Details of the Target

General Information of Target

Target ID LDTP11011
Target Name E3 ubiquitin-protein ligase RNF5 (RNF5)
Gene Name RNF5
Gene ID 6048
Synonyms
G16; NG2; RMA1; E3 ubiquitin-protein ligase RNF5; EC 2.3.2.27; RING finger protein 5; Ram1 homolog; HsRma1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDG
SSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGE
VLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASL
LSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTR
KPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLP
RPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAV
LADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPP
SAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAF
PGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKS
QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRD
HLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTS
TVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP
Target Bioclass
Enzyme
Family
RNF5 family
Subcellular location
Cell membrane
Function
Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin. Catalyzes ubiquitination of Salmonella type III secreted protein sopA. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy.
Uniprot ID
Q99942
Ensemble ID
ENST00000375094.4
HGNC ID
HGNC:10068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K75(2.33)  LDD0277  [1]
IPM
 Probe Info  		C64(0.00); C67(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C27(1.50); C30(1.50); C64(1.38); C67(1.38)  LDD0080  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C30(0.95); C64(1.22); C67(1.22)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C27(0.93); C30(0.93); C64(0.99); C67(0.99)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C27(0.80); C30(0.80); C64(0.84); C67(0.84)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C27(0.73); C30(0.73); C64(0.86); C67(0.86)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C27(0.93); C30(0.93); C64(1.10); C67(1.10)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C27(0.89); C30(0.89); C64(0.92); C67(0.92)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C27(0.92); C30(0.92); C64(0.97); C67(0.97)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C27(0.84); C30(0.84); C64(1.24); C67(1.24)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C27(0.78); C30(0.78); C64(1.37); C67(1.37)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C27(1.27); C30(0.73); C64(0.89); C67(1.14)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C27(0.63); C30(0.82); C64(0.89); C67(0.90)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C27(0.66); C30(1.06); C64(1.00); C67(1.04)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C27(1.10); C30(1.10); C64(1.00); C67(1.00)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C27(0.62); C30(0.90); C64(0.97); C67(0.98)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C27(0.81); C30(1.07); C64(0.86); C67(0.90)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C27(0.83); C30(0.79); C64(0.98); C67(1.10)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C64(0.99); C67(0.99)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C64(1.01); C67(1.01)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C64(1.19); C67(1.19)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C64(1.10); C67(1.10)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C64(1.14); C67(1.14)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C64(1.04); C67(1.04)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C64(1.02); C67(1.02)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C27(1.03); C30(1.03); C64(1.03); C67(1.03)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C64(1.05); C67(1.05)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C64(1.10); C67(1.10)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C64(1.14); C67(1.14)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C64(0.92); C67(0.92)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C64(1.02); C67(1.02)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C64(1.01); C67(1.01)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C64(1.14); C67(1.14)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C64(1.07); C67(1.07)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C27(1.15); C30(1.15); C64(1.15); C67(1.15)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C27(0.80); C30(0.80); C64(0.67); C67(0.67)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C27(0.61); C30(0.61); C64(0.86); C67(0.86)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C27(0.61); C30(0.61); C64(0.92); C67(0.92)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C27(0.53); C30(0.53); C64(0.76); C67(0.76)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C27(0.84); C30(0.84); C64(1.06); C67(1.06)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C27(0.76); C30(0.76); C64(0.98); C67(0.98)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C27(1.05); C30(1.05); C64(0.96); C67(0.96)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C27(0.94); C30(0.94); C64(1.00); C67(1.00)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C27(1.14); C30(1.14); C64(1.02); C67(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C27(0.90); C30(0.90); C64(0.85); C67(0.85)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C27(0.72); C30(0.72); C64(0.99); C67(0.99)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C27(0.98); C30(0.98); C64(1.03); C67(1.03)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C27(1.00); C30(1.00); C64(0.95); C67(0.95)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C27(0.71); C30(0.71); C64(0.93); C67(0.93)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C27(0.86); C30(0.86); C64(0.77); C67(0.77)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C64(0.72); C67(0.72)