Details of the Target

General Information of Target

Target ID LDTP11264
Target Name WD repeat-containing protein 18 (WDR18)
Gene Name WDR18
Gene ID 57418
Synonyms
WD repeat-containing protein 18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN
ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW
YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ
PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK
AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN
EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN
TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS
VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE
SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA
MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS
Target Bioclass
Other
Family
WD repeat IPI3/WDR18 family
Subcellular location
Nucleus, nucleolus
Function
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.
Uniprot ID
Q9BV38
Ensemble ID
ENST00000585809.6
HGNC ID
HGNC:17956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C384(1.00)  LDD2117  [3]
AHL-Pu-1
 Probe Info  		C384(2.07)  LDD0172  [4]
DBIA
 Probe Info  		C384(0.85)  LDD0533  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		C384(0.00); H342(0.00)  LDD0217  [11]
Crotonaldehyde
 Probe Info  		H342(0.00); H256(0.00)  LDD0219  [11]
W1
 Probe Info  		N.A.  LDD0236  [2]
AOyne
 Probe Info  		14.00  LDD0443  [12]
NAIA_5
 Probe Info  		C180(0.00); C274(0.00); C384(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C384(1.00)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C384(2.07)  LDD0172  [4]
 LDCM0214  AC1 HEK-293T C384(1.01); C151(1.05)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C384(1.01); C274(1.12); C151(0.89)  LDD1508  [15]
 LDCM0216  AC100 HCT 116 C384(0.85)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C384(0.86)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C384(0.88)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C384(1.14)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C384(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C384(1.01)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C384(1.11)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C384(0.78)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C384(0.73)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C384(0.72)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C384(0.98); C151(0.78)  LDD1509  [15]
 LDCM0227  AC110 HCT 116 C384(0.73)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C384(0.69)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C384(0.78)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C384(0.77)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C384(0.92)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C384(0.96)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C384(0.80)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C384(0.84)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C384(0.70)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C384(0.99)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C384(1.01); C151(1.07)  LDD1510  [15]
 LDCM0238  AC120 HCT 116 C384(1.10)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C384(0.74)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C384(0.59)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C384(0.80)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C384(0.88)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C384(0.78)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C384(0.97)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C384(0.78)  LDD0562  [5]
 LDCM0259  AC14 HEK-293T C384(0.98); C151(1.09)  LDD1512  [15]
 LDCM0263  AC143 HCT 116 C384(1.16)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C384(0.97)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C384(1.33)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C384(1.07)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C384(1.01)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C384(1.14)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C384(1.45)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C384(0.95); C151(1.15)  LDD1513  [15]
 LDCM0271  AC150 HCT 116 C384(1.01)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C384(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C384(1.21)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C384(1.13)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C384(1.31)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C384(1.17)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C384(1.14)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C384(1.30)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C384(1.00); C151(1.25)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C384(0.98); C274(1.01); C151(1.01)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C384(1.27); C151(0.70)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C384(0.97); C274(0.95); C151(0.93)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C384(0.98); C151(1.09)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C384(0.99); C151(1.00)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C384(0.95); C151(1.10)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C384(1.03); C151(1.17)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C384(0.97); C151(1.02)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C384(1.06); C151(0.76)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C384(0.99); C274(0.86); C151(1.10)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C384(1.01); C151(0.88)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C384(1.04); C151(0.91)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C384(1.01); C151(0.86)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C384(0.96); C151(1.11)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C384(0.96); C151(0.91)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C384(0.93); C151(1.08)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C384(0.98); C151(0.99)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C384(1.04); C151(1.33)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C384(1.00); C274(0.88); C151(0.91)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C384(0.97); C151(0.85)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C384(1.00); C151(1.02)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C384(1.01); C151(0.82)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C384(0.93); C151(1.11)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C384(0.96); C151(1.09)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C384(0.97); C151(1.06)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C384(0.89); C151(0.94)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C384(0.97); C151(1.03)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C384(0.98); C274(1.08); C151(0.86)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C384(0.95); C151(1.02)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C384(1.02); C151(0.94)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C384(1.03); C151(0.93)  LDD1546  [15]
 LDCM0308  AC46 HCT 116 C384(1.05)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C384(0.94)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C384(0.98)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C384(1.17)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C384(1.02); C151(0.79)  LDD1551  [15]
 LDCM0313  AC50 HCT 116 C384(1.11)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C384(0.86)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C384(0.83)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C384(0.98)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C384(1.02)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C384(0.99)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C384(1.20)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C384(1.00)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C384(0.75)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C384(0.93)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C384(0.98); C151(1.04)  LDD1562  [15]
 LDCM0324  AC60 HCT 116 C384(1.03)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C384(0.82)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C384(1.19)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C384(0.85)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C384(1.07)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C384(0.89)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C384(0.83)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C384(0.87)  LDD0648  [5]
 LDCM0334  AC7 HEK-293T C384(1.01); C151(1.14)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C384(0.94); C151(0.76)  LDD1569  [15]
 LDCM0365  AC98 HCT 116 C384(1.19)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C384(0.84)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C384(1.05); C151(0.94)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C384(1.03); C151(1.11)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C384(1.00); C151(0.85)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.87  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H342(0.00); C384(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C384(0.67)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C384(0.66)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C384(1.48)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C384(0.96); C151(0.96)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C384(0.95); C151(1.08)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C384(0.94); C151(0.94)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C384(1.02); C151(1.01)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C384(0.94); C151(0.89)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C384(1.04); C151(1.14)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C384(1.05); C151(1.06)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C384(1.06); C151(0.99)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C384(0.93); C151(0.77)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C384(0.99); C151(0.94)  LDD1582  [15]
