Details of the Target

General Information of Target

Target ID LDTP10738
Target Name Myotubularin-related protein 9 (MTMR9)
Gene Name MTMR9
Gene ID 66036
Synonyms
C8orf9; MTMR8; Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGCKKELPRLQEPEEDEDCYILNVQSSSDDTSGSSVARRAPKRQASCILNVQSRSGDTS
GSSVARRAPKRQASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPP
IVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPD
DNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSD
DSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSD
DSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAA
VSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTI
VEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKAKTKNVSVTPGHKKRGPSKKKPGA
AKVEKRKTRTPKCKVPGCFLQDLEKSKKYSGKNLKRNKDELVQRIYDLFNRSVCDKKLPE
KLRIGWNNKMVKTAGLCSTGEMWYPKWRRFAKIQIGLKVCDSADRIRDTLIHEMCHAASW
LIDGIHDSHGDAWKYYARKSNRIHPELPRVTRCHNYKINYKVHYECTGCKTRIGCYTKSL
DTSRFICAKCKGSLVMVPLTQKDGTRIVPHV
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Subcellular location
Cytoplasm
Function
Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine.
Uniprot ID
Q96QG7
Ensemble ID
ENST00000221086.8
HGNC ID
HGNC:14596

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.E547K .
COLO800 SNV: p.Y232Ter .
HCT116 SNV: p.R180Ter DBIA    Probe Info 
HT115 SNV: p.S339P .
IM95 SNV: p.P84T .
Ishikawa (Heraklio) 02 ER SNV: p.Q42Ter .
JURKAT SNV: p.R230C .
MOLT4 SNV: p.T178I .
NCIH1793 SNV: p.G85E .
RPMI8226 SNV: p.P484S .
SKMEL2 SNV: p.L299S .
UACC257 SNV: p.L239R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.53  LDD0403  [1]
DBIA
 Probe Info  		C380(0.68); C386(0.68)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C155(0.00); C285(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C155(0.00); C285(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C285(0.00); C155(0.00)  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C380(0.68); C386(0.68)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C155(0.59); C316(1.16); C321(1.16); C380(0.80)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C155(1.06); C316(0.82); C321(0.82); C380(0.45)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C155(0.81); C316(0.82); C321(0.82); C380(0.47)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C155(0.68); C316(0.96); C321(0.96); C380(0.54)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C155(0.73); C316(0.73); C321(0.73); C380(0.45)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C155(0.98); C316(0.83); C321(0.83); C380(0.56)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C155(0.83); C316(0.65); C321(0.65); C380(0.42)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C155(0.88); C316(1.18); C321(1.18); C380(0.44)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C155(0.90); C316(0.67); C321(0.67); C380(0.45)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C155(0.84); C316(0.90); C321(0.90); C380(0.48)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C155(0.84); C316(1.01); C321(1.01); C380(0.61)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C155(0.55); C316(1.27); C321(1.27); C380(0.71)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C155(0.82); C316(0.74); C321(0.74); C380(0.45)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C155(0.93); C316(0.67); C321(0.67); C380(0.45)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C155(0.80); C316(0.62); C321(0.62); C380(0.44)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C316(1.01); C321(1.01); C380(0.90); C386(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C316(0.90); C321(1.02); C380(0.76); C386(0.82)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C316(0.90); C321(1.06); C380(0.72); C386(0.76)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C316(0.81); C321(1.04); C380(1.07); C386(1.10)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C316(0.98); C321(1.11); C380(0.86); C386(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C316(0.77); C321(0.90); C380(0.89); C386(0.96)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C316(0.83); C321(1.14); C380(0.84); C386(0.94)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C155(0.71); C316(1.03); C321(1.03); C380(0.82)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C316(0.64); C321(1.20); C380(0.82); C386(0.90)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C316(1.03); C321(1.12); C380(0.98); C386(1.07)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C316(0.80); C321(1.31); C380(0.92); C386(0.99)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C316(0.81); C321(0.83); C380(1.08); C386(1.05)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C316(0.88); C321(1.03); C380(0.97); C386(1.02)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C316(0.83); C321(1.24); C380(0.94); C386(0.99)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C316(0.65); C321(0.94); C380(0.69); C386(0.70)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C316(0.86); C321(0.86); C380(0.77); C386(0.83)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C316(1.18); C321(1.18); C380(1.21); C386(1.21)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C316(1.09); C321(1.09); C380(1.32); C386(1.32)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C316(1.08); C321(1.08); C380(1.02); C386(1.02)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C316(1.13); C321(1.13); C380(1.32); C386(1.32)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C316(1.15); C321(1.15); C380(1.13); C386(1.13)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C316(1.06); C321(1.06); C380(1.00); C386(1.00)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C316(0.85); C321(0.85); C380(1.05); C386(1.05)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C316(0.99); C321(0.99); C380(0.98); C386(0.98)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C316(0.91); C321(0.91); C380(0.95); C386(0.95)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C316(1.04); C321(1.04); C380(1.06); C386(1.06)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C316(0.81); C321(0.81); C380(1.07); C386(1.07)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C316(0.89); C321(0.89); C380(1.06); C386(1.06)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C155(0.49); C316(1.11); C321(1.11); C380(0.75)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C316(0.88); C321(0.88); C380(1.03); C386(1.03)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C316(0.86); C321(0.86); C380(1.04); C386(1.04)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C316(1.07); C321(1.07); C380(0.97); C386(0.97)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C380(0.85); C386(0.85)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C380(0.62); C386(0.64)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C386(0.78); C380(0.78)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C386(0.63); C380(0.65)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C386(0.74); C380(0.75)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C380(0.70); C386(0.71)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C386(0.60); C380(0.62)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C155(0.56); C380(0.85); C386(0.90); C316(1.01)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C386(0.73); C380(0.75)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C380(0.59); C386(0.60)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C380(0.63); C386(0.65)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C386(0.65); C380(0.66)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C380(0.82); C386(0.81)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C380(0.64); C386(0.67)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C380(0.98); C386(0.96)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C380(0.85); C386(0.85)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C380(0.95); C386(0.95)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C380(1.27); C386(1.27)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C380(1.17); C386(1.17)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C380(0.69); C386(0.69)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C380(0.95); C386(0.95)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C380(1.15); C386(1.15)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C380(0.97); C386(0.97)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C380(1.17); C386(1.17)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C380(0.84); C386(0.84)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C316(0.52); C321(0.52); C380(0.72); C386(0.81)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C380(0.56); C386(0.57); C316(0.67); C321(0.67)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C380(0.56); C386(0.58); C316(0.77); C321(0.77)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C316(0.54); C321(0.54); C380(0.57); C386(0.60)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C386(0.52); C380(0.57); C316(0.90); C321(0.90)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C380(0.62); C386(0.62)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C386(0.49); C380(0.51); C316(0.68); C321(0.68)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C386(0.51); C380(0.52); C316(0.60); C321(0.60)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C380(0.45); C386(0.46); C316(0.63); C321(0.63)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C386(0.55); C380(0.58); C316(0.70); C321(0.70)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C380(0.58); C316(0.62); C321(0.62); C386(0.64)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C155(1.01); C380(1.25); C386(1.25)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C155(0.71); C380(1.12); C386(1.12)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C155(0.62); C380(1.12); C386(1.12)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C155(0.65); C380(1.15); C386(1.15)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C380(0.99); C386(0.99); C155(1.07)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C380(0.61); C386(0.61)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C155(0.60); C380(1.04); C386(1.04)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C155(0.46); C380(0.94); C386(0.94)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C155(0.60); C380(1.00); C386(1.00)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C155(0.52); C380(0.86); C386(0.86)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C155(0.49); C380(1.11); C386(1.11)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C155(0.53); C380(1.03); C386(1.03)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C316(0.81); C321(0.81); C380(0.84); C386(0.84)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C380(0.74); C386(0.74); C316(0.86); C321(0.86)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C380(0.73); C386(0.73); C316(0.79); C321(0.79)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C316(0.80); C321(0.80); C380(0.86); C386(0.86)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C380(0.64); C386(0.64)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C316(0.81); C321(0.81); C380(0.86); C386(0.86)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C316(1.08); C321(1.08); C380(1.31); C386(1.31)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C380(0.90); C386(0.90); C316(0.90); C321(0.90)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C380(0.81); C386(0.81); C316(0.94); C321(0.94)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C380(0.88); C386(0.88); C316(0.95); C321(0.95)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C380(0.79); C386(0.79); C316(0.87); C321(0.87)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C316(0.82); C321(0.82); C380(0.89); C386(0.89)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C316(0.74); C321(0.74); C380(0.83); C386(0.83)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C380(0.79); C386(0.79); C316(0.79); C321(0.79)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C380(0.78); C386(0.78); C316(0.84); C321(0.84)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C155(0.55); C386(0.68); C380(0.74); C316(0.98)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C380(0.72); C386(0.72); C316(0.73); C321(0.73)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C316(0.71); C321(0.71); C380(0.80); C386(0.80)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C380(0.84); C386(0.84); C316(1.09); C321(1.09)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C316(0.70); C321(0.70); C380(0.86); C386(0.86)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C380(0.82); C386(0.82); C316(0.83); C321(0.83)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C380(0.71); C386(0.71); C316(0.94); C321(0.94)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C380(0.73); C386(0.73); C316(0.91); C321(0.91)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C316(0.65); C321(0.65); C380(0.67); C386(0.67)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C316(0.65); C321(0.65); C380(0.71); C386(0.71)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C316(0.68); C321(0.68); C380(0.71); C386(0.71)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C155(0.65); C386(0.73); C380(0.75); C316(0.90)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C316(0.63); C321(0.63); C380(0.75); C386(0.75)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C316(0.65); C321(0.65); C380(0.81); C386(0.81)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C380(0.83); C386(0.83); C316(0.94); C321(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C316(0.75); C321(0.75); C380(0.76); C386(0.76)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C316(0.61); C321(0.61); C380(0.80); C386(0.80)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C316(0.65); C321(0.65); C380(0.79); C386(0.79)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C316(0.76); C321(0.76); C380(0.88); C386(0.88)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C316(0.75); C321(0.75); C380(0.84); C386(0.84)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C316(0.62); C321(0.62); C380(0.74); C386(0.74)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C316(0.86); C321(0.86); C380(0.86); C386(0.86)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C155(0.61); C380(0.75); C386(0.75); C316(0.80)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C316(0.65); C321(0.65); C380(0.83); C386(0.83)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C316(0.83); C321(0.83); C380(0.84); C386(0.84)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C316(0.66); C321(0.66); C380(0.82); C386(0.82)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C380(0.58); C386(0.58)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C380(0.55); C386(0.55)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C380(0.58); C386(0.58)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C380(0.77); C386(0.77)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C380(0.68); C386(0.68)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C380(0.74); C386(0.74)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C380(0.61); C386(0.61)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C380(1.55); C386(1.55)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C380(0.69); C386(0.69)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C380(0.66); C386(0.66)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C380(0.68); C386(0.68)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C380(0.72); C386(0.72)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C380(0.63); C386(0.63)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C380(0.66); C386(0.66)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C380(0.62); C386(0.62)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C380(0.39); C386(0.39); C316(0.70); C321(0.70)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C380(0.48); C386(0.48); C155(0.79); C316(1.00)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C155(0.83); C316(1.09); C321(1.09); C380(0.85)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C155(0.62); C380(0.75); C386(0.77); C316(1.12)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C155(0.48); C386(0.66); C380(0.68); C316(0.86)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 11.53  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C316(1.10); C321(1.10); C380(1.16); C386(1.16)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C380(0.67); C386(0.67); C316(0.68); C321(0.68)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C380(0.71); C386(0.71)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C155(0.49); C386(0.77); C380(0.79); C316(0.98)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C155(0.62); C380(0.80); C386(0.82); C316(1.06)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C155(0.62); C380(0.91); C386(0.93); C316(1.19)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C155(0.63); C380(0.94); C386(0.96); C316(1.02)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C380(1.20); C386(1.20)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C380(1.60); C386(1.60)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C380(1.15); C386(1.15)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C380(1.08); C386