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C64(0.83); C67(0.87)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C64(0.81); C67(0.87)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C64(0.85); C67(0.93)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C67(0.94); C64(0.96)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C64(0.93); C67(1.00)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C64(0.91); C67(0.98)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C27(0.94); C30(0.94); C64(1.05); C67(1.05)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C64(0.80); C67(0.81)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C67(0.83); C64(0.83)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C64(0.93); C67(0.99)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C64(1.01); C67(1.16)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C64(0.80); C67(0.85)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C64(0.94); C67(1.02)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C64(0.69); C67(0.77)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C64(0.85); C67(0.91)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C64(0.98); C67(0.98); C27(0.99); C30(0.99)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C27(0.87); C30(0.87); C64(0.98); C67(0.98)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C64(1.00); C67(1.00); C27(1.18); C30(1.18)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C30(1.01); C64(1.06); C67(1.06)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C64(1.01); C67(1.01); C27(1.26); C30(1.26)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C64(0.90); C67(0.90); C27(1.01); C30(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C27(0.89); C30(0.89); C64(0.96); C67(0.96)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C64(0.81); C67(0.81); C27(1.00); C30(1.00)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C64(0.94); C67(0.94); C27(1.24); C30(1.24)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C27(0.98); C30(0.98); C64(0.98); C67(0.98)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C27(1.06); C30(1.06); C64(1.13); C67(1.13)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C27(0.95); C30(0.95); C64(1.11); C67(1.11)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C27(0.99); C30(0.99); C64(1.13); C67(1.13)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C64(1.03); C67(1.03); C27(1.07); C30(1.07)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C64(0.86); C67(0.86); C30(0.99)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C64(0.98); C67(0.98); C27(1.07); C30(1.07)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C27(1.02); C30(1.02); C64(1.04); C67(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C64(1.09); C67(1.09); C27(1.12); C30(1.12)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C64(0.91); C67(0.91); C27(1.00); C30(1.00)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C64(0.95); C67(0.95); C27(1.06); C30(1.06)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C27(0.80); C30(0.80); C64(1.04); C67(1.04)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C27(1.02); C30(1.02); C64(1.05); C67(1.05)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C27(0.91); C30(0.91); C64(1.09); C67(1.09)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C27(0.91); C30(0.91); C64(1.04); C67(1.04)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C27(0.78); C30(0.78); C64(1.18); C67(1.18)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C30(0.92); C64(1.06); C67(1.06)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C27(0.91); C30(0.91); C64(1.16); C67(1.16)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C27(0.91); C30(0.91); C64(1.21); C67(1.21)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C27(0.87); C30(0.87); C64(1.14); C67(1.14)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C27(1.10); C30(1.10); C64(1.17); C67(1.17)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C27(0.81); C30(0.81); C64(1.09); C67(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C27(0.99); C30(0.99); C64(1.10); C67(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C27(1.04); C30(1.04); C64(1.10); C67(1.10)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C64(1.06); C67(1.06); C27(1.12); C30(1.12)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C64(1.06); C67(1.06); C27(1.07); C30(1.07)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C64(1.09); C67(1.09); C27(1.58); C30(1.58)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C30(0.85); C64(1.01); C67(1.01)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C64(1.05); C67(1.05); C27(1.28); C30(1.28)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C27(0.97); C30(0.97); C64(1.07); C67(1.07)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C64(1.02); C67(1.02); C27(1.09); C30(1.09)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C27(1.07); C30(1.07); C64(1.13); C67(1.13)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C64(1.05); C67(1.05); C27(1.11); C30(1.11)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C64(1.12); C67(1.12); C27(1.49); C30(1.49)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C64(1.30); C67(1.30); C27(1.55); C30(1.55)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C64(1.25); C67(1.25); C27(1.34); C30(1.34)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C64(0.93); C67(0.93); C27(1.28); C30(1.28)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C64(1.07); C67(1.07); C27(1.53); C30(1.53)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C64(1.09); C67(1.09); C27(1.12); C30(1.12)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C64(0.91); C67(0.91); C27(1.59); C30(1.59)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C64(0.98); C67(0.98); C27(1.47); C30(1.47)