 LDCM0379  CL11 HCT 116 C384(1.01)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C384(0.95); C151(0.93)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C384(1.01); C151(0.95)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C384(0.91); C151(1.20)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C384(1.01); C151(0.91)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C384(0.92); C151(0.78)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C384(0.97); C151(1.04)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C384(0.99); C151(0.83)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C384(0.97); C151(0.99)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C384(1.12); C151(0.89)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C384(1.08); C151(0.98)  LDD1593  [15]
 LDCM0390  CL12 HCT 116 C384(1.55)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C384(0.97); C151(1.05)  LDD1595  [15]
 LDCM0392  CL121 HCT 116 C384(0.85)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C384(0.88)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C384(0.97)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C384(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C384(0.91)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C384(0.76)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C384(1.15)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C384(1.01)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C384(1.26)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C384(0.89)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C384(0.85)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C384(1.15)  LDD0720  [5]
 LDCM0404  CL17 HEK-293T C384(0.95); C151(1.16)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C384(1.03); C274(1.00); C151(1.13)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C384(1.04); C151(0.91)  LDD1610  [15]
 LDCM0407  CL2 HCT 116 C384(0.85)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C384(1.01); C151(1.49)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C384(1.00); C151(1.03)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C384(0.94); C151(1.93)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C384(1.07); C151(1.45)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C384(1.04); C151(0.99)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C384(0.84); C151(1.18)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C384(0.97); C151(0.87)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C384(1.00); C151(0.97)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C384(0.98); C151(0.80)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C384(0.99); C151(1.05)  LDD1621  [15]
 LDCM0418  CL3 HCT 116 C384(1.15)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C384(0.96); C274(0.98); C151(0.87)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C384(0.95); C151(1.00)  LDD1624  [15]
 LDCM0421  CL32 HCT 116 C384(1.23)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C384(0.94)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C384(0.97)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C384(1.20)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C384(1.03)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C384(1.14)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C384(1.03)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C384(1.23)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C384(0.97)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C384(0.99)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C384(1.00)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C384(1.14)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C384(1.14)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C384(1.20)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C384(0.95); C151(1.36)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C384(0.98); C151(1.44)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C384(0.96); C151(1.64)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C384(0.87); C151(0.94)  LDD1643  [15]
 LDCM0440  CL5 HCT 116 C384(0.89)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C384(0.91); C151(0.85)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C384(0.91); C151(1.35)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C384(0.92); C151(0.84)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C384(0.96); C274(1.02); C151(0.96)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C384(0.95); C151(1.00)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C384(0.99); C151(1.19)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C384(1.05); C151(1.00)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C384(0.89); C151(1.80)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C384(1.00); C151(1.31)  LDD1653  [15]
 LDCM0451  CL6 HCT 116 C384(0.96)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C384(0.87); C151(1.30)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C384(0.89); C151(1.07)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C384(1.04); C151(0.83)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C384(1.05); C151(0.99)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C384(0.82); C151(0.94)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C384(1.07); C151(1.02)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C384(0.93); C274(1.13); C151(0.95)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C384(0.98); C151(0.97)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C384(1.01); C151(1.47)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C384(1.04); C151(1.07)  LDD1664  [15]
 LDCM0462  CL7 HCT 116 C384(1.34)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C384(0.95); C151(1.42)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C384(0.97); C151(1.34)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C384(0.92); C151(1.26)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C384(0.74); C151(0.97)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C384(1.04); C151(1.07)  LDD1670  [15]
 LDCM0469  CL76 HCT 116 C384(1.09)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C384(1.09)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C384(0.95)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C384(1.32)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C384(0.69)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C384(1.13)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C384(1.25)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C384(1.22)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C384(1.15)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C384(1.04)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C384(1.09)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C384(1.22)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C384(1.52)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C384(1.17)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C384(1.17)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C384(0.77)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C384(0.98)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C384(0.89); C151(1.08)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C384(0.93); C151(0.96)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C384(0.99); C151(1.03)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C384(0.91); C151(1.43)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C384(0.80); C151(1.24)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C384(0.86); C151(0.83)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C384(0.90); C151(0.78)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C384(0.99); C151(0.93)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C384(0.96); C151(0.98)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C384(0.99); C151(0.97)  LDD1698  [15]
 LDCM0625  F8 Ramos C384(1.01)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C384(0.56)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C384(2.19)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C384(0.80)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C384(0.47)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C384(1.15)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C384(0.71)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C384(0.83)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C384(0.99)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C384(0.63)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C384(1.14)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C384(0.64)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C384(0.39)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C384(0.39)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C384(0.98); C151(0.90)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C384(0.42)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C384(1.04)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C384(1.01)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C384(0.36)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C384(0.50)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C384(0.62)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C384(0.55)  LDD2188  [16]
 LDCM0107  IAA HeLa H256(0.00); H342(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C384(0.92)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C384(1.05)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C384(1.52)  LDD3310  [17]
 LDCM0109  NEM HeLa H256(0.00); H342(0.00); H354(0.00)  LDD0223  [11]
 LDCM0131  RA190 MM1.R C384(1.96)  LDD0304  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sentrin-specific protease 3 (SENP3) Peptidase C48 family Q9H4L4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-expressed protein 10 (TEX10) IPI1/TEX10 family Q9NXF1
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) RIX1/PELP1 family Q8IZL8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.