Details of the Target

General Information of Target

Target ID LDTP11157
Target Name Translational activator of cytochrome c oxidase 1 (TACO1)
Gene Name TACO1
Gene ID 51204
Synonyms
CCDC44; Translational activator of cytochrome c oxidase 1; Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVMLENYNSIVSLGLPVPQP
DVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASDKKSEGSLRECLGRQSP
LCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGK
TFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSRHLMSHTGESPYECSVCSKAFFD
RSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSIL
TRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQ
KIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECTVCGKVFSSKSSVIQHQRRYA
KQGID
Target Bioclass
Other
Family
TACO1 family
Subcellular location
Mitochondrion
Function Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
Uniprot ID
Q9BSH4
Ensemble ID
ENST00000258975.7
HGNC ID
HGNC:24316

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y135(58.22); Y138(16.45)  LDD3495  [2]
BTD
 Probe Info  		C234(1.45)  LDD2093  [3]
DBIA
 Probe Info  		C42(1.36)  LDD0531  [4]
5E-2FA
 Probe Info  		H101(0.00); H240(0.00); H158(0.00)  LDD2235  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C112(0.00); C234(0.00); C256(0.00); C252(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C234(0.00); C112(0.00); C256(0.00); C252(0.00)  LDD0037  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		C160(0.00); C112(0.00)  LDD0027  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
Phosphinate-6
 Probe Info  		C256(0.00); C112(0.00); C85(0.00); C160(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		C234(0.00); C112(0.00)  LDD0217  [15]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [15]
Crotonaldehyde
 Probe Info  		C234(0.00); C85(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C112(0.00); C234(0.00)  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C160(0.00); C112(0.00); C234(0.00); C85(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe3
 Probe Info  		18.37  LDD0464  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C234(0.62)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C234(0.99)  LDD2112  [3]
 LDCM0214  AC1 HCT 116 C42(1.36)  LDD0531  [4]
 LDCM0215  AC10 PaTu 8988t C42(1.39)  LDD1094  [4]
 LDCM0216  AC100 HCT 116 C42(1.07)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C42(0.95)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C42(1.12)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C42(1.06)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C42(1.09)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C42(1.10)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C42(1.42)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C42(1.07)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C42(1.14)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C42(1.09)  LDD0542  [4]
 LDCM0226  AC11 PaTu 8988t C42(1.19)  LDD1105  [4]
 LDCM0227  AC110 HCT 116 C42(1.02)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C42(0.97)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C42(1.09)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C42(1.01)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C42(1.11)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C42(1.24)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C42(1.41)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C42(1.34)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C42(1.18)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C42(1.39)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C42(1.21)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C42(1.20)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C42(1.30)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C42(1.08)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C42(1.06)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C42(1.14)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C42(1.18)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C42(1.60)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C42(1.53)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C252(0.38); C256(0.38)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C252(1.09); C256(1.09)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C252(0.65); C256(0.65)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C252(1.32); C256(1.32)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C252(1.11); C256(1.11)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C252(0.90); C256(0.90)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C252(0.62); C256(0.62)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C252(0.65); C256(0.65)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C252(0.86); C256(0.86)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C252(1.08); C256(1.08)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C252(0.74); C256(0.74)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C252(0.90); C256(0.90)  LDD0575  [4]
 LDCM0259  AC14 PaTu 8988t C42(1.40)  LDD1138  [4]
 LDCM0260  AC140 HCT 116 C252(0.66); C256(0.66)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C252(1.04); C256(1.04)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C252(1.21); C256(1.21)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C42(1.41)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C42(1.92)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C42(1.17)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C42(1.43)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C42(1.41)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C42(2.35)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C42(3.20)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C42(1.48)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C42(1.93)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C42(2.96)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C42(2.79)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C42(2.04)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C42(3.03)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C42(2.75)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C42(3.05)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C42(2.29)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C42(2.39)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C42(1.12)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C42(1.60)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C42(1.10)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C42(0.87)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C42(0.80)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C42(1.12)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C42(0.88)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C42(1.30)  LDD0601  [4]
 LDCM0285  AC25 PaTu 8988t C42(0.77)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C42(0.95)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C42(1.05)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C42(1.07)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C42(1.06)  LDD1168  [4]
 LDCM0290  AC3 HCT 116 C42(1.34)  LDD0607  [4]