(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C380(1.06); C386(1.06)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C316(0.64); C321(0.64); C380(0.67); C386(0.67)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C380(1.05); C386(1.05)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C380(0.98); C386(0.98)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C316(0.73); C321(0.73); C380(0.82); C386(0.84)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C380(0.52); C386(0.52); C316(0.62); C321(0.62)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C386(0.55); C380(0.57); C316(0.59); C321(0.59)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C386(0.54); C380(0.58); C316(0.58); C321(0.58)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C386(0.60); C380(0.62); C316(0.64); C321(0.64)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C155(0.81); C380(0.95); C386(0.95)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C155(0.78); C380(0.96); C386(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C155(0.80); C380(0.97); C386(0.97)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C380(0.74); C386(0.74); C316(0.79); C321(0.79)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C155(0.64); C380(1.04); C386(1.04)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C380(0.79); C386(0.79); C316(0.94); C321(0.94)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C316(0.88); C321(0.88); C380(0.98); C386(0.98)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C380(0.72); C386(0.72); C316(0.92); C321(0.92)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C380(0.71); C386(0.71); C316(0.80); C321(0.80)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C316(0.90); C321(0.90); C380(0.94); C386(0.94)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C316(0.84); C321(0.84); C380(1.07); C386(1.07)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C380(0.76); C386(0.76); C316(0.81); C321(0.81)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C380(0.79); C386(0.79); C316(1.01); C321(1.01)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C316(0.68); C321(0.68); C380(0.71); C386(0.71)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C316(0.83); C321(0.83); C380(0.83); C386(0.83)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C316(0.59); C321(0.59); C380(0.72); C386(0.72)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C155(0.67); C316(0.68); C321(0.68); C380(0.69)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C155(0.44); C316(0.52); C321(0.52); C380(0.70)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C155(0.37); C316(0.57); C321(0.57); C380(0.63)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C155(0.47); C316(0.58); C321(0.58); C380(0.67)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C380(0.99); C386(0.99); C316(1.14); C321(1.14)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C155(0.51); C316(0.57); C321(0.57); C380(0.72)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C155(0.43); C316(0.54); C321(0.54); C380(0.66)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C316(0.47); C321(0.47); C155(0.51); C380(0.68)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C155(0.55); C316(0.58); C321(0.58); C380(0.69)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C155(0.51); C316(0.51); C321(0.51); C380(0.67)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C155(0.51); C316(0.58); C321(0.58); C380(0.65)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C155(0.53); C316(0.64); C321(0.64); C380(0.66)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C155(0.57); C316(0.63); C321(0.63); C380(0.66)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C155(0.47); C316(0.58); C321(0.58); C380(0.54)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C155(0.49); C316(0.54); C321(0.54); C380(0.65)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C316(0.76); C321(0.76); C380(0.90); C386(0.90)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C155(0.56); C316(0.65); C321(0.65); C380(0.71)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C380(0.78); C386(0.78)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C380(0.62); C386(0.62)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C380(0.59); C386(0.59)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C380(0.65); C386(0.65)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C380(0.75); C386(0.75)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C380(0.81); C386(0.81)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C380(0.67); C386(0.67)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C380(0.68); C386(0.68)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C316(0.84); C321(0.84); C380(0.87); C386(0.87)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C380(0.69); C386(0.69)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C380(0.77); C386(0.77)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C380(0.70); C386(0.70)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C380(0.64); C386(0.64)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C380(0.65); C386(0.65)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C380(0.62); C386(0.62)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C316(0.83); C321(0.83); C380(1.49); C386(1.49)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C316(0.76); C321(0.76); C380(1.32); C386(1.32)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C316(0.94); C321(0.94); C380(1.50); C386(1.50)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C316(1.03); C321(1.03); C380(1.16); C386(1.16)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C316(0.84); C321(0.84); C380(0.92); C386(0.92)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C316(0.83