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C64(0.99); C67(0.99); C27(1.26); C30(1.26)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C64(0.90); C67(0.90); C27(1.40); C30(1.40)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C64(1.07); C67(1.07); C27(1.43); C30(1.43)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C64(0.84); C67(0.84); C27(1.08); C30(1.08)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C64(0.86); C67(0.86); C27(1.10); C30(1.10)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C64(0.90); C67(0.90); C27(1.01); C30(1.01)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C27(0.93); C30(0.93); C64(1.01); C67(1.01)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C27(0.87); C30(0.87); C64(0.91); C67(0.91)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C27(1.02); C30(1.02); C64(1.10); C67(1.10)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C27(0.56); C30(0.56); C64(0.71); C67(0.71)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C27(0.67); C30(0.67); C64(0.69); C67(0.69)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C27(0.90); C30(0.90); C64(1.04); C67(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C64(0.85); C67(0.85); C27(0.96); C30(0.96)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C27(0.95); C30(0.95); C64(0.99); C67(0.99)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C64(1.19); C67(1.19); C27(1.28); C30(1.28)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C27(0.85); C30(0.85); C64(0.97); C67(0.97)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C27(0.79); C30(0.79); C64(1.00); C67(1.00)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C27(0.70); C30(0.70); C64(0.89); C67(0.89)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C27(0.77); C30(0.77); C64(0.78); C67(0.78)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C27(1.08); C30(1.08); C64(1.19); C67(1.19)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C64(0.83); C67(0.83); C27(0.93); C30(0.93)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C64(0.72); C67(0.72); C27(0.74); C30(0.74)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C64(0.98); C67(0.98); C27(0.98); C30(0.98)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C64(1.18); C67(1.18); C27(1.26); C30(1.26)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C27(1.00); C30(1.00); C64(1.06); C67(1.06)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C27(0.98); C30(0.98); C64(1.00); C67(1.00)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C64(1.06); C67(1.06); C27(1.15); C30(1.15)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C27(0.90); C30(0.90); C64(1.05); C67(1.05)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C27(1.00); C30(1.00); C64(1.12); C67(1.12)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C64(1.07); C67(1.07); C27(1.14); C30(1.14)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C27(0.82); C30(0.82); C64(1.36); C67(1.36)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C27(1.23); C30(1.23); C64(1.38); C67(1.38)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C27(1.17); C30(1.17); C64(1.32); C67(1.32)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C27(0.97); C30(0.97); C64(1.09); C67(1.09)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C64(1.08); C67(1.08); C27(1.08); C30(1.08)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C27(0.85); C30(0.85); C64(1.00); C67(1.00)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C64(0.96); C67(0.96); C27(1.04); C30(1.04)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C27(1.09); C30(1.09); C64(1.10); C67(1.10)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C27(1.04); C30(1.04); C64(1.37); C67(1.37)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C27(0.74); C30(0.74); C64(0.88); C67(0.88)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C27(1.04); C30(1.04); C64(0.99); C67(0.99)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C27(0.98); C30(0.98); C64(1.09); C67(1.09)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C27(1.28); C30(1.28); C64(1.29); C67(1.29)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C27(1.09); C30(1.09)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C64(0.73); C67(0.73); C27(0.99); C30(0.99)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C27(1.08); C30(1.08); C64(1.10); C67(1.10)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C30(0.92); C64(1.12); C67(1.12)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C27(1.19); C30(1.19); C64(1.29); C67(1.29)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C27(0.93); C30(0.93); C64(1.02); C67(1.02)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C27(0.99); C30(0.99); C64(1.12); C67(1.12)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C64(0.96); C67(0.96); C27(1.02); C30(1.02)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C64(0.87); C67(0.87); C27(1.08); C30(1.08)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C64(0.82); C67(0.82); C27(1.27); C30(1.27)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C64(0.90); C67(0.90); C27(1.29); C30(1.29)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C64(0.96); C67(0.96); C27(1.25); C30(1.25)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C64(0.87); C67(0.87); C27(1.13); C30(1.13)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C64(0.99); C67(0.99); C27(1.17); C30(1.17)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C64(0.77); C67(0.77); C27(1.05); C30(1.05)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C64(0.87); C67(0.87); C27(1.00); C30(1.00)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C64(0.86); C67(0.86); C27(0.87); C30(0.87)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C64(0.98); C67(0.98); C27(1.10); C30(1.10)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C27(0.88