317(1.13); C319(1.13)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C317(1.38); C319(1.38)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C317(1.03); C319(1.03)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C317(1.28); C319(1.28)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C317(1.40); C319(1.40)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C317(1.10); C319(1.10)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C317(2.04); C319(2.04)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C317(1.36); C319(1.36)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C317(1.96); C319(1.96)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C317(0.77); C319(0.77)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C317(0.28); C319(0.28); C322(0.28)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C317(0.28); C319(0.28); C322(0.28)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C319(0.58); C322(0.58); C67(1.37)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C319(0.69); C322(0.69); C67(1.43)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C319(0.44); C322(0.44); C67(1.18)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 13.13  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C317(0.64); C319(0.64); C322(0.64); C67(1.00)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C317(0.76); C319(0.76); C322(0.76); C67(1.69)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C67(1.01)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C319(0.60); C322(0.60); C67(1.28)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C319(0.56); C322(0.56); C67(1.27)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C319(0.85); C322(0.85); C67(1.54)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C319(0.85); C322(0.85); C67(1.21)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C317(0.83); C319(0.73); C322(0.80)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C317(0.69); C319(0.58); C322(0.65)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C317(0.73); C319(0.75); C322(0.81)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C317(0.74); C319(0.63); C322(0.69)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C317(0.80); C319(0.61); C322(0.68)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C317(0.94); C319(0.94); C322(0.94); C67(1.58)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C317(0.78); C319(0.50); C322(0.64)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C317(0.93); C319(0.68); C322(0.87)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C317(1.39); C319(1.40); C322(1.40); C67(0.92)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C317(1.24); C319(1.34); C322(1.34); C67(0.97)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C317(1.57); C319(1.49); C322(1.49); C67(1.91)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C317(1.21); C319(1.33); C322(1.33); C67(1.51)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C317(1.32); C319(1.31); C322(1.31); C67(1.27)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C317(0.87); C319(0.86); C322(0.86)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C317(0.85); C319(1.22); C322(1.22)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C317(0.84); C319(1.35); C322(1.35)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C317(1.06); C319(1.06); C322(1.06); C67(1.27)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C317(0.83); C319(0.92); C322(0.92)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C317(0.90); C319(0.90); C322(0.90); C67(1.23)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C317(0.83); C319(0.83); C322(0.83); C67(1.29)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C317(0.76); C319(0.76); C322(0.76); C67(1.02)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C317(1.00); C319(1.00); C322(1.00); C67(1.08)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C317(1.01); C319(1.01); C322(1.01)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C317(0.73); C319(0.73); C322(0.73)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C317(1.09); C319(1.09); C322(1.09)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C317(1.12); C319(1.12); C322(1.12)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C317(1.10); C319(1.10); C322(1.10); C67(1.68)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C317(0.80); C319(0.80); C322(0.80); C67(1.70)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C317(0.77); C319(0.77); C322(0.77); C67(1.67)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C317(0.54); C319(0.54); C322(0.54)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C317(0.84); C319(0.84); C322(0.84)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C317(0.72); C319(0.72); C322(0.72)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C317(0.95); C319(0.95); C322(0.95)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C317(0.82); C319(0.82); C322(0.82); C67(1.77)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C317(0.99); C319(0.99); C322(0.99)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C317(0.90); C319(0.90); C322(0.90)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C317(1.02); C319(1.02); C322(1.02)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C317(0.59); C319(0.59); C322(0.59)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C317(0.90); C319(0.90); C322(0.90)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C317(0.62); C319(0.62); C322(0.62)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C317(0.53); C319(0.53); C322(0.53)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C317(0.95); C319(0.95); C322(0.95)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C317(0.65); C319(0.65); C322(0.65)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C317(0.99); C319(0.99); C322(0.99)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C317(0.75); C319(0.75); C322(0.75); C67(1.09)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C317(0.86); C319(0.86); C322(0.86)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C317(1.14); C319(1.01); C322(1.01); C67(0.93)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C317(0.94); C319(0.75); C322(0.75); C67(1.27)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C317(0.97); C319(0.78); C322(0.78); C67(1.14)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C317(1.01); C319(0.88); C322(0.88); C67(1.60)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C317(1.14); C319(0.81); C322(0.81); C67(1.41)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C317(0.96); C319(0.76); C322(0.76); C67(1.56)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C317(0.96); C319(0.71); C322(0.71); C67(1.26)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C317(1.48); C319(0.91); C322(0.91); C67(2.15)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C317(0.77); C319(0.77); C322(0.77); C67(1.06)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C317(1.16); C319(1.02); C322(1.02); C67(1.43)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C317(1.23); C319(1.05); C322(1.05); C67(2.44)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C317(1.55); C319(0.97); C322(0.97); C67(1.66)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C317(1.35); C319(0.92); C322(0.92); C67(2.07)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C317(1.09); C319(1.05); C322(1.05); C67(1.69)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C317(1.24); C319(0.77); C322(0.77); C67(1.98)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C317(0.81); C319(0.81); C322(0.81); C67(0.63)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C317(0.85); C319(0.85); C322(0.85); C67(0.57)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C317(0.93); C319(0.93); C322(0.93); C67(0.39)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C317(0.81); C319(0.81); C322(0.81); C67(0.70)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C317(0.91); C319(0.91); C322(0.91); C67(1.22)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C317(0.88); C319(0.88); C322(0.88); C67(0.74)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C317(0.51); C319(0.51); C322(0.51); C67(0.44)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C317(0.68); C319(0.68); C322(0.68); C67(0.50)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C317(0.69); C319(0.69); C322(0.69); C67(0.48)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C317(0.56); C319(0.56); C322(0.56); C67(0.45)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C317(0.68); C319(0.68); C322(0.68); C67(0.60)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C317(0.61); C319(0.61); C322(0.61); C67(0.55)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C317(0.53); C319(0.53); C322(0.53); C67(0.59)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C317(0.69); C319(0.69); C322(0.69); C67(0.53)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C317(0.61); C319(0.61); C322(0.61); C67(0.80)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C317(0.79); C319(0.79); C322(0.79); C67(1.04)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C317(0.45); C319(0.45); C322(0.45); C67(0.67)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C317(1.34); C67(1.12)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C317(1.14); C67(1.16)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C317(1.16); C67(0.94)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C317(1.05); C67(1.04)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C317(0.92); C67(1.17)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C317(1.17); C67(1.14)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C317(1.14); C67(1.55)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C317(1.41); C67(1.32)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C317(1.09); C67(1.01)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C317(0.93); C319(0.93); C322(0.93); C67(1.31)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C317(0.90); C67(1.43)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C317(1.11); C67(0.87)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C317(1.08); C67(0.98)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C317(1.20); C67(1.32)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C317(1.66); C67(1.51)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C317(0.79); C319(0.79); C322(0.79)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C317(0.70); C319(0.70); C322(0.70)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C317(0.96); C319(0.96); C322(0.96)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C317(0.78); C319(0.78); C322(0.78)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C317(0.96); C319(0.79); C322(0.76); C67(1.47)  LDD1071  [6]
 LDCM0474  CL80 HEK-293T C317(0.89); C319(0.89); C322(0.89)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C317(1.03); C319(1.03); C322(1.03)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C317(0.97); C319(0.97); C322(0.97)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C317(0.96); C319(0.96); C322(0.96)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C317(0.79); C319(0.79); C322(0.79)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C317(0.66); C319(0.66); C322(0.66)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C317(0.59); C319(0.59); C322(0.59)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C317(0.61); C319(0.61); C322(0.61)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C317(0.46); C319(0.46); C322(0.46)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C317(0.77); C319(0.77); C322(0.77)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C317(1.02); C319(0.84); C322(0.81); C67(1.06)  LDD1082  [6]
 LDCM0485  CL90 HEK-293T C317(0.67); C319(0.67); C322(0.67)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C67(0.70)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C67(0.74)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C67(0.94)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C67(0.96)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C67(1.09)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C67(1.01)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C67(1.15)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C67(1.15)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C67(1.08)  LDD1092  [6]
 LDCM0468  Fragment33 HEK-293T C317(1.58); C67(1.64)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C317(0.98); C319(0.92); C322(0.92); C67(1.23)  LDD1025  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0123  JWB131 DM93 Y131(1.90)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y131(0.47)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y131(0.71)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y131(1.82)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y131(1.18)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y131(1.94)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y131(0.77)  LDD0291  [4]
 LDCM0022  KB02 HEK-293T C213(1.03)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C213(0.96)  LDD1497  [13]
 LDCM0024  KB05 G361 C213(1.62); C23(1.98)  LDD3311  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C213(1.00)  LDD2126  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C23(0.74)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Queuine tRNA-ribosyltransferase accessory subunit 2 (QTRT2) Queuine tRNA-ribosyltransferase family Q9H974

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840