); C321(0.83); C380(1.27); C386(1.27)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C316(0.83); C321(0.83); C380(1.26); C386(1.26)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C316(0.87); C321(0.87); C380(1.17); C386(1.17)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C316(0.69); C321(0.69); C380(1.36); C386(1.36)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C316(0.75); C321(0.75); C380(1.24); C386(1.24)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C316(0.75); C321(0.75); C380(1.38); C386(1.38)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C316(0.79); C321(0.79); C380(1.12); C386(1.12)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C316(0.99); C321(0.99); C380(1.15); C386(1.15)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C316(0.95); C321(0.95); C380(1.23); C386(1.23)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C316(1.03); C321(1.03); C380(1.08); C386(1.08)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C316(0.54); C321(0.54); C380(0.65); C386(0.65)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C316(0.86); C321(0.86); C380(1.14); C386(1.14)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C155(0.87); C316(0.74); C321(0.74); C380(0.71)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C155(0.94); C316(0.76); C321(0.76); C380(0.74)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C155(0.73); C316(0.50); C321(0.50); C380(0.64)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C155(0.76); C316(0.53); C321(0.53); C380(0.70)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C155(0.83); C316(0.70); C321(0.70); C380(0.79)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C155(0.76); C316(0.58); C321(0.58); C380(0.69)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C155(0.77); C316(0.44); C321(0.44); C380(0.76)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C155(0.59); C316(0.42); C321(0.42); C380(0.66)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C155(0.75); C316(0.66); C321(0.66); C380(0.60)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C316(0.70); C321(0.70); C380(0.75); C386(0.75)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C155(0.68); C316(0.50); C321(0.50); C380(0.60)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C155(0.79); C316(0.49); C321(0.49); C380(0.65)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C155(0.97); C316(0.66); C321(0.66); C380(0.77)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C155(0.76); C316(0.57); C321(0.57); C380(0.81)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C155(0.75); C316(0.57); C321(0.57); C380(0.76)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C380(0.70); C386(0.70)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C380(1.11); C386(1.11)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C380(0.84); C386(0.84)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C380(0.67); C386(0.67)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C316(0.67); C321(0.67); C380(0.73); C386(0.73)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C380(0.70); C386(0.70)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C380(0.74); C386(0.74)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C380(0.72); C386(0.72)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C380(0.68); C386(0.68)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C380(0.66); C386(0.66)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C380(0.70); C386(0.70)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C380(0.85); C386(0.85)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C380(0.74); C386(0.74)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C380(0.76); C386(0.76)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C380(0.74); C386(0.74)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C316(0.71); C321(0.71); C380(0.77); C386(0.77)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C380(1.15); C386(1.15)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C380(0.61); C386(0.61)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C380(0.80); C386(0.80)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C380(0.85); C386(0.85)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C380(0.76); C386(0.76)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C380(0.59); C386(0.59)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C380(0.61); C386(0.61)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C380(0.55); C386(0.55)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C380(0.55); C386(0.55)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C380(0.57); C386(0.57)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C316(0.95)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C155(0.73); C316(0.49); C321(0.49); C380(0.64)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C380(0.66); C386(0.66)  LDD0744  [2]
 LDCM0022  KB02 CMK C70(1.64)  LDD2302  [6]
 LDCM0023  KB03 CMK C70(2.29)  LDD2719  [6]
 LDCM0024  KB05 UACC257 C70(2.57)  LDD3325  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Myotubularin-related protein 6 (MTMR6) Protein-tyrosine phosphatase family Q9Y217
Myotubularin-related protein 7 (MTMR7) Protein-tyrosine phosphatase family Q9Y216
Myotubularin-related protein 8 (MTMR8) Protein-tyrosine phosphatase family Q96EF0
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Soluble lamin-associated protein of 75 kDa (FAM169A) FAM169 family Q9Y6X4
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
N-myc-interactor (NMI) NMI family Q13287
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
EMILIN-1 (EMILIN1) . Q9Y6C2
GRAM domain-containing protein 4 (GRAMD4) . Q6IC98
Protein hinderin (KIAA1328) . Q86T90

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840