); C30(0.88); C64(1.03); C67(1.03)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C64(0.88); C67(0.88); C27(0.96); C30(0.96)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C64(0.88); C67(0.88); C27(0.97); C30(0.97)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C27(1.02); C30(1.02); C64(1.21); C67(1.21)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C27(0.86); C30(0.86); C64(1.08); C67(1.08)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C27(0.88); C30(0.88); C64(1.20); C67(1.20)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C64(1.19); C67(1.19); C27(1.57); C30(1.57)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C27(0.83); C30(0.83); C64(1.04); C67(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C64(1.12); C67(1.12); C27(2.70); C30(2.70)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C64(0.91); C67(0.91); C27(1.02); C30(1.02)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C64(0.88); C67(0.88); C27(1.20); C30(1.20)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C27(0.86); C30(0.86); C64(1.10); C67(1.10)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C64(1.03); C67(1.03); C27(1.33); C30(1.33)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C27(1.13); C30(1.13); C64(1.46); C67(1.46)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C64(0.85); C67(0.85); C27(1.25); C30(1.25)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C64(1.14); C67(1.14); C27(1.53); C30(1.53)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C64(1.36); C67(1.36); C27(1.38); C30(1.38)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C64(0.93); C67(0.93); C27(1.01); C30(1.01)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C64(0.98); C67(0.98); C27(1.17); C30(1.17)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C64(1.31); C67(1.31); C27(1.50); C30(1.50)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C27(0.72); C30(0.72); C64(0.95); C67(0.95)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C64(1.51); C67(1.51); C27(1.83); C30(1.83)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C27(1.09); C30(1.09); C64(1.12); C67(1.12)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C27(0.98); C30(0.98); C64(1.04); C67(1.04)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C27(1.20); C30(1.20); C64(1.32); C67(1.32)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C27(0.95); C30(0.95); C64(1.47); C67(1.47)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C27(1.20); C30(1.20); C64(2.38); C67(2.38)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C27(1.06); C30(1.06); C64(1.64); C67(1.64)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C27(1.40); C30(1.40); C64(1.69); C67(1.69)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C27(1.39); C30(1.39); C64(1.60); C67(1.60)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C27(1.67); C30(1.67); C64(1.76); C67(1.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C27(1.22); C30(1.22); C64(1.60); C67(1.60)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C27(1.23); C30(1.23); C64(1.51); C67(1.51)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C27(1.32); C30(1.32); C64(2.04); C67(2.04)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C27(0.93); C30(0.93); C64(1.08); C67(1.08)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C27(1.60); C30(1.60); C64(1.36); C67(1.36)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C64(0.88); C67(0.88)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C64(0.97); C67(0.97)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C64(0.77); C67(0.77)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C64(0.92); C67(0.92)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C64(1.10); C67(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C64(0.97); C67(0.97)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C64(0.93); C67(0.93)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C64(1.01); C67(1.01)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C27(1.30); C30(1.30); C64(1.00); C67(1.00)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C64(0.93); C67(0.93)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C64(0.93); C67(0.93)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C64(1.05); C67(1.05)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C64(1.09); C67(1.09)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C64(0.89); C67(0.89)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C64(1.06); C67(1.06)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C27(0.94); C30(0.94); C64(1.06); C67(1.06)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C27(1.01); C30(1.01); C64(1.12); C67(1.12)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C27(0.87); C30(0.87); C64(1.11); C67(1.11)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C27(0.89); C30(0.89); C64(1.01); C67(1.01)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C27(1.27); C30(1.27); C64(1.17); C67(1.17)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C27(0.77); C30(0.77); C64(1.12); C67(1.12)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C27(0.88); C30(0.88); C64(0.98); C67(0.98)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C27(1.01); C30(1.01); C64(1.06); C67(1.06)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C27(0.84); C30(0.84); C64(0.83); C67(0.83)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C27(0.90); C30(0.90); C64(1.13); C67(1.13)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C27(0.90); C30(0.90); C64(1.04); C67(1.04)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C27(1.04); C30(1.04); C64(1.06); C67(1.06)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C27(0.88); C30(0.88); C64(1.24); C67(1.24)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C27(0.80); C30(0.80); C64(0.96); C67(0.96)