Details of the Target

General Information of Target

Target ID LDTP11315
Target Name HIRA-interacting protein 3 (HIRIP3)
Gene Name HIRIP3
Gene ID 8479
Synonyms
HIRA-interacting protein 3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAGFTTANNIANLKISLLN
KDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGLTKIQVKMEKLSSTTKGIC
ELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKELLLKRTVAKELAHTGDPDLTL
SYLSMWLHQPYVESDSRLHLESMLLETGHRAL
Target Bioclass
Other
Subcellular location
Nucleus
Function May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
Uniprot ID
Q9BW71
Ensemble ID
ENST00000279392.8
HGNC ID
HGNC:4917

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC70 SNV: p.E57K DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.G17C .
KELLY SNV: p.R328G .
MOLT4 SNV: p.C436R IA-alkyne    Probe Info 
NCIH446 SNV: p.A479T .
NCIH716 SNV: p.A479G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C86(0.72)  LDD2092  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C449(1.55); C450(1.55)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C449(0.00); C450(0.00); C86(0.00)  LDD0037  [5]
Compound 10
 Probe Info  		C449(0.00); C86(0.00)  LDD2216  [6]
IPM
 Probe Info  		C86(0.00); C450(0.00)  LDD0005  [7]
Phosphinate-6
 Probe Info  		C449(0.00); C86(0.00)  LDD0018  [8]
Methacrolein
 Probe Info  		C449(0.00); C450(0.00)  LDD0218  [2]
AOyne
 Probe Info  		11.30  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C86(0.91)  LDD2142  [1]
 LDCM0214  AC1 HCT 116 C86(0.81)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C449(0.79); C450(0.79); C86(1.03)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C449(0.90)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C449(0.84)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C449(0.78)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C449(0.92)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C449(0.94)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C449(1.13)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C449(1.33)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C449(0.83)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C449(1.16)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C449(0.81)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C449(1.10); C450(1.10); C86(1.00)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C449(0.77)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C449(1.03)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C449(0.81)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C449(1.25); C450(1.25)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C449(1.11); C450(1.11)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C449(1.00); C450(1.00)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C449(1.03); C450(1.03)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C449(1.05); C450(1.05)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C449(1.00); C450(1.00)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C449(1.09); C450(1.09)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C449(0.77); C450(0.77); C86(0.80)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C449(0.95); C450(0.95)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C449(1.03); C450(1.03)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C449(0.78); C450(0.78)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C449(0.89); C450(0.89)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C449(1.02); C450(1.02)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C449(0.87); C450(0.87)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C449(0.71); C450(0.71)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C449(0.77); C450(0.77)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C449(1.04); C450(1.12)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C449(0.98); C450(1.01)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C449(0.85); C450(1.01)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C449(0.98); C450(1.14)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C449(1.02); C450(0.96)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C449(0.94); C450(1.09)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C449(0.79); C450(0.91)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C449(0.90); C450(1.02)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C449(0.87); C450(0.79)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C449(1.24); C450(1.01)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C449(1.19); C450(1.02)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C449(0.84); C450(0.97)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C449(0.92); C450(0.92); C86(1.46)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C449(0.76); C450(0.93)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C449(0.81); C450(0.88)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C449(0.79); C450(0.96)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C450(1.19)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C450(0.96)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C450(1.01)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C450(1.36)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C450(0.92)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C450(1.16)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C450(1.31)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C449(0.60); C450(0.60); C86(1.04)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C450(1.07)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C450(1.11)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C450(1.10)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C450(1.20)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C450(1.06)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C450(1.24)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C450(1.24)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C450(1.19)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C86(0.76); C449(0.99); C450(0.99)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C86(0.96); C449(1.02); C450(1.02)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C86(0.88); C449(1.08); C450(1.08)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C86(0.83)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C86(0.91); C449(0.98); C450(0.98)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C86(0.97); C449(1.07); C450(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C449(0.83); C450(0.83); C86(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C449(0.82); C450(0.82); C86(1.21)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C86(0.70); C449(1.00); C450(1.00)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C86(1.13); C450(1.02); C449(1.08)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C86(1.01); C450(1.00)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C86(1.01); C450(1.04); C449(1.11)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C86(0.91); C450(0.92)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C86(0.99); C450(0.95)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C86(0.91)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C86(1.01); C450(0.94); C449(0.88)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C86(0.98); C450(0.94); C449(0.99)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C86(0.96); C450(1.00)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C86(1.06); C450(1.04); C449(1.04)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C86(0.98); C450(1.02)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C449(0.99); C450(0.99); C86(0.94)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C449(1.04); C450(1.04); C86(0.86)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C449(0.82); C450(0.82); C86(1.06)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C449(1.11); C450(1.11); C86(1.19)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C449(1.14); C450(1.14); C86(1.05)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C86(0.81)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C449(1.04); C450(1.04); C86(1.15)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C449(1.24); C450(1.24); C86(0.89)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C449(1.16); C450(1.16); C86