 LDCM0291  AC30 PaTu 8988t C42(1.10)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C42(0.85)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C42(0.88)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C42(1.04)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C42(1.30)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C42(1.38)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C42(1.64)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C42(1.23)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C42(1.27)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C42(1.69)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C42(1.55)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C42(1.47)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C42(1.45)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C42(1.23)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C42(1.17)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C42(1.28)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C42(1.31)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C42(1.00)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C42(1.07)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C42(1.03)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C42(1.03)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C42(1.69)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C42(1.54)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C42(1.04)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C42(1.28)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C42(1.35)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C42(1.57)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C42(1.31)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C42(1.39)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C42(1.59)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C42(1.44)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C42(1.57)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C42(1.17)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C42(1.30)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C42(1.09)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C42(1.65)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C42(1.34)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C42(1.97)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C42(1.17)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C42(1.08)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C42(1.50)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C252(0.58); C256(0.58)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C252(0.56); C256(0.56)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C42(0.69)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C252(0.19); C256(0.19)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C252(0.84); C256(0.84)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C252(0.52); C256(0.52)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C252(0.17); C256(0.17)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C252(0.21); C256(0.21)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C252(0.19); C256(0.19)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C252(0.39); C256(0.39)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C252(0.35); C256(0.35)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C252(0.69); C256(0.69)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C252(0.72); C256(0.72)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C42(0.73)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C252(0.47); C256(0.47)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C252(0.86); C256(0.86)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C252(0.19); C256(0.19)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C42(1.41)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C42(1.47)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C42(1.21)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C42(1.60)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C42(1.16)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C42(1.65)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C42(1.34)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C42(1.28)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C42(1.92)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C42(1.71)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C42(1.40)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C42(2.23)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C42(2.15)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C42(1.33)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C42(1.65)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C42(0.97)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C42(1.25)  LDD0683  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C42(1.44)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C42(1.01)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C42(1.11)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 12.15  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C112(1.45)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C252(0.93); C256(0.93)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C252(0.38); C256(0.38)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C42(1.33)  LDD0686  [4]
 LDCM0370  CL101 PaTu 8988t C42(0.82)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C42(0.87)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C42(2.01)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C42(1.00)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C42(1.09)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C42(0.74)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C42(0.81)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C42(1.61)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C42(0.95)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C252(0.32); C256(0.32)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C42(2.36)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C42(2.34)  LDD0698  [4]
 LDCM0382  CL112 PaTu 8988t C42(0.94)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C42(0.78)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C42(0.96)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C42(1.04)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C42(0.78)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C42(1.36)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C42(1.12)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C42(1.57)  LDD1268  [4]
 LDCM0390  CL12 HCT 116 C252(0.28); C256(0.28)  LDD0707  [4]
 LDCM0391  CL120 PaTu 8988t C42(1.69)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C42(1.24)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C42(1.18)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C42(1.49)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C42(1.50)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C42(0.85)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C42(1.19)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C42(0.95)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C42(1.77)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C252(0.47); C256(0.47)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C252(0.62); C256(0.62)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C252(0.50); C256(0.50)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C42(1.06); C252(1.88); C256(1.88)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C252(1.09); C256(1.09); C42(1.51)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C42(1.01); C252(1.01); C256(1.01)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C252(1.11); C256(1.11); C42(1.13)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C252(1.03); C256(1.03)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C42(1.18); C252(1.20); C256(1.20)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C252(0.67); C256(0.67); C42(2.12)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C252(0.38); C256(0.38); C42(3.59)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C42(1.12); C252(1.15); C256(1.15)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C252(0.68); C256(0.68); C42(1.50)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C252(0.84); C256(0.84); C42(1.74)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C252(1.17); C256(1.17); C42(1.05)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C252(1.12); C256(1.12); C42(1.48)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C252(1.03); C256(1.03); C42(1.53)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C252(0.94); C256(0.94); C42(1.60)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C252(0.85); C256(0.85)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