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C27(0.99); C30(0.99); C64(1.01); C67(1.01)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C27(1.32); C30(1.32); C64(0.82); C67(0.82)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C27(1.01); C30(1.01); C64(1.11); C67(1.11)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C64(1.23); C67(1.23)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C64(1.00); C67(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C64(1.23); C67(1.23)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C64(1.23); C67(1.23)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C64(1.06); C67(1.06)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C64(1.29); C67(1.29)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C64(1.10); C67(1.10)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C64(1.02); C67(1.02)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C64(1.09); C67(1.09)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C27(1.19); C30(1.19); C64(1.56); C67(1.56)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C64(1.07); C67(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C64(1.06); C67(1.06)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C64(1.00); C67(1.00)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C64(1.03); C67(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C64(1.07); C67(1.07)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C27(0.74); C30(0.74); C64(0.87); C67(0.87)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C27(0.68); C30(0.68); C64(0.71); C67(0.71)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C27(0.69); C30(0.69); C64(0.97); C67(0.97)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C27(0.91); C30(0.91); C64(1.09); C67(1.09)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C27(1.37); C30(1.37); C64(1.02); C67(1.02)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C27(0.81); C30(0.81); C64(0.90); C67(0.90)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C27(0.77); C30(0.77); C64(1.01); C67(1.01)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C27(0.86); C30(0.86); C64(1.06); C67(1.06)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C27(0.80); C30(0.80); C64(1.09); C67(1.09)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C27(0.76); C30(0.76); C64(1.27); C67(1.27)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C27(0.82); C30(0.82); C64(0.92); C67(0.92)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C27(0.84); C30(0.84); C64(0.94); C67(0.94)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C27(0.78); C30(0.78); C64(0.87); C67(0.87)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C27(0.81); C30(0.81); C64(1.06); C67(1.06)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C27(0.90); C30(0.90); C64(1.23); C67(1.23)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C27(1.38); C30(1.38); C64(0.93); C67(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C27(0.64); C30(0.64); C64(0.67); C67(0.67)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C30(0.97); C64(1.24); C67(1.24)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C30(0.86); C64(1.07); C67(1.07)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C30(0.77); C64(0.88); C67(0.88)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C30(0.84); C64(0.97); C67(0.97)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C30(0.85); C64(0.85); C67(0.85)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C30(0.85); C64(1.03); C67(1.03)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C30(0.90); C64(1.23); C67(1.23)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C30(0.94); C64(1.00); C67(1.00)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C30(0.94); C64(0.96); C67(0.96)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C67(0.99); C30(0.84)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C64(1.16); C67(1.16)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C64(1.16); C67(1.16)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C27(1.50); C30(1.50); C64(1.38); C67(1.38)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C27(3.45); C30(3.45); C64(2.01); C67(2.01)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C27(1.78); C30(1.78); C64(1.25); C67(1.25)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C27(1.09); C30(1.09)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Cystic fibrosis transmembrane conductance regulator (CFTR) ABCC family P13569
Probable palmitoyltransferase ZDHHC24 (ZDHHC24) DHHC palmitoyltransferase family Q6UX98
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Rhomboid-related protein 4 (RHBDD1) Peptidase S54 family Q8TEB9
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Ubiquitin-conjugating enzyme E2 W (UBE2W) Ubiquitin-conjugating enzyme family Q96B02
E3 ubiquitin-protein ligase RNF185 (RNF185) . Q96GF1
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Ubiquitin domain-containing protein 1 (UBTD1) . Q9HAC8
Ubiquitin thioesterase OTU1 (YOD1) . Q5VVQ6
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) Amino acid/polyamine transporter 2 family Q96QD8
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Excitatory amino acid transporter 3 (SLC1A1) Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family P43005
Neutral amino acid transporter B(0) (SLC1A5) Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family Q15758
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Solute carrier family 35 member E3 (SLC35E3) TPT transporter family Q7Z769
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Protein YIPF2 (YIPF2) YIP1 family Q9BWQ6
Optineurin (OPTN) . Q96CV9
Proteolipid protein 2 (PLP2) . Q04941
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Paxillin (PXN) Paxillin family P49023
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402