(0.87)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C449(1.37); C450(1.37); C86(1.01)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C449(1.21); C450(1.21); C86(0.98)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C449(1.28); C450(1.28); C86(1.23)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C449(1.38); C450(0.89)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C449(1.16); C450(1.26)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C449(1.40); C450(0.99)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C449(0.77); C450(0.89)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C86(0.86)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C449(1.05); C450(0.73)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C449(0.79); C450(0.90)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C449(0.78); C450(0.90)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C449(1.11); C450(0.87)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C449(0.97); C450(1.16)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C449(0.96); C450(1.12)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C449(0.90); C450(0.87)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C450(0.97)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C450(1.05)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C450(1.00)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C449(0.70); C450(0.70); C86(0.99)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C450(1.01)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C450(1.12)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C450(0.95)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C450(0.93)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C450(0.93)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C450(0.96)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C450(1.14)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C450(1.05)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C450(0.73); C86(0.82)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C86(0.68); C450(0.76)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C449(0.89); C450(0.89); C86(0.91)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C86(0.73); C450(0.84)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C86(0.72); C450(0.81)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C86(0.77); C450(0.93)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C450(0.96); C86(1.00)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C450(0.70); C86(0.89)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C450(0.79); C86(0.84)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C450(0.77); C86(1.06)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C450(0.70); C86(0.79)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C450(0.78); C86(0.90)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C450(0.85); C86(0.90)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C449(0.85); C450(0.85); C86(0.81)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C86(0.84); C450(0.85)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C450(0.78); C86(0.82)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C450(0.81); C86(0.92)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C86(1.07)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C86(1.10)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C86(1.35)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C86(1.10)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C86(0.95)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C86(0.94)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C86(1.08)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C86(1.04)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C86(1.20)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C86(1.24)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C86(1.11)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C86(1.33)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C86(1.08)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C86(1.35)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C86(1.36)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C449(0.75)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C449(0.67)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C449(0.74); C450(0.74); C86(0.95)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C449(0.98); C450(0.98); C86(0.89)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C449(1.16); C450(1.16); C86(1.39)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C86(1.24)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C86(0.89)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C86(0.98)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C449(0.81); C450(0.81); C86(1.22)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C449(1.17); C450(1.17); C86(1.49)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C449(0.92); C450(0.92); C86(1.16)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C449(0.54); C450(0.54); C86(1.03)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C449(1.00); C450(1.00); C86(1.13)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C86(0.89); C449(1.23); C450(1.23)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C86(0.85); C449(1.17); C450(1.17)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C86(0.82); C449(1.40); C450(1.40)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C449(0.86); C450(0.86); C86(1.32)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C86(1.37)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C86(0.94); C449(1.11); C450(1.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C449(1.07); C450(1.07); C86(1.11)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C86(1.06); C450(1.00); C449(0.95)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C86(1.02); C450(0.96); C449(1.07)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C86(0.96); C450(0.86)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C86(1.09); C450(0.98); C449(1.04)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C86(1.01); C450(1.00); C449(1.22)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C449(1.08); C450(1.08); C86(1.25)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C449(1.17); C450(1.17); C86(0.79)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C449(1.03); C450(1.03); C86(0.78)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C86(1.10)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C449(1.18); C450(1.18); C86(1.17)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C449(0.94); C450(0.97)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C449(0.74); C450(0.68)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C449(0.99); C450(0.70)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C449(0.71); C450(0.72)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C450(0.97)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C450(1.12)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C450(1.02)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C450(1.17)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C86(0.83)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C86(1.03)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C86(1.14)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C86(1.28)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C449(1.01); C450(1.01); C86(1.40)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C449(0.87); C450(0.87); C86(0.96)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C86(0.95); C449(1.02); C450(1.02)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C86(0.99)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C449(0.87); C450(0.87); C86(0.98)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C449(0.85); C450(0.85); C86(1.72)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C449(1.05); C450(1.05); C86(1.19)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C449(1.05); C450(1.05); C86(1.53)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C449(0.78); C450(0.78); C86(1.18)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C449(0.77); C450(0.77); C86(1.17)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C449(0.85); C450(0.85); C86(1.36)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