C252(1.53); C256(1.53); C42(1.19)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C42(1.08)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C42(1.17)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C42(1.21)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C42(1.36)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C42(1.07)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C42(0.95)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C42(1.06)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C42(0.87)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C252(0.87); C256(0.87)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C42(1.42)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C42(0.93)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C42(0.93)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C42(1.11)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C42(1.26)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C42(1.35)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C42(1.81)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C42(1.20)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C42(1.66)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C42(1.60)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C252(0.71); C256(0.71)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C42(1.36)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C42(1.86)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C42(1.64)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C42(0.65)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C42(1.00)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C42(1.02)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C42(0.79)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C42(0.79)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C42(1.22)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C42(0.98)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C252(0.52); C256(0.52)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C42(1.73)  LDD0769  [4]
 LDCM0453  CL61 PaTu 8988t C42(1.09)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C42(1.20)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C42(1.35)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C42(1.39)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C42(1.29)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C42(1.63)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C42(1.49)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C42(1.86)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C42(1.83)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C252(0.40); C256(0.40)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C42(2.04)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C42(1.30)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C42(1.00)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C42(1.76)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C42(1.36)  LDD1346  [4]
 LDCM0469  CL76 HCT 116 C252(1.01); C256(1.01); C42(1.54)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C252(0.95); C256(0.95); C42(1.62)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C252(1.04); C256(1.04); C42(1.46)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C252(0.93); C256(0.93); C42(1.86)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C252(0.29); C256(0.29)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C252(1.08); C256(1.08); C42(1.27)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C252(0.97); C256(0.97); C42(1.57)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C252(0.73); C256(0.73); C42(3.19)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C252(0.69); C256(0.69); C42(2.23)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C252(0.59); C256(0.59); C42(3.15)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C252(1.03); C256(1.03); C42(1.43)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C252(0.89); C256(0.89); C42(1.17)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C252(1.00); C256(1.00); C42(1.45)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C252(0.70); C256(0.70); C42(2.04)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C252(0.56); C256(0.56); C42(4.00)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C252(0.62); C256(0.62)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C252(1.00); C256(1.00); C42(1.22)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C42(1.25)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C42(1.50)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C42(1.16)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C42(1.28)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C42(1.40)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C42(1.26)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C42(1.29)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C42(1.71)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C42(1.44)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C112(0.99); C256(1.01)  LDD1698  [18]
 LDCM0625  F8 Ramos C112(1.05); C234(0.62)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C112(0.63); C234(0.33)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C112(0.64)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C112(0.81); C234(0.37)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C112(0.95); C234(1.57)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C112(0.77); C234(1.37)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C112(0.54); C234(0.35)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C112(0.99); C234(0.74)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C112(0.25); C234(0.23)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C112(0.96); C234(0.67)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C112(0.79)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C112(0.99); C234(0.77)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C112(0.93); C234(0.76)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C112(0.65); C234(0.34)  LDD2201  [19]
 LDCM0468  Fragment33 PaTu 8988t C42(1.56)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C112(0.85)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C112(0.69); C234(0.67)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C42(1.45)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C112(1.17)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C112(1.14); C234(0.84)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C112(0.65); C234(0.47)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C112(0.61); C234(0.34)  LDD2188  [19]
 LDCM0107  IAA HeLa C234(0.00); H240(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C234(1.04); C112(0.84); C256(0.99); C252(1.03)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C234(1.03); C112(0.99); C256(1.01); C252(1.02)  LDD1497  [18]
 LDCM0024  KB05 G361 C160(1.65)  LDD3311  [20]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C234(1.45)  LDD2093  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C234(0.60)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C234(1.01)  LDD2107  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C234(0.79)  LDD2114  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C234(1.05)  LDD2123  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C234(0.46)  LDD2134  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C234(0.94)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C234(1.93)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C234(0.99)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C234(0.58)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C234(1.20)  LDD2150  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C256(0.76)  LDD2206  [21]
 LDCM0131  RA190 MM1.R C252(1.70); C256(1.70)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Calcium and integrin-binding family member 4 (CIB4) . A0PJX0
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.