C449(0.89); C450(0.89); C86(1.09)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C449(0.79); C450(0.79); C86(1.43)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C449(0.90); C450(0.90); C86(0.95)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C86(0.96)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C449(0.78); C450(0.78); C86(0.96)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C449(0.85); C450(0.88)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C449(0.79); C450(0.81); C86(1.31)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C449(0.76); C450(0.81); C86(2.22)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C449(0.96); C450(0.99); C86(1.24)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C449(0.75); C450(0.88); C86(1.33)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C449(0.67); C450(0.79); C86(0.86)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C449(0.65); C450(0.72); C86(0.98)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C449(0.65); C450(0.62); C86(1.21)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C86(1.05)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C449(0.53); C450(0.53); C86(1.81)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C449(0.77); C450(0.63); C86(1.15)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C449(0.59); C450(0.57); C86(0.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C449(0.69); C450(0.59); C86(1.11)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C449(0.66); C450(0.57); C86(0.89)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C449(0.71); C450(0.62); C86(0.95)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C449(0.94); C450(1.12); C86(2.04)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C449(1.00); C450(1.10); C86(1.27)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C449(1.11); C450(1.04); C86(1.13)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C449(1.05); C450(1.06); C86(0.97)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C86(0.76)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C449(0.99); C450(1.08); C86(1.10)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C449(1.01); C450(1.13); C86(1.43)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C449(1.19); C450(1.14); C86(1.49)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C449(0.93); C450(0.93); C86(1.11)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C449(0.88); C450(0.92); C86(1.22)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C449(0.86); C450(0.85); C86(1.49)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C449(1.33); C450(1.13); C86(1.05)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C449(1.13); C450(1.05); C86(1.04)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C449(1.10); C450(0.99); C86(1.88)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C449(1.09); C450(0.98); C86(1.01)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C86(1.07)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C449(0.99); C450(0.99); C86(1.27)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C86(0.88); C450(0.87); C449(1.06)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C86(1.01); C450(0.85)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C86(1.13); C450(0.92); C449(1.08)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C86(1.01); C450(0.90); C449(0.97)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C86(1.09); C450(1.06); C449(1.10)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C86(0.99); C450(0.97)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C86(1.11); C450(0.98); C449(1.22)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C86(1.04); C450(0.88)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C86(1.09); C450(0.88)  LDD1664  [12]
 LDCM0462  CL7 HCT 116 C86(0.89)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C86(0.97); C450(0.95); C449(1.10)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C86(1.25); C450(0.99); C449(1.13)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C86(1.29); C450(0.97)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C86(0.91); C450(0.84); C449(0.92)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C86(0.95); C450(0.93)  LDD1670  [12]
 LDCM0469  CL76 HCT 116 C86(0.73)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C86(0.75)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C86(1.00)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C86(0.66)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C86(1.40)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C86(0.66)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C86(0.80)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C86(0.63)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C86(0.78)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C86(0.86)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C86(0.81)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C86(0.64)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C86(0.75)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C86(0.69)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C86(0.64)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C86(0.95)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C86(1.06)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C86(0.77)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C86(0.99)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C86(1.09)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C86(1.03)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C86(1.35)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C86(0.81)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C86(0.93)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C86(0.95)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C86(0.97)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C86(1.17); C450(0.89); C449(0.96)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C450(1.63)  LDD1702  [1]
 LDCM0625  F8 Ramos C86(1.27)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C86(1.49)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C86(1.01)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C86(0.77)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C86(0.99)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C86(0.79)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C86(0.93)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C86(1.01)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C86(1.11)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C86(1.06)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C86(0.73)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C86(1.02)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C86(0.84)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C86(2.31)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C86(1.05); C450(0.88); C449(0.96)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C86(0.95)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C86(0.91)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C449(0.50); C450(0.68); C86(1.21)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C86(1.51)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C86(1.50)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C86(1.27)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C86(0.94)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C449(1.55); C450(1.55)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C449(2.16); C450(2.16)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C449(2.25); C450(2.25)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C86(0.72)  LDD2092  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C86(0.99)  LDD2094  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C86(1.00)  LDD2098  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C436(0.89)  LDD2104  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C86(0.84)  LDD2106  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C86(0.95)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C86(0.76)  LDD2114  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C86(0.68)  LDD2141  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C436(0.93